Tue.Jan 07, 2025

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ALS drugs from Denali, Calico come up short, marking more failures for Healey trial

BioPharma Drive: Drug Pricing

Denali’s medicine and a similar one from Calico Life Sciences and AbbVie were not much different than a placebo, bringing the tally of failed drugs in the innovative “Healey platform trial” to seven.

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Dinosaurs roamed the northern hemisphere millions of years earlier than previously thought, according to new analysis of the oldest North American fossils

Science Daily: Pharmacology News

A newly described dinosaur whose fossils were recently uncovered is challenging the existing narrative, with evidence that the reptiles were present in the northern hemisphere millions of years earlier than previously known.

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Metsera reveals study data supporting long-acting obesity shot

BioPharma Drive: Drug Pricing

The startup, which has already raised more than half a billion dollars, released Phase 2 results that could position its drug as a future threat to weight loss medicines from Novo Nordisk and Eli Lilly.

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Health Advocates Are Unhappy with FDA Guidance on Lead Levels in Baby Food

Drugs.com

TUESDAY, Jan. 7, 2025 -- The U.S. Food and Drug Association (FDA) released the first-ever guidelines for levels of lead in processed baby foods this week. However, many health and safety advocates say they are not satisfied with the guidance.Under.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Morning coffee may protect the heart better than all-day coffee drinking

Science Daily: Pharmacology News

People who drink coffee in the morning have a lower risk of dying from cardiovascular disease and a lower overall mortality risk compared to all-day coffee drinkers, according to new research.

Disease 78
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Access to Medical Test Results Is Confusing, Anxiety-Provoking

Drugs.com

TUESDAY, Jan. 7, 2025 -- Patients have more access to their own medical test results than ever before, thanks to legislation requiring results be released as soon as theyre available.But thats not necessarily a good thing, a new study warns.Many p.

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FDA Calls for Better Accuracy of Pulse Oximeters in People of Color

Drugs.com

TUESDAY, Jan. 7, 2025 -- Pulse oximeters -- those tiny devices that measure blood oxygen levels with a quick clip to your finger -- may soon get a major upgrade to ensure they work just as well for people of all skin tones.The U.S. Food and Drug.

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AI Unleashed: Transforming Drug Discovery from Theory to Practice

Plenge Gen

When I last wrote about AI on this blog three years ago, I spoke of it being a tool with the potential to transform scientific discovery, but the application I described was primarily theoretical. For AI to be a meaningful tool in R&D, I argued, we needed better sources of truth better data sets that AI tools could query and learn from over time and technology capable of integrating multiples steps into a semi-automated system.

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Multilingual Children with Autism Show Improved Cognitive Function

Drugs.com

TUESDAY, Jan. 7, 2025 -- Kids with autism who speak more than one language tend to have fewer symptoms from their disorder.Being multilingual not only enhances their general cognitive abilities, but also helps them better control their daily.

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Vertex, startup Orna to partner on gene editing research

BioPharma Drive: Drug Pricing

The three-year partnership is another example of Vertex’s interest in improving on Casgevy, its CRISPR medicine for sickle cell and beta thalassemia.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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More Evidence Bolsters the Oral Herpes and Alzheimer’s Link

Drugs.com

TUESDAY, Jan. 7, 2025 -- That cold sore on your lip might be painful and unsightly, but it could also be a harbinger of debilitating brain aging.The oral herpes virus appears to be linked with Alzheimers disease, suggesting that the common i.

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N-Acyl-N-alkyl/aryl Sulfonamide Chemistry Assisted by Proximity for Modification and Covalent Inhibition of Endogenous Proteins in Living Systems

Covalent Modifiers

Tomonori Tamura and Itaru Hamachi Accounts of Chemical Research 2025 58 (1), 87-100 DOI: 10.1021/acs.accounts.4c00628 Selective chemical modification of endogenous proteins in living systems with synthetic small molecular probes is a central challenge in chemical biology. Such modification has a variety of applications important for biological and pharmaceutical research, including protein visualization, protein functionalization, proteome-wide profiling of enzyme activity, and irreversible inhi

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Fluoride May Be Linked to Decreased IQ, Says "Limited Data," Hard-to-Interpret Study

Drugs.com

TUESDAY, Jan. 7, 2025 -- Fluoride exposure appears to slightly decrease IQ scores in children, a new federal meta-analysis has concluded -- but not at the low levels recommended for U.S. drinking water. Fluoride in drinking water was associated.

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J&J says cancer drug combination showed survival benefit over Tagrisso

BioPharma Drive: Drug Pricing

Results from a study called Mariposa found a regimen of Rybrevant and Lazcluze helped patients with a common form of advanced lung cancer live longer.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Caregivers Face Mental, Physical Health Risks

Drugs.com

TUESDAY, Jan. 7, 2025 -- More and more adults are stuck in the middle of their families, caring not only for their children but also for aging parents and other older family members.The mental and physical health of these sandwich carers is more l.

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Inflation-Adjusted U.S. Brand-Name Drug Prices Fell for the Seventh Consecutive Year as a New Era of Drug Pricing Dawns

Drug Channels

It's time for Drug Channels annual examination of U.S. brand-name drug pricing. For 2024, average brand-name drugs list prices grew by only 2.3%. Whats more, after adjusting for overall inflation, brand-name drug net prices dropped for an unprecedented seventh consecutive year. Details and additional commentary below. As I predicted two years ago , the combined impact of changes to Medicaid rebates, the Inflation Reduction Act (IRA), and novel formulary access strategies have led multiple m

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Blood Test May Help Predict How Long Immunity Lasts

Drugs.com

TUESDAY, Jan. 7, 2024 -- Its long been a mystery why folks need a flu vaccine every year, even though immunizations they got in childhood continue to protect them from measles and mumps.Researchers now think they know why vaccine effectiveness v.

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American Society of Clinical Psychopharmacology (ASCP) Annual Meeting

Alta Sciences

American Society of Clinical Psychopharmacology (ASCP) Annual Meeting iianiro Wed, 01/08/2025 - 01:49 Image GettyImages-1402212936.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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First U.S. Death From Bird Flu Reported in Louisiana

Drugs.com

TUESDAY, Jan. 7, 2025 -- A Louisiana resident has died after being hospitalized with bird flu in December of last year, marking the first known U.S. death from the virus. The patient who, "was over the age of 65 and was reported to have underlying.

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ARVO 2025 Annual Meeting

Alta Sciences

ARVO 2025 Annual Meeting iianiro Wed, 01/08/2025 - 01:58 Image GettyImages-2105788910.

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Educating Patients about Generic Drugs: Strategies for Success

Drug Patent Watch

Generic drugs play a crucial role in providing affordable medication options to patients. However, many individuals still harbor misconceptions and doubts about the efficacy and safety of generic alternatives. As healthcare professionals, it’s our responsibility to educate patients about generic drugs and empower them to make informed decisions about their treatment options.

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AAPS National Biotechnology Conference

Alta Sciences

AAPS National Biotechnology Conference iianiro Wed, 01/08/2025 - 02:08 Image GettyImages-928417954.

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Earth's air war: Explaining the delayed rise of plants, animals on land

Science Daily: Pharmacology News

If you like the smell of spring roses, the sounds of summer birdsong, and the colors of fall foliage, you have the stabilization of the ozone layer to thank for it. Located in the stratosphere, where it shields the Earth from harmful ultraviolet radiation, the ozone layer plays a key role in preserving the planet's biodiversity. And now we may have a better idea of why that took so long -- more than 2 billion years -- to happen.

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American Society of Gene and Cell Thereapy's (ASGCT) 28th Annual Meeting

Alta Sciences

American Society of Gene and Cell Thereapy's (ASGCT) 28th Annual Meeting iianiro Wed, 01/08/2025 - 02:28 Image GettyImages-1292266833.

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Overview of.NET MAUI: Easily Developing Cross-Platform Applications

Perficient: Drug Development

Applications that run smoothly across numerous platforms are in demand more than ever in today’s ever-changing technological landscape. Introducing Microsoft’s robust framework,NET Multi-platform App UI (.NET MAUI ), which makes it easier to create native desktop and mobile apps with a single codebase.NET MAUI: What is it? NET MAUI is an open-source framework that lets programmers use C# and XAML to create Windows, macOS, iOS, and Android applications.

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BIO-EUROPE SPRING

Alta Sciences

BIO-EUROPE SPRING iianiro Wed, 01/08/2025 - 01:08 Image GettyImages-493223692.

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DoxyPEP Lowers Rate of Sexually Transmitted Infections (STIs), Data Suggests

Drugs.com

TUESDAY, Jan. 7, 2025 -- Worried about the risky sex you had last night?Using a common antibiotic following sex can dramatically reduce a persons risk of some sexually transmitted infections (STIs), a new study says.Taking doxycycline within 72 h.

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19TH WRIB

Alta Sciences

19TH WRIB iianiro Wed, 01/08/2025 - 01:14 Image nola-0.

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Pluto-Charon formation scenario mimics Earth-Moon system

Science Daily: Pharmacology News

A researcher has used advanced models that indicate that the formation of Pluto and Charon may parallel that of the Earth-Moon system. Both systems include a moon that is a large fraction of the size of the main body, unlike other moons in the solar system. The scenario also could support Pluto's active geology and possible subsurface ocean, despite its location at the frozen edge of the solar system.

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A clinical genomicist harnesses team-based science to help rare-disease patients

Broad Institute

A clinical genomicist harnesses team-based science to help rare-disease patients By Allessandra DiCorato January 7, 2025 Breadcrumb Home A clinical genomicist harnesses team-based science to help rare-disease patients Heidi Rehm convinced labs and scientists to work together and share data. This has helped many people with rare disease find answers.

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