Tue.Jul 30, 2024

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Breaking MAD: Generative AI could break the internet, researchers find

Science Daily: Pharmacology News

Researchers have found that training successive generations of generative artificial intelligence models on synthetic data gives rise to self-consuming feedback loops.

Research 131
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Talk of the Towne episode 11: American Kidney Fund

Antidote

In the latest installment of Talk of the Towne, we sat down with Melanie Paris, M.A., MPH, the Senior Director of Strategic Partnerships and Kidney Disease Education at the American Kidney Fund (AKF). In the discussion, we got her insights into the types of kidney disease, treatment disparities, and the importance of clinical research in the field. She also shared many valuable resources for individuals and their loved ones living with kidney disease, which are linked here.

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What no one has seen before -- simulation of gravitational waves from failing warp drive

Science Daily: Pharmacology News

Physicists have been exploring the theoretical possibility of spaceships driven by compressing the four-dimensional spacetime for decades. Although this so-called 'warp drive' originates from the realm of science fiction, it is based on concrete descriptions in general relativity. A new study takes things a step further -- simulating the gravitational waves such a drive might emit if it broke down.

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Pfizer quits Duchenne gene therapy, lays off staff following study setback

BioPharma Drive: Drug Pricing

The company is letting go of 150 staffers alongside a decision to officially terminate the high-profile program, which was acquired in 2016.

Therapies 135
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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FDA Warns of Accidental Overdoses from Compounded Versions of Ozempic

Drugs.com

TUESDAY, July 30, 2024 -- People taking compounded versions of Ozempic have been overdosing on the drug, the U.S. Food and Drug Administration warns.These ODs typically are due to miscommunications or miscalculations regarding dosage, the FDA.

FDA 115
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Super-black wood can improve telescopes, optical devices and consumer goods

Science Daily: Pharmacology News

Thanks to an accidental discovery, researchers have created a new super-black material that absorbs almost all light, opening potential applications in fine jewelry, solar cells and precision optical devices.

Research 110

More Trending

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Scientists discover entirely new wood type that could be highly efficient at carbon storage

Science Daily: Pharmacology News

Researchers undertaking an evolutionary survey of the microscopic structure of wood from some of the world's most iconic trees and shrubs have discovered an entirely new type of wood.

Research 102
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Suicides Among Kids Ages 8 to 12 Are Rising, Especially Among Girls

Drugs.com

TUESDAY, July 30, 2024 -- The kids are not alright.New data shows a troubling 8% annual increase in the number of American children ages 8 to 12 who died by suicide, with the sharpest increase seen among girls.Suicide has now become the fifth.

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What shapes a virus's pandemic potential? SARS-CoV-2 relatives yield clues

Science Daily: Pharmacology News

Two of the closest known relatives to SARS-CoV-2 -- a pair of bat coronaviruses discovered by researchers in Laos -- may transmit poorly in people despite being genetically similar to the COVID-19-causing virus, a new study reveals. The findings provide clues as to why some viruses have greater 'pandemic potential' than others and how researchers might go about identifying those that do before they become widespread.

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Doctor-Patient Connection: The Eyes Have It

Drugs.com

TUESDAY, July 30, 2024 -- Doctors might be authority figures, but a new review suggests hospital patients feel more comfortable when their physician comes across as less imposing.Getting to a patient’s eye level while talking about their diagnosis o.

Doctors 105
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Bug Fixing: Lazy loaded property value is not supported by the current property instance

Perficient: Drug Development

While upgrading from CMS v11 to v12, we ran into an error that read “Lazy loaded property value is not supported by the current property instance” Unfortunately, the stack trace didn’t really say what the problem was. Here is that stack trace: System.InvalidOperationException: Lazy loaded property value is not supported by the current property instance at EPiServer.DataAccess.Internal.LazyPropertyValueLoader.SetValue(PropertyData property, PropertyDataRecord dataRecord, Func`3

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Tooth Loss Could Point to Serious Heart Issues

Drugs.com

TUESDAY, July 30, 2024 -- A healthy mouth also means a healthy heart, a new review suggests.People who’ve lost teeth are more likely to die from heart problems – and the more teeth lost, the higher the risk, researchers found.“Our findings clearly s.

Research 104
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Benefits of Drug Patent Licensing Agreements

Drug Patent Watch

The Power of Patent Licensing: Unlocking Innovation and Access to Medicines Patent licensing agreements have become a crucial tool in the pharmaceutical industry, allowing companies to collaborate and…

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Most U.S. Youth Who Die by Suicide Don't Have Diagnosed Mental Health Issue

Drugs.com

TUESDAY, July 30, 2024 -- Three out of five young people who die by suicide don’t have any prior mental health diagnosis, a new study finds.People are missing the telltale signs that children, teens and young adults are troubled in ways that put t.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Common blood tests could improve cancer diagnosis for people with stomach pain or bloating

Science Daily: Pharmacology News

A new study looked at data from more than 400,000 people aged 30 or older in the UK who had visited a GP due to stomach pain and more than 50,000 who had visited their GP due to bloating.

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USDA Toughens Rules on Salmonella in Poultry

Drugs.com

TUESDAY, July 30, 2024 -- Chicken, turkey and other poultry might get a little safer after new rules to limit salmonella proposed Monday by the U.S. Department of Agriculture (USDA).Poultry companies would be expected to keep salmonella levels.

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The corona is weirdly hot: Parker Solar Probe rules out one explanation

Science Daily: Pharmacology News

By diving into the sun's corona, NASA's Parker Solar Probe has ruled out S-shaped bends in the sun's magnetic field as a cause of the corona's searing temperatures.

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Pickleball: A Tendency for Tendon Injuries

Drugs.com

TUESDAY, July 30, 2024 -- Pickleball is the fastest-growing sport in the United States, particularly among older adults.It’s also a quick way for seniors to hurt themselves, unless they watch their form and warm up properly, experts say.“We are see.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Direct RAS inhibitors turn 10

Covalent Modifiers

Ostrem, J.M.L., Peters, U. & Shokat, K.M Nat Chem Biol (2024). [link] RAS proteins, central drivers of cancer, appeared ‘undruggable’ for almost 30 years. Here we provide a personal perspective on the effort leading to our initial report of KRASG12C inhibitors in 2013, and the decade of discoveries that followed.

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Black Americans 20 Times More Prone to Gun Injuries Than Whites

Drugs.com

TUESDAY, July 30, 2024 -- Black Americans, especially young Black men, face 20 times the odds of gun injury compared to whites, new data shows."Black persons made up only 12.6% of the U.S. population in 2020, but suffered 61.5% of all firearm.

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Pfizer’s Bourla confident in company’s obesity drug position, despite delays

BioPharma Drive: Drug Pricing

The CEO noted how Pfizer's danuglipron could still be the second oral GLP-1 treatment to enter registrational tests after Lilly's orforglipron.

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Twenty Years of Sharing: Addgene's Viral Vector Service

addgene Blog

As part of Addgene’s 20 th anniversary celebration, we’ve been finding and sharing stories unique to our repository and resources. As editor of Addgene’s eBooks — including the recently released Viral Vectors 101 2 nd edition — I was incredibly excited when we picked our viral vector service as one of those stories. Viral vectors are viruses engineered to be safely used to deliver a genetic payload to cells, and the complexity of effectively deploying them in the lab somewhat mirrors the complex

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Ozempic's Latest Role: Helping Smokers Quit

Drugs.com

TUESDAY, July 30, 2024 -- Smokers with diabetes or obesity who take semaglutide (Ozempic/Wegovy) might reap an added benefit: Help in quitting smoking.A yearlong study found that, compared to people using other diabetes drugs, fewer patients who.

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FDA Poised to Make Impact on Underrepresented Populations in Clinical Studies

H1 Blog

Diversity Action Plans (DAPs) aim to improve data that the FDA receives by increasing the clinical enrollment of historically underrepresented participants. Increasing diversity in clinical trials not only makes the findings more relevant to various patient groups, but also enhances knowledge about the disease or medical product being studied. This, in turn, provides crucial insights that help ensure the medical product’s safe and effective use among patients.

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The Summit for Women Leaders in Life Sciences Law

FDA Law Blog: Biosimilars

By Sara M Keup & Véronique Li, Senior Medical Device Regulation Expert — The American Conference Institute (“ACI”) held its 11th Annual Summit for Women Leaders in Life Sciences Law at the Seaport Hotel in Boston, Massachusetts on July 25th & 26th of last week. Several leading ladies in law at HPM attended the conference and, based on their feedback, gave the annual event an A+ rating.

Science 52
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New tentative approval for Alembic drug dabigatran etexilate mesylate

Drug Patent Watch

Dabigatran etexilate mesylate is the generic ingredient in two branded drugs marketed by Alkem Labs Ltd, Apotex, Hetero Labs Ltd Iii, and Boehringer Ingelheim and, and is included in five NDAs.

Drugs 52
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The Ultimate Guide for Cutting AWS Costs

Perficient: Drug Development

AWS cloud solution is becoming a requirement of the fast-evolving infrastructure needed in today’s IT business. All clients wish to move to cloud because it has higher availability and durability. The current consumers on cloud are always concerned with the ways that they can cut costs by a huge on Amazon web service monthly and or yearly billing cycle.

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The minimum inhibitory concentration of antibiotics | BMG LABTECH

BMG Labtech

Introduction The minimum inhibitory concentration or MIC is a crucial metric often used to gauge the effect of antimicrobial agents on microorganisms. In this blog, we take a look at MIC, what distinguishes it from other metrics, trends in the way it is measured, the factors that affect it, and how it can be measured using microplates.

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Drugs facing the most patent expirations this year

Drug Patent Watch

Expiring drug patents are continuously driving innovation, as branded firms seek out new high-margin opportunities.

Drugs 52
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Enhancing Workplace Safety: A Systematic Review of Hearing Protection Fit-Testing Systems and Training

NIOSH Science Blog: Drugs

Exposure to excessive noise at work poses significant health risks for workers. These include hearing loss, tinnitus, and various other health conditions. To mitigate these risks, hearing protection devices (HPDs) such as earplugs and earmuffs are commonly used. However, the effectiveness of HPDs relies heavily on proper usage and fit. Ill-fitting earplugs are a common challenge faced by workers, compromising their ability to adequately protect their hearing.

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Drug Channels News Roundup, July 2024: My $0.02 on FTC’s PBM Report, GoodRx & Humira, Averon = CVS + Cardinal, IRA vs. 340B, and My Favorite Chart

Drug Channels

Bello! The hot and hazy days of summer are here. Go for a swim to cool off and then enjoy this refreshing selection of articles chosen by Drug Channels para tu. Did the FTC’s compelling interim report prove its case? GoodRx joins the Humira biosimilar price war with Boehringer Ingelheim Averon revealed to be a new buying group for biosimilars for CVS Health and Cardinal Health Why the IRA will be bad news for 340B hospitals Plus, the June 2024 update to my all-time favorite chart.

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Incyte trims cancer drug pipeline in R&D refocus

BioPharma Drive: Drug Pricing

The company will stop developing five experimental treatments, including two oral checkpoint inhibitors targeting PD-L1.