Drug Discovery World
OCTOBER 19, 2023
A partnership has been set up to promote the development of new treatments to tackle the global threat of antimicrobial resistance (AMR). Innovate UK, LifeArc, and Medicines Discovery Catapult (MDC) have joined forces to create PACE (Pathways to Antimicrobial Clinical Efficacy), a £30 ($36) million initiative supporting early-stage innovation against AMR.
Antidote
OCTOBER 19, 2023
Since 1985, Breast Cancer Awareness Month has been held every October with the goal of raising awareness about the importance of breast cancer screening and prevention. Catching breast cancer early is one of the best ways to increase a person’s prognosis — though one in 8 women in the United States will be diagnosed with breast cancer in their lifetime , when caught in early stages, the 5-year survival rate is 99%.
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Drug Discovery World
OCTOBER 19, 2023
The latest sponsored DDW Sitting Down With podcast features Professor Jonathan Blackburn, Chief Scientific Officer of Sengenics, who discusses the advantages of functional protein microarrays, challenges to overcome for biomarker discovery, Sengenics ’ new i-Ome Discovery chip, and more. As CSO, Professor Blackburn heads the R&D and product development strategy.
BioPharma Drive: Drug Pricing
OCTOBER 19, 2023
The base editing specialist will prioritize medicines for sickle cell and alpha-1 antitrypsin deficiency, while trimming its plans for other programs in cancer and hepatitis B.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drug Discovery World
OCTOBER 19, 2023
Register now to join this unique online event. Hosted by DDW and co-sponsored by ACRO Biosystems, ‘Innovative advances in neuroscience’ will be free to attend on 8 November 2023 at 7AM PDT / 10AM EST / 3PM GMT / 4PM CET. You will hear from Fiona Elwood, VP, Disease Area Stronghold Lead, Neurodegeneration, Janssen, and Jenny Barnett, CEO of Monument TX, as well as Rosanna Zhang, Vice President of Corporate Development at ACROBiosystems.
Drug Target Review
OCTOBER 19, 2023
Scientists at the University of California, San Francisco (UCSF) have been exploring this question, and their recent breakthrough will focus on the treatment of conditions such as eczema and allergies. Their research centres around a remarkable immune protein called IL-31, which not only induces itching but also plays a crucial role in regulating inflammation.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
addgene Blog
OCTOBER 19, 2023
Adeno-associated viruses (AAV) are an important biological tool that allow scientists to express a gene of interest in a cell or animal model. AAV plasmids contain several important elements, but among the most important are the inverted terminal repeats (ITRs). ITRs are the elements that make an AAV plasmid an AAV plasmid.
Science Daily: Pharmacology News
OCTOBER 19, 2023
People who eat just two servings of red meat per week may have an increased risk of developing type 2 diabetes compared to people who eat fewer servings, and the risk increases with greater consumption, according to a new study. Researchers also found that replacing red meat with healthy plant-based protein sources, such as nuts and legumes, or modest amounts of dairy foods, was associated with reduced risk of type 2 diabetes.
ProRelix Research
OCTOBER 19, 2023
Pharmacovigilance is defined as the science and activities relating to the detection, assessment, understanding, and prevention of adverse effects and other drug-related problems. It is an important component of the […] The post Digital Health Technologies in Pharmacovigilance appeared first on ProRelix Research.
Science Daily: Pharmacology News
OCTOBER 19, 2023
A team of researchers have mapped almost 6,000 proteins from different cell types within the eye by analyzing tiny drops of eye fluid that are routinely removed during surgery. The researchers used an AI model to create a 'proteomic clock' from this data that can predict a healthy person's age based on their protein profile. The clock revealed that diseases such as diabetic retinopathy and uveitis cause accelerated aging within specific cell types.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Covalent Modifiers
OCTOBER 19, 2023
Ramachandran, S., Makukhin, N., Haubrich, K. et al. Nat Commun 14, 6345 ( 2023 ). [link] The Src homology 2 (SH2) domain recognizes phosphotyrosine (pY) post translational modifications in partner proteins to trigger downstream signaling. Drug discovery efforts targeting the SH2 domains have long been stymied by the poor drug-like properties of phosphate and its mimetics.
Science Daily: Pharmacology News
OCTOBER 19, 2023
In an unusual trial, researchers found that a patient's belief that they had received ketamine, even if they didn't, could improve their depression.
thought leadership
OCTOBER 19, 2023
Our "Meet the Expert" series introduces you to our team of experts around the world. This "behind the curtain" view will help you get to know who we are on a professional and personal level, and highlight how our colleagues work together on our higher purpose to improve patient health and safety throughout the complete product lifecycle.
Science Daily: Pharmacology News
OCTOBER 19, 2023
A research team has discovered that parasites manipulate their hosts using stolen genes that they likely acquired through a phenomenon called horizontal gene transfer.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
BioPharma Drive: Drug Pricing
OCTOBER 19, 2023
A second deal with Royalty Pharma around the Roche therapy Evrysdi will allow PTC to retire Blackstone debt and keep more cash for future operations.
Science Daily: Pharmacology News
OCTOBER 19, 2023
An international team has spotted a remote blast of cosmic radio waves lasting less than a millisecond. This 'fast radio burst' (FRB) is the most distant ever detected. Its source was pinned down by the European Southern Observatory's (ESO) Very Large Telescope (VLT) in a galaxy so far away that its light took eight billion years to reach us. The FRB is also one of the most energetic ever observed; in a tiny fraction of a second it released the equivalent of our Sun's total emission over 30 year
BioPharma Drive: Drug Pricing
OCTOBER 19, 2023
The Swiss pharma reported expanding U.S. market share for its new AMD drug Vabysmo as Regeneron tries to rebound from a now-resolved delay for its high-dose Eylea.
Science Daily: Pharmacology News
OCTOBER 19, 2023
Bats may have lived in caves and used soundwaves to navigate much earlier than first thought.
Drug Patent Watch
OCTOBER 19, 2023
Annual Drug Patent Expirations for IGALMI Igalmi is a drug marketed by Bioxcel and is included in one NDA. It is available from one supplier. There are four patents protecting… The post New patent for Bioxcel drug IGALMI appeared first on DrugPatentWatch - Make Better Decisions.
Science Daily: Pharmacology News
OCTOBER 19, 2023
An international team of scientists has recently developed a novel type of nano engine made of DNA. It is driven by a clever mechanism and can perform pulsing movements. The researchers are now planning to fit it with a coupling and install it as a drive in complex nano machines.
Drug Patent Watch
OCTOBER 19, 2023
Annual Drug Patent Expirations for EPIDIOLEX Epidiolex is a drug marketed by Gw Res Ltd and is included in one NDA. It is available from one supplier. There are twenty-seven… The post New patent for Gw Res drug EPIDIOLEX appeared first on DrugPatentWatch - Make Better Decisions.
Science Daily: Pharmacology News
OCTOBER 19, 2023
Baltic amber is a luxury material used in jewellery and handicrafts all over the world. Researchers have shown that Baltic amber arrived on the Iberian Peninsula at least in the 4th millennium BC, more than a millennium earlier than previously thought.
Drug Patent Watch
OCTOBER 19, 2023
Annual Drug Patent Expirations for INJECTAFER Injectafer is a drug marketed by Am Regent and is included in one NDA. It is available from one supplier. There are ten patents… The post New patent expiration for Am Regent drug INJECTAFER appeared first on DrugPatentWatch - Make Better Decisions.
Covalent Modifiers
OCTOBER 19, 2023
Bradley M. Lipka, Daniel S. Honeycutt, Gregory M. Bassett, Taylor N. Kowal, Max Adamczyk, Zachary C. Cartnick, Vincent M. Betti, Jacob M. Goldberg, and Fang Wang Journal of the American Chemical Society 2023 DOI: 10.1021/jacs.3c10334 Rapid bond-forming reactions are crucial for efficient bioconjugation. We describe a simple and practical strategy for facilitating ultra-rapid electrophilic cysteine arylation.
Broad Institute
OCTOBER 19, 2023
MPG Primer: Introduction to fine-mapping By Rose Circeo October 19, 2023 Breadcrumb Home MPG Primer: Introduction to fine-mapping The Primer on Medical and Population Genetics is a series of weekly lectures on genetics topics related to human populations and disease. Experts from across the Medical and Population Genetics community at the Broad Institute give in-depth introductions to research in human genetics through overviews of core concepts and practical tutorials on tools for biostatistics
SCIENMAG: Medicine & Health
OCTOBER 19, 2023
Researchers from Tokyo Medical and Dental University(TMDU) find that a periodontal pathogen, Porphyromonas gingivalis, inhibits autophagosome–lysosome fusion, and can therefore worsen cardiac remodeling and cause cardiac rupture after myocardial infarction Credit: Department of Cardiovascular Medicine, TMDU Researchers from Tokyo Medical and Dental University(TMDU) find that a periodontal pathogen, Porphyromonas gingivalis, inhibits autophagosome–lysosome fusion, and can […]
ProRelix Research
OCTOBER 19, 2023
Data analytics, technology, and accessibility to the internet and healthcare has led to a paradigm shift in the way clinical trials have been conducted. Traditional clinical trials that have been […] The post Future Trends in Clinical Data Management appeared first on ProRelix Research.
SCIENMAG: Medicine & Health
OCTOBER 19, 2023
With smartphone videos, clinicians can analyze human movement using open source “OpenCap” platform, 25x faster and at a fraction of the cost of labs. Credit: Ulrich et al., 2023, PLOS Computational Biology, CC-BY 4.
Fierce BioTech
OCTOBER 19, 2023
How cell and gene therapies are forcing sponsors to rethink safety and efficacy monitoring In this whitepaper, we look at how the industry is rising to the challenge, focusing on how cell and gene therapies are radically improving health outcomes and the technologies and techniques that are facilitating their development. Download Now. sdees Thu, 10/19/2023 - 09:39 In this whitepaper, we look at how the industry is rising to the challenge, focusing on how cell and gene therapies are radically im
Advarra
OCTOBER 19, 2023
The clinical trial startup process has seen significant shifts over the past five years: growth in decentralized trials, improved technology, and an increased demand for accelerated timelines in getting therapies to market. Each of these have contributed to a rapidly evolving clinical research landscape. To learn more about the influx of sponsor-provided technology, site enablement tools, and their impact on study startup over the past five years, Advarra surveyed clinical research professionals
Perficient: Drug Development
OCTOBER 19, 2023
If you have worked with EPM Pipelines, you know how incredibly relevant it is for customers who do not have the resources for data integration automation. It has been a saving grace for streamlining tasks and data load processes within the EPM application itself. However, one important element that had been missing from it was a comprehensive scheduling option.
BioPharma Drive: Drug Pricing
OCTOBER 19, 2023
The troubled RNA biotech is merging with Senda, another Flagship company that has drawn hundreds of millions of dollars in investment.
Perficient: Drug Development
OCTOBER 19, 2023
In the fast-paced world of healthcare, operations teams juggle various roles to ensure everything runs smoothly. While their efforts are indispensable, these teams often face hurdles that can affect patient care and services and overall efficiency. Forrester highlights that strategic operational improvements can enhance revenue, control costs, and reinforce resilience.
SCIENMAG: Medicine & Health
OCTOBER 19, 2023
Recognizing the many milestones it has reached in recent months, Strategies to Prevent Spillover, or STOP Spillover, a project funded by the U.S.
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