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The warming climate in polar regions may significantly disrupt ocean circulation patterns, a new study indicates. Scientists discovered that in the distant past, growing inflows of freshwater from melting Arctic sea-ice into the Nordic Seas likely significantly affected ocean circulation, sending temperatures plummeting across northern Europe.
MONDAY, Oct. 28, 2025 -- Halloween is meant to be a spooky season, but it can be downright terrifying to someone suffering from Alzheimer’s disease or dementia.“Halloween is full of scary sights and frightful sounds that create additional cha.
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Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
The development of investigational new drugs (INDs) involves performing clinical trials (or studies) to assess the safety and efficacy of the IND in humans. These trials are usually classified into 4 phases of development (Phase 1 to 4), with each potentially lasting for several years. Successful completion of each phase and approval by the appropriate regulatory authority or authorities (the European Medicines Agency [EMA] in the European Union, Food and Drug Administration [FDA] in the United
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Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
The development of investigational new drugs (INDs) involves performing clinical trials (or studies) to assess the safety and efficacy of the IND in humans. These trials are usually classified into 4 phases of development (Phase 1 to 4), with each potentially lasting for several years. Successful completion of each phase and approval by the appropriate regulatory authority or authorities (the European Medicines Agency [EMA] in the European Union, Food and Drug Administration [FDA] in the United
Adrian L. Gill, Mathew A. Marx RAS Drug Discovery Past, Present and Future 2025 , 205-227 [link] Krazati (adagrasib/MRTX849) is a potent, selective, and covalent KRAS G12C inhibitor, representing a significant breakthrough in directly targeting KRAS. Adagrasib demonstrates favorable drug-like properties, selectively modifying mutant cysteine 12 in GDP-bound KRAS G12C , leading to the inhibition of KRAS-dependent signaling both in vitro and in vivo, and tumor regression in many KRAS G12C -positiv
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By Deborah L. Livornese & John W.M. Claud & Charles D. Snow — On October 21, 2024, the Alliance for Natural Health USA (“ANH”), and Meditrend Inc., a homeopathic drug company, filed a complaint on behalf of the homeopathic drug industry against FDA in the District Court for the District of Columbia (“D.D.C.”). This lawsuit presents an interesting reading of the statute at issue, one that is diametrically opposed to that of FDA.
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Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
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