Chemical Biology and Drug Design

OCTOBER 6, 2024

Alzheimer's disease (AD) is a progressive age-related neurodegenerative disorder characterized by loss of memory and other cognitive functions. The problem of this disease is even more fundamental because the available therapies only provide symptomatic relief without addressing the basic factor of the disease. This review article comprehensively summarized the recent advancement in memantine and its hybrid analogs as potential disease-modifying agents for the management of AD.

Disease 100

Disease Treatment Therapies 100

Drugs.com

OCTOBER 6, 2024

SUNDAY, Oct. 6, 2024 — Pain, tingling and cramps in your legs and feet may be giving you a warning.They could be signs of poor blood circulation, which can lead to serious heart and health problems if left untreated, according to a doctor at Baylor.

Doctors 103

Doctors 103

SugarCone Biotech

OCTOBER 6, 2024

By Paul D. Rennert, SugarCone Biotech LLC. Cell surface degraders are weird but cool. There is an emerging class of therapeutics, brilliant really, that make use of cell surface proteins that will respond to antibody binding by moving quickly inside the cell and then shuttling over to lysosomes for degradation. The trick is bind to these “internalizer proteins” with a bispecific antibody or fusion protein so they drag a second bound targeted protein with them.

Targeted Protein Degradation 73

Targeted Protein Degradation International Engineering Therapies 73

Drug Patent Watch

OCTOBER 6, 2024

NUCYNTA ER (tapentadol hydrochloride) Collegium pharm inc Patent: 8,114,383 Expiration: Oct 10, 2024 See More … Source

Drugs 52

Drugs 52

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Codon

OCTOBER 6, 2024

Tom Ireland writes about technological advances — and roadblocks — in artificial wombs for Issue 04 of Asimov Press. The womb is a remarkable organ — a muscular, pear-shaped chamber that supports the transformation of a tiny cluster of dividing cells into an entirely new person. All humans begin their lives in this sturdy chamber. At least for now.

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FDA Hospitals Engineering Research 89

Common Sense for Drug Policy Blog

OCTOBER 6, 2024

Marijuana, Psychosis, and Policy Development "Two things are needed to move beyond policy-biased appraisals of the evidence on cannabis and psychosis. "First, we need to use explicit criteria to assess the evidence for contributory causal relationships and apply them in an even-handed and consistent way. We should avoid the example of the tobacco industry in setting such a high standard of evidence for a causal inference that no evidence can satisfy it ( 30 ).

Regulations 52

Regulations Government Production Marketing 52