Drug Discovery World

JULY 31, 2023

Promontory Therapeutics has treated its first patients in France as part of the ongoing Phase II clinical trial of PT-112 in patients with late-stage metastatic castration-resistant prostate cancer (mCRPC). The Phase II proof-of-concept study has the objective of characterising the benefit-risk ratio and selecting the optimal dose regimen for pivotal development of PT-112, in line with the FDA’s Project Optimus.

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BioPharma Drive: Drug Pricing

JULY 31, 2023

According to the company, FDA officials have signaled openness to using a surrogate endpoint for assessing accelerated approval of a treatment for limb-girdle muscular dystrophy.

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Drug Discovery World

JULY 31, 2023

The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. To coincide with the publication of the DDW eBook ‘ Antibody discovery: Breakthroughs accelerating therapeutic antibodies ’, our news highlights this week all focus on antibodies, particularly the recommendation by the EU’s CHMP for two bispecific antibodies that treat multiple myeloma

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Perficient: Drug Development

JULY 31, 2023

In a comedy special, Jerry Seinfeld once humorously said, “I saw a study that said speaking in front of a crowd is considered the number one fear of the average person. I found that amazing. Number two was death. Death was number two? This means to the average person if you have to be at a funeral, you would rather be in the casket than doing the eulogy.” The crowd roared with laughter.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

JULY 31, 2023

The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. To coincide with the publication of the DDW eBook ‘ Antibody discovery: Breakthroughs accelerating therapeutic antibodies ’, our news highlights this week all focus on antibodies, particularly the recommendation by the EU’s CHMP for two bispecific antibodies that treat multiple myeloma

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Drugs.com

JULY 31, 2023

MONDAY, July 31, 2023 – Millions of people live with acne, and it can take a dramatic toll on their quality of life, but is any one treatment better than the rest? Yes, suggests a new review of more than 200 studies. When researchers compared.

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Drugs.com

JULY 31, 2023

MONDAY, July 31, 2023 -- Scientists have struggled for decades to come up with something that can successfully treat Alzheimer's disease, with new drugs now showing their ability to clear the amyloid plaques that are a hallmark of the memory-robbing.

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Drug Discovery World

JULY 31, 2023

Biogen has revealed an agreement to acquire Reata Pharmaceuticals for approximately $7.3 billion. The news follows an announcement by the company last week that it would cut around 1,000 jobs, or 11% of its workforce, to allow investment into its product pipeline. In its second quarter results, the company said its new ‘Fit for Growth’ programme would generate approximately $1 billion in gross operating expense savings.

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Drug Target Review

JULY 31, 2023

Dear Readers, I am thrilled to announce the launch of our new series, “Beyond the Lab,” which promises to deliver high-level insights commissioned exclusively by Drug Target Review magazine. Our inaugural report is a groundbreaking exploration of the remarkable advancements in cell and gene therapy that are revolutionising the field of drug discovery.

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Drug Discovery World

JULY 31, 2023

CS Pharmaceuticals (CSP) has acquired AxeroVision, a company developing novel therapies for the treatment of dry eye disease (DED) and other ophthalmic inflammatory diseases that address the underlying inflammatory processes. Darren Mercer, Chief Executive of CSP, said: “We are thrilled to acquire AxeroVision, and in particular the pipeline product AXR-270 which contains a novel selective glucocorticoid receptor agonist formulated in a cutting-edge drug delivery system that overcomes the issues

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Clinical Trials

Drugs.com

JULY 31, 2023

MONDAY, July 31, 2023 -- Women are catching up to men when it comes to dying from alcohol abuse, a new study finds. Although men are nearly three times more likely to die from alcohol abuse than women, such deaths among women are rising at a faster.

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Drug Discovery World

JULY 31, 2023

Humanized mouse model CRO TransCure bioServices and South Korean CRO Preclina have agreed a partnership to improve preclinical development services in the APAC region. Drug developers in APAC have typically faced many challenges when it comes to preclinical development, from limited access to animal model providers and poor service offering breadth and capacity, to a scarcity of comprehensive, one-stop-shop preclinical partners.

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Drugs.com

JULY 31, 2023

MONDAY, July 31, 2023 -- Sleep apnea may increase the risk of heart attack and stroke as erratic breathing causes oxygen levels to drop, new research shows. "These findings will help better characterize high-risk versions of obstructive sleep.

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Research 98

FDA Law Blog: Biosimilars

JULY 31, 2023

By Larry K. Houck — President Barack Obama signed the Comprehensive Addiction and Recovery Act of 2016 (“CARA”) intended to reverse serious prescription drug abuse trend in the United States on July 22, 2016. CARA amended the Controlled Substances Act (“CSA”) to enable physicians or patients to request pharmacists to partially fill prescriptions for schedule II substances including opioids and to allow remaining quantities to be filled up to 30 days after issuance of the prescription (up to 72

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

JULY 31, 2023

MONDAY, July 31, 2023 -- Whether knocking back a little alcohol or a lot, daily drinking is tied to higher blood pressure, a new research review warns. Compared with not drinking, just one alcoholic drink a drink a day is associated with higher.

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Research 98

SCIENMAG: Medicine & Health

JULY 31, 2023

The p53 protein — a protein that controls cell division and plays a key role in the prevention of tumor growth — is the most commonly mutated protein across all cancer types, found in more than half of all tumors.

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Drugs.com

JULY 31, 2023

MONDAY, July 31, 2023 -- When parents meet U.S. Surgeon General Dr. Vivek Murthy, one concern comes up time after time. "The most common question parents ask me is: 'Is social media safe for my kids,' " Murthy said. "The answer is that we don't have.

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SCIENMAG: Medicine & Health

JULY 31, 2023

WEST LAFAYETTE, Ind. – To live on the moon or Mars, humans will need heat and air conditioning that can operate long term in reduced gravity and temperatures hundreds of degrees above or below what we experience on Earth. Credit: Photo provided by NASA/Danielle Johnson WEST LAFAYETTE, Ind.

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Science 88

Science Daily: Pharmacology News

JULY 31, 2023

Scientists analyzed data from more than 150,000 adults across 29 countries between 2001 and 2022 with results demonstrating the high prevalence of mental health disorders, with 50 per cent of the population developing at least one disorder by the age of 75.

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SCIENMAG: Medicine & Health

JULY 31, 2023

New York, NY (July 31, 2023)—Psychosocial stress profoundly affects people’s lives globally, not least because it can be a critical risk factor for cardiovascular disease. Thanks to an $11.

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Science Daily: Pharmacology News

JULY 31, 2023

The artificial intelligence language model GPT-3 performed as well as college students in solving certain logic problems like those that appear on standardized tests. The researchers who conducted the experiment write that the results prompt the question of whether the technology is mimicking human reasoning or using a new type of cognitive process.

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SCIENMAG: Medicine & Health

JULY 31, 2023

Researchers from the University of Tokyo and Stanford University show what differentiates slow and fast earthquakes and how their magnitudes vary with time. Credit: Image modified from “Science of slow earthquakes” leaflet.

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Drugs.com

JULY 31, 2023

MONDAY, July 31, 2023 -- Large numbers of Americans who were dropped from Medicaid this spring lost their coverage because of paperwork problems, and not because they weren’t still eligible for the public health insurance program. “I am.

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SCIENMAG: Medicine & Health

JULY 31, 2023

WASHINGTON — People with type-II diabetes who drank the fermented tea drink kombucha for four weeks had lower fasting blood glucose levels compared to when they consumed a similar-tasting placebo beverage, according to results from a clinical trial conducted by researchers at Georgetown University’s School of Health, the University of Nebraska-Lincoln and MedStar Health.

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Clinical Trials Trials Research 87

Science Daily: Pharmacology News

JULY 31, 2023

Simply remembering events can trigger brain rhythms, even more so than when people are experiencing the actual event, says a new study. The findings could lay foundations for cognitive impairment therapy and help improve memory.

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SCIENMAG: Medicine & Health

JULY 31, 2023

**Embargo: 23.30 [UK time] / 6.30pm [ET] Monday, July 31, 2023** Peer-reviewed The Lancet: New study reveals global anemia cases remain persistently high among women and children.

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Science Daily: Pharmacology News

JULY 31, 2023

Pain experts suggest that scrambler therapy, a noninvasive pain treatment, can yield significant relief for approximately 80% -- 90% of patients with chronic pain, and it may be more effective than another noninvasive therapy: transcutaneous electrical nerve stimulation (TENS).

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SCIENMAG: Medicine & Health

JULY 31, 2023

Plant-based diets confer various health benefits, including lowering the risk of cardiovascular disease and certain cancers. However, the relationship between plant protein intake and the risk of chronic kidney disease (CKD) remains unclear. This study led by Ga Young Heo aimed to investigate the association between plant protein intake and the development of CKD.

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Science Daily: Pharmacology News

JULY 31, 2023

Engineers have created a 'supercapacitor' made of ancient, abundant materials, that can store large amounts of energy. Made of just cement, water, and carbon black (which resembles powdered charcoal), the device could form the basis for inexpensive systems that store intermittently renewable energy, such as solar or wind energy.

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SCIENMAG: Medicine & Health

JULY 31, 2023

Oat is among the top ten cereal crop species in terms of global production. It can adapt to different climates, and farmers can grow it successfully even in harsh environments where other crops such as rice and corn fail. However, not all oat plants are the same.

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Drugs.com

JULY 31, 2023

MONDAY, July 31, 2023 – For the fourth summer in a row, Americans are experiencing a COVID-19 surge, this one marked by a rise in hospital admissions, emergency room visits, test positivity rates and wastewater data. The good news: It’s unlikely.

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Hospitals 75

SCIENMAG: Medicine & Health

JULY 31, 2023

Only 28.5% of Thai women are diagnosed at stage I of cervical cancer when survival rates are highest, according to a study published by the Mahidol University. To further motivate action to combat cervical cancer, BGI Genomics released its State of Cervical Cancer Awareness Report in Thailand.

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Science Daily: Pharmacology News

JULY 31, 2023

Researchers have discovered that nuclear spin influences biological processes, challenging long-held beliefs. They found that certain isotopes behave differently in chiral environments, affecting oxygen dynamics and transport. This breakthrough could advance biotechnology, quantum biology, and NMR technology, with potential applications in isotope separation and medical imaging.

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SCIENMAG: Medicine & Health

JULY 31, 2023

Researchers at RMIT University have helped map European health and digital health literacy, in an important step towards informing health policy and practice across the region. Credit: Digital Health Hub RMIT University. The Global Atlas of Literacies for Heath. 2023. Barcelona: RMIT Europe/IDEAHL Project funded by the EU.

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