Drug Discovery World
OCTOBER 10, 2023
Editor Reece Armstrong provides an introduction to the Fall 2023 issue of Drug Discovery World. Find out more about the issue and how to read it. That this issue should feature a market report on the state of the United Kingdom’s drug discovery sector at the same time the country has regained access to Horizon Europe is somewhat of a happy coincidence.
addgene Blog
OCTOBER 10, 2023
Plasmids need antibiotic resistance genes so that you can specifically isolate bacteria containing your constructs of interest. But does it matter which antibiotic resistance gene you select? In this blog, we’ll break down the mechanism of action of the most common antibiotic resistance genes and which applications are best (or worst) for each antibiotic.
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Drug Discovery World
OCTOBER 10, 2023
The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. In celebration of the Nobel Prize for Medicine going to two of the early proponents of mRNA technology for creating therapeutics, Katalin Karikó and Drew Weissman, this week our round-up highlights the importance of genetics, genomics and gene editing in drug discovery.
Chemical Biology and Drug Design
OCTOBER 10, 2023
Compared with flavonoids, quinolones, and G007-LK , compound 14e showed the best inhibition potency against TNKS2, as it simultaneously occupied both the adenosine and nicotinamide pockets and formed a hydrogen bond with the amino group of Met1054. Abstract A new series of flavonoids and quinolone derivatives were designed, synthesized and, evaluated for their biological activity.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drug Discovery World
OCTOBER 10, 2023
Over recent months, there have been a number of ground-breaking discoveries in drug discovery for mental health conditions. A new class of antidepressants In July 2023, AlzeCure Pharma published the results of a preclinical study supporting the antidepressive effects ACD856, the first in a new class of antidepressants. The article in the journal Psychopharmacology focuses on new data showing that ACD856, the lead clinical drug candidate in the NeuroRestore platform, exhibits antidepressant effec
Chemical Biology and Drug Design
OCTOBER 10, 2023
Molecular insights of HIV Reverse transcriptase and it's inhibitors. Abstract Human immunodeficiency virus (HIV) causes acquired immunodeficiency syndrome (AIDS), a lethal disease that is prevalent worldwide. According to the Joint United Nations Programme on HIV/AIDS (UNAIDS) data, 38.4 million people worldwide were living with HIV in 2021. Viral reverse transcriptase (RT) is an excellent target for drug intervention.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
BioPharma Drive: Drug Pricing
OCTOBER 10, 2023
There have been few bigger-ticket acquisitions recently. But a string of deals announced in early October may affirm the forecasts of analysts who expect M&A to tick up in the coming months.
Drug Discovery World
OCTOBER 10, 2023
Aulos Bioscience has revealed new safety and efficacy data from the Phase I dose escalation portion of its Phase I/II clinical trial of AU-007 in patients with unresectable locally advanced or metastatic solid tumour cancers. The data will be presented at the Society for Immunotherapy of Cancer (SITC) 38th Annual Meeting, being held in San Diego, California, from 1-5 November 2023.
BioPharma Drive: Drug Pricing
OCTOBER 10, 2023
The pharma plans for the new Berkeley facility to produce clinical, and potentially commercial, supplies of a Parkinson’s disease cell therapy being tested by its subsidiary BlueRock.
Drug Discovery World
OCTOBER 10, 2023
Rejuvenate Biomed, a clinical-stage company advancing therapeutics to delay the onset of age-related diseases, has completed a six-week clinical proof-of-mechanism study with lead candidate RJx-01 for the treatment of sarcopenia. Sarcopenia is a musculoskeletal disease characterised by the progressive loss of skeletal muscle strength and mass, which manifests chronically with age or as an acute condition induced by muscle disuse, for example following immobilisation due to a stay in hospital.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Drugs.com
OCTOBER 10, 2023
MONDAY, Oct. 9, 2023 -- A California bill would have made free condoms available for high schoolers, but it was vetoed Sunday by Gov. Gavin Newsom because of cost. California has a budget deficit of $30 billion, Newsom noted in his veto of Senate.
Drug Discovery World
OCTOBER 10, 2023
The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. In celebration of the Nobel Prize for Medicine going to two of the early proponents of mRNA technology for creating therapeutics, Katalin Karikó and Drew Weissman, this week our round-up highlights the importance of genetics, genomics and gene editing in drug discovery.
Drugs.com
OCTOBER 10, 2023
MONDAY, Oct. 9, 2023 -- Researchers have developed an antibody that can reduce Alzheimer's-like brain damage in lab mice — inspired by the case of one woman with remarkable resistance to the disease. The work, by researchers at Mass General.
Drug Target Review
OCTOBER 10, 2023
Houston, Texas – October 9 th , 2023 — Sino Biological, Inc. (“Sino Biological” or the “Company”), a biotechnology company listed on the Shenzhen stock exchange subsidiary ChiNext (SZSE: 301047), which provides biological research reagents and related technical contract research services , is pleased to announce the formal opening of its new Center for Bioprocessing (C4B) in Houston, Texas USA at Levit Green , adjacent to the world-renowned Texas Medical Center.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Drugs.com
OCTOBER 10, 2023
MONDAY, Oct. 9, 2023 -- Flavoring added to small, cheap cigars is making these the second-most popular tobacco product among youth, a new report shows. The report comes as federal regulators prepare to bar flavored cigars. They are marketed with.
Science Daily: Pharmacology News
OCTOBER 10, 2023
Artificial intelligence (AI) comes with promises of helping coders code faster, drivers drive safer, and making daily tasks less time-consuming. But a recent study demonstrates that the tool, when adopted widely, could have a large energy footprint, which in the future may exceed the power demands of some countries.
Drugs.com
OCTOBER 10, 2023
MONDAY, Oct. 9, 2023 -- Exercise has been dubbed "nature's antidepressant" by doctors for years, and now a new study confirms the notion. The finding follows a four-month look at the impact that running had on anxiety and depression when compared.
Covalent Modifiers
OCTOBER 10, 2023
Muhammad Murtaza Hassan, Yen-Der Li, Michelle W. Ma, Mingxing Teng, Woong Sub Byun, Kedar Puvar, Ryan Lumpkin, Brittany Sandoval, Justine C. Rutter, Cyrus Y. Jin, Michelle Y. Wang, Shawn Xu, Anna M. Schmoker, Hakyung Cheong, Brian J. Groendyke, Jun Qi, Eric S Fischer, Benjamin L. Ebert, Nathanael Gray bioRxiv 2023 [link] Small molecules that can induce protein degradation by inducing proximity between a desired target and an E3 ligase have the potential to greatly expand the number of proteins t
NIOSH Science Blog: Drugs
OCTOBER 10, 2023
The workplace is an important setting to address mental health conditions, excessive alcohol use, and other substance use disorders among workers. In 2021, more than half of U.S. adults who reported a mental illness in the last year were employed. National U.S. data show that 70% of all adults with a substance use disorder (including alcohol or illicit drug use disorders) are employed.
Drugs.com
OCTOBER 10, 2023
MONDAY, Oct. 9, 2023 -- Not all children diagnosed with autism as toddlers continue to have that diagnosis once they reach elementary school, a new study shows. While some past research has suggested this could be true, the new research backs that.
Science Daily: Pharmacology News
OCTOBER 10, 2023
People who carry three gene variants that have bene inherited from Neanderthals are more sensitive to some types of pain, according to a new study.
Drugs.com
OCTOBER 10, 2023
MONDAY, Oct. 9, 2023 -- Young children who are close to their parents are more likely to grow up to be kind, caring and considerate. These kids may also have fewer mental health problems during early childhood and adolescence, a new study finds. By.
Science Daily: Pharmacology News
OCTOBER 10, 2023
Though scientists have long known through observational data that the Milky Way is warped and its edges are flared like a skirt, no one could explain why. Now, astronomers have performed the first calculations that fully explain this phenomenon, with compelling evidence pointing to the Milky Way's envelopment in an off-kilter halo of dark matter.
Drugs.com
OCTOBER 10, 2023
MONDAY, Oct. 9, 2023 – One way to help lower the odds for long COVID in people with pre-existing conditions may be to get more sleep. A new study discovered the risk was lower in those who slept six to nine hours a night compared to "short.
Science Daily: Pharmacology News
OCTOBER 10, 2023
Twelve people crossed the Atlantic Ocean in a rowing boat. One of them was Ciara Burns, a scientist, who monitored her own heartbeat. Now the data was analyzed and the results were published: It turns out that the variability of the heart rate provides a lot of information about physical and mental wellbeing.
Drugs.com
OCTOBER 10, 2023
Croup can be a scary thing for new parents to watch their babies struggle with, so here is a primer on what it is and how to best treat it. Croup is a common respiratory illness, characterized by a narrowing of the main airway (the trachea), just.
Science Daily: Pharmacology News
OCTOBER 10, 2023
An unexpectedly high number of young stars has been identified in the direct vicinity of a supermassive black hole and water ice has been detected at the center of our galaxy.
Cytel
OCTOBER 10, 2023
Cytel’s Functional Service Provision (FSP) teams work on exciting projects with biotech and pharmaceutical companies as statistical programmers and biostatisticians. We spoke with Brooke Smith, Senior Biostatistician, who’s based in the US and working with a global pharmaceutical company, about the meaningful and impactful projects she’s working on and what it’s like to work as a biostatistician with Cytel’s FSP.
Drug Patent Watch
OCTOBER 10, 2023
Annual Drug Patent Expirations for WEGOVY Wegovy is a drug marketed by Novo and is included in one NDA. It is available from two suppliers. There are five patents protecting… The post New patent for NOVO drug WEGOVY appeared first on DrugPatentWatch - Make Better Decisions.
Perficient: Drug Development
OCTOBER 10, 2023
Many people would argue that the workplace has changed significantly in the past couple of years. A lot of individuals credit this change to COVID-19 because of the instant shift to online work. COVID-19 forced companies online with little to no prep time. This was a clunky adjustment, at best, for some industries but for others, it was a smooth transition that ended up sticking around.
Drug Patent Watch
OCTOBER 10, 2023
Annual Drug Patent Expirations for SUNOSI Sunosi is a drug marketed by Axsome Malta and is included in one NDA. It is available from two suppliers. There are thirteen patents… The post New patent for Axsome Malta drug SUNOSI appeared first on DrugPatentWatch - Make Better Decisions.
Drugs.com
OCTOBER 10, 2023
MONDAY, Oct. 9, 2023 -- For a subset of patients with advanced lung cancer, radiation therapy can sometimes substantially extend their lives. Now a new study hints that a blood test could be used to identify the people most likely to.
Drug Patent Watch
OCTOBER 10, 2023
For more information on how DrugPatentWatch can help with your pharmaceutical business intelligence needs, contact admin@DrugPatentWatch.com or visit www.DrugPatentWatch.com The post New tentative approval for Mylan Gmbh drug trastuzumab-dkst appeared first on DrugPatentWatch - Make Better Decisions.
BioPharma Drive: Drug Pricing
OCTOBER 10, 2023
The biotech claimed the results still showed promise for its experimental fatty liver disease treatment, but shares sank sharply on the news.
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