Mon.Jan 13, 2025

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Chornobyl dogs' genetic differences not due to mutation

Science Daily: Pharmacology News

Radiation-induced mutation is unlikely to have induced genetic differences between dog populations in Chornobyl City and the nearby Chornobyl Nuclear Power Plant.

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Evaluating GenMol as a Generalist Foundation Model for Molecular Generation

Nvidia Developer: Drug Discovery

Traditional computational drug discovery relies almost exclusively on highly task-specific computational models for hit identification and lead optimization. Traditional computational drug discovery relies almost exclusively on highly task-specific computational models for hit identification and lead optimization. Adapting these specialized models to new tasks requires substantial time, computational power, and expertisechallenges that grow when researchers simultaneously work across multiple ta

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What Do Sleep Medications Do to Your Brain?

Drugs.com

MONDAY, Jan. 13, 2025 (HealthDay news) -- The sleep aid Ambien could be allowing toxic proteins to pollute the brain, potentially increasing a persons risk of disorders like Alzheimers disease.Drugs like the main ingredient in Ambien, zolpidem, sup.

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J&J to buy psychiatric drug developer Intra-Cellular for $14.6B

BioPharma Drive: Drug Pricing

Intra-Cellular has had success selling Caplyta, a brain-rebalancing drug that's approved to treat schizophrenia and bipolar depression.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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United States dementia cases estimated to double by 2060

Science Daily: Pharmacology News

A new study shows that the risk of developing dementia anytime after age 55 among Americans is 42%, more than double the risk reported by older studies.

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Moderna shares tumble on slashed sales guidance

BioPharma Drive: Drug Pricing

The company lost more than $3 billion in market value after cutting its forecast for 2025 revenue from its COVID-19 and RSV vaccines.

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Lilly pads cancer drug pipeline with Scorpion deal

BioPharma Drive: Drug Pricing

The pharma will spend up to $2.5 billion to acquire an experimental PI3K inhibitor from Scorpion, which will spin out a new company holding its employees and other assets.

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X-ray flashes from a nearby supermassive black hole accelerate mysteriously

Science Daily: Pharmacology News

Astronomers observed flashes of X-rays coming from a supermassive black hole at a steadily increasing clip. The source could be the core of a dead star that's teetering at the black hole's edge.

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Multiple Violations Found At McDonald's Onion Supplier After Deadly E.Coli Outbreak

Drugs.com

MONDAY, Jan. 13, 2025 -- U.S. Food and Drug Administration (FDA) officials have uncovered dozens of violations at a McDonald's supplier tied to last year's deadly E.coli outbreak, which sickened over 100 people and led to a massive recall of onions.

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Engineering quantum entanglement at the nanoscale

Science Daily: Pharmacology News

Researchers have developed a drastically smaller and more energy efficient method of creating coveted photon pairs that influence each other from any distance. The technology could transform computing, telecommunications, and sensing.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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JPM25: Deals, Summit’s bravado and gene therapy headwinds

BioPharma Drive: Drug Pricing

Security was tight for the first day of the J.P. Morgan Healthcare Conference, which featured two deals involving privately held biotechs.

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NASA's Hubble tracks down a 'blue lurker' among stars

Science Daily: Pharmacology News

The name 'blue lurker' might sound like a villainous character from a superhero movie. But it is a rare class of star that NASA's Hubble Space Telescope explored by looking deeply into the open star cluster M67, roughly 2,800 light-years away.

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Biogen’s ‘cold and calculated’ offer to buy Sage receives a mixed reaction on Wall Street

BioPharma Drive: Drug Pricing

Analysts say the deal, which would give Biogen full control over the drug Zurzuvae, could be a smart financial move. Yet it's also unlikely to appease broader investor concerns.

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New study unveils breakthrough in understanding cosmic particle accelerators

Science Daily: Pharmacology News

Scientists have come a step closer to understanding how collisionless shock waves -- found throughout the universe -- are able to accelerate particles to extreme speeds.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Fecal Transplants May Help People Who Have Diabetes, Gut Issues, Study Says

Drugs.com

Monday, Jan. 13, 2025 -- A fecal transplant could help people whose type 1 diabetes has fouled up their digestive system.Swallowing a handful of capsules filled with donor feces helped ease gut pain, nausea, bloating and diarrhea stemming from.

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World's oldest 3D map discovered

Science Daily: Pharmacology News

Researchers have discovered what may be the world's oldest three-dimensional map, located within a quartzitic sandstone megaclast in the Paris Basin.

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Accelerate Protein Engineering with the NVIDIA BioNeMo Blueprint for Generative Protein Binder Design

Nvidia Developer: Drug Discovery

Designing a therapeutic protein that specifically binds its target in drug discovery is a staggering challenge. Traditional workflows are often a painstaking. Designing a therapeutic protein that specifically binds its target in drug discovery is a staggering challenge. Traditional workflows are often a painstaking trial-and-error processiterating through thousands of candidates, each synthesis and validation round taking months if not years.

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Will We Have Fewer Doctors of Color?

Drugs.com

MONDAY, Jan. 13, 2025 -- Medical schools have experienced a steep decline in enrollment among Black and Hispanic students since the Supreme Court banned the consideration of race in admissions.The number of Black medical students fell by nearly 12%.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Lack of regulatory harmonization and other challenges facing clinical services organizations in the APAC market

BioPharma Drive: Drug Pricing

How clinical services organizations are overcoming challenges in the APAC market.

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How To Handle Travel Stress

Drugs.com

MONDAY, Jan. 13, 2025 -- Traffic, delays, disruptions due to storms or wildfires, and other surprises may be part of your next business or pleasure trip. In short: Travel is more stressful (and more expensive) than ever.But you don't have to.

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Analyzing biosimilar market dynamics in different patient populations

Drug Patent Watch

Biosimilars have emerged as a game-changing force, promising to revolutionize patient access to life-saving biologics while simultaneously reducing healthcare costs. As we delve into the intricate world of biosimilar market dynamics, we’ll explore how these complex molecules are reshaping treatment paradigms across diverse patient populations.

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First-Time Moms In This State May Be Using Welfare for Paid Family Leave

Drugs.com

MONDAY, Jan. 13, 2025 (HealthDay news) -- Low-income single mothers appear to be using welfare as a form of paid family leave following childbirth.Most women who enter the Temporary Assistance for Needy Families (TANF) program after childbirth are.

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Atop the Oregon Cascades, team finds a huge buried aquifer

Science Daily: Pharmacology News

Scientists have mapped the amount of water stored beneath volcanic rocks at the crest of the central Oregon Cascades and found an aquifer many times larger than previously estimated -- at least 81 cubic kilometers. The finding has implications for the way scientists and policymakers think about water in the region -- an increasingly urgent issue across the Western United States as climate change reduces snowpack, intensifies drought and strains limited resources.

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Tragic Pet Cat Deaths Linked to Bird Flu in Raw Milk

Drugs.com

MONDAY, Jan. 13, 2025 -- A California man's tragic story highlights the growing risks associated with bird flu infections in domestic animals.Joseph Journell of San Bernadino lost two of his beloved cats, a 14-year-old tabby, Alexander, and Tuxsie.

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Drug Channels Leadership Forum: Request an Invitation Before It’s Too Late!

Drug Channels

The inaugural Drug Channels Leadership Forum (DCLF) is coming soon! This exclusive event will be held from March 17 to 19, 2025, at the Turnberry Resort and Spa in Miami. Our first event will provide attendees with an opportunity to explore the most pressing strategic issues and crucial uncertainties that will impact all participants across U.S. drug channels.

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Link Between Gum Disease, Brain Function Exists, Small Study Says

Drugs.com

MONDAY, Jan. 13, 2025 -- Gum disease appears to disrupt brain activity, potentially increasing a persons risk of cognitive decline.People with gum disease experienced altered connections between different brain regions, compared to folks with good.

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Neha Pasi Leads Global Development for Perficient’s Sitecore Team with Precision and Passion

Perficient: Drug Development

Meet Neha Pasi, a lead technical consultant based in Nagpur, India, whose exceptional contributions, agility, precision, and guidance have set an example for her Sitecore development teams. Neha embraces Growth for Everyone and continuously strives to further her knowledge by taking courses, earning certifications, and applying new concepts to improve processes.

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Neglect Can Be as Damaging to Child Development as Abuse, in Some Ways

Drugs.com

MONDAY, Jan. 13, 2025 -- Simple neglect can be as damaging to a childs social development as physical, sexual or emotional abuse.Children whose basic needs arent met can have lifelong damage done to their ability to form friendships and romantic r.

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Broad Institute and Manifold collaborate to build AI-enabled life sciences research platform to accelerate global discoveries

Broad Institute

Broad Institute and Manifold collaborate to build AI-enabled life sciences research platform to accelerate global discoveries By Corie Lok January 13, 2025 Breadcrumb Home Broad Institute and Manifold collaborate to build AI-enabled life sciences research platform to accelerate global discoveries Strategic collaboration will introduce AI-enabled tools, optimized data-sharing, bring your own cloud (BYOC) support, and enhanced scalability.

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How to Protect Workers and the Public from Wildfire Smoke

NIOSH Science Blog: Drugs

As fires continue in the Los Angeles area, the Centers for Disease Control and Preventions National Institute for Occupational Safety and Health (NIOSH) and National Center for Environmental Health and the Environmental Protection Agency (EPA) are providing employers, workers, and the general public information to help stay protected from wildfire smoke.

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To Be or Coco-Not To Be: That’s One Question Answered in FDA’s Final Guidance Documents on Food Allergens

FDA Law Blog: Biosimilars

By Sophia R. Gaulkin & Ritte van Laack On January 6, 2025, FDA released two final guidance documents on food allergens: Questions and Answers Regarding Food Allergens, Including the Food Allergen Labeling Requirements of the Federal Food, Drug, and Cosmetic Act (Edition 5) , and Evaluating the Public Health Importance of Food Allergens Other Than the Major Food Allergens Listed in the Federal Food, Drug, and Cosmetic Act.

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Covalent Plant Natural Product that Potentiates Antitumor Immunity

Covalent Modifiers

Misao Takemoto, Sara Delghandi, Masahiro Abo, Keiko Yurimoto, Minami Odagi, Vaibhav Pal Singh, Jun Wang, Reiko Nakagawa, Shin-ichi Sato, Yasushi Takemoto, Asmaa M. A. S. Farrag, Yoshimasa Kawaguchi, Kazuo Nagasawa, Tasuku Honjo, Kenji Chamoto, and Motonari Uesugi Journal of the American Chemical Society 2025 DOI: 10.1021/jacs.4c17837 Despite the unprecedented therapeutic potential of immune checkpoint antibody therapies, their efficacy is limited partly by the dysfunction of T cells within the c

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Healthcare messaging matrix: 4 ways this asset can supercharge your content strategy

Perficient: Drug Development

Healthcare content marketing requires time, effort and strong strategy three resources that are always in demand within healthcare organizations (HCOs). Creating high-quality content that resonates with your audiences means figuring out what those audiences want and showing why your team is the best choice to help them. A messaging matrix can play a key role in that work.