Drug Discovery World

MARCH 14, 2024

NeuroSense Therapeutics has reported additional positive data from its six-month double-blind Phase IIb PARADIGM trial of its lead drug candidate PrimeC for the treatment of amyotrophic lateral sclerosis (ALS). The PARADIGM trial’s secondary clinical efficacy outcome measure endpoints included Quality of Life and Survival. Consistent with the previously reported results, PrimeC displayed a clinically meaningful effect on various aspects of patients’ quality of life, including ment

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Trials Clinical Trials Disease Treatment 130

Broad Institute

MARCH 14, 2024

Scientists generate new targeted protein degradation system that tunes a cell’s own proteins By Leah Eisenstadt March 14, 2024 Breadcrumb Home Scientists generate new targeted protein degradation system that tunes a cell’s own proteins Researchers have engineered a compact degron tag that can be precisely edited into a cell’s genome, enabling scientists to trigger the rapid breakdown of native target proteins.

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Targeted Protein Degradation Small Molecule Medical Schools Science 141

Drug Discovery World

MARCH 14, 2024

Roche and Johnson & Johnson are the only pharma companies to feature in Clarivate’s 2024 list of Top 100 Global Innovators, which highlights organisations leading the world in technology research and innovation. This is the first year that Clarivate is ranking, rather than just listing, the top innovators. Johnson & Johnson claimed the 71 st spot, while Roche secured the 89 th position according to this year’s ranking.

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Science Daily: Pharmacology News

MARCH 14, 2024

A healthier diet is associated with a reduced dementia risk and slower pace of aging, according to a new study. The findings show that a diet-dementia association was at least partially facilitated by multi-system processes of aging. Until now, the biological mechanism of this protection was not well understood.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

MARCH 14, 2024

Pharmaceutical company Promontory Therapeutics has completed enrolment of its Phase II clinical trial of lead therapeutic candidate, PT-112, in patients with late-line metastatic castration-resistant prostate cancer (mCRPC). The study is evaluating PT-112 in patients who have been treated with at least three prior life-prolonging therapies for mCRPC, and who exhibited radiographic evidence of disease progression at study entry.

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Clinical Trials Pharmaceutical Companies Drugs FDA 130

BioPharma Drive: Drug Pricing

MARCH 14, 2024

Rezdiffra’s clearance is a turning point in the fight against the liver disease. But its sales potential is unclear, and competition could emerge from popular weight loss drugs.

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FDA Approval FDA Drugs Disease 130

Science Daily: Pharmacology News

MARCH 14, 2024

Inspired by the classic drinking bird toy, scientists have developed an engine that efficiently converts energy from water evaporation into electricity to power small electronics. The device produces energy outputs exceeding 100 volts -- much higher than other techniques that generate electricity from water -- and can operate for several days using only 100 milliliters of water as fuel, according to a new study.

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Engineering 121

BioPharma Drive: Drug Pricing

MARCH 14, 2024

The funding for the startup, which partnered with Bristol Myers Squibb last year, adds to a surge of recent investments in developers of antibody-drug conjugates.

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Drugs 126

Science Daily: Pharmacology News

MARCH 14, 2024

Materials that are incredibly thin, only a few atoms thick, exhibit unique properties that make them appealing for energy storage, catalysis and water purification. Researchers have now developed a method that enables the synthesis of hundreds of new 2D materials.

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Research 118

BioPharma Drive: Drug Pricing

MARCH 14, 2024

Pressed by lawmakers, the lobbying group is also “taking steps” to end its relationship with Wuxi-AppTec, a major contract manufacturer to the biopharmaceutical industry.

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

MARCH 14, 2024

THURSDAY, March 14, 2024 -- The blockbuster weight-loss medication Zepbound (tirzepatide) appears to help folks quickly shed pounds regardless of how overweight they are, or how long they've lived being overweight or obese. Those are the findings.

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Antidote

MARCH 14, 2024

Receiving a multiple sclerosis (MS) diagnosis can feel overwhelming and isolating for many. MS is a neurodegenerative disease that often involves challenging symptoms — but knowing what to expect and what resources are available can help.

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Disease 116

Science Daily: Pharmacology News

MARCH 14, 2024

A recent study observing wild chimpanzees over a period of more than 10 years revealed that when food gets scarcer, the adults put play aside and focus on survival, while mother chimps continue to be their children's primary playmate -- suggesting their indispensable role to foster their young's physical and social development.

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Perficient: Drug Development

MARCH 14, 2024

Last week, I attended TrailblazerDX in San Francisco, where the content was all about Salesforce Data Cloud and AI! There were over 300 sessions to attend, from technical talks to hands-on workshops where attendees could learn how to build copilots and how to use the latest Salesforce platform features directly from product managers , architects, and fellow developers.

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Production Science Marketing 111

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drugs.com

MARCH 14, 2024

THURSDAY, March 14, 2024 — Do you struggle to sleep during the week and play catch up on the weekend? Do you toss and turn all night long and start the day in a fog? Are you a napper? Or are you among the lucky folks who have no.

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Research 98

SCIENMAG: Medicine & Health

MARCH 14, 2024

Extracorporeal membrane oxygenation (ECMO) can be a life-saving therapy for patients with acute heart or lung failure. During ECMO therapy, a patient’s blood flows out of their veins through tubes and into a machine that does both the actions of the heart and lungs.

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Therapies 96

Drugs.com

MARCH 14, 2024

THURSDAY, March 14, 2024 -- There's a toxic stew of chemicals in polluted air that can all trigger asthma attacks in kids, new research shows. Also, where a child lives -- for example, near factories or highways -- greatly influences how much.

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Research 98

SCIENMAG: Medicine & Health

MARCH 14, 2024

Coronavirus envelope protein is a drug target for new platform for the identification and optimization of peptides against SARS-CoV-2 Credit: Image Credit: Masayuki Yazawa (CC-BY 4.

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Drugs 84

Drugs.com

MARCH 14, 2024

THURSDAY, March 14, 2024 -- An experimental blood test accurately detected colon cancer in more than 8 in 10 people confirmed to have the disease, researchers report. The test — which could be an option for people who want to avoid.

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Disease Research 98

SCIENMAG: Medicine & Health

MARCH 14, 2024

Our nervous systems are naturally wired to sense fear. Whether prompted by the eerie noises we hear alone in the dark or the approaching growl of a threatening animal, our fear response is a survival mechanism that tells us to remain alert and avoid dangerous situations.

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Drugs.com

MARCH 14, 2024

THURSDAY, March 14, 2024 -- Researchers hope findings from a new study of liver transplant patients will lead to improved interventions for those from racial and ethnic minority groups. The study — led by researchers at UT Southwestern.

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Research 96

addgene Blog

MARCH 14, 2024

In the last decade, the use of degron tags has become increasingly popular for the modulation of endogenously and exogenously expressed proteins. Here we will review what advantages degron tags can offer over other protein control methods and compare the commonly available types of degron tags.

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Drugs.com

MARCH 14, 2024

THURSDAY, March 14, 2024 -- Combat veterans who suffered traumatic brain injuries due to explosive blasts may have markers in their spinal fluid similar to those of Alzheimer's disease, new research finds. "Previous research has shown that moderate.

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Disease Research 75

BioPharma Drive: Drug Pricing

MARCH 14, 2024

The deal gives AstraZeneca a prospect in late-stage testing for parathyroidism and bolsters a rare disease portfolio that mainly consists of drugs from Alexion.

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Disease Drugs 73

Drugs.com

MARCH 14, 2024

THURSDAY, March 14, 2024 -- Following a cyberattack on one of the nation's largest health insurers that's thrown health care payments into disarray and likely exposed reams of private patient data, the U.S. Department of Health and Human Services.

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Drug Patent Watch

MARCH 14, 2024

Annual Drug Patent Expirations for METAXALONE Metaxalone is a drug marketed by Actavis Labs Fl Inc, Amneal Pharms, Appco, Ingenus Pharms Llc, Lannett Co Inc, Mountain, Primus Pharms, Sandoz, and… Source

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Drugs Marketing 59

Drugs.com

MARCH 14, 2024

THURSDAY, March 14, 2024 -- College students who use drugs like Adderall to help them focus on their studies may be setting themselves up for trouble. Researchers asked 700 undergraduates across the United States about drugs commonly used by.

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Drugs Research 97

Drug Patent Watch

MARCH 14, 2024

Annual Drug Patent Expirations for FARXIGA Farxiga is a drug marketed by Astrazeneca Ab and is included in one NDA. It is available from five suppliers.

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Drugs Marketing 59

Drugs.com

MARCH 14, 2024

THURSDAY, March 14, 2024 -- Delivering dual-targeted, immune-focused CAR T cancer therapy via a patient's spinal fluid quickly shrank deadly brain tumors, researchers report.

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Therapies Research 64

Broad Institute

MARCH 14, 2024

Spatial Technology Platform Team By Rose Circeo March 14, 2024 Breadcrumb Home Spatial Technology Platform Team To advance and apply cutting edge spatial and imaging technologies Sami Farhi Director Lindsey Erion-Barner Senior Research Scientist Nicolas Fernandez Senior Computational Scientist Michal Lipinski Senior Computational Scientist Keisha Matthew Lab Manager, histotechnologist Sara Sime Senior Project Coordinator Jack Nelson Research Associate II Chanell Mangum Research Associate I

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Research 52

Perficient: Drug Development

MARCH 14, 2024

Perficient Receives Seven “Most Valuable Professional” Recognitions We are proud to share our inclusion in the Coveo MVP Program with 7 of our own selected for the recognition. The Coveo MVP program recognizes individuals for their invaluable contributions and expertise within the Coveo ecosystem. To be considered for the recognition of Coveo MVP, one must possess a deep understanding of the platform and its business value to demonstrate strong thought leadership in the community.

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Marketing 52

Drugs.com

MARCH 14, 2024

THURSDAY, March 14, 2024 -- Actress and "X-Men" star Olivia Munn announced Wednesday that she has been fighting breast cancer. Posting on her Instagram account, beside a photo of herself in a hospital bed, Munn wrote, “I was diagnosed.

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Hospitals 52

Perficient: Drug Development

MARCH 14, 2024

The ability to offer healthcare products and services digitally is more important than ever. In fact, the global healthcare eCommerce market is projected to reach $994.2 billion by 2030. But a complex regulatory landscape and data privacy and security concerns are formidable obstacles. Additionally, consumer demand for proactive, personalized experiences is at an all-time high.

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Science Pharmacy Marketing Production 52

Drugs.com

MARCH 14, 2024

THURSDAY, March 14, 2024 -- It only appears to work until age 74, but a new study has identified a gene variant that protects men from from severe illness and death when COVID lands them in the hospital. The protective gene appears to help tamp.

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