NIOSH Science Blog: Drugs

NOVEMBER 7, 2024

Introduction No Shave November is a great opportunity to grow out your beard for a good cause. But if you rely on a tight-fitting respirator for work, that extra facial hair could pose a safety concern. Respirators protect workers from harmful particles, but their effectiveness depends on forming a tight seal against your skin. So, what does that mean for your growing beard during No Shave November?

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Science Daily: Pharmacology News

NOVEMBER 7, 2024

It's common knowledge that our brains -- and, specifically, our brain cells -- store memories. But a team of scientists has discovered that cells from other parts of the body also perform a memory function, opening new pathways for understanding how memory works and creating the potential to enhance learning and to treat memory-related afflictions.

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Drugs.com

NOVEMBER 7, 2024

THURSDAY, Nov. 7, 2024 -- More than a year after its advisory panel unanimously declared the drug phenylephrine to be useless against nasal congestion, the U.S. Food and Drug Administration is proposing that it be removed from common.

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Science Daily: Pharmacology News

NOVEMBER 7, 2024

Researchers have developed an innovative technique to search for black hole light echoes. Their novel method, which will make it easier for the mass and the spin of black holes to be measured, represents a major step forward, since it operates independently of many of the other ways in which scientists have probed these parameters in the past.

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Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

BioPharma Drive: Drug Pricing

NOVEMBER 7, 2024

Elevidys sales have increased since the FDA made a controversial choice to expand the therapy's use. Now, Sarepta is abandoning a successor to its drug Exondys 51, citing an “evolving" treatment landscape.

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Science Daily: Pharmacology News

NOVEMBER 7, 2024

Researchers have used ancient DNA to challenge long-held interpretations of the people of Pompeii. Contrary to physical appearances, the DNA evidence revealed unexpected variations in gender and kinship, revising the story as written since 1748. The genetic data also underlined the cosmopolitan nature of the Roman Empire, showing that Pompeians were mainly descended from immigrants from the eastern Mediterranean.

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Science Daily: Pharmacology News

NOVEMBER 7, 2024

Plastic pollution exacerbates the impacts of all planetary boundaries, including climate change, ocean acidification and biodiversity loss, a new paper shows. Ahead of the final negotiations of the international Plastics Treaty, researchers urge decision-makers to stop viewing plastics pollution as merely a waste management problem.

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Drugs.com

NOVEMBER 7, 2024

THURSDAY, Nov. 7, 2024 -- The head of the company that makes the diabetes and obesity drugs Ozempic and Wegovy has warned that compounded versions of the active ingredient in those medications have now been linked to at least 100 hospitalizations.

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Science Daily: Pharmacology News

NOVEMBER 7, 2024

Using a computer model that reveals how plants grow thicker over time, biologists have uncovered how cells are activated to produce wood tissue. Understanding the genetic and molecular signals behind this growth, they hope to advance forestry practices and carbon dioxide storage in trees.

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Drugs.com

NOVEMBER 7, 2024

THURSDAY, Nov. 7, 2024 -- About 7% of dairy workers exposed to the avian flu that is spreading through U.S. herds have become infected themselves, federal experts estimate.That number highlights concerns that circulating strains of bird flu might.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Science Daily: Pharmacology News

NOVEMBER 7, 2024

Readily available thermoelectric generators operating under modest temperature differences can power CO2 conversion, according to a proof-of-concept study by chemists. The findings open up the intriguing possibility that the temperature differentials encountered in an array of environments -- from a typical geothermal installation on Earth to the cold, desolate surface of Mars -- could power the conversion of CO2 into a range of useful fuels and chemicals.

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Drugs.com

NOVEMBER 7, 2024

THURSDAY, Nov. 7, 2024 (HeathDay News) -- The active chemical in “magic mushrooms” may help treat anorexia, a new study has found.Following psilocybin treatment, 4 of 10 study participants showed clinically significant reductions in their ano.

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thought leadership

NOVEMBER 7, 2024

Patient Support Programs (PSPs) in the pharmaceutical sector offer a range of services to help patients start and adhere to their therapies, including Patient Assistance Programs (PAPs), patient education, provider support, field role partnerships for injection and device training, concierge services for travel and lodging, and clinical trial support.

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Drugs.com

NOVEMBER 7, 2024

THURSDAY, Nov. 7, 2024 -- Rates of anxiety and depression among U.S. adults, especially younger folks, continues to rise, the latest federal data shows.Nearly 1 in every 5 (18.2%) adults reported anxiety issues in 2022, up from 15.6% in 2019.

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Clinical Trials

thought leadership

NOVEMBER 7, 2024

Current Landscape of Medication and Healthcare Access in India India's healthcare system is a complex landscape with significant disparities in access to medical services and medications. Despite progress over the years, challenges such as high out-of-pocket costs, geographical disparities, and cultural barriers continue to affect healthcare accessibility, especially for economically vulnerable populations.

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Drugs.com

NOVEMBER 7, 2024

THURSDAY, Nov. 7, 2024 -- Four cases of the more infectious variant of mpox have been reported in the U.K., making it the first cluster of infections that have surfaced outside of Africa.British authorities announced the first case in that country.

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Drug Patent Watch

NOVEMBER 7, 2024

The rising cost of prescription drugs has become a significant public health concern, with millions of Americans struggling to afford their medications. One crucial factor in mitigating this issue is the increased use of generic drugs. Generic drugs have been instrumental in reducing healthcare costs, and their impact cannot be overstated.

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Drugs.com

NOVEMBER 7, 2024

THURSDAY, Nov.7, 2024 -- Women who take vitamin D supplements during a pregnancy may be giving their kids the legacy of stronger bones, new British research suggests.Children whose moms took vitamin D supplements when pregnant had stronger, denser.

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Clinical Trials

keypoint

NOVEMBER 7, 2024

This month's Fellows Spotlight goes to Keystone Symposia Fellow Dr. LaQuita Jones! Dr. Jones is an Assistant Professor of Pediatrics at Cincinnati Children’s Hospital and the University of Cincinnati College of Medicine , where she specializes in hematologic malignancies, targeted therapeutics and resistance. In addition, she co-leads the health equity efforts within the Division of Oncology at Cincinnati Children’s Hospital, examining the distribution of immunotherapy to children with relapsed/

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Drugs.com

NOVEMBER 7, 2024

THURSDAY, Nov. 7, 2024 -- It doesn't take much: Adding just five minutes of exercise to your daily routine lowers your blood pressure and might cut your odds for heart disease, new research shows.“The good news is that whatever your physical a.

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addgene Blog

NOVEMBER 7, 2024

When Addgene opened in 2004, we focused on creating a repository that made it easy to share plasmids, both for people depositing plasmids and for people requesting them. Prior to this, many plasmids were available, but they often weren’t easily accessible, due to a wide range of logistical barriers. Addgene worked to identify, reduce, and remove these logistical barriers, allowing people to access a wide catalog of plasmids from all over the world.

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Science Daily: Pharmacology News

NOVEMBER 7, 2024

A recent study finds that color vision evolved in animals more than 100 million years before the emergence of colorful fruits and flowers. And there has been a dramatic explosion of color signals in the last 100 million years.

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Covalent Modifiers

NOVEMBER 7, 2024

Thomas M. Geiger, Radosław P. Nowak Annual Reports in Medicinal Chemistry , 2024 [link] Proteolysis targeting chimeras (PROTACs) are hetero-bifunctional molecules that remove disease-causing proteins through the means of targeted protein degradation (TPD). Since their proof-of-concept over 20 years ago, PROTACs emerged as new modality in drug discovery and chemical biology.

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FDA Law Blog: Biosimilars

NOVEMBER 7, 2024

By Véronique Li, Senior Medical Device Regulation Expert & Jeffrey N. Gibbs — In most instances, it is clear if a product will be considered a “device” under the Federal Food, Drug, and Cosmetic Act (FD&C Act). Sometimes, though, the question of classification defies an easy answer. When a company is unsure if its product is a device, there are a number of resources that can provide the answer, such as the device regulations at 21 CFR parts 800 – 898; any of the databases that cover pr

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Drug Channels

NOVEMBER 7, 2024

Today’s guest post comes from Chris Dowd, Senior VP of Market Development at ConnectiveRx. Chris examines three key trends that will affect patient support programs: the Inflation Reduction Act (IRA), legal/regulatory battles over copay adjustment programs, and uncertainties following a national election. He then outlines three actions that should guide manufacturers' preparation.

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Science Daily: Pharmacology News

NOVEMBER 7, 2024

Genes contain instructions for making proteins, and a central dogma of biology is that this information flows from DNA to RNA to proteins. But only two percent of the human genome actually encodes proteins; the function of the remaining 98 percent remains largely unknown. One pressing problem in human genetics is to understand what these regions of the genome do -- if anything at all.

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Perficient: Drug Development

NOVEMBER 7, 2024

In the PC-IDMC conversion process, it can be challenging to gather detailed information about workflows. Specifically, we often need to determine: The number of transformations used in each mapping. The number of sessions utilized within the workflow. Whether any parameters or variables are being employed in the mappings. The count of reusable versus non-reusable sessions used in the workflow etc.

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Common Sense for Drug Policy Blog

NOVEMBER 7, 2024

Physical and Behavioral Effects of Trenbolone "Outside of animal or clinical use, trenbolone has three times the androgen receptor binding affinity of testosterone ( Yarrow et al., 2011 ) and thus is renowned for its ability to rapidly increase lean muscle mass while minimising fat accumulation or promoting fat loss. Nevertheless, these benefits are accompanied by significant risk.

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Drugs.com

NOVEMBER 7, 2024

THURSDAY, Nov. 7, 2024 -- Memories are constantly adapting in the brain over time, dynamically updating as people encounter new information and fresh experiences.Researchers think they’ve figured out the brain mechanism that drives this memory i.

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Common Sense for Drug Policy Blog

NOVEMBER 7, 2024

Trenbolone and Verbal Aggression "These findings from the present study suggest that trenbolone use may be linked to increased verbal aggression among males using AAS, particularly at higher doses. This extends on current literature highlighting the potential effects of AAS on non-physical aggression ( Chegeni, Pallesen, et al., 2021 ), of which trenbolone is a potent example.

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Drugs.com

NOVEMBER 7, 2024

THURSDAY, Nov. 7, 2024 -- An experimental portable device might be able to detect lung cancer from a person’s exhaled breath, researchers report.The device contains “nanoflake” sensors that can detect small changes in the gases exhaled by a person w.

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Common Sense for Drug Policy Blog

NOVEMBER 7, 2024

Xylazine and Soft Tissue Injury "Xylazine (also known as “tranq, tranq dope, Philly dope, sleep-cut, or zombie drug”) is a non-opioid veterinary tranquilizer that has become a common additive with illicit fentanyl and other opioids. 1 When xylazine is injected with fentanyl, the result can be severe soft tissue injury ranging from superficial irritation to deep tissue necrosis and even bony involvement ( Fig. 1 ).

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Drugs.com

NOVEMBER 7, 2024

THURSDAY, Nov. 7, 2024 -- Seniors who are drowsy during the day and find it hard to muster enthusiasm for activities could be at higher risk of a brain condition that precedes dementia, a new study warns.These sleep-related problems are associated.

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