Thu.Jan 02, 2025

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Herpes virus might drive Alzheimer's pathology

Science Daily: Pharmacology News

Viral infections may play a role in Alzheimer's disease.

Virus 116
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10 clinical trials to watch in the first half of 2025

BioPharma Drive: Drug Pricing

Expected readouts in diabetes, cancer and depression headline a series of study results that could help the biotechnology sector regain its footing after a shaky year.

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Zebrafish protein unlocks dormant genes for heart repair

Science Daily: Pharmacology News

Researchers have successfully repaired damaged mouse hearts using a protein from zebrafish. They discovered that the protein Hmga1 plays a key role in heart regeneration in zebrafish. In mice, this protein was able to restore the heart by activating dormant repair genes without causing side effects, such as heart enlargement. This study marks an important step toward regenerative therapies to prevent heart failure.

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How do GLP-1s Boost Weight Loss, Heart Health?

Drugs.com

THURSDAY, Jan. 2, 2024 -- Weight loss tops many folks list of New Years resolutions, and lots of people are turning to cutting-edge weight-loss drugs like Ozempic to help them drop excess pounds.These drugs, called glucagon-like peptide-1 receptor.

Drugs 102
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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New method turns e-waste to gold

Science Daily: Pharmacology News

A research team has developed a method for extracting gold from electronics waste, then using the recovered precious metal as a catalyst for converting carbon dioxide (CO2), a greenhouse gas, to organic materials.

Research 108
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Every Cigarette Smoked Could Cost You 22 Minutes of Life, Research Says

Drugs.com

THURSDAY, Jan. 2, 2025 -- Considering a New Year’s resolution to quit smoking? New research might provide all the motivation you need: Each cigarette could shorten your life by up to 22 minutes, researchers say. The findings, published Dec.

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Experts Warn of Growing Risks as Bird Flu Cases Rise

Drugs.com

THURSDAY, Jan. 2, 2025 -- A Canadian teen's severe bird flu infection has highlighted growing concerns about the H5N1 virus, commonly known as bird flu, which has seen a steady rise in human cases across the U.S. According to a news release, the.

Virus 88
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Increased wildfire activity may be a feature of past periods of abrupt climate change

Science Daily: Pharmacology News

A new study investigating ancient methane trapped in Antarctic ice suggests that global increases in wildfire activity likely occurred during periods of abrupt climate change throughout the last Ice Age.

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Cases of Tularemia, Highly Infectious Disease Spread by Rodents, Rabbits, and Bugs That Bite Them, Climb

Drugs.com

THURSDAY, Jan. 2, 2025 -- Cases of a bacterial infection called rabbit fever have been increasing during the past decade.Cases of tularemia increased by 56% during the 2010s compared to the previous decade, researchers report in the CDCs Morbi.

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Study reveals that sleep prevents unwanted memories from intruding

Science Daily: Pharmacology News

The link between poor sleep and mental health problems could be related to deficits in brain regions that keep unwanted thoughts out of mind.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Who Knew Talk Therapy Could Ease Symptoms of this Skin Problem?

Drugs.com

THURSDAY, Jan. 2, 2025 -- Eczema can be maddening, causing thick, scaly patches of dry skin that itch like the devil.Theres no cure for the skin condition, but a new study shows that self-guided talk therapy can help a person deal with the i.

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Gene expression in the human brain: cell types become more specialized, not just more numerous

Science Daily: Pharmacology News

Our brain is arguably the organ that most distinguishes humans from other primates. Its exceptional size, complexity and capabilities far exceed those of any other species on Earth. Yet humans share upwards of 95% of our genome with chimpanzees, our closest living relatives.

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Fast, Easy Nasal Swab Helps Diagnose Asthma Type in Kids

Drugs.com

THURSDAY, Jan. 2, 2024 -- Not sure what’s causing your child’s asthma? A new quick-and-easy nasal swab test for kids can diagnose the specific immune system drivers behind their asthma, potentially opening the door to better treatments.

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Detecting disease with only a single molecule

Science Daily: Pharmacology News

Scientists have developed a nanopore-based tool that could help diagnose illnesses much faster and with greater precision than current tests allow, by capturing signals from individual molecules.

Disease 86
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Neumora plummets on depression drug data

BioPharma Drive: Drug Pricing

The well-funded biotech lost most of its value after its drug flunked a late-stage trial. One analyst described the results as a “worst-case scenario for the program.

Drugs 67
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How does a hula hoop master gravity? Mathematicians prove that shape matters

Science Daily: Pharmacology News

Hula hooping is so commonplace that we may overlook some interesting questions it raises: 'What keeps a hula hoop up against gravity?' and 'Are some body types better for hula hooping than others?' A team of mathematicians explored and answered these questions with findings that also point to new ways to better harness energy and improve robotic positioners.

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Phone App May Help Treat Opioid Use Disorder, Data Suggests

Drugs.com

TUESDAY, Dec. 31, 2024 -- A smartphone app appears to help people battle opioid use disorder (OUD).People with OUD had 35% fewer days of opioid use when they were handed the app alongside medications for opioid use disorder like methadone.

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Newborn brain circuit stabilizes gaze

Science Daily: Pharmacology News

An ancient brain circuit, which enables the eyes to reflexively rotate up as the body tilts down, tunes itself early in life as an animal develops, a new study finds.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Trees and Student Test Scores: What's the Link?

Drugs.com

THURSDAY, Jan. 2, 2025 -- Tree-lined streets and lush public parks appear to provide city schoolkids a brain boost.Chicago students test scores suffered when an invasive insect wiped out half the citys ash trees, researchers reported in the jou.

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FDA approves drugs from Vertex, Novo, Bristol Myers to wrap 2024

BioPharma Drive: Drug Pricing

The agency’s main drug review office cleared 50 novel medicines last year, short of 2018’s record total but on the higher end of recent annual tallies.

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The Twelve Days of Antibodies

addgene Blog

Every year, we like to add in some holiday cheer to our blog and social media. This year, we're doing so through the twelve days of antibodies. We hope you enjoy it, and we wish you a great 2025!

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Pfizer exits Sangamo pact; Roche, Ideaya strike ADC deals

BioPharma Drive: Drug Pricing

Sangamo shares fell on Pfizer’s decision to hand back rights to a hemophilia gene therapy. Elsewhere, Novartis got long-awaited data and BioNTech settled with the NIH.

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How FSP Models Help Biotech Companies Augment Their Clinical Development Needs

PPD

The biotech industry is a dynamic sector, rapidly evolving and poised for continued growth. Its ability to maneuver persistent drug development challenges, like patient recruitment, trial complexity and rising costs, will ultimately determine its success. Because biotech companies need to remain flexible and agile while remaining on time and on budget they are harnessing innovations to navigate unexpected drug development challenges and leveraging strategies to fill gaps in resources and exper

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Universal Design for Visual Disabilities in Healthcare – Impact on Access and Delivery – 10

Perficient: Drug Development

Welcome to our ongoing series on Universal Design for Healthcare! In this segment, well explore the importance of Visual Disabilities in Healthcare. Implementing universal design principles in healthcare to accommodate individuals with visual disabilities can profoundly impact both healthcare access and delivery. By creating environments and systems that are inherently accessible to all, healthcare providers can ensure that everyone receives equitable and high-quality care.

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Asimov Press’ New Book, Written in DNA

Codon

Our second book is now available for pre-order. Asimov Press’ latest anthology features nine essays and three works of science fiction. Embracing the book’s technology theme, we did something very special: With the help of three companies — CATALOG, Imagene, and Plasmidsaurus — we’ve encoded a complete copy of the book into DNA, thus merging bits with atoms.

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Micro-Moments in eCommerce & DXP: Capturing Customers at Their Most Intent-Driven

Perficient: Drug Development

In todays fast-paced digital landscape, eCommerce professionals must seize fleeting opportunities to engage consumers. These opportunities, known as micro-moments, represent brief, intent-driven actions where customers turn to their devices to address an immediate needwhether to know, go, do, or buy. Understanding and leveraging these moments can dramatically enhance customer engagement and drive sales.

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Bats surf storm fronts during continental migration

Science Daily: Pharmacology News

Birds are the undisputed champions of epic travel -- but they are not the only long-haul fliers. A handful of bats are known to travel thousands of kilometers in continental migrations across North America, Europe, and Africa. The behavior is rare and difficult to observe, which is why long-distance bat migration has remained an enigma. Now, scientists have studied 71 common noctule bats on their spring migration across the European continent, providing a leap in understanding this mysterious be

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Christmas at Work: Bringing Joy to Your Office Celebrations

Perficient: Drug Development

Christmas Celebrations at Perficient Bangalore: A Day of Joy and Togetherness The Christmas celebrations at Perficient Bangalore, held on Monday, 23rd December 2024, were filled with festive cheer, laughter, and unforgettable moments. Though a day before Christmas, the pre-Christmas celebration made us feel as if Christmas had already arrived. The office was beautifully decorated with a magnificent Christmas tree, twinkling lights, and festive ornaments, creating the perfect ambiance for the hol

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FDA’s Final Rule on the Implied Nutrient Content Claim “Healthy” Maintains Focus on Foods Rather than on Nutrients

FDA Law Blog: Biosimilars

By Ritte van Laack As we previously reported in 2022, FDA published a proposed rule defining the nutrient content claim healthy. The proposed revised rule constituted a radical change from the original definition of healthy, which focused on the presence of individual (beneficial) nutrients. In contrast, the 2022 proposed redefinition focused on food groups recommended by nutrition science and the Dietary Guidelines (DGs), 2020-2025.

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Optimizely Configured Commerce – Email Administration And More

Perficient: Drug Development

Optimizely Configured Commerce provides a unique way of managing emails. This allows administrators to configure and manage the email templates and settings used for automated email communications with users. This feature is essential for ensuring consistent branding, and operational efficiency in a B2B e-commerce environment. And most importantly, those emails are setup automatically and should not require many updates.

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The Role of Organoids in Antibody-Drug Conjugate Development

Crown Bioscience

Antibody-drug conjugates (ADCs) offer a potentially revolutionary advance in targeted cancer therapy as they combine antibodies and potent cytotoxic payloads to deliver drugs straight into cancer cells. Currently, there are 13 ADCs with FDA approval and more than 100 ADCs in various stages of clinical development. However, this promising new drug class faces significant development challenges, resulting in high attrition rates.

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BIMO Inspection Readiness Audits: Clinical and Biological Research Compliance

thought leadership

In the world of clinical and biological research programs, ensuring compliance with regulatory standards is not only essential for maintaining the integrity of studies but also for safeguarding the well-being of study participants. A critical part of this process is Bioresearch Monitoring (BIMO) inspections, which the U.S. Food and Drug Administration (FDA) conducts to ensure that Good Clinical Practices (GCP) and Good Laboratory Practices (GLP) are followed.