Drug Discovery World
JUNE 18, 2024
Researchers have developed a new antibiotic that reduced or eliminated drug-resistant bacterial infections in mouse models of acute pneumonia and sepsis while sparing healthy microbes in the gut. The drug, called lolamicin, also warded off secondary infections with Clostridioides difficile, and was effective against more than 130 multidrug-resistant bacterial strains in cell culture.
Broad Institute
JUNE 18, 2024
Simple test for flu could improve diagnosis and surveillance By Allessandra DiCorato June 18, 2024 Breadcrumb Home Simple test for flu could improve diagnosis and surveillance A low-cost CRISPR-based paper strip test distinguishes between influenza types and can be reprogrammed to recognize different viruses including the H5N1 bird flu virus. By Allessandra DiCorato June 18, 2024 Credit: Jon Arizti-Sanz SHINE, a rapid diagnostic test developed by Pardis Sabeti's lab in 2020, uses paper strips an
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Chemical Biology and Drug Design
JUNE 18, 2024
Medicinal chemistry of piperazine and its derivatives. Abstract The versatile basic structure of piperazine allows for the development and production of newer bioactive molecules that can be used to treat a wide range of diseases. Piperazine derivatives are unique and can easily be modified for the desired pharmacological activity. The two opposing nitrogen atoms in a six-membered piperazine ring offer a large polar surface area, relative structural rigidity, and more acceptors and donors of hyd
Science Daily: Pharmacology News
JUNE 18, 2024
Scientists discovered that Neolamprologus savoryi fish use punishment to encourage offspring to cooperate in brood care, revealing advanced cognitive abilities previously thought unique to higher vertebrates. This study highlights that punishment for promoting cooperation exists beyond human societies, prompting a reevaluation of animal intelligence.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drugs.com
JUNE 18, 2024
TUESDAY, June 18, 2024 -- Patients are less likely to fill prescriptions for the overdose-reversing drug naloxone when they have to shell out more at the pharmacy, a new study finds.Naloxone (also known by the brand name Narcan) is a critical.
Science Daily: Pharmacology News
JUNE 18, 2024
The potential of quantum computers is currently thwarted by a trade-off problem. Quantum systems that can carry out complex operations are less tolerant to errors and noise, while systems that are more protected against noise are harder and slower to compute with. Now a research team has created a unique system that combats the dilemma, thus paving the way for longer computation time and more robust quantum computers.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Science Daily: Pharmacology News
JUNE 18, 2024
The rise of advanced artificial intelligence (edge AI) could well mark the beginning of a new era for sustainable agriculture. A recent study proposes a roadmap for integrating this technology into farming practices. The aim? To improve the efficiency, quality and safety of agricultural production, while addressing a range of environmental, social and economic challenges.
Drugs.com
JUNE 18, 2024
TUESDAY, June 18, 2024 -- Two new studies offer reassurance that using the diabetes drug metformin before and during pregnancy is not linked to birth defects.The latest findings, which apply to men planning to conceive with their partners or women.
Science Daily: Pharmacology News
JUNE 18, 2024
In late 2019 the previously unremarkable galaxy SDSS1335+0728 suddenly started shining brighter than ever before. To understand why, astronomers have used data from several space and ground-based observatories, including the European Southern Observatory's Very Large Telescope (ESO's VLT), to track how the galaxy's brightness has varied. In a study out today, they conclude that they are witnessing changes never seen before in a galaxy -- likely the result of the sudden awakening of the massive b
Drugs.com
JUNE 18, 2024
TUESDAY, June 18, 2024 -- As marijuana use becomes legal and more accepted across America, more seniors are developing unhealthy relationships with the drug, a new report suggests.A look at data on almost 56 million Medicare beneficiaries finds.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Drug Patent Watch
JUNE 18, 2024
Branded generics are generic drugs that are marketed under a brand name by the manufacturer. These products contain the same active ingredients as their brand-name counterparts but are typically sold at a lower price point. Branded generics can be an attractive option for both consumers and pharmaceutical companies, offering cost savings while leveraging brand recognition.
Drugs.com
JUNE 18, 2024
TUESDAY, June 18, 2024 -- A new blood test might be able to predict Parkinson’s disease up to seven years before symptoms of the movement disorder surface, researchers said.The test correctly predicted a high risk of Parkinson’s in 16 patients who w.
Science Daily: Pharmacology News
JUNE 18, 2024
New simulations show that hot neutrinos created at the interface of merging binary neutron stars are briefy trapped and remain out of equilibrium with the cold cores of the stars for 2 to 3 milliseconds.
Drugs.com
JUNE 18, 2024
TUESDAY, June 18, 2024 -- The average American diet has only improved modestly over the past two decades, despite tons of research tying unhealthy food to obesity, type 2 diabetes and heart disease, a new study finds.The percentage of U.S. adults.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Crown Bioscience
JUNE 18, 2024
Explore the ‘undruggable’ oncology target RAS, inhibitory techniques used on downstream pathways, and the preclinical models available to test up-and-coming RAS targeted agents.
Drugs.com
JUNE 18, 2024
TUESDAY, June 18, 2024 -- There's more good news in the battle against sickle cell disease, with another trial finding CRISPR gene-editing therapy delivering impressive results for patients.“It’s encouraging that this gene-editing treatment con.
Science Daily: Pharmacology News
JUNE 18, 2024
The effects of coffee consumption on human health is a knotty question, but one thing is sure: coffee is a psychoactive substance.
BioPharma Drive: Drug Pricing
JUNE 18, 2024
Belharra will use its chemoproteomics technology to identify immune drugs for Sanofi. Elsewhere, Regenxbio mapped a regulatory path and Taysha shared updated results for its Rett treatment.
Science Daily: Pharmacology News
JUNE 18, 2024
A new technique can model an entire 3D scene, including areas hidden from view, from just one camera image. The method relies on image shadows, which provide information about the geometry and location of hidden objects.
Fierce BioTech
JUNE 18, 2024
Experts recommend that CGT manufacturers proactively design a comprehensive market access strategy early in clinical development and commercial planning timelines, ideally more than three years pri | CGT companies should consider developing a market access strategy early in clinical development, ideally more than three years prior to launch.
Science Daily: Pharmacology News
JUNE 18, 2024
A new study shows soot from large wildfires in California traps sunlight, making days warmer and drier than they ought to be.
BioPharma Drive: Drug Pricing
JUNE 18, 2024
While the Swiss pharma recently pruned its neurology drug pipeline, it has shown interest in the possibilities of RNA-focused approaches like what Ascidian is exploring.
Science Daily: Pharmacology News
JUNE 18, 2024
A white wine over 2,000 years old, of Andalusian origin, is the oldest wine ever discovered.
BioPharma Drive: Drug Pricing
JUNE 18, 2024
With a drug licensed from Novartis, the new biotech startup aims to reduce the ‘remnant’ cholesterol it says existing medicines can’t address.
Drug Patent Watch
JUNE 18, 2024
Annual Drug Patent Expirations for XIFAXAN Xifaxan is a drug marketed by Salix Pharms and is included in one NDA. It is available from three suppliers. There are twenty-nine patents protecting this drug and two Paragraph IV challenges. XIFAXAN drug price trends. Drug patent litigation for XIFAXAN.
BioPharma Drive: Drug Pricing
JUNE 18, 2024
The results position the company to unlock what’s believed to be a multibillion-dollar sales opportunity for Caplyta, which is already used to treat schizophrenia and bipolar disorder.
Drug Patent Watch
JUNE 18, 2024
Annual Drug Patent Expirations for JAKAFI Jakafi is a drug marketed by Incyte Corp and is included in one NDA. It is available from one supplier. There are eight patents protecting this drug and one Paragraph IV challenge. Drug patent litigation for JAKAFI. The generic ingredient in JAKAFI is ruxolitinib phosphate.
Drugs.com
JUNE 18, 2024
TUESDAY, June 18, 2024 -- Eating fish while pregnant doesn’t appear to increase a child’s later risk of juvenile arthritis, particularly if the fish is oily like salmon, trout or sardines, new research shows.“We cannot caution pregnant women again.
Drug Patent Watch
JUNE 18, 2024
Annual Drug Patent Expirations for RINVOQ Rinvoq is a drug marketed by Abbvie and is included in two NDAs. It is available from one supplier. There are thirty-three patents protecting this drug. Drug patent litigation for RINVOQ. This drug has one hundred and seventy-seven patent family members in forty-one countries.
Drugs.com
JUNE 18, 2024
TUESDAY, June 18, 2024 -- Adults' phobias can be correlated with changes in the structure of their brains, a new study finds.What’s more, the neurological differences seen in adults with phobias are more extensive than those observed in people with.
Drug Patent Watch
JUNE 18, 2024
Annual Drug Patent Expirations for RINVOQ+LQ Rinvoq Lq is a drug marketed by Abbvie and is included in one NDA. It is available from one supplier. The generic ingredient in RINVOQ LQ is upadacitinib. One supplier is listed for this compound. Additional details are available on the upadacitinib profile page.
Drugs.com
JUNE 18, 2024
TUESDAY, June 18, 2024 -- In a success story for Americans seeking affordable healthcare coverage, tax credits put in place during the pandemic helped millions gain health insurance, a new report found.Trouble is, the credits are set to expire at.
BioPharma Drive: Drug Pricing
JUNE 18, 2024
The new vaccine, which Merck will sell as Capvaxive, will compete with Pfizer’s blockbuster Prevnar franchise.
Vial
JUNE 18, 2024
The success of clinical trials hinges on increasing access to participation by all eligible patients, including populations that have been underrepresented due to the barriers highlighted below. Researchers understand the importance of diversity in clinical trials, and to ensure or increase it, they must evaluate each study and its unique characteristics to uncover the barriers and facilitators of participation.
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