Science Daily: Pharmacology News

JULY 15, 2024

One of the most important controversies about human evolution and expansion is when and by what route the first hominids arrived in Europe from the African continent. Now, geological dating techniques at the Orce sites (Baza basin, Granada, Spain) place the human remains found in this area as the oldest in Europe, at approximately 1.3 million years old.

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BioPharma Drive: Drug Pricing

JULY 15, 2024

Updated results show the biotech's RAS inhibitor shrank pancreatic tumors in 20% to 25% of study participants, but with high rates of side effects like rash and nausea.

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Trials Drugs 126

Chemical Biology and Drug Design

JULY 15, 2024

The ability of binding pose metadynamics to improve the rankings of true targets predicted via pharmacophore mapping was investigated using three diverse ligands and their six true targets. Binding pose metadynamics improved the predicted rankings for four out of the six true targets, while also providing the highest-ranked predictions. Abstract Computational target fishing plays an important role in target identification, particularly in drug discovery campaigns utilizing phenotypic screening.

Drugs 100

Drugs Research 100

ASPET

JULY 15, 2024

XELOX therapy, which comprises capecitabine and oxaliplatin, is the standard first-line chemotherapeutic regimen for colorectal cancer. However, its myelosuppressive effects pose challenges for its clinical management. Mathematical modeling combining pharmacokinetics (PK) and toxicodynamics (TD) is a promising approach for optimizing dosing strategies and reducing toxicity.

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Pharmacokinetics Therapies Drugs Treatment 100

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Science Daily: Pharmacology News

JULY 15, 2024

Drastically cutting back on caloric intake to lose weight ahead of competition is commonplace among athletes. However, this type of 'dieting' doesn't just diminish performances, it can also compromise their immune systems.

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ASPET

JULY 15, 2024

Cannabis sativa L. has a long history of medicinal use, particularly for gastrointestinal diseases. Patients with inflammatory bowel disease (IBD) report using cannabis to manage their symptoms, despite little data to support the use of cannabis or cannabis products to treat the disease. In this study, we utilize the well-described dextran sodium sulfate (DSS) model of colitis in mice to assess the impact of commercially available, non-euphorigenic, high cannabigerol (CBG) hemp extract (20 mg/mL

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Disease Treatment Production 100

Antidote

JULY 15, 2024

Obesity, a condition that impacts 2 out of 5 adults in the United States , has become a significant health concern, both due to the impacts it has on individuals with the condition and the effect it can have on the overall medical system. It is estimated that obesity is responsible for nearly $1.73 billion in excess treatment costs annually, compounded by the fact that individuals with obesity are far more likely to have other conditions such as hypertension, diabetes, and osteoarthritis.

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Treatment 111

Science Daily: Pharmacology News

JULY 15, 2024

A network of proteins found in the central nervous system could be harnessed to increase the effectiveness and reduce the side effects of popular diabetes and weight-loss drugs, according to new research.

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Research Drugs 113

Drugs.com

JULY 15, 2024

MONDAY, July 15, 2024 -- An experimental drug appears to help women deal with stress incontinence, clinical trial data show.The drug, for now dubbed TAS-303, reduced the frequency of leaks related to stress incontinence by about 58%, compared with.

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Clinical Trials Trials Drugs 111

Science Daily: Pharmacology News

JULY 15, 2024

An international study reveals the extreme atmospheric conditions on the celestial objects, which are swathed in swirling clouds of hot sand amid temperatures of 950C. Using NASA's powerful James Webb Space Telescope (JWST), researchers set out to capture the weather on a pair of brown dwarfs -- cosmic bodies that are bigger than planets but smaller than stars.

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International Research 107

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drugs.com

JULY 15, 2024

MONDAY, July 15, 2024 -- Actress Shannen Doherty, best known for her roles in 1990s television hits such as “Beverly Hills, 90210” and “Charmed," has died at 53 after a long struggle with breast cancer.In a statement, Doherty's publicist, Leslie Slo.

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Science Daily: Pharmacology News

JULY 15, 2024

Our universe is around 13.8 billion years old. Over the vastness of this time, the tiniest of initial asymmetries have grown into the large-scale structures we can see through our telescopes in the night sky: galaxies like our own Milky Way, clusters of galaxies, and even larger aggregations of matter or filaments of gas and dust. How quickly this growth takes place depends, at least in today's universe, on a sort of wrestling match between natural forces: Can dark matter, which holds everything

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Drugs.com

JULY 15, 2024

MONDAY, July 15, 2024 -- Some diabetes drugs appear to lower the risk that people with type 2 diabetes will develop dementia or Alzheimer’s disease, a new evidence review says.The risk of dementia and Alzheimer’s is significantly lower in patients t.

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Drugs Disease 97

Science Daily: Pharmacology News

JULY 15, 2024

Researchers announced the latest findings from the James Webb Space Telescope (JWST) of the supernova remnant, Cassiopeia A (Cas A). These observations of the youngest known core collapse supernova in the Milky Way provide insights into the conditions that lead to the formation and destruction of molecules and dust within supernova ejecta. The study's findings change our understanding of dust formation in the early universe in the galaxies detected by JWST 300 million years after the Big Bang.

Research 101

Research 101

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

NIOSH Science Blog: Drugs

JULY 15, 2024

A Discussion Paper, Streamlining Regulatory Oversight of Respirators Used in Health Care Settings will Improve Worker Protection, was recently published in the National Academy of Medicine’s NAM Perspectives journal by respiratory experts outside of the federal government. This paper highlights continued confusion amongst interested parties including health care organizations and manufacturers seeking approval regarding federal regulations and guidance on the use of air-purifying respirators (AP

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Regulations Government 95

Science Daily: Pharmacology News

JULY 15, 2024

Researchers using NASA's James Webb Space Telescope have finally confirmed what models have previously predicted: An exoplanet has differences between its eternal morning and eternal evening atmosphere. WASP-39 b, a giant planet with a diameter 1.3 times greater than Jupiter, but similar mass to Saturn that orbits a star about 700 light-years away from Earth, is tidally locked to its parent star.

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Research 99

Drugs.com

JULY 15, 2024

MONDAY, July 15, 2024 -- Five poultry workers in Colorado have been diagnosed with bird flu, state health officials reported Sunday."In coordination with the Colorado Department of Agriculture, the State Emergency Operations Center and Centers for.

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Drug Patent Watch

JULY 15, 2024

The Strategic Advantage of Complex Drug Delivery Systems In the highly competitive pharmaceutical landscape, adopting complex drug delivery systems can […] Source

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Pharmaceuticals Drugs 89

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Science Daily: Pharmacology News

JULY 15, 2024

Early exposure to antibiotics can trigger long term susceptibility to asthma, according to new research. Importantly the research team isolated a molecule produced by gut bacteria that in the future could potentially be trialed as a simple treatment, in the form of a dietary supplement, for children at risk of asthma to prevent them developing the disease.

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Trials Treatment Disease Research 81

The ChEMBL-og

JULY 15, 2024

Dear SureChEMBL users, About six months ago, we introduced the new version of SureChEMBL. It brought significant improvements in terms of performance and stability, and it also allows us to implement new functionalities. After the survey at the beginning of the year, we prioritised what should be delivered first. You should see the materialisation of our work in the coming months.

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BioPharma Drive: Drug Pricing

JULY 15, 2024

The company claims the results support exploring the possibility of an accelerated approval, citing flexibility by FDA officials in reviewing rare disease gene therapies.

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Therapies FDA Disease 73

Drugs.com

JULY 15, 2024

MONDAY, July 15, 2024 -- More than four years after the pandemic began, childhood vaccination rates worldwide have yet to recover, a new report shows.The latest data, issued Monday by the World Health Organization and the United Nations.

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Vaccine 64

FDA Law Blog: Biosimilars

JULY 15, 2024

By John W.M. Claud & JP Ellison — The Supreme Court’s recent decision in Loper Bright v. Raimondo has done away with Chevron deference to federal agencies’ interpretation of ambiguous statutes, including the FDA. The decision commands that federal judges must make their own decisions in suits against FDA, considering—but not deferring to—the Agency’s interpretation of ambiguous statutory provisions.

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FDA International Biosimilars Drugs 57

Drug Patent Watch

JULY 15, 2024

An HHS report titled “The Potential Role of The Nonprofit Pharmaceutical Industry in Addressing Shortages and Increasing Access to Essential […] Source

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Pharmaceuticals 59

Fierce BioTech

JULY 15, 2024

Nitrosamines in Focus: Regulatory Requirements and Best Practices dwunderlin Mon, 07/15/2024 - 11:10 Thu, 09/12/2024 - 10:00 Resource Type Webinar Chris Williams Chad Bastian Duration 60 Minutes Nitrosamines, potent carcinogens, have prompted stringent regulations for their detection and control in various products. Regulatory bodies demand robust analytical methods and timely risk assessments.

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Compliance Laboratories Pharmaceuticals Regulations 52

Drug Patent Watch

JULY 15, 2024

This chart shows the drugs with the most patents in Sweden. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is desired.

Pharmaceuticals 52

Pharmaceuticals Drugs 52

Crown Bioscience

JULY 15, 2024

The rapid increase of precision oncology approaches in recent years has been fueled in part by technological innovations and an increased interest in personalized therapies. Precision medicine approaches rely on biomarkers to define optimal treatment strategies and also play important roles in the diagnosis of disease, treatment efficacy assessment, and/or disease progression.

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RNA Therapies Treatment Disease 52

Drug Patent Watch

JULY 15, 2024

Dabigatran etexilate mesylate is the generic ingredient in two branded drugs marketed by Alkem Labs Ltd, Apotex, Hetero Labs Ltd Iii, and Boehringer Ingelheim and, and is included in five NDAs.

Drugs 52

Drugs Marketing 52

Crown Bioscience

JULY 15, 2024

In the world of RNA analysis, researchers have an array of technologies at their disposal. Each method comes with its unique strengths, making the choice dependent on specific research needs and constraints. In this post, we'll delve into three popular RNA analysis methods— transcriptome-wide RNA-Seq, Nanostring nCounter, and targeted RNA-Seq panels—comparing their features and discussing when to use each.

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RNA Research 52

Drug Patent Watch

JULY 15, 2024

Annual Drug Patent Expirations for XEGLYZE Xeglyze is a drug marketed by Hatchtech and is included in one NDA. It is available from one supplier. There are five patents protecting this drug.

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Drugs Marketing 52

thought leadership

JULY 15, 2024

The term Functional Service Provider (FSP) concept is highly regarded in the field of clinical research. With drug discovery and clinical trials becoming more complex, pharmaceutical firms and research organizations are searching for flexible and customized solutions. The tried and true FSP model has been a practical and cost-effective approach to address these challenges effectively.

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Clinical Research Research Clinical Trials Pharmaceuticals 52

Drugs.com

JULY 15, 2024

MONDAY, July 15, 2024 -- Many tweens and teens are filling prescriptions for opioids far in advance of surgeries unlikely to be associated with severe pain afterward, a new study says.Worse, a significant minority continue to fill those opioid.

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Perficient: Drug Development

JULY 15, 2024

I recently worked with a client who wanted to restrict access to specific properties of the content types. We set up some Editor Descriptor attributes, and applied a decorator to the properties in the model classes, which worked well. Then they wanted changes. The problem is that figuring out who has access requires looking at the code. Any updates require code changes, which becomes a big deal when the properties are already in Production.

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Production 52