Expanding the ligandable proteome by paralog hopping with covalent probes
Covalent Modifiers
JANUARY 20, 2024
Yuanjin Zhang , Zhonglin Liu , Marsha Hirschi , Oleg Brodsky , Eric Johnson , Sang Joon Won , Asako Nagata , Matthew D Petroski , Jaimeen D Majmudar , Sherry Niessen , Todd VanArsdale , Adam M Gilbert , Matthew M Hayward , Al E Stewart , Andrew R Nager , Bruno Melillo , Benjamin F Cravatt bioRxiv 2024.01.18.576274; doi: [link] More than half of the ~20,000 protein-encoding human genes have at least one paralog.
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