Thu.May 23, 2024

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Scientists map networks regulating gene function in the human brain

Science Daily: Pharmacology News

A consortium of researchers has produced the largest and most advanced multidimensional maps of gene regulation networks in the brains of people with and without mental disorders. These maps detail the many regulatory elements that coordinate the brain's biological pathways and cellular functions. The research used postmortem brain tissue from over 2,500 donors to map gene regulation networks across different stages of brain development and multiple brain-related disorders.

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Costs, Side Effects Drive Folks to Quit New Weight-Loss Meds

Drugs.com

THURSDAY, May 23, 2024 -- Three months after starting one of the new GLP-1 weight-loss drugs, more than a quarter of patients have already quit the medications, and by a year from first use more than a third have stopped, new research shows.Reasons.

Research 124
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Birth of universe's earliest galaxies observed for first time

Science Daily: Pharmacology News

Researchers have now seen the formation of three of the earliest galaxies in the universe, more than 13 billion years ago. The sensational discovery contributes important knowledge about the universe.

Research 136
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1 in 9 U.S. Children Have Been Diagnosed With ADHD

Drugs.com

THURSDAY, May 23, 2024 -- About 1 in 9 American children have ever received an ADHD diagnosis, slightly more than the number of kids currently being treated for the disorder, a new study shows.About 7.1 million kids (11.4%) have ever been.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Mental disorders may spread in young people's social networks

Science Daily: Pharmacology News

A recently completed study demonstrates that mental disorders may be transmitted between individuals within social networks. The finding was the most evident in the case of mood, anxiety and eating disorders.

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Orna, a circular RNA specialist, acquires a buzzy startup

BioPharma Drive: Drug Pricing

After laying off staff late last year, Orna is expanding through the purchase of ReNAgade Therapeutics, which was built around technology designed to more effectively deliver RNA-based medicines.

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Shared Fentanyl Pipe Residue a New Overdose Danger

Drugs.com

THURSDAY, May 23, 2024 -- San Francisco researchers report that smoking has now replaced injections as the most common way of ingesting illicit fentanyl.That switch has created a potentially deadly new danger, however, as fentanyl residues slowly.

Research 116
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Planet hunters unveil massive catalog of strange worlds

Science Daily: Pharmacology News

While thousands of planets have been discovered around other stars, relatively little is known about them. A NASA catalog featuring 126 exotic, newly discovered worlds includes detailed measurements that allow for comparisons with our own solar system.

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ASCO24: An early look at cancer drug study results

BioPharma Drive: Drug Pricing

Clinical trial abstracts posted by ASCO Thursday give a peek at anticipated datasets from Immunocore, Merck & Co., J&J and Arcus Biosciences.

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Foraging ants navigate more efficiently when given energy-drink-like doses of caffeine

Science Daily: Pharmacology News

Ants who receive a caffeine-laced sugary reward become more efficient at navigating back to the reward's location compared to ants that only receive sugar. Caffeinated ants move toward the reward via a more direct path but do not increase their speed, suggesting that caffeine improved their ability to learn. The study was conducted on Argentine ants (Linepithema humile), a globally invasive species, and the researchers say that incorporating caffeine into ant baits could aid efforts to control t

Research 121
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Stroke Rates Are Rising, Especially Among the Young

Drugs.com

THURSDAY, May 23, 2024 -- The rate at which Americans under the age of 65 suffered a stroke rose by about 15% between 2011 and 2022, new government data shows.That was true even among the young: The rate of stroke jumped 14.6% among people ages 18.

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Birdsong and human voice built from same genetic blueprint

Science Daily: Pharmacology News

Humans have been long fascinated by bird song and the cacophony of other avian sounds -- from coos and honks to quacks and peeps. But little is known about how the unique vocal organ of birds -- the syrinx -- varies from species to species or its deeper evolutionary origins. A trio of recent studies is changing that. The studies include high-resolution anatomical scans of syrinxes from hummingbirds and ostriches -- the world's smallest and largest bird species -- and the discovery that the syrin

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Certain menopausal hormone therapy could raise ovarian cancer risk, study finds

BioPharma Drive: Drug Pricing

The findings, from two trials involving tens of thousands of women, could influence guidelines around the use of hormonal treatment for menopausal symptoms.

Therapies 114
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A promising approach to develop a birth control pill for men

Science Daily: Pharmacology News

Researchers show in animal models that a novel, non-hormonal sperm-specific approach offers a promising option for reversible human male contraception.

Research 127
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Ultra-Processed Foods Could Be Harming Your Brain

Drugs.com

THURSDAY, May 22, 2024 -- Ultra-processed foods are bad for more than your waistline: New research shows they seem to raise the risk of stroke and dementia-related memory or thinking problems.A 10% increase in the amount of ultra-processed foods a.

Research 105
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Potentially habitable 'exo-Venus' with Earth-like temperature discovered

Science Daily: Pharmacology News

Astronomers have made the rare and tantalizing discovery of an Earth-like exoplanet 40 light-years away that may be just a little warmer than our own world. The potentially-habitable planet, named Gliese 12 b, orbits its host star every 12.8 days, is comparable in size to Venus -- so slightly smaller than Earth -- and has an estimated surface temperature of 42 C (107 F), which is lower than most of the 5,000-odd exoplanets confirmed so far.

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CDC Reports Second Dairy Worker Infected With Bird Flu

Drugs.com

THURSDAY, MAY 23, 2024 -- A second case of bird flu has been detected in another dairy worker, this time in Michigan, U.S. health officials reported Wednesday.The first case was reported in a dairy worker in Texas in early April.Officials said the.

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Key role of plant-bacteria communication for the assembly of a healthy plant microbiome supporting sustainable plant nutrition

Science Daily: Pharmacology News

In an interdisciplinary study, researchers discovered that symbiotic bacteria communicate with legume plants through specific molecules and that this communication influences which bacteria grow near the plant roots. The findings provide insights into how plants and soil bacteria form beneficial partnerships for nutrient uptake and resilience. These results are a step towards understanding how communication between plants and soil bacteria can lead to specific beneficial associations providing p

Research 112
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Science Pinpoints Nutrients Crucial to Brain Health

Drugs.com

THURSDAY, May 23, 2024 -- Specific nutrients could play a pivotal role in the healthy aging of your brain, a new study finds.What’s more, those nutrients correlate closely with those found in the Mediterranean diet, an eating pattern already.

Science 105
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The global clean water crisis looms large

Science Daily: Pharmacology News

Water scarcity will intensify with climate and socioeconomic change, disproportionately impacting populations located in the Global South.

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Parents' Vaping Might Help Spur Eczema in Kids

Drugs.com

THURSDAY, May 23, 2024 -- A mom or dad who vapes at home might be setting their child up for eczema, new research suggests.In a study involving data from over 35,000 U.S. households, children with a parent who used e-cigarettes had a 24% higher.

Research 105
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Sexual parasitism helped anglerfish invade the deep sea during a time of global warming

Science Daily: Pharmacology News

Members of the vertebrate group including anglerfishes are unique in possessing a characteristic known as sexual parasitism, in which males temporarily attach or permanently fuse with females to mate. Now, researchers show that sexual parasitism arose during a time of major global warming and rapid transition for anglerfishes from the ocean floor to the deep, open sea.

Research 101
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Tips for Traveling With a Loved One With Alzheimer's

Drugs.com

THURSDAY, May 23, 2024 -- Experts are expecting this Memorial Day weekend to be the busiest yet, with nearly 44 million Americans projected to travel between Thursday and Monday.A fair number of those travelers will have a companion suffering from.

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What are PDX-Derived Organoids (PDXOs)?

Crown Bioscience

Learn about PDX-derived organoids, including PDXO establishment and utility in a pioneering drug discovery platform combining the benefits of in vitro PDXO and highly predictive in vivo PDX models.

Drugs 98
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'Moving Forward': Battling Parkinson's, He's Rowing His Way to Paralympic Games

Drugs.com

THURSDAY, May 23, 2024 -- For decades, Todd Vogt has been dedicated to the sport of rowing, believing he was in peak physical condition. Then, a series of symptoms began to emerge, turning his life upside down. "My left arm stopped swinging, and I.

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Will Coffee Plants Survive Climate Change? Genomes Reveal Clues from the Past

PLOS: DNA Science

I gaze at the ever-changing Starbucks menu, flummoxed. Should I get a skinny caramel macchiato? A java chip frappucino? Or a plain flat white? The many variations on the coffee theme might suggest a great diversity among the plants behind the drinks, but actually, about 60 percent of coffee is of the Arabica variety. Starbucks uses these beans exclusively, which are grown in only a few places in the world, where pathogens are scarce and climate favorable.

DNA 98
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Want to Feel Less Lonely? Spend Money on Experiences, not Things

Drugs.com

THURSDAY, May 23, 2024 -- Materialism could be fueling America’s epidemic of loneliness and isolation, a new study claims.People who spend their money on experiences tend to have stronger feelings of social connection with others than those who.

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Predicting cancer risks on the basis of national health data

Science Daily: Pharmacology News

Scientists are predicting individual risks for 20 different types of cancer with a high degree of accuracy. The prediction model could help to identify people with a high risk of cancer, for whom individualized early detection programs could be tested in studies.

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Hot Plasmids Spring 2024

addgene Blog

Every few months we highlight some of the new plasmids, antibodies, and viral preps in our repository through our Hot Plasmids articles.

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First pictures from Euclid satellite reveal billions of orphan stars

Science Daily: Pharmacology News

The first scientific pictures from the Euclid satellite mission have revealed more than 1,500 billion orphan stars scattered throughout the Perseus cluster of galaxies.

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Cytokinetics secures up to $575M in royalty deal, frustrating investors

BioPharma Drive: Drug Pricing

The biotech’s decision to give Royalty Pharma a greater share of future drug sales suggests a lower likelihood it is readying to be acquired, analysts said.

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YouTubers cheer people up more than casual friends, study suggests

Science Daily: Pharmacology News

One-sided relationships with YouTubers are more emotionally fulfilling than talking to casual friends, a new study suggests.

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Improving treatment responses to solid tumours with trispecific TCEs

Drug Target Review

What is the main advantage of TriTCE Co-Stim over conventional CD3-engaging bispecific T cell engagers (TCEs) in the treatment of solid tumours? The development of conventional CD3-engaging bispecific TCEs for solid tumours has progressed slowly compared to TCE development for hematologic malignancies and demonstrated limited antitumour activity. These challenges are related in part to limited intratumoural T cell availability and poor T cell function (T cell anergy) commonly present in solid tu