Broad Institute

SEPTEMBER 23, 2024

New approach may yield modified messenger RNAs for treating a wide range of conditions By Ari Navetta September 23, 2024 Breadcrumb Home New approach may yield modified messenger RNAs for treating a wide range of conditions The LEGO framework could help scientists create mRNA therapies that last longer and require smaller doses. By Ari Navetta September 23, 2024 Credit: Natalie Velez, Broad Communications Related news Messenger RNAs with multiple “tails” could lead to more effective therapeutics

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RNA Vaccine Small Molecule Therapies 133

BioPharma Drive: Drug Pricing

SEPTEMBER 23, 2024

The companies now plan on starting this year another large study of their drug, dapirolizumab pegol, in the hopes that they can confirm its safety and effectiveness to drug regulators.

Regulations 122

Regulations Drugs 122

Science Daily: Pharmacology News

SEPTEMBER 23, 2024

With Medicare now covering semaglutide for people with obesity and cardiovascular disease who don't have diabetes, a study looks at who that might include, depending on what cutoffs prescription plans apply.

Disease 120

Disease 120

Drugs.com

SEPTEMBER 23, 2024

MONDAY, Sept. 23, 2024 -- Psilocybin, the active ingredient in magic mushrooms, appears to ease depression symptoms at least as well as one of the most commonly used antidepressants, a new clinical trial shows.Patients showed significant.

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Clinical Trials Trials 111

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

BioPharma Drive: Drug Pricing

SEPTEMBER 23, 2024

With fresh, positive data in hand, Biohaven now believes its medicine could be the first to receive FDA approval for spinocerebellar ataxia.

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FDA Approval FDA Drugs 120

Drugs.com

SEPTEMBER 23, 2024

MONDAY, Sept. 23, 2024 -- One in three former NFL players believe they have football-related brain damage that’s doing untold harm to their lives, a new study finds.Unfortunately, their fears might be harming their mental health on top of whatever r.

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Drugs.com

SEPTEMBER 23, 2024

MONDAY, Sept. 23, 2024 -- Antidepressants have the potential to improve memory and thinking skills, a new study suggests.Some patients experienced a boost on brain tests after taking the SSRI antidepressant escitalopram (Lexapro), researchers.

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Research 105

Science Daily: Pharmacology News

SEPTEMBER 23, 2024

Top ocean experts have published a report that redefines the concept of 'sustainable fishing' and proposes 11 'golden rules' that radically challenge the flawed approach that currently prevails in fisheries management.

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Drugs.com

SEPTEMBER 23, 2024

MONDAY, Sept. 23, 2024 -- Another health care worker who was exposed to a Missouri patient who tested positive for bird flu developed respiratory symptoms but wasn't tested for the flu, U.S. health officials reported Friday.The news is rekindling.

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Science Daily: Pharmacology News

SEPTEMBER 23, 2024

Researchers explored the powerful effect of repetition on people's beliefs.

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Science Research 123

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Clinical Trials

Drugs.com

SEPTEMBER 23, 2024

MONDAY, Sept. 23, 2024 -- Kids born during the first year of the COVID-19 pandemic appear to have no higher risk of autism, even if they were exposed to COVID in the womb, a new study finds.The study offers reassurance to doctors and parents who’ve.

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Doctors 98

Drug Patent Watch

SEPTEMBER 23, 2024

The generic drug market has experienced significant growth over the past few decades, driven by the expiration of patents on branded drugs and the increasing demand for affordable healthcare solutions. However, the industry faces several challenges, including commoditization, regulatory hurdles, and intense competition.

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Marketing Drugs 80

Drugs.com

SEPTEMBER 23, 2024

MONDAY, Sept. 23, 2024 -- Having a husband or boyfriend with adult ADHD can harm a woman's mental stability, a new study suggests.About 3 in 5 women (59%) with male partners with attention-deficit/hyperactivity disorder (ADHD) had symptoms of.

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Collaborative Drug

SEPTEMBER 23, 2024

Upcoming Webinar 9-26-24: Generative Chemistry, Deep Learning and Traditional Models - Practical Insights and Emerging Technologies

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Small Molecule 86

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

SEPTEMBER 23, 2024

MONDAY, Sept. 23, 2024 -- Research in rats and hibernating squirrels has pinpointed a naturally occurring protein that appears to reverse cataracts, scientists report.Animal studies don't always pan out in people, of course. But the discovery of.

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Science Research 96

BioPharma Drive: Drug Pricing

SEPTEMBER 23, 2024

Regulatory and strategic challenges can delay the delivery of life-changing cell and gene therapies.

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Therapies 98

Drugs.com

SEPTEMBER 23, 2024

MONDAY, Sept. 23, 2024 -- If global warming is left largely unchecked, the number of Americans who succumb to extreme heat will triple by mid-century, new projections estimate.These deaths could affect poor and minority Americans much more than the.

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Perficient: Drug Development

SEPTEMBER 23, 2024

Perficient is happy to announce that Consulting Magazine recently recognized Rupa Amin and Lina Maria Jaramillo Lopera in the 2024 Women Leaders in Consulting Awards. The awards program seeks to recognize women within the consulting industry who demonstrate excellence in their work and who are making an impact. Rupa and Lina were chosen because they embody the characteristics and leadership qualities that make a difference in the industry and pave the way for future women leaders.

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Production Research 69

Collaborative Drug

SEPTEMBER 23, 2024

Learn how CDD Vault is utilizing AI to improve your drug discovery process.

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Drugs 99

BioPharma Drive: Drug Pricing

SEPTEMBER 23, 2024

The company’s technology, which enables it to target viral proteins in their “prefusion” shape and skip a manufacturing step, could lead to vaccines that are more potent and easier to produce, said CEO Emmanuel Hanon.

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Vaccine 62

Perficient: Drug Development

SEPTEMBER 23, 2024

In an increasingly digital world, ensuring that everyone can access and enjoy online content is more important than ever. This is where Universal Design comes into play in the healthcare system, aiming to create products and environments that are usable by all people, to the greatest extent possible, without the need for adaptation or specialized design.

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Regulations Production 59

FDA Law Blog: Biosimilars

SEPTEMBER 23, 2024

By Kurt R. Karst — Forty years ago today—on a sunny Monday, September 24, 1984 at approximately 3:30 PM Eastern Time in the Rose Garden at the White House—President Ronald Reagan signed into law Public Law 98-417 , the Drug Price Competition and Patent Term Restoration Act of 1984, stating that “[t]he legislation will speed up the process of Federal approval of inexpensive generic versions of many brand name drugs, make the generic versions more widely available to consumers, and grant pharmaceu

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FDA Drugs International Pharmaceuticals 59

Drugs.com

SEPTEMBER 23, 2024

MONDAY, Sept. 23, 2024 -- Diabetes can worsen the state of your gums, but a new study suggests that diabetes medications may undo some of that damage. Researchers in Japan found a positive turnaround in markers of gum well-being after people with.

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Treatment Disease Research 59

Crown Bioscience

SEPTEMBER 23, 2024

Patient-derived xenograft (PDX) models have become a cornerstone in cancer research, offering valuable insights into tumor biology and drug efficacy. However, recent studies have uncovered significant quality issues that threaten the reliability of these models. As researchers, we must be aware of these challenges to ensure the validity of our findings.

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Research Drugs 59

BioPharma Drive: Drug Pricing

SEPTEMBER 23, 2024

The partners said their antibody-drug conjugate datopotomab deruxtecan didn’t extend survival in a breast cancer study, fueling additional doubts about its approval prospects.

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Drugs 57

New Drug Approvals

SEPTEMBER 23, 2024

Votoplam CAS 2407849-89-0 Molecular Formula C21H25N9O Molecular Weight 419.4829 PHENOL, 2-(3-(2,2,6,6-TETRAMETHYL-4-PIPERIDINYL)-3H-1,2,3-TRIAZOLO(4,5-C)PYRIDAZIN-6-YL)-5-(2H-1,2,3-TRIAZOL-2-YL)- 2-[3-(2,2,6,6-tetramethylpiperidin-4-yl)triazolo[4,5-c]pyridazin-6-yl]-5-(triazol-2-yl)phenol UNII D7EZ7B585X Votoplam is a gene splicing modulator, used to inhibit Huntington’s disease.

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Small Molecule RNA DNA Disease 57

Science Daily: Pharmacology News

SEPTEMBER 23, 2024

Knowing how animals use their environments to survive and thrive is a key challenge for predicting how global climate change will affect wildlife. A global collaborative study of four species of crane has shed light on the way that migrations are finely tuned to unpredictable and complex environments. A team from 10 countries combined novel animal tracking technology, remote-sensed information about the environment, and a new statistical framework to gain insight into four iconic species: common

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Broad Institute

SEPTEMBER 23, 2024

About MIA By nkarpova@broadinstitute.org September 23, 2024 Breadcrumb Home MIA About MIA Follow MIA on Twitter and on the Schmidt Center LinkedIn. MIA weekly meetings feature a primer, breakfast, seminar, and discussion; these meetings are interactive and have a pedagogical focus. Instead of an emphasis on research results, speakers dive into the methods — their mechanics, intuition, and philosophy — in the context of their research, so that participants can leave the talk having absorbed new i

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Research 52

Perficient: Drug Development

SEPTEMBER 23, 2024

In today’s digital age, creating inclusive and accessible user experiences is more important than ever. Universal design aims to make products and environments usable by all people, to the greatest extent possible, without the need for adaptation or specialized design. This blog post is part of our Universal Design Series, focusing on how to enhance user experience (UX) for individuals with auditory disabilities.

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Production 52

Fierce BioTech

SEPTEMBER 23, 2024

Apply the Power of Automation to GxP Systems This timely whitepaper explores the capabilities life sciences companies should expect from an end-to-end automation solution to streamline compliance, increase reliability, and reduce costs. Download now. jkarimi Mon, 09/23/2024 - 16:48 This timely whitepaper explores the capabilities life sciences companies should expect from an end-to-end automation solution to streamline compliance, increase reliability, and reduce costs.

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Compliance Science 52

Drugs.com

SEPTEMBER 23, 2024

MONDAY, Sept. 23, 2024 -- Kidney stone fragments sometimes just need a little push to be flushed out of a person’s system, a new trial finds.About seven in 10 patients who got ultrasound treatment to encourage fragments to clear from their kidneys w.

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Trials Treatment 52

Drug Channels

SEPTEMBER 23, 2024

Informa Connnect's Pharma/Biotech GTN Summit November 18-20, 2024 | W Philadelphia Hotel, Philadelphia, PA Drug Channels Readers Receive 15% Off* with Code 24DGC15. View the Complete Agenda Book Your Place The complex components of gross-to-net management requires cross-functional collaboration in order to effectively develop sound accrual estimates, proper forecasting, optimized pricing and contracting models and accurate financial reporting, all with minimal disruption to market access strateg

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Compliance Pharmaceuticals Marketing Government 52

Perficient: Drug Development

SEPTEMBER 23, 2024

In my career journey, I’ve been fortunate to work in different environments, each shaping my professional growth. However, my experience with Perficient has been unparalleled. Here’s why my passion for this organization continues to grow, day after day. Appreciation and Recognition: A Culture of Acknowledgment In my previous role, despite delivering outstanding results, recognition was often elusive.

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BioPharma Drive: Drug Pricing

SEPTEMBER 23, 2024

GLP-1 drugs went from helping with blood sugar management to supporting weight loss. What’s next?

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Drugs 62