Drug Discovery World
AUGUST 21, 2023
Talus Bio has received $4.3 million in new grants from the National Institutes for Health (NIH) and the Washington State Andy Hill CARE Fund to advance its paediatric cancer therapeutics. The Seattle-based company received two grants totalling $2.3M from the CARE Fund to fuel the discovery of new transcription factor inhibitors for rhabdomyosarcoma and neuroblastoma, two childhood cancers.
Chemical Biology and Drug Design
AUGUST 21, 2023
The present study's results demonstrated DEX's pharmacological benefit against myocardial reperfusion injury. It has been found that DEX showed a protective effect against MIR injury possibly via amelioration of oxidative stress and apoptosis of cardiomyocytes. It also showed a strong anti-inflammatory effect possibly via inhibition of NF-κB. Abstract The present study was conducted to determine the protective effect of Dexmedetomidine (DEX) in myocardial ischemia–reperfusion injury in hyperlipi
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Drug Discovery World
AUGUST 21, 2023
Medications containing semaglutide such as Ozempic, licensed for diabetes, and Wegovy, for weight loss, are being studied to see if they can treat a range of different conditions, including addiction and dementia. Semaglutide manufacturer Novo Nordisk reported earlier this month that the drug reduces the risk of major adverse cardiovascular events by 20% in adults with overweight or obesity, as shown in the SELECT trial.
Chemical Biology and Drug Design
AUGUST 21, 2023
Syringic acid suppressed ferroptosis and inflammation to alleviate lower limb ischemia/reperfusion injury in mice by blocking the HMGB1 pathway. Abstract Ischemia/reperfusion (I/R) of skeletal muscle in the lower limbs is an important factor affecting the outcome of lower limbs ischemia patients, with no effective preventive or therapeutic approaches available.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drug Discovery World
AUGUST 21, 2023
The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. Diana Spencer has chosen news stories this week which all discuss pre-clinical research studies that could have a huge impact on our therapeutic approach to several hard-to-treat diseases, helping to overcome drug-resistance and make treatments more targeted in the future.
Drugs.com
AUGUST 21, 2023
MONDAY, Aug. 21, 2023 -- Guns are now the leading cause of death among kids in the United States. That's the chilling message from a new study that looked at numbers of U.S. children killed by guns from 2018 to 2021. During this time, there was.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Drugs.com
AUGUST 21, 2023
MONDAY, Aug. 21, 2023 -- Certain adult vaccines, including shingles and pneumonia shots, may also help seniors fight off Alzheimer's disease, new research reveals. Prior vaccination with the shingles vaccine, pneumococcus vaccine or the tetanus and.
Drug Discovery World
AUGUST 21, 2023
Ipsen’s Sohonos (palovarotene) has become the first drug approved for patients with fibrodysplasia ossificans progressiva (FOP) in the US, following the granting of a marketing authorisation by the Food and Drug Administration (FDA). The capsules are approved for reduction in the volume of new heterotopic ossification (extra-skeletal bone formation) in adults and children aged eight years and older for females, and 10 years and older for males.
Antidote
AUGUST 21, 2023
Before any new treatment is able to be approved, it is required to go through the vigorous testing process known as clinical trials. These trials are aimed at determining whether or not a drug, medical device, therapy, or other type of intervention is safe and effective for the public.
Drugs.com
AUGUST 21, 2023
MONDAY, Aug. 21, 2023 -- There's been another case of locally acquired malaria in the United States, this time in Maryland, authorities report. It's the first time this has happened in that state in 40 years. No evidence connects this case to seven.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Drug Patent Watch
AUGUST 21, 2023
Loss of exclusivity (LOE) doesn’t have to spell doom for branded drug revenue streams. In the face of impending patent expirations, pharmaceutical companies can adopt key approaches to preserve meaningful… The post Strategies to Maximize Product Value Amid Loss of Exclusivity in the Pharmaceutical Industry appeared first on DrugPatentWatch - Make Better Decisions.
Perficient: Drug Development
AUGUST 21, 2023
If you’ve been following Sitecore’s architectural movement over the last few years, a lot has changed. Instead of the “all-in-one” approach of Sitecore XP, XM Cloud , and Headless encourage a composable architecture – one where Sitecore itself offers 11 SaaS products categorized into three clouds : Content Cloud, Engagement Cloud, and Commerce Cloud.
Drugs.com
AUGUST 21, 2023
MONDAY, Aug. 21, 2023 -- Women who have larger breasts tend to exercise less or less intensely, according to a new study that suggests having breast reduction surgery could be a game changer. Australian researchers looking at exercise participation.
Drug Target Review
AUGUST 21, 2023
To unravel the mysteries behind the treatment response, researchers from the Department of Otolaryngology/Head and Neck Surgery at UNC School of Medicine collaborated with experts from Yale Cancer Center, the Yale Head and Neck Cancer Specialised Program of Research Excellence (SPORE), and the ECOG-ACRIN Cancer Research Group. Their study, published in Proceedings of the National Academy of Sciences , unveiled the existence of two distinct subtypes of HPV + head and neck cancers.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
BioPharma Drive: Drug Pricing
AUGUST 21, 2023
Analysts expect the approval of Ingrezza in Huntington’s patients with a movement disorder known as chorea to intensify a commercial battle between Neurocrine and Teva.
Drugs.com
AUGUST 21, 2023
MONDAY, Aug. 21, 2023 -- COVID-19 patients face a markedly greater risk for developing persistently high blood pressure, even if they never had blood pressure concerns before, new research indicates. The rise in risk seen among otherwise.
SCIENMAG: Medicine & Health
AUGUST 21, 2023
A study published in the journal of Engineering reveals a remarkable development in the field of green coating materials for leather. Researchers have successfully synthesized a solvent-free, bio-based antibacterial agent and aromatic monomer called methacrylated vanillin (MV).
BioPharma Drive: Drug Pricing
AUGUST 21, 2023
The Series B round brings the total funding for Genesis, a California startup backed by Andreessen Horowitz and Nvidia’s VC arm, to over $280 million.
SCIENMAG: Medicine & Health
AUGUST 21, 2023
Osaka, Japan – How is a donut similar to a coffee cup? This question often serves as an illustrative example to explain the concept of topology. Topology is a field of mathematics that examines the properties of objects that remain consistent even when they are stretched or deformed—provided they are not torn or stitched together.
BioPharma Drive: Drug Pricing
AUGUST 21, 2023
The agency cleared high-dose Eylea less than two months after rejecting it, and approved a separate Regeneron drug for an ultra-rare disease as well.
SCIENMAG: Medicine & Health
AUGUST 21, 2023
The REIMAGINE study, published today in BMJ Oncology, is the first study to use MRI scans with prostate specific antigen (PSA) density to assess the need for further standard NHS tests.
BioPharma Drive: Drug Pricing
AUGUST 21, 2023
The hold is the latest setback for a drug that was the center of Gilead’s $5 billion acquisition of biotech Forty Seven in 2020.
SCIENMAG: Medicine & Health
AUGUST 21, 2023
A study of 14 astronauts suggests that while space travel depletes red blood cells and bone, the body can eventually replenish them back on Earth with the help of fat stored in the bone marrow. The study, published in Nature Communications, has important implications for health in space and on Earth.
BioPharma Drive: Drug Pricing
AUGUST 21, 2023
The expanded approval follows the FDA’s May clearance of the shot, called Abrysvo, in older adults.
SCIENMAG: Medicine & Health
AUGUST 21, 2023
Relatively short-term use of immunosuppressant medications to control an inflammatory disease was not associated with an increased risk of later developing cancer, according to new research led by scientists at the University of Pittsburgh and Mass Eye and Ear, a member of the Mass General Brigham health care system, and published today in the journal […]
BioPharma Drive: Drug Pricing
AUGUST 21, 2023
By partnering with an accomplished CTDMO, gene therapy innovators can benefit from guidance and support.
SCIENMAG: Medicine & Health
AUGUST 21, 2023
FROM: James Urton Credit: NASA/MODIS Rapid Response Team/Goddard Space Flight Center FROM: James Urton University of Washington 206-543-2580 jurton@uw.edu (Note: researcher contact information at the end) For Immediate Release August 21, 2023 In 2006, the Tripod Complex Fire burned more than 175,000 acres in north-central Washington.
Drugs.com
AUGUST 21, 2023
MONDAY, Aug. 21, 2023 -- When people suffering a stroke need a transfer to another hospital, time is of the essence. But a new study finds that most Americans in that situation face delays. The study, published recently in the Journal of the.
SCIENMAG: Medicine & Health
AUGUST 21, 2023
Ames, IA — Twenty years ago, the National Football League adopted the Rooney Rule. It attempted to address racial disparity in top positions by requiring teams to interview at least one person of color for every head coach opening.
Drugs.com
AUGUST 21, 2023
MONDAY, Aug. 21, 2023 -- An estimated 26 million Americans 50 and older live alone, and researchers estimate that more than 4 million have dementia or cognitive impairment. That means a large number of older Americans are at risk for medication.
SCIENMAG: Medicine & Health
AUGUST 21, 2023
“Our findings may provide a useful therapeutic approach for treating breast cancer patients who may suffer from early relapse and intrinsic resistance.” Credit: 2023 Liu and Wang. “Our findings may provide a useful therapeutic approach for treating breast cancer patients who may suffer from early relapse and intrinsic resistance.
Drugs.com
AUGUST 21, 2023
MONDAY, Aug. 21, 2023 -- Walkable neighborhoods -- with sidewalks, parks and paths -- encourage pregnant women to get more exercise, which leads to good outcomes for both mom and baby. New research looks at the influence of these walkable.
SCIENMAG: Medicine & Health
AUGUST 21, 2023
The University of Arkansas celebrated an important milestone with the groundbreaking on a building that Chancellor Charles Robinson suggested might someday rival the U of A’s most iconic structure, Old Main, in significance to the university and the state of Arkansas.
Science Daily: Pharmacology News
AUGUST 21, 2023
People who have recovered from a major depressive episode, when compared with individuals who have never experienced one, tend to spend more time processing negative information and less time processing positive information, putting them at risk for a relapse, according to new research.
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