Tue.Jun 25, 2024

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New podcast: How to utilise clinical trials in drug discovery

Drug Discovery World

This is the latest episode of the free DDW narrated podcast, titled “How to utilise clinical trials in drug discovery” which covers three articles written for Volume 24 – Issue 1, Winter 2022/2023 of DDW. They are called: Medicinal cannabis: Why more clinical trials and better access is needed , What are the opportunities for decentralised clinical trials?

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Non-stop flight: 4,200 km transatlantic flight of the Painted Lady butterfly mapped

Science Daily: Pharmacology News

In October 2013 a researcher made a surprising discovery of Painted Lady Butterflies on the Atlantic beaches of French Guiana -- a species not typically found in South America. This unusual sighting prompted an international study to investigate the origin of these butterflies.

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New study reveals promising drug target for treating osteoporosis

Drug Discovery World

Researchers have identified a novel target downstream of parathyroid hormone (PTH) signalling that suppresses bone formation in osteoporosis. The PTH-derived peptide teriparatide has demonstrated strong bone promoting effects. However, it is also to known to exert bone-resorbing effects. A new study uncovers a novel PTH-inducible target gene – Gprc5a which suppresses the proliferation and differentiation of ‘osteoblasts’ or bone-forming cells, and may serve as a therapeutic target in the treatme

RNA 147
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'A hearty debate' concludes plant-based meat alternatives are healthier for your heart than meat

Science Daily: Pharmacology News

Even though there is substantial variability in the contents and nutritional profiles of plant-based meat alternatives (PBMAs), the nutritional profiles tend to reflect a heart-healthy dietary pattern. A review article of the available studies directly comparing the impact of plant-based and animal-based meats consistently suggests that the plant-based alternatives improve cardiovascular risk factors.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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AI digital twins could replace control arm in clinical trials

Drug Discovery World

A new study demonstrates that AI-powered digital twin solutions can potentially replace the standard-of-care (SOC) control arm of a clinical trial. The paper was co-authored by analytics company Phesi and Dr Yi-Bin Chen, Director for the Blood and Marrow Transplant Program at Massachusetts General Hospital. Phesi created a digital twin for chronic graft versus host disease (cGvHD) in the primary treatment setting.

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Moving objects precisely with sound

Science Daily: Pharmacology News

Researchers have succeeded in directing floating objects around an aquatic obstacle course using only soundwaves. Their novel, optics-inspired method holds great promise for biomedical applications such as noninvasive targeted drug delivery.

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Wildfires increasingly threaten oil and gas drill sites, compounding potential health risks

Science Daily: Pharmacology News

More than 100,000 oil and gas wells across the western U.S. are in areas burned by wildfires in recent decades, a new study has found, and some 3 million people live next to wells that in the future could be in the path of fires worsened by climate change.

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FDA expands gene therapy use in Duchenne muscular dystrophy

Drug Discovery World

The US Food and Drug Administration (FDA) has expanded its approval for Elevidys (delandistrogene moxeparvovec-rokl) to include individuals with Duchenne muscular dystrophy (DMD) with a confirmed mutation in the DMD gene who are at least four years of age. Confirming the functional benefits, the FDA granted traditional approval for ambulatory patients.

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Slow-Release Ketamine Pill Eases Depression: Study

Drugs.com

TUESDAY, June 25, 2024 -- A new slow-release pill form of ketamine can quell hard-to-treat depression without producing psychedelic side effects normally associated with the drug, early research suggests. Patients on the strongest dose of ketamine.

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How to utilise clinical trials in drug discovery

Drug Discovery World

This is the latest episode of the free DDW narrated podcast, titled “How to utilise clinical trials in drug discovery” which covers three articles written for Volume 24 – Issue 1, Winter 2022/2023 of DDW. They are called: Medicinal cannabis: Why more clinical trials and better access is needed , What are the opportunities for decentralised clinical trials?

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Cholesterol Med, Fenofibrate, Might Slow Vision Loss in People With Diabetes

Drugs.com

TUESDAY, June 25, 2024 -- A well-established cholesterol-lowering drug appears to significantly slow the progression of a diabetes-related eye disease, a new trial shows. Fenofibrate (Tricor) has been approved since 2004 as a means of lowering.

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eBook: The impact of therapeutic antibody discovery

Drug Discovery World

A new eBook, sponsored by Sino Biological, is now available for download entitled ‘ The impact of therapeutic antibody discovery ’. The first monoclonal antibody (mAb), Orthoclone, was approved in 1986 to help prevent rejection in organ transplantation. Since then, the US Food and Drug Administration (FDA) has approved over 100 therapeutic antibodies.

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Marsquakes may help reveal whether liquid water exists underground on red planet

Science Daily: Pharmacology News

If liquid water exists today on Mars, it may be too deep underground to detect with traditional methods used on Earth. But listening to earthquakes that occur on Mars -- or marsquakes -- could offer a new tool in the search.

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Summer COVID Cases Are Rising Across America

Drugs.com

TUESDAY, June 25, 2024 -- As scorching summer temperatures drive Americans indoors and millions travel for vacations and family gatherings, COVID infections are again climbing, U.S. health officials warned Monday.In evidence that suggests a COVID.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Introducing DrugChatter: Revolutionizing Information Access

Drug Patent Watch

DrugChatter is an innovative AI-powered search and answer engine designed to revolutionize how we access and comprehend information. Harnessing the power of advanced natural language processing, DrugChatter provides concise, accurate, and contextually relevant answers to a wide array of questions, making information retrieval faster and more intuitive than ever before.

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Listeria Fears Spur Nationwide Ice Cream Recall

Drugs.com

TUESDAY, June 25, 2024 -- Check your freezer for multiple brands of ice cream that are being recalled by the maker, Totally Cool Inc., due to worries over listeria contamination. The full list of brands and recalled products can be found online.

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Telltale greenhouse gases could signal alien activity

Science Daily: Pharmacology News

If aliens modified a planet in their solar system to make it warmer, we'd be able to tell. A new study identifies the artificial greenhouse gases that would be giveaways of a terraformed planet.

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Loneliness Can Raise Older People's Odds for Stroke

Drugs.com

TUESDAY, June 25, 2024 -- A lonely middle and old age could bring higher odds for a stroke, new data suggests.A 12-year study of people over 50 found that those who experienced chronic loneliness were 56% more likely to have a stroke, versus those.

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Your future medications could be personalized for you on a 3D printer

Science Daily: Pharmacology News

Scientists are helping to develop standards and safety protocols that would allow pharmacies to print drugs onsite at a dosage best for you.

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Stem Cell Therapy Could Be Breakthrough Against Type 1 Diabetes

Drugs.com

TUESDAY, June 25, 2024 -- An experimental stem cell therapy can essentially cure type 1 diabetes by restoring insulin production in some patients, early clinical trial results show.Seven out of 12 patients no longer needed daily insulin shots after.

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USPTO Study Reveals Trends and Insights into Drug Patent and Exclusivity Trends in the Pharmaceutical Industry

Drug Patent Watch

Introduction: The United States Patent and Trademark Office (USPTO) has recently released a comprehensive study on drug patents and exclusivity trends in the pharmaceutical industry. The report, titled “USPTO Drug Patent and Exclusivity Study Report,” provides valuable insights into the patent landscape, patent duration, and exclusivity trends that shape the pharmaceutical industry.

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Despite Falling Out of Favor With Doctors, Daily Aspirin Still Popular

Drugs.com

TUESDAY, June 25, 2024 -- For decades, millions of Americans popped a low-dose aspirin each day to lower their heart risks. Then, accumulated data prompted the nation's two leading cardiology groups -- the American College of Cardiology and the.

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Exsilio debuts with $82M, pitching a ‘leap’ forward for genetic medicine

BioPharma Drive: Drug Pricing

The company claims it can address some of the field’s limitations with medicines delivered via messenger RNA and lipid nanoparticles.

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Cholesterol Med Might Slow Vision Loss in People With Diabetes

Drugs.com

TUESDAY, June 25, 2024 -- A well-established cholesterol-lowering drug appears to significantly slow the progression of a diabetes-related eye disease, a new trial shows.Fenofibrate (Tricor) has been approved since 2004 as a means of lowering.

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Robots face the future

Science Daily: Pharmacology News

Researchers have found a way to bind engineered skin tissue to the complex forms of humanoid robots. This brings with it potential benefits to robotic platforms such as increased mobility, self-healing abilities, embedded sensing capabilities and an increasingly lifelike appearance. Taking inspiration from human skin ligaments, the team included special perforations in a robot face, which helped a layer of skin take hold.

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U.S. Pedestrian Deaths Decline for First Time Since Pandemic

Drugs.com

TUESDAY, June 25, 2024 -- For the first time since the pandemic, it got a little safer to cross America's streets in 2023, new statistics show.According to data released Monday from the Governors Highway Safety Association (GHSA), 7,318 American.

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PRIDICT: Predicting Efficiencies of Prime Editing Guide RNAs

addgene Blog

Prime editing is a versatile genome editing technology that allows precise modifications of DNA (replacements, small insertions, and deletions) without introducing DNA double-strand breaks (Anzalone et al., 2019; Chen & Liu, 2023). This method uses a prime editor (typically a Cas9 H840A nickase fused to a reverse transcriptase) together with a prime editing guide RNA (pegRNA).

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Simple Paper-Strip Test Might Spot Flu, and Which Type You Have

Drugs.com

TUESDAY, June 25, 2024 -- A simple and inexpensive paper strip test could help diagnose a case of the flu, and even identify the influenza strain that caused it, a new study finds.The test can distinguish between influenza A and B -- the two main.

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Wave, with new data, plots path forward for Huntington’s drug

BioPharma Drive: Drug Pricing

The company plans to make a case to regulators for a new accelerated approval pathway. But investors didn't seem as hopeful, sending shares down by double digits.

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U.S. Surgeon General Declares Gun Violence a Public Health Emergency

Drugs.com

TUESDAY, June 25, 2024 -- Gun violence in the United States has become a national public health crisis, the U.S. Surgeon General declared Tuesday."Today, for the first time in the history of our office, I am issuing a Surgeon General's Advisory on.

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Testing Lightning Components from a QA Perspective

Perficient: Drug Development

Testing Lightning components is a crucial step in ensuring the quality and reliability of Salesforce applications. As a QA professional, it is essential to understand the unique challenges and best practices involved in testing these components. In this blog, we will explore the various approaches and tools available for testing Lightning components, highlighting the importance of both manual and automated testing methods.

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Wegovy Helps Heart Failure Patients Lose Weight, Improve Symptoms

Drugs.com

TUESDAY, June 24, 2024 -- Weight-loss drugs like Wegovy can improve symptoms in heart failure patients, a new clinical trial shows.Both men and women showed improved heart function after a year on semaglutide, the active ingredient in Ozempic and.

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Testing Visualforce Pages in Salesforce

Perficient: Drug Development

Testing Visualforce pages is essential to ensure the quality and reliability of Salesforce applications. As a QA professional, it’s important to understand the unique challenges and best practices involved in testing these pages. This blog will explore different methods and tools for testing Visualforce pages, highlighting the importance of both manual and automated testing.

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New tentative approval for Alembic drug dabigatran etexilate mesylate

Drug Patent Watch

Dabigatran etexilate mesylate is the generic ingredient in two branded drugs marketed by Alkem Labs Ltd, Apotex, Hetero Labs Ltd Iii, and Boehringer Ingelheim and, and is included in five NDAs. There are three patents protecting this compound. Drug patent litigation for DABIGATRAN ETEXILATE MESYLATE. Nine suppliers are listed for this compound.

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