Broad Institute

JUNE 18, 2024

Simple test for flu could improve diagnosis and surveillance By Allessandra DiCorato June 18, 2024 Breadcrumb Home Simple test for flu could improve diagnosis and surveillance A low-cost CRISPR-based paper strip test distinguishes between influenza types and can be reprogrammed to recognize different viruses including the H5N1 bird flu virus. By Allessandra DiCorato June 18, 2024 Credit: Jon Arizti-Sanz SHINE, a rapid diagnostic test developed by Pardis Sabeti's lab in 2020, uses paper strips an

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Chemical Biology and Drug Design

JUNE 18, 2024

Medicinal chemistry of piperazine and its derivatives. Abstract The versatile basic structure of piperazine allows for the development and production of newer bioactive molecules that can be used to treat a wide range of diseases. Piperazine derivatives are unique and can easily be modified for the desired pharmacological activity. The two opposing nitrogen atoms in a six-membered piperazine ring offer a large polar surface area, relative structural rigidity, and more acceptors and donors of hyd

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Production Disease Research Drugs 100

Science Daily: Pharmacology News

JUNE 18, 2024

A single large population of healer cells, called regulatory T cells, is whizzing around our body -- not multiple specialist populations restricted to specific parts of the body as previously thought. These cells shut down inflammation and repair the collateral damage to cells caused after our immune system has responded to injury or illness. Tests, in mice, of a drug developed by the researchers showed that regulatory T cells can be attracted to specific body parts, boosted in number, and activ

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Treatment Immune Response Disease Clinical Trials 124

Drugs.com

JUNE 18, 2024

TUESDAY, June 18, 2024 -- Patients are less likely to fill prescriptions for the overdose-reversing drug naloxone when they have to shell out more at the pharmacy, a new study finds.Naloxone (also known by the brand name Narcan) is a critical.

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Pharmacy Drugs 115

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Science Daily: Pharmacology News

JUNE 18, 2024

Scientists discovered that Neolamprologus savoryi fish use punishment to encourage offspring to cooperate in brood care, revealing advanced cognitive abilities previously thought unique to higher vertebrates. This study highlights that punishment for promoting cooperation exists beyond human societies, prompting a reevaluation of animal intelligence.

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Drugs.com

JUNE 18, 2024

TUESDAY, June 18, 2024 -- Despite all the grumbling at the time, most Americans now look back upon pandemic-era policies as a good idea, a new poll shows.A majority of Americans see four key pandemic policies as “generally a good idea” in ret.

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Drugs.com

JUNE 18, 2024

TUESDAY, June 18, 2024 -- Two new studies offer reassurance that using the diabetes drug metformin before and during pregnancy is not linked to birth defects.The latest findings, which apply to men planning to conceive with their partners or women.

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Drugs 111

Science Daily: Pharmacology News

JUNE 18, 2024

The rise of advanced artificial intelligence (edge AI) could well mark the beginning of a new era for sustainable agriculture. A recent study proposes a roadmap for integrating this technology into farming practices. The aim? To improve the efficiency, quality and safety of agricultural production, while addressing a range of environmental, social and economic challenges.

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Production 116

Drugs.com

JUNE 18, 2024

TUESDAY, June 18, 2024 -- As marijuana use becomes legal and more accepted across America, more seniors are developing unhealthy relationships with the drug, a new report suggests.A look at data on almost 56 million Medicare beneficiaries finds.

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Drugs 105

Science Daily: Pharmacology News

JUNE 18, 2024

In late 2019 the previously unremarkable galaxy SDSS1335+0728 suddenly started shining brighter than ever before. To understand why, astronomers have used data from several space and ground-based observatories, including the European Southern Observatory's Very Large Telescope (ESO's VLT), to track how the galaxy's brightness has varied. In a study out today, they conclude that they are witnessing changes never seen before in a galaxy -- likely the result of the sudden awakening of the massive b

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drugs.com

JUNE 18, 2024

TUESDAY, June 18, 2024 -- A new blood test might be able to predict Parkinson’s disease up to seven years before symptoms of the movement disorder surface, researchers said.The test correctly predicted a high risk of Parkinson’s in 16 patients who w.

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Disease Research 105

Science Daily: Pharmacology News

JUNE 18, 2024

New simulations show that hot neutrinos created at the interface of merging binary neutron stars are briefy trapped and remain out of equilibrium with the cold cores of the stars for 2 to 3 milliseconds.

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Drugs.com

JUNE 18, 2024

TUESDAY, June 18, 2024 -- The average American diet has only improved modestly over the past two decades, despite tons of research tying unhealthy food to obesity, type 2 diabetes and heart disease, a new study finds.The percentage of U.S. adults.

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Disease Research 105

Crown Bioscience

JUNE 18, 2024

Explore the ‘undruggable’ oncology target RAS, inhibitory techniques used on downstream pathways, and the preclinical models available to test up-and-coming RAS targeted agents.

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Clinical Trials

Drugs.com

JUNE 18, 2024

TUESDAY, June 18, 2024 -- There's more good news in the battle against sickle cell disease, with another trial finding CRISPR gene-editing therapy delivering impressive results for patients.“It’s encouraging that this gene-editing treatment con.

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Therapies Trials Treatment Disease 105

Advarra

JUNE 18, 2024

Clinical research is complex and resource-intensive, and to understand just how far an organization’s resources can go, assessing a study’s feasibility is critical for success. Evaluating feasibility elements enable organizations to make informed decisions and allows for seamless execution and reporting of clinical studies. How can your organization utilize feasibility to its fullest extent?

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Clinical Trials Trials Clinical Research International 97

Science Daily: Pharmacology News

JUNE 18, 2024

The effects of coffee consumption on human health is a knotty question, but one thing is sure: coffee is a psychoactive substance.

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Drug Patent Watch

JUNE 18, 2024

This chart shows the drugs with the most patents in New Zealand. Patents must be filed in each country (or, in some cases regional patent office) where patent protection is desired.

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Drugs Pharmaceuticals 88

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Science Daily: Pharmacology News

JUNE 18, 2024

A new technique can model an entire 3D scene, including areas hidden from view, from just one camera image. The method relies on image shadows, which provide information about the geometry and location of hidden objects.

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Research 86

Drug Patent Watch

JUNE 18, 2024

Branded generics are generic drugs that are marketed under a brand name by the manufacturer. These products contain the same active ingredients as their brand-name counterparts but are typically sold at a lower price point. Branded generics can be an attractive option for both consumers and pharmaceutical companies, offering cost savings while leveraging brand recognition.

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Pharmaceutical Companies Pharmaceuticals Production Marketing 81

Science Daily: Pharmacology News

JUNE 18, 2024

A new study shows soot from large wildfires in California traps sunlight, making days warmer and drier than they ought to be.

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Fierce BioTech

JUNE 18, 2024

Experts recommend that CGT manufacturers proactively design a comprehensive market access strategy early in clinical development and commercial planning timelines, ideally more than three years pri | CGT companies should consider developing a market access strategy early in clinical development, ideally more than three years prior to launch.

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Marketing Clinical Development 75

Science Daily: Pharmacology News

JUNE 18, 2024

A white wine over 2,000 years old, of Andalusian origin, is the oldest wine ever discovered.

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BioPharma Drive: Drug Pricing

JUNE 18, 2024

Belharra will use its chemoproteomics technology to identify immune drugs for Sanofi. Elsewhere, Regenxbio mapped a regulatory path and Taysha shared updated results for its Rett treatment.

Drug Research 67

Drug Research Research Drugs Treatment 67

Codon

JUNE 18, 2024

In the 1890s, a German microbiologist named Dr. Heinrich Klebahn took a train to the quaint town of Plön and met a friend at the train station there. The following day, the two men rowed a canoe through one of the nearby cerulean lakes, their oars slicing through the water’s calm surface. As the men glided further into the lake, they arrived at a “yellowish clump” that appeared strangely bright in the sun’s afternoon rays.

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Engineering Laboratories International Clinical Trials 65

BioPharma Drive: Drug Pricing

JUNE 18, 2024

While the Swiss pharma recently pruned its neurology drug pipeline, it has shown interest in the possibilities of RNA-focused approaches like what Ascidian is exploring.

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RNA Drugs 67

Drug Patent Watch

JUNE 18, 2024

Annual Drug Patent Expirations for XIFAXAN Xifaxan is a drug marketed by Salix Pharms and is included in one NDA. It is available from three suppliers. There are twenty-nine patents protecting this drug and two Paragraph IV challenges. XIFAXAN drug price trends. Drug patent litigation for XIFAXAN.

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Drugs Marketing 59

BioPharma Drive: Drug Pricing

JUNE 18, 2024

With a drug licensed from Novartis, the new biotech startup aims to reduce the ‘remnant’ cholesterol it says existing medicines can’t address.

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Licensing Licensing Drugs 67

Drug Patent Watch

JUNE 18, 2024

Annual Drug Patent Expirations for JAKAFI Jakafi is a drug marketed by Incyte Corp and is included in one NDA. It is available from one supplier. There are eight patents protecting this drug and one Paragraph IV challenge. Drug patent litigation for JAKAFI. The generic ingredient in JAKAFI is ruxolitinib phosphate.

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Drugs Marketing 59

BioPharma Drive: Drug Pricing

JUNE 18, 2024

The results position the company to unlock what’s believed to be a multibillion-dollar sales opportunity for Caplyta, which is already used to treat schizophrenia and bipolar disorder.

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Drugs 60

Drug Patent Watch

JUNE 18, 2024

Annual Drug Patent Expirations for RINVOQ Rinvoq is a drug marketed by Abbvie and is included in two NDAs. It is available from one supplier. There are thirty-three patents protecting this drug. Drug patent litigation for RINVOQ. This drug has one hundred and seventy-seven patent family members in forty-one countries.

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Drugs Marketing 59

Drugs.com

JUNE 18, 2024

TUESDAY, June 18, 2024 -- Eating fish while pregnant doesn’t appear to increase a child’s later risk of juvenile arthritis, particularly if the fish is oily like salmon, trout or sardines, new research shows.“We cannot caution pregnant women again.

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Research 59

Drug Patent Watch

JUNE 18, 2024

Annual Drug Patent Expirations for RINVOQ+LQ Rinvoq Lq is a drug marketed by Abbvie and is included in one NDA. It is available from one supplier. The generic ingredient in RINVOQ LQ is upadacitinib. One supplier is listed for this compound. Additional details are available on the upadacitinib profile page.

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Drugs Marketing 59