Drugs.com

DECEMBER 23, 2023

SATURDAY, Dec. 23, 2023 -- The holidays are all about treats and most pets are thrilled to partake in the indulging, but some foods you might give them could make them sick or worse. "Pets tend to get more treats at holiday time -- from their.

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Covalent Modifiers

DECEMBER 23, 2023

Jared R. Ramsey, Patrick M. M. Shelton, Tyler K. Heiss, Paul Dominic B. Olinares, Lauren E. Vostal, Heather Soileau, Michael Grasso, Sara W. Casebeer, Stephanie Adaniya, Michael Miller, Shan Sun, David J. Huggins, Robert W. Myers, Brian T. Chait, Ekaterina V. Vinogradova, and Tarun M. Kapoor Journal of the American Chemical Society 2024 DOI: 10.1021/jacs.3c10581 Helicases, classified into six superfamilies, are mechanoenzymes that utilize energy derived from ATP hydrolysis to remodel DNA and RNA

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RNA DNA Virus 77

Drug Patent Watch

DECEMBER 23, 2023

This chart shows the drugs with the most patents in Germany. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is desired.… The post Which pharmaceutical drugs have the most drug patents in Germany? appeared first on DrugPatentWatch - Make Better Decisions.

Pharmaceuticals 59

Pharmaceuticals Drugs 59

Covalent Modifiers

DECEMBER 23, 2023

Kristopher W. Hoyt, Daniel A. Urul, Blessing C. Ogboo, Florian Wittlinger, Stefan A. Laufer, Erik M. Schaefer, Earl W. May, and David E. Heppner Journal of Medicinal Chemistry 2024 DOI: 10.1021/acs.jmedchem.3c01502 Enzyme inhibitors that form covalent bonds with their targets are being increasingly pursued in drug development. Assessing their biochemical activity relies on time-dependent assays, which are distinct and more complex compared with methods commonly employed for reversible-binding in

Drug Development 55

Drug Development Drugs 55

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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