Sun.Oct 06, 2024

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Recent Advances in Medicinal Chemistry of Memantine Against Alzheimer's Disease

Chemical Biology and Drug Design

Alzheimer's disease (AD) is a progressive age-related neurodegenerative disorder characterized by loss of memory and other cognitive functions. The problem of this disease is even more fundamental because the available therapies only provide symptomatic relief without addressing the basic factor of the disease. This review article comprehensively summarized the recent advancement in memantine and its hybrid analogs as potential disease-modifying agents for the management of AD.

Disease 100
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Poor Circulation: How to Prevent It, How to Spot It

Drugs.com

SUNDAY, Oct. 6, 2024 — Pain, tingling and cramps in your legs and feet may be giving you a warning.They could be signs of poor blood circulation, which can lead to serious heart and health problems if left untreated, according to a doctor at Baylor.

Doctors 105
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Attacking Cancers Using Novel Methods of Targeted Protein Degradation

SugarCone Biotech

By Paul D. Rennert, SugarCone Biotech LLC. Cell surface degraders are weird but cool. There is an emerging class of therapeutics, brilliant really, that make use of cell surface proteins that will respond to antibody binding by moving quickly inside the cell and then shuttling over to lysosomes for degradation. The trick is bind to these “internalizer proteins” with a bispecific antibody or fusion protein so they drag a second bound targeted protein with them.

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Drug Patent Expirations for the Week of October 6, 2024

Drug Patent Watch

NUCYNTA ER (tapentadol hydrochloride) Collegium pharm inc Patent: 8,114,383 Expiration: Oct 10, 2024 See More … Source

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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To Be Born in a Bag

Codon

Tom Ireland writes about technological advances — and roadblocks — in artificial wombs for Issue 04 of Asimov Press. The womb is a remarkable organ — a muscular, pear-shaped chamber that supports the transformation of a tiny cluster of dividing cells into an entirely new person. All humans begin their lives in this sturdy chamber. At least for now.

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Marijuana, Psychosis, and Policy Development

Common Sense for Drug Policy Blog

Marijuana, Psychosis, and Policy Development "Two things are needed to move beyond policy-biased appraisals of the evidence on cannabis and psychosis. "First, we need to use explicit criteria to assess the evidence for contributory causal relationships and apply them in an even-handed and consistent way. We should avoid the example of the tobacco industry in setting such a high standard of evidence for a causal inference that no evidence can satisfy it ( 30 ).