Hydromorphone hydrochloride preconditioning combined with postconditioning attenuates myocardial ischemia/reperfusion injury in rats by improving mitochondrial function and activating the PI3K/Akt signaling pathway
Chemical Biology and Drug Design
FEBRUARY 11, 2024
Hydromorphone hydrochloride (HH) attenuates myocardial ischemia/reperfusion injury in rats by by promoting mitochondrial biogenesis to improve mitochondrial function and reduce oxidative stress, and activating the PI3K/Akt signaling pathway. HH preconditioning combined with postconditioning showed optimal efficacy. Abstract Thrombolytic therapy or percutaneous coronary intervention for myocardial infarction often cause myocardial ischemia/reperfusion injury (MIRI) and poor prognosis of patients.
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