Fri.Oct 04, 2024

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New therapy for Huntington’s disease gets £35 million boost

Drug Discovery World

Biotechnology company LoQus23 Therapeutics has closed its £35 million (c.$43 million) Series A financing. The financing round was led by Forbion, alongside existing investors SV Health Investors’ Dementia Discovery Fund (DDF) and Novartis Venture Fund (NVF). Forbion General Partner Rogier Rooswinkel will join LoQus23’s Board of Directors. LoQus23 was founded in 2019 by Entrepreneurs in Residence at DDF Dr David Reynolds, Dr Caroline Benn, and Dr Ruth McKernan CBE, FMedSci and seeded by SV’s Deme

Disease 147
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Three new life science start-ups thrive at Discovery Park

Drug Discovery Today

Sandwich, Kent, UK. 24th September 2024 A group of former Pfizer employees have successfully created their own businesses based at and supported by Discovery Park, a thriving life sciences community in Kent.

Science 113
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This week in drug discovery (30 Sept – 4 Oct) 

Drug Discovery World

News round-up for 30 Sept – 4 Oct by DDW Senior Digital Content Editor Diana Spencer. The theme of the news highlights this week is funding, with companies raising considerable levels of private investment, alongside new funding grants to advance the development of therapeutics for lung infections in cystic fibrosis, paediatric brain cancer, and rare diseases.

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Colonoscopies Among the Young Are on the Rise

Drugs.com

FRIDAY, Oct. 4, 2024 -- Colon cancers are increasing among younger Americans, so much so that experts advised in 2021 that colonoscopy screening begin at the age of 45, not 50 as had been previously recommended.Now, research shows the new guideline.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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The latest advancements driving neuroscience drug discovery research

Drug Discovery World

In this webinar, hosted by DDW and sponsored by ApconiX, you will hear from Dr Isaac Klein, Chief Scientific Officer at Dewpoint Therapeutics, Dr Sam Clark, CEO of Terran Biosciences, and Professor Ruth Roberts, Co-founder and Director of Safety Science at ApconiX. Dr Klein shares how Dewpoint applies insights into the subcellular organisation of biochemical processes into membrane-less compartments to discover novel drug targets and revolutionary drugs for diseases with high unmet need, includi

Research 130
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Pterosaurs needed feet on the ground to become giants

Science Daily: Pharmacology News

A study determines when and how pterosaurs went from tiny tree-climbers to towering terrestrial titans Flying reptiles first came down from the trees in the mid-Jurassic Period, paving the way for giants with 10-meter wingspans. Fingers and toes point to secrets of flying reptile success.

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Even Low Levels of Radon May Raise Children's Risk for Leukemia

Drugs.com

FRIDAY, Oct. 4, 2024 — Growing up in a city with pockets of high radon levels, Matthew Bozigar wondered whether the radioactive gas might have anything to do with the high rates of cancer he saw around him, especially in young people. "As an e.

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Infographic: Discover how to optimise mAb manufacturing

Drug Discovery World

A new Infographic is now available to download from Thermo Fisher Scientific, entitled ‘ Optimize Your mAb Manufacturing with Proven Analytical Strategies ‘ Key takeaways: Boost Workflow Efficiency: Discover how end-to-end testing can enhance the efficiency of your monoclonal antibody production process. Ensure Compliance: Learn about the importance of accurate and precise testing at various production stages to meet or exceed regulatory guidelines.

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Mpox Vaccine's Protection Wanes Within 1 Year; Boosters Needed

Drugs.com

FRIDAY, Oct. 4, 2024 -- Antibodies provided by mpox vaccination all but disappear within six to 12 months, new research finds, underscoring the need for boosters to maintain strong protection.Mpox -- previously known as monkeypox -- is a.

Vaccine 79
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Scientists uncover auditory 'sixth sense' in geckos

Science Daily: Pharmacology News

Researchers discover that geckos use a mechanism usually associated with balance to sense vibrations, leading to new insights about how animals hear and feel their surroundings.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Attention Skiers & Riders-- Discount Passes for Keystone or Breckenridge Resort!

keypoint

Pro tip! If you’re planning to attend a meeting at Keystone or Breckenridge Resort this year, getting an Epic Pass or Day Pass in advance will save you 50-60% off ticket window pricing. Plus, there are some extra perks like food and retail discounts, and it will save you time at the resort.

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Trends in Pharmaceutical Mergers and Acquisitions

DrugBank

Deal Structuring Deal structuring in pharmaceutical M&A requires a balance of financial, legal, and strategic considerations. The optimal structure can significantly impact the financial and tax implications for both parties involved and the likelihood of regulatory approval. The choice between an all-cash transaction, a stock swap, or a combination thereof is influenced by factors such as the buyer's and seller's financial positions and their desired level of risk.

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Water Fluoridation May Be Less Beneficial Than in Past, Review Finds

Drugs.com

FRIDAY, Oct. 4, 2024 -- The health benefits of fluoridated drinking water may be waning as Americans increasingly turn to using toothpastes and mouthwashes that already contain fluoride, a new review suggests. The research, published Thursday in.

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Sanofi’s rare disease drug finds yet another home

BioPharma Drive: Drug Pricing

Having already been on a winding journey, Enjaymo, which Sanofi acquired through a 2018 buyout of Bioverativ, is now headed to Recordati as part of a deal announced Friday.

Disease 65
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Hospital Drug Tests Far More Likely for Minority Teens

Drugs.com

FRIDAY, Oct. 4, 2024 -- Teens from minority groups seeking treatment at pediatric trauma centers are more likely than their white counterparts to be tested for drugs and alcohol.That's the takeaway from a new study led by researchers at UCLA and.

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An Alzheimer’s drugmaker is accused of data manipulation. Should its trials be stopped?

BioPharma Drive: Drug Pricing

An experimental Alzheimer’s therapy from Cassava Sciences is still being tested in two Phase 3 studies, even as the company has come under regulatory scrutiny.

Trials 65
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Folks With Chronic Pain & Their Doctors Often Differ on Medical Marijuana

Drugs.com

FRIDAY, Oct. 4, 2024 -- If you're in chronic pain and believe medical marijuana to be the solution, there's a good chance your doctor might not agree. In a new survey of people living in states where medical cannabis is legal, 71% of people with.

Doctors 59
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Opdivo gets ‘perioperative’ approval; pharmas cut jobs in New Jersey, Ireland

BioPharma Drive: Drug Pricing

Bristol Myers' immunotherapy can now be used before and after surgery in the U.S. Elsewhere, J&J, Bayer, Bristol Myers Squibb and Pfizer are trimming staff.

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California Reports Two Cases of Bird Flu in Dairy Workers, a First for the State

Drugs.com

FRIDAY, Oct. 4, 2024 -- As an outbreak of bird flu among dairy cows continues to spread in the United States, two more cases have been reported in dairy workers, this time in California.These are the first human cases of bird flu reported in that.

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Editas trades Vertex fees for upfront cash in DRI deal

BioPharma Drive: Drug Pricing

The gene editing company is selling to DRI Healthcare Trust future license fees that are owed to it under an agreement with Vertex last year.

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Changes in Criteria for Identifying Cannabis Dependence: From DSM-IV to DSM-V

Common Sense for Drug Policy Blog

Changes in Criteria for Identifying Cannabis Dependence: From DSM-IV to DSM-V "Based on NSDUH estimates, rates of cannabis abuse and dependence remained relatively stable from 2002 to 2019, with the highest rates of abuse and dependence among young adults (aged 18–25) (Figure 3-27). For 2020, except for youth (aged 12–17), for whom the data suggest a slight decline in rates of cannabis abuse and dependence, the data are generally consistent with the longer-term trends for the other age groups.

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Food Allergies Spur Serious Anxiety in Most of Those Affected, Survey Finds

Drugs.com

FRIDAY, Oct. 4, 2024 -- The large majority of people with food allergy, and the caregivers of kids with such allergies, say the condition has led to psychological distress, a new study finds.However, only about 1 in every 5 such people have ever.

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Consumer Protection and Vape Products

Common Sense for Drug Policy Blog

Consumer Protection and Vape Products "The 2021 review of cannabis policy found that states also have limits on ingredients that can be contained in cannabis products. Many states have banned or are testing for vitamin E acetate because of the 2019 outbreak of e-cigarette or vaping product–associated lung injury (EVALI) (Schauer, 2021). Colorado has banned medium-chain triglycerides oil and polyethylene glycol oil entirely.

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Hearing Loss Can Raise Risks for Cognitive Decline

Drugs.com

FRIDAY, Oct. 4, 2024 -- A new, large study from France underscores the link between adult hearing loss and dementia."Given the major burden of cognitive decline and the absence of curative treatment, identifying modifiable risk factors is of.

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Three Simple Steps to Make Oracle ERP Ready for 1099 Season

Perficient: Drug Development

It’s 1099 season – is your ERP ready? It only takes a few simple steps to verify your data and make sure you are fully prepared to meet the IRS deadline to publish your 1099’s. Step 1: Validate that your “Reporting Entities” are setup, and that they have assigned “Balancing Segments” A reporting entity contains the federal reporting number.

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Trauma at Life's Beginning Can Mar Its End, Study Finds

Drugs.com

FRIDAY, Oct. 4, 2024 -- Whether abusive parents, drug addiction or gun violence are to blame, the fallout from childhood traumas can reverberate until a person's final days of life, new research shows."We found that early-life trauma in particular.

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Innovative Models for Improving Access and Visibility for Specialty-Lite and Retail Therapies

Drug Channels

Today’s guest post comes from Timothy Nielsen, Vice President of Customer Success at AssistRx. Timothy discusses the affordability and patient journey challenges of specialty-lite products for patients, manufacturers, and health care providers. He explains how AssistRx's Advanced Access Anywhere (AAA) solution streamlines processes for specialty-lite products and facilitates enrollment via a digital hub.

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Endpoints News: Clive Meanwell's New Obesity Biotech, Metsera, Unveils Early GLP-1 Data With an Eye on Phase 3 Next Year

Alta Sciences

Endpoints News: Clive Meanwell's New Obesity Biotech, Metsera, Unveils Early GLP-1 Data With an Eye on Phase 3 Next Year aasimakopoulos Fri, 10/04/2024 - 15:21 Category News Weight 1

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NK:IO progresses ovarian cancer natural killer therapy

Drug Discovery World

Imperial College spin-out company NK:IO has completed a seed round to a total of £5.9 ($7.8) million. The round included additional funding from UK Innovation Science and Seed Fund (UKI2S), managed by Future Planet Capital, Cambridge Angels and Cancer Research Horizons. The company says the funds will be used to progress NK cell therapeutics, initially in ovarian cancer.

Therapies 130
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Seattle

Alta Sciences

Seattle ldrouin Fri, 10/04/2024 - 18:40 Address_1 6605 Merrill Creek Parkway Address 2 Everett, WA 98203 Country U.S.A.

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Chiesi opens €400m Biotech Center of Excellence in Italy

Drug Discovery World

Chiesi Group has launched its Biotech Center of Excellence, dedicated to developing and producing monoclonal antibodies, enzymes, and other proteins, in Parma, Italy. From the production of drug substances from mammalian cells to their transformation into drug products and final packaging, the company says that everything will be done in a single location.

Packaging 130
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Drupal for Enterprise Solutions

Perficient: Drug Development

Drupal for Enterprise Solutions Drupal is a powerful platform for enterprise solutions, offering a range of features and capabilities that cater specifically to the needs of large organizations. The key features such as Scalability, Security, Content Management, Customization & Flexibility, and Enterprise Integration. These features are shown connecting with various enterprise applications like CRM (Customer Relationship Management), ERP (Enterprise Resource Planning), and Marketing Automa

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Shaping the Future of Medicine: Pharmaceutical Formulation Development

Alta Sciences

Shaping the Future of Medicine: Pharmaceutical Formulation Development tchichekian Fri, 10/04/2024 - 19:16 Publication Infographic-Manufacturing-Pharmaceutical-Formulation-Development.