Top Drug Discovery Digest Targeted Protein Degradation Clinical Development Content for Wed.Dec 27, 2023

Wed.Dec 27, 2023

New pyrrolidine?carboxamide derivatives as dual antiproliferative EGFR/CDK2 inhibitors

Chemical Biology and Drug Design

DECEMBER 27, 2023

Rational design of new targets. Abstract Cancer is one of the leading causes of mortality worldwide, making it a public health concern. A novel series of pyrrolidine-carboxamide derivatives 7a-q were developed and examined in a cell viability assay utilizing a human mammary gland epithelial cell line (MCF-10A), where all the compounds exhibited no cytotoxic effects and more than 85% cell viability at a concentration of 50 μM.

Drugs

Drugs Research

Marijuana Use Increasingly Linked to Addiction, Psychosis

Drugs.com

DECEMBER 27, 2023

WEDNESDAY, Dec. 27, 2023 (HealthDay news) -- A rising tide of cannabis-related mental health problems is resulting from the widespread legalization of recreational weed in the United States, warns a new evidence review.Nearly one in five Americans.

The potential of CD24 in cancer immunotherapy

Drug Target Review

DECEMBER 27, 2023

Pheast Therapeutics is developing macrophage-focused immunotherapies to treat cancer. The company’s lead programme is targeting CD24, an immune inhibitory signal that is hijacked by cancer to suppress immune attack. Pheast’s drug candidate, PHST001, blocks CD24, thereby allowing immune cells, including macrophages, to attack the cancer. What is the significance of the interaction between CD24 and Siglec-10 in the context of cancer immunotherapy?

Immune Response

Immune Response Science Clinical Development Drugs

Webinars

From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

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Anti-Vaxxers More Likely to Skip Vaccinating Their Pets, Survey Finds

Drugs.com

DECEMBER 27, 2023

WEDNESDAY, Dec. 27, 2023 -- People whose beliefs or concerns make them hesitant to get vaccinated are also likely to forgo vaccinating their pets, new research shows.

Vaccine

Vaccine Research

From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Ask Me Anything: An interview with Dr. Aaron Kowalski of JDRF [Video]

Antidote

DECEMBER 27, 2023

This interview features Dr. Aaron Kowalski from JDRF, who discusses diabetes clinical trials, upcoming research, and more.

Clinical Trials

Clinical Trials Trials Research

Cases of Lead Poisoning Linked to Fruit Puree Pouches Reaches 251

Drugs.com

DECEMBER 27, 2023

WEDNESDAY, Dec. 27, 2023 -- At least 251 cases of lead poisoning linked to tainted fruit puree pouches have now been reported in 34 states, U.S. health officials said.That's up from 205 cases reported in the last weekly tally, the U.S. Centers of.

A study of the genetics of pericarditis increases understanding of newly approved drug treatment

SCIENMAG: Medicine & Health

DECEMBER 27, 2023

A study of the genetics of pericarditis increases understanding of newly approved drug treatment Credit: deCODE genetics A study of the genetics of pericarditis increases understanding of newly approved drug treatment Sequence variants that protect against pericarditis have been discovered at a genomic locus encoding interleukin-1 immune cytokines.

Treatment

Treatment Drugs

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A study of the genetics of pericarditis increases understanding of newly approved drug treatment

SCIENMAG: Medicine & Health

DECEMBER 27, 2023

Treatment

Treatment Drugs

A Parkinson's Diagnosis Can Come With Some Hope, Experts Say

Drugs.com

DECEMBER 27, 2023

WEDNESDAY, Dec. 27, 2023 — Patients with Parkinson's disease call it "D-Day," the date they were told they had the incurable movement disorder.Now, a new study suggests they might be getting the wrong message when they get the news."A lot of.

Disease

Virtual care works best when patients see their own family doctor, study finds

SCIENMAG: Medicine & Health

DECEMBER 27, 2023

Toronto, ON, December 27, 2023 – Compared to patients who had a virtual visit with their own family doctor, those who received virtual care from a doctor outside of their family care team were 66 percent more likely to visit the emergency department within seven days, according to new research.

Doctors

Doctors Research

Post-Trauma Support Can Prevent Repeat Hospitalizations

Drugs.com

DECEMBER 27, 2023

WEDNESDAY, Dec. 27, 2023 -- When hospitals support trauma survivors' mental health during and after treatment, patients are less likely to return in crisis, researchers report.There's no uniform guidance on how to offer mental health services to.

Hospitals

Hospitals Treatment Research

New patent for IMPAX drug TWINJECT 0.15

Drug Patent Watch

DECEMBER 27, 2023

Annual Drug Patent Expirations for TWINJECT+0.15 Twinject 0.15 is a drug marketed by Impax and is included in one NDA. It is available from four suppliers. There are two patents… The post New patent for IMPAX drug TWINJECT 0.15 appeared first on DrugPatentWatch - Make Better Decisions.

Drugs

Drugs Marketing

How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Colon Cancer Screening May Be Even More Effective Than Experts Thought

Drugs.com

DECEMBER 27, 2023

WEDNESDAY, Dec. 27, 2023 -- Getting your preventive screening colonoscopy could be even more of a lifesaver than you thought, a new analysis finds.The two gold standard tests for spotting cancers and polyps of the colon -- colonoscopy and.

New patent for IMPAX drug TWINJECT 0.3

Drug Patent Watch

DECEMBER 27, 2023

Annual Drug Patent Expirations for TWINJECT+0.3 Twinject 0.3 is a drug marketed by Impax and is included in one NDA. It is available from four suppliers. There are two patents… The post New patent for IMPAX drug TWINJECT 0.3 appeared first on DrugPatentWatch - Make Better Decisions.

Drugs

Drugs Marketing

Blue Ridge Beef Raw Pet Food Recalled Due to Salmonella Risk

Drugs.com

DECEMBER 27, 2023

WEDNESDAY, Dec. 27, 2023 -- Blue Ridge Beef, a maker of raw pet foods, has announced it is recalling some of its products for kittens and puppies because of possible contamination with salmonella and listeria.After being.

Production

New patent for IMPAX drug ADRENACLICK

Drug Patent Watch

DECEMBER 27, 2023

Annual Drug Patent Expirations for ADRENACLICK Adrenaclick is a drug marketed by Impax and is included in one NDA. It is available from four suppliers. There are two patents protecting… The post New patent for IMPAX drug ADRENACLICK appeared first on DrugPatentWatch - Make Better Decisions.

Drugs

Drugs Marketing

Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Pets Bring Health Boost to Single Seniors' Brains: Study

Drugs.com

DECEMBER 27, 2023

WEDNESDAY, Dec. 27, 2023 -- For the growing number of American seniors who live alone, having a beloved dog or cat by their side could help them maintain a healthy brain.New research on more than 7,900 people averaging 66 years of age found that.

Research

Being a 'Night Owl' Could Be Tough on Your Arteries

Drugs.com

DECEMBER 27, 2023

WEDNESDAY, Dec. 27, 2023 -- Hardened arteries are almost twice as common in night owls as in early birds, a new study shows.About two in five people (40%) who stay up very late had severely hardened arteries, compared with 22% of people who wake.

Unlocking Access: Direct-to-Patient Cash Solutions for Pharma Manufacturers

Fierce BioTech

DECEMBER 27, 2023

Unlocking Access: Direct-to-Patient Cash Solutions for Pharma Manufacturers dwunderlin Wed, 12/27/2023 - 14:25 Thu, 02/15/2024 - 11:00 Resource Type Webinar Duration 60 Minutes In today’s healthcare market, pharma manufacturers face many challenges such as payer coverage restrictions, generic competition, and crowded therapeutic categories that often hinder patient access to brand-name therapies.

Pharmaceutical Companies

Pharmaceutical Companies Pharmacy Therapies Pharmaceuticals

Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Even a Little Less Carb Intake Can Help Folks With Type 1 Diabetes

Drugs.com

DECEMBER 27, 2023

WEDNESDAY, Dec. 27, 2023 -- It may not take as strict a diet as thought to keep type 1 diabetes under control: New Swedish research shows that a moderate low-carb diet still helped people with type 1 diabetes stick to blood-sugar targets."The study.

Research

Developing and Manufacturing Drugs with HPAPIs

Fierce BioTech

DECEMBER 27, 2023

Developing and Manufacturing Drugs with HPAPIs Developing and manufacturing complex novel oral solid dose products of highly potent compounds requires specialized expertise. This article discusses how to effectively classify highly potent APIs and the steps required to develop containment protocols and manufacturing processes that are both safe and efficient. jpiatt Wed, 12/27/2023 - 14:56 Discover how to effectively classify highly potent APIs and the steps required to develop containment proto

Drugs

Drugs Production

Bureau of Justice Statistics Has Stopped Collecting and Reporting Data on Deaths in Jails and Prisons Due to HIV

Common Sense for Drug Policy Blog

DECEMBER 27, 2023

Bureau of Justice Statistics Has Stopped Collecting and Reporting Data on Deaths in Jails and Prisons Due to HIV "Data on deaths are no longer presented in this report. BJS ceased collection of detailed mortality data in state and local correctional facilities after the 2019 data year." dwf_admin Wed, 12/27/2023 - 19:41 Source Maruschak, Laura M. HIV In Prisons, 2021 - Statistical Tables.

OCC Highlights, AML & CRA Risks

Perficient: Drug Development

DECEMBER 27, 2023

This blog post was co-authored by: Connor Opalka Bank Compliance Executives can rest easier at night knowing they receive insights from Perficient’s Financial Services Risk and Regulatory Center of Excellence (CoE). In this article, we highlight the key emerging industry compliance risks as they were outlined by the Office of the Comptroller of the Currency’s (OCC) National Risk Committee in their recently released Semiannual Risk Perspective.

Compliance

Compliance Regulations Production

'Tummy Tucks' Still Very Safe; Often Done Along With Liposuction, Review Finds

Drugs.com

DECEMBER 27, 2023

WEDNESDAY, Dec. 27, 2023 -- Thinking of getting a tummy tuck in the new year? The procedure has remained very safe, a new 16-year analysis shows, with many patients opting for a little liposuction at the same time."Abdominoplasty [tummy tuck].

Which pharmaceutical companies have the most drug patents in Czech Republic?

Drug Patent Watch

DECEMBER 27, 2023

This chart shows the pharmaceutical companies with the most patents in Czech Republic. Patents must be filed in each country (or, in some cases regional patent office) where patent protection… The post Which pharmaceutical companies have the most drug patents in Czech Republic? appeared first on DrugPatentWatch - Make Better Decisions.

Pharmaceutical Companies

Pharmaceutical Companies Pharmaceuticals Drugs

Outsourcing in Clinical Trials New England

Alta Sciences

DECEMBER 27, 2023

Outsourcing in Clinical Trials New England iianiro Wed, 12/27/2023 - 21:45 Image boston-massachusetts-BOSTONTG0221-719aef2eeb1c4929b6c839715e34a69e.

Clinical Trials

Clinical Trials Trials

Are MDLs Fields of Dreams (or Nightmares)?

Drug & Device Law

DECEMBER 27, 2023

Last week Bexis posted a link to his comment on draft proposed Federal Rule of Civil Procedure 16.1, which deals with multidistrict litigations (MDLs). If you haven’t read proposed Rule 16.1 and the Bexis comment, you should. MDLs make up an enormous chunk of the federal civil case population and, at least from the defense perspective, MDLs are sadness machines.

Government

Government Trials Production Drugs