Sun.Oct 27, 2024

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Melting Arctic sea-ice could affect global ocean circulation

Science Daily: Pharmacology News

The warming climate in polar regions may significantly disrupt ocean circulation patterns, a new study indicates. Scientists discovered that in the distant past, growing inflows of freshwater from melting Arctic sea-ice into the Nordic Seas likely significantly affected ocean circulation, sending temperatures plummeting across northern Europe.

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Halloween Can Be Extra Scary for Folks With Dementia. An Expert Offers Caregiver Tips

Drugs.com

MONDAY, Oct. 28, 2025 -- Halloween is meant to be a spooky season, but it can be downright terrifying to someone suffering from Alzheimer’s disease or dementia.“Halloween is full of scary sights and frightful sounds that create additional cha.

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With $92M, Kivu sets out to make ‘kinder, gentler’ ADCs

BioPharma Drive: Drug Pricing

The startup claims its proprietary linker molecules can yield ADCs that are more precise and potent than existing options.

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More social species live longer

Science Daily: Pharmacology News

New research has revealed that species that are more social live longer and produce offspring for a greater time-span. This is the first study on this topic which spans the animal kingdom, from jellyfish to humans.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Chemical Biology and Drug Design

Cover Image © molekuul_be/Shutterstock.

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Discovery and development of Krazati (adagrasib/MRTX849), a potent, selective, orally bioavailable, covalent KRASG12C(OFF) inhibitor

Covalent Modifiers

Adrian L. Gill, Mathew A. Marx RAS Drug Discovery Past, Present and Future 2025 , 205-227 [link] Krazati (adagrasib/MRTX849) is a potent, selective, and covalent KRAS G12C inhibitor, representing a significant breakthrough in directly targeting KRAS. Adagrasib demonstrates favorable drug-like properties, selectively modifying mutant cysteine 12 in GDP-bound KRAS G12C , leading to the inhibition of KRAS-dependent signaling both in vitro and in vivo, and tumor regression in many KRAS G12C -positiv

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The Persistent Problem: Why Hospitals Keep Running Out of Generic Drugs

Drug Patent Watch

A troubling trend has emerged in recent years, leaving both healthcare providers and patients grappling with an unexpected challenge: the persistent shortage of generic drugs in hospitals. This issue has far-reaching consequences, affecting patient care, hospital operations, and the broader healthcare system.

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Homeopathic Industry Group Wants Court to Exclude It From FDA’s Enforcement Plans

FDA Law Blog: Biosimilars

By Deborah L. Livornese & John W.M. Claud & Charles D. Snow — On October 21, 2024, the Alliance for Natural Health USA (“ANH”), and Meditrend Inc., a homeopathic drug company, filed a complaint on behalf of the homeopathic drug industry against FDA in the District Court for the District of Columbia (“D.D.C.”). This lawsuit presents an interesting reading of the statute at issue, one that is diametrically opposed to that of FDA.

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The Forgotten Pandemic

Codon

This essay by Kamal Nahas is the first in a two-part series on tuberculosis. The second part — focused on vaccines and medicines — will be published next Sunday, concluding Issue 04 of Asimov Press. The Most Deadly Infectious Disease “Each successive episode of bleeding left him weaker than before,” wrote Mary Doria Russell of Doc Holliday, the gunslinging gambler, in her eponymous book, Doc.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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C-ZIPTF: stable tensor factorization for zero-inflated multi-dimensional genomics data

Broad Institute

C-ZIPTF: stable tensor factorization for zero-inflated multi-dimensional genomics data By Pinar Demetci October 27, 2024 C-ZIPTF: stable tensor factorization for zero-inflated multi-dimensional genomics data Neriman Tokcan Assistant Professor of Applied Mathematics University of Massachusetts, Boston Abstract: In this talk, we will delve into the challenges associated with tensor decompositions and present innovative models designed to tackle these obstacles effectively.

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