Fri.Sep 06, 2024

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100x improvement in sight seen after gene therapy trial

Science Daily: Pharmacology News

The vision of people with a rare inherited condition that causes them to lose much of their sight early in childhood was 100 times better after they received gene therapy to address the genetic mutation causing it. Some patients even experienced a 10,000-fold improvement in their vision after receiving the highest dose of the therapy, according to researchers.

Therapies 127
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Almost 1 in 4 U.S. Adults Under 40 Have High Blood Pressure

Drugs.com

FRIDAY, Sept. 6, 2024 -- An epidemic of high blood pressure is occurring in young adults and children in the United States, a pair of new studies show.Nearly a quarter of people ages 18 to 39 have high blood pressure, with readings above the.

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Researchers create a one-dimensional gas out of light

Science Daily: Pharmacology News

Physicists have created a one-dimensional gas out of light. This has enabled them to test theoretical predictions about the transition into this exotic state of matter for the first time. The method used in the experiment by the researchers could be used for examining quantum effects.

Research 122
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Saltwater Drops in Nose Could Shorten Kids' Colds

Drugs.com

FRIDAY, Sept. 6, 2024 -- Saltwater nose drops can reduce the length of a kid’s cold by two days, a new study demonstrates.“We found that children using saltwater nose drops had cold symptoms for an average of six days, where those with usual care ha.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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New filtration material could remove long-lasting chemicals from water

Science Daily: Pharmacology News

A new filtration material might provide a nature-based solution to water contamination by PFAS chemicals. The material, based on natural silk and cellulose, can remove a wide variety of these 'forever' chemicals as well as heavy metals, and its antimicrobial properties can help keep the filters from fouling.

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Brain's Wiring May Trigger Depression in Some People

Drugs.com

FRIDAY, Sept. 6, 2024 -- A distinct brain pattern appears to make some people more likely to develop depression, a new study indicates.“Deep” functional MRI brain scans revealed that a brain feature called the salience network is nearly twice as lar.

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More Trending

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Gene Therapy Reverses a Rare Cause of Vision Loss

Drugs.com

FRIDAY, Sept. 6, 2024 -- Gene therapy may restore vision to children and adults robbed of their sight by a rare inherited condition called Leber congenital amaurosis, researchers report.The illness is caused by mutations in the GUCY2D gene, which.

Therapies 105
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'Ice bucket challenge' reveals that bacteria can anticipate the seasons

Science Daily: Pharmacology News

Bacteria use their internal 24-hour clocks to anticipate the arrival of new seasons, according to research carried out with the assistance of an 'ice bucket challenge.

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Tips for Managing Personal Protective Equipment in Your Stockpile: Respirator Selection and Purchase

NIOSH Science Blog: Drugs

Happy Respiratory Protection Week 2024! Another year provides another opportunity to highlight resources to support informed workplace respiratory protection practices. NIOSH has been at the forefront of this effort for decades, testing and approving respirators used in U.S. occupational settings while also striving to provide the science necessary to inform complex respiratory protection decisions.

Science 98
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Study suggests US droughts, rainy extremes becoming more severe

Science Daily: Pharmacology News

Severe drought in the American Southwest and Mexico and more severe wet years in the Northeast are the modern norm in North America, according to new research -- and the analysis suggests these seasonal patterns will be more extreme in the future. The middle of the United States, meanwhile, can expect bigger swings between wetter wet periods -- high-rainfall years known as pluvials -- and drier summers through the rest of this century, the study predicts.

Research 114
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Register now for Lab Innovations 2024

Drug Discovery Today

Secure your ticket to visit the biggest lab industry trade show in the UK.

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Massive merger: Study reveals evidence for origin of supermassive black hole at galaxy's center

Science Daily: Pharmacology News

Researchers have discovered compelling evidence suggesting that the supermassive black hole at the center of our Milky Way galaxy, known as Sagittarius A* (Sgr A*), is likely the result of a past cosmic merger. The study builds on recent observations from the Event Horizon Telescope (EHT), which captured the first direct image of Sgr A* in 2022.

Research 107
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Cuffs on At-Home Blood Pressure Monitors Don't Fit Some Patients

Drugs.com

FRIDAY, Sept. 6, 2024 -- People are encouraged to monitor their blood pressure at home, but many folks will find that household blood-pressure cuffs are literally a bad fit, a new study warns.For as many as 18 million U.S. adults -- nearly 7% of.

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AI helps distinguish dark matter from cosmic noise

Science Daily: Pharmacology News

An AI-powered tool can distinguish dark matter's elusive effects from other cosmic phenomena, which could bring us closer to unlocking the secrets of dark matter.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Gun Deaths to Children and Teens Have Risen in Almost All States

Drugs.com

FRIDAY, Sept. 6, 2024 -- As news of yet another senseless school shooting makes headlines, a new report finds the number of children who lose their lives to injury and gun violence has risen in almost all states since 2018. Rates of deaths caused.

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Astrophysics: AI shines a new light on exoplanets

Science Daily: Pharmacology News

A team models the atmospheres of distant planets using neural networks.

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Too Much Light at Night Linked to Higher Alzheimer's Risk

Drugs.com

FRIDAY, Sept. 6, 2024 -- People who live in areas with more nighttime light pollution could be at increased risk of Alzheimer’s disease, particularly those in middle age, a new study says.Nightly light pollution is more strongly linked to A.

Disease 98
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Sept 2024 - Q3 Product Update Webinar: Curves, AI, Inventory, and ELN

Collaborative Drug

We recently hosted our Sept 2024 Q3 Product Update Webinar, showcasing significant enhancements to the CDD Vault platform. The webinar covered four key modules: Curves, AI, Inventory Management, and Electronic Lab Notebook (ELN). Let's dive into the exciting updates for each module.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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First Doses of Mpox Vaccine Reach Africa, But Many More Are Needed

Drugs.com

FRIDAY, Sept. 6, 2024 -- As mpox continues to spread in Africa, Congolese authorities said Thursday that the first batch of vaccines have arrived in that country's capital. The shipment comes three weeks after the World Health Organization.

Vaccine 64
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Afimetoran

New Drug Approvals

Afimetoran BMS-986256, WHO 11516 cas 2171019-55-7 2-[4-[2-(7,8-dimethyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)-3-propan-2-yl-1 H -indol-5-yl]piperidin-1-yl]acetamide C 26 H 32 N 6 O,444.583, phase 1 Afimetoran is an immunomodulator and an antagonist of toll-like receptors 7 and 8. 1 , 2 It is also is under investigation in clinical trial NCT04269356 (Study to Assess the Way the Body Absorbs, Distributes, Breaks Down and Eliminates Radioactive BMS-986256 in Healthy Male Participants).

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Obesity drug startup raises $67M; Vor’s ‘shielded transplant’ shows promise

BioPharma Drive: Drug Pricing

OrsoBio is advancing several weight loss medicines. Elsewhere, Boehringer Ingelheim pushed forward with a geographic atrophy drug and Vaxcyte raised $1.3 billion.

Drugs 64
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Exposure to PFAS 'Forever Chemicals' in Pregnancy Could Boost Long-Term Obesity Risk

Drugs.com

FRIDAY, Sept. 6, 2024 -- PFAS “forever chemicals” could cause pregnant women to experience long-term weight gain, increasing their risk of obesity in middle age, a new study warns.Women with higher levels of PFAS in their blood during early pre.

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How SFCC dominates the market 2024

Perficient: Drug Development

What Makes Salesforce a Leader in B2B E-Commerce: Key Takeaways from the Forrester Wave Q2 2024 Michael Affronti , Executive VP & GM of Commerce Cloud at Salesforce, recently expressed his excitement on LinkedIn about Salesforce being named a Leader in the Forrester Wave: Commerce Solutions for B2B, Q2 2024 report. This achievement highlights Salesforce’s reputation as a driving force in the B2B commerce industry, centered around innovative approach, robust platform, and customer-centr

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The rising demand for lentiviral vectors for in vivo gene therapy

Drug Target Review

What trends are driving the increased use of in vivo delivery methods in gene therapy? The increased use of lentiviral vectors in vivo delivery in gene therapy has been driven by various industry trends, including development of in vivo CAR-Ts, the use of in vivo vectors for rare diseases as well as the significant increase in their use in vaccination, both for oncology and infectious disease applications.

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GSK antibody drug reduces COPD attacks in trial

BioPharma Drive: Drug Pricing

New trial results could offer support for an expansion of Nucala’s label after U.S. regulators rejected GSK’s submission in 2018.

Trials 69
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Maximize Established Brands Value

Fierce BioTech

Maximize Established Brands Value swheeler Fri, 09/06/2024 - 18:25 Wed, 10/23/2024 - 10:00 Resource Type Webinar Mathieu Emanuelli Michel Auvillain Thomas Steffen Duration 60 minutes Established brands comprise the lion’s share of portfolios across pharma’s global affiliates. These are brands that are often neglected as they near maturity, with revenue and profit growth suboptimized.

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Perficient Listed as an IT Services Provider for CX in IDC Market Glance

Perficient: Drug Development

Customer experience remains a top priority for organizations worldwide to gain and retain business. Even one unsatisfactory experience can cause customers to turn to a competitor, causing estimated losses of up $1.6 trillion in the United States annually. On the other hand, good omnichannel experiences turn connections into lasting experiences, brands into trusted partners, and customers into life-long advocates.

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RWE Impact: When Empowered Patients Drive Pharma Outcomes

Fierce BioTech

RWE Impact: When Empowered Patients Drive Pharma Outcomes pesurya Fri, 09/06/2024 - 11:33 Thu, 10/03/2024 - 11:00 Resource Type Webinar Leigh Ann Bruhn Arturo LoAIza-Bonilla MD Nico O'Kuinghttons Cathy Zaremba Promotion Start Mon, 09/09/2024 - 11:45 Promotion End Sun, 03/09/2025 - 11:45 Duration 60 Minutes Discover the transformative power of RWE. Join our webinar to learn how real-world evidence can revolutionize your pharma strategy.

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Three Areas to Watch: The Inflation Reduction Act and Prescription Pricing

Drug Channels

Today’s guest post comes from H. John Beardsley, Senior Vice President of Corporate Strategy at CoverMyMeds John discusses how the new maximum fair prices (MFPs) published by the Centers for Medicaid & Medicare Services (CMS) will affect medication affordability, formulary negotiations, evidence-based strategies, and other aspects of the market.

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Can AI or ML Help You Design a Better Clinical Trial?

Quanticate

The integration of Artificial Intelligence (AI) and Machine Learning (ML) in clinical trial design is beginning to reshape the pharmaceutical and medical research industries. Our article explores the methods by which AI and ML are modifying clinical trial design, with a focus on recent advancements and methodologies endorsed by regulatory bodies and used by industry leaders.

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lazertinib

New Drug Approvals

lazertinib CAS 1903008-80-9 554.655, C 30 H 34 N 8 O 3 2-PROPENAMIDE, N-(5-((4-(4-((DIMETHYLAMINO)METHYL)-3-PHENYL-1H-PYRAZOL-1-YL)-2-PYRIMIDINYL)AMINO)-4-METHOXY-2-(4-MORPHOLINYL)PHENYL)- N-(5-((4-(4-((DIMETHYLAMINO)METHYL)-3-PHENYL-1H-PYRAZOL-1-YL)PYRIMIDIN-2-YL)AMINO)-4-METHOXY-2-MORPHOLINOPHENYL)ACRYLAMIDE C-18112003-G GNS 1480 GNS-1480 GNS1480 JNJ-73841937-AAA YH 25448 YH-25448 YH25448 FDA APPROVED 8/19/2024 To treat non-small cell lung cancer, Lazcluze Ingredient UNII CAS InChI Key Lazerti

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Seeing Through: Scientists Use Food Dye to Render Mouse Skin Transparent

Drugs.com

FRIDAY, Sept. 6, 2024 -- It seems like a kind of superpower, but scientists say they've used a common food dye to render the skin of a mouse transparent, revealing the workings of blood vessels and organs underneath.It's not yet clear if the.

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Judge orders J&J to pay Auris investors more than $1B for merger violations

BioPharma Drive: Drug Pricing

J&J did not provide Auris Health with resources to achieve regulatory milestones after acquiring the robotics company in 2019, the judge found.

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