Thu.Jul 18, 2024

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UK life sciences can lead the way in cannabinoid R&D, says report

Drug Discovery World

The UK has the potential to become the global leader in pharmaceutical cannabinoid R&D, according to a new report published by the Cannabinoid Research and Development Group (CRDG). The report suggests the UK can build on the success of GW Pharmaceuticals, whose multiple sclerosis treatment product nabiximols was the first natural cannabis plant derivative to gain market approval in any country.

Science 130
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Artiva prices $167M IPO, riding optimism for autoimmune cell therapy

BioPharma Drive: Drug Pricing

The offering comes days after the publication of a paper showing what analysts said was early proof that “off-the-shelf” cell therapies can treat inflammatory diseases.

Therapies 130
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CatalYm raises $150m for cancer therapy visugromab

Drug Discovery World

CatalYm has completed a $150 million Series D financing to support the Phase II development of its cancer therapy visugromab. The oversubscribed round was led by new investors, Canaan Partners and Bioqube Ventures, and joined by Forbion’s Growth Opportunities Fund, Omega Funds and Gilde Healthcare. Existing investors Jeito Capital, Brandon Capital Partners, Novartis Venture Fund and Vesalius Biocapital III also participated in the round.

Therapies 130
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New MS Drug Kesimpta May Help Keep Symptoms at Bay

Drugs.com

THURSDAY, July 18, 2024 -- A new monoclonal antibody treatment called Kesimpta (ofatumumab) appears to improve on an older drug in pushing multiple sclerosis (MS) into remission, a new trial shows.Funded by Kesimpta's maker, Novartis, the trial.

Drugs 116
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Acute myeloid leukaemia drug gets fast-tracked

Drug Discovery World

The US Food and Drug Administration (FDA) has granted Fast Track designation to Sumitomo Pharma’s DSP-5336 for relapsed or refractory acute myeloid leukaemia (AML). The drug is intended for patients with a KMT2A rearrangement, also known as, mixed lineage leukaemia rearrangement (MLLr) or nucleophosmin mutation (NPM1m). DSP-5336 is an investigational small molecule inhibitor of the menin and mixed-lineage leukaemia (MLL) protein interaction, which plays key roles in gene expression and protein i

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Fall of Roe v. Wade Has Made Access to Ob/Gyns Tougher in Many States: Report

Drugs.com

THURSDAY, July 18, 2024 -- Ever since the Supreme Court overturned Roe v. Wade in June 2022, even more women have struggled to find reproductive care, a new report warns.Issued Thursday by the Commonwealth Fund, the report shows that women living.

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Science Reveals 'Magic Mushroom' Chemical's Mind-Altering Effects

Drugs.com

THURSDAY, July 18, 2024 -- “Magic” mushrooms achieve their psychedelic effects by temporarily scrambling a brain network involved in introspective thinking like daydreaming and remembering, a new study reports.Brain scans of people who took psi.

Science 115
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Good timing: Study unravels how our brains track time

Science Daily: Pharmacology News

Ever hear the old adage that time flies when you're having fun? A new study suggests that there's a lot of truth to the trope.

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Long COVID Risk Has Declined Over the Pandemic and Vaccines May Be Key

Drugs.com

THURSDAY, July 18, 2024 -- You're far less likely to develop Long COVID now than you were in the midst of the pandemic, promising new data shows.Changes in strains of SARS-CoV-2, the virus that causes COVID-19, are playing a role in the lowered.

Vaccine 110
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Another intermediate-mass black hole discovered at the center of our galaxy

Science Daily: Pharmacology News

So far, only about ten intermediate-mass black holes have been discovered in the entire universe. The newly identified black hole causes surrounding stars in a cluster to move in an unexpectedly orderly way.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Endometriosis Linked to Four-fold Higher Odds for Ovarian Cancer

Drugs.com

THURSDAY, July 18, 2024 -- Women who struggle with endometriosis may be vulnerable to another health danger: New research shows they are about four times more likely to develop ovarian cancer than women who don't have the painful condition.The odds.

Research 105
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How to Transition to a New CDMO Smoothly

Drug Patent Watch

Transitioning to a new Contract Development and Manufacturing Organization (CDMO) can be a complex and challenging process.

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Race, Insurance Stop Many Hispanics From Getting Post-Stroke Care

Drugs.com

THURSDAY, July 18, 2024 -- Hispanic people -- particularly those without insurance -- are less likely to get the additional care needed to recover from a stroke, a new study finds.Hispanic folks are less likely to be treated at a rehab facility or.

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The Vaccine Development Landscape and Its Associated Challenges

DrugBank

Vaccines have consistently demonstrated their efficacy in protecting people from infectious diseases. This led to the eradication of smallpox and polio – two debilitating diseases that historically caused global epidemics. Yet, the recent COVID-19 pandemic highlighted the obstacles that are inherent today in the development of vaccines. Let’s take a deeper dive into these challenges.

Vaccine 81
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Frequent House Moves Take Lifetime Toll on Kids' Mental Health

Drugs.com

THURSDAY, July 18, 2024 -- Kids whose families frequently move have a significantly higher risk of depression later in life, a new study warns.Children who move once between the ages of 10 and 15 are 41% more likely to be diagnosed with depression.

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Boehringer cuts price of Humira biosimilar in bid to build use

BioPharma Drive: Drug Pricing

The German drugmaker will offer a 92% discount on a copycat version of Humira for people who pay cash for the drug through GoodRx.

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Is Your Child With Type 1 Diabetes Facing 'Diabetes Distress'?

Drugs.com

THURSDAY, July 18, 2024 -- Children born with type 1 diabetes are much more likely to develop certain mental health issues than those without the condition, a new study warns.Kids with type 1 diabetes are more than twice as likely to develop a mood.

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Liquid biopsy helps advance oncology drug development

Drug Target Review

Why is detecting cancers via liquid biopsy before they become visible on imaging important for drug development, not just diagnostics? We believe liquid biopsy is very helpful for oncology drug development because the reduction and clearance of circulating DNA occurs quickly before radiographic imaging is available. From our experience, we have found that by using liquid biopsy we were able to more rapidly determine the Phase II dose to optimise the potential antitumour effect in our study.

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Retired Rugby Players Face Risks for Dementia, CTE

Drugs.com

THURSDAY, July 18, 2024 -- Alix Popham played in two rugby World Cups and won a Six Nations Grand Slam before retiring in 2011 as a professional in the rough-and-tumble game. By 2020, he had already been diagnosed with early onset dementia and.

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Need To Conduct a Multi-Variable Study? REPROCELL Can Help with That!

Reprocell

In April 2015, the 106 th annual meeting of the American Association for Cancer Research was held in Philadelphia, Pennsylvania. REPROCELL USA was in attendance and submitted a poster titled , Family History of Cancer in First-degree Relatives and Increased Cancer Risk: A Multinational Study.

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Altered Mealtimes Linked to Depression, Anxiety in Shift Workers

Drugs.com

THURSDAY, July 18, 2024 -- Folks need to have their meals at regular intervals or risk slipping into anxiety or depression, a new study of airline personnel has found.Delaying breakfast or dinner appears to increase a person’s risk of developing a m.

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PARP Inhibitors: Where Are We in 2024 and What’s Coming Next?

Crown Bioscience

Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) have revolutionized the treatment of various cancers, including breast, ovarian, castration-resistant metastatic prostate (mCRPC) and metastatic pancreatic cancer. As PARPi continues to evolve, it is crucial for healthcare professionals to stay updated with recent developments to optimize patient care.

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New tentative approval for Alembic drug dabigatran etexilate mesylate

Drug Patent Watch

Dabigatran etexilate mesylate is the generic ingredient in two branded drugs marketed by Alkem Labs Ltd, Apotex, Hetero Labs Ltd Iii, and Boehringer Ingelheim and, and is included in five NDAs.

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Why Universal Design in Health Systems Matters for Enhancing Health Outcomes – 4

Perficient: Drug Development

Welcome to the fourth installment of our Universal Design and Health System blog series. In this edition, we focus on the significant impact that Universal Design has on enhancing health outcomes. By creating healthcare environments that are accessible, inclusive, and user-friendly, Universal Design contributes to better health management, patient engagement, and overall well-being.

Disease 52
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New patent for Verity drug TLANDO

Drug Patent Watch

Annual Drug Patent Expirations for TLANDO Tlando is a drug marketed by Verity and is included in one NDA. It is available from two suppliers. There are twelve patents protecting this drug.

Drugs 52
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Why Universal Design in Health Systems Matters for Economic and Social Impact – 5

Perficient: Drug Development

Welcome to our new installment of the Universal Design and Health System blog series. In this edition, we will explore the profound economic and social impacts of implementing Universal Design in health systems. While the primary goal of Universal Design is to create inclusive and accessible environments, its benefits extend far beyond individual patient experiences.

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Inside The Altascientist: How to Achieve Optimal Preclinical Formulation and Drug Product Manufacture

Alta Sciences

Inside The Altascientist: How to Achieve Optimal Preclinical Formulation and Drug Product Manufacture aasimakopoulos Thu, 07/18/2024 - 20:33 Formulating and manufacturing drugs for preclinical testing is an early—and necessary—step towards pushing your molecule through to human clinical trials. At the preclinical stage, the goal is to maximize exposure for safety testing, formulating the limits of solubility and maximum volume.

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Driving the Future of Wealth Management

Perficient: Drug Development

Wealth management is evolving rapidly, driven by generational shifts, changing advisor roles, new business models, regulatory demands, and a growing preference for low-cost passive products. In response to these changes, our fintech client partnered with one of the world’s largest financial institutions to develop a next-generation, open-source, front-to-back wealth management platform.

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Telemedicine May Help Folks Battling Opioid Addiction Stick With Treatment

Drugs.com

THURSDAY, July 28, 2024 -- Telemedicine could be a better way to get opioid addicts to seek out and stick with treatment, a new study suggests.People referred to an addiction treatment clinic following a telemedicine evaluation were more likely to.

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Efficient-Pro Medium and Feed 1 enable rapid and seamless upstream process development and scale-up for CHO-K1 cells

Fierce BioTech

Efficient-Pro Medium and Feed 1 enable rapid and seamless upstream process development and scale-up for CHO-K1 cells Download the white paper to learn how this innovative solution can help optimize your mAb production processes. The findings demonstrate the system's robust capability to sustain strong cell growth and high productivity, facilitating a smooth transition from laboratory to production scale. jpiatt Thu, 07/18/2024 - 14:53 Download the white paper to learn how this innovative solutio

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New patent for Orasis Pharms drug QLOSI

Drug Patent Watch

Annual Drug Patent Expirations for QLOSI Qlosi is a drug marketed by Orasis Pharms and is included in one NDA. There are three patents protecting this drug.

Drugs 52
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Meet the Expert: Dana E. Vanderwall, PhD.

thought leadership

Our "Meet the Expert" series introduces you to our team of experts around the world. This "behind the curtain" view will help you get to know who we are on a professional and personal level, and highlight how our colleagues work together on our higher purpose to improve patient health and safety throughout the complete product lifecycle.

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Anti-IL-11 drug extends lifespan by over 20% in mice

Drug Discovery World

Scientists have discovered that ‘switching off’ protein interleukin 11 (IL-11) can significantly increase the healthy lifespan of mice by almost 25%. The scientists at the Medical Research Council Laboratory of Medical Science (MRC LMS) and Imperial College London, working with colleagues at Duke-NUS Medical School in Singapore, created mice that had the gene producing IL-11 deleted.

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Pharmaceutical companies with the most ‘New Combination’ drugs

Drug Patent Watch

This chart shows the companies which have received the most New Combination exclusivities in the past five years.