Medicare names first 10 drugs for price negotiations
BioPharma Drive: Drug Pricing
AUGUST 29, 2023
The list includes the top-selling blood thinners Eliquis and Xarelto, as well as the arthritis drug Enbrel and heart failure medicine Entresto.
August, 2023
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How to Get Drugs Into the Brain
Drug Hunter
AUGUST 21, 2023
Obtaining adequate drug exposure in the brain is key to treating CNS diseases effectively. Recently, Dennis Koester gave us a crash course in CNS drug discovery in a Drug Hunter Flash Talk. Here, he sums up some key points on how to find compounds that cross the blood-brain barrier, including: How to Get Drugs Into the Brain The Blood-Brain Barrier, Gatekeeper of the Brain What Makes a Compound Brain-Penetrant?
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Evolved prime editors are smaller and more efficient for therapeutic applications
Broad Institute
AUGUST 31, 2023
Evolved prime editors are smaller and more efficient for therapeutic applications By Corie Lok August 31, 2023 Breadcrumb Home Evolved prime editors are smaller and more efficient for therapeutic applications Researchers have evolved the editing machine at the heart of the prime editing system, which can make a wide range of changes to the genome. By Sarah C.P.
Marijuana Should Be Moved to Lower-Risk Drug Category, U.S. Health Officials Say
Drugs.com
AUGUST 31, 2023
THURSDAY, Aug. 31, 2023 – The U.S. Department of Health and Human Services has asked the U.S. Drug Enforcement Agency to reclassify marijuana as a less dangerous drug under the Controlled Substances Act, a move that could potentially expand.
Bridging Innovation & Patient Care: The Growing Role of AI
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
CDD Vault Update (August 2023)
Collaborative Drug
AUGUST 31, 2023
Wrapping Column Headers in Search Results Table Column headers at the top of the Search Results Table are now wrapped to ensure all text is visible without needing to hover over the text with the mouse.
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Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
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Sanofi appoints a venture investor to R&D head as executive team expands
BioPharma Drive: Drug Pricing
AUGUST 31, 2023
Houman Ashrafian, currently a scientific advisor at SV Health Investors, will fill the role left by John Reed, who oversaw the transformation of research and development during his five years at Sanofi.
ACS Fall 2023 First Disclosures
Drug Hunter
AUGUST 18, 2023
The First Disclosures sessions at the 2023 ACS Fall Meeting in San Francisco, organized by Nikki Goodwin , presented a variety of new orally available small molecules. The standing room-only sessions were so highly attended that many attendees were unfortunately kicked out due to the fire code. In case you missed any of these exciting molecules, from Scorpion’s mutant-selective PI3Kα inhibitor to Nurix’s CNS-penetrant BTK degrader, here we share the structures and targets of all the novel molecu
Development of a covalent cereblon-based PROTAC employing a fluorosulfate warhead [@LynJonesChemBio]
Covalent Modifiers
AUGUST 31, 2023
Radosław P. Nowak, Leah Ragosta, Fidel Huerta, Hu Liu, Scott B. Ficarro, Justin T. Cruite, Rebecca J. Metivier, Katherine A. Donovan, Jarrod A. Marto, Eric S. Fischer, Breanna L. Zerfas and Lyn H Jones RSC Chem. Biol. , 2023 [link] Many cereblon (CRBN) ligands have been used to develop proteolysis targeting chimeras (PROTACs), but all are reversible binders of the E3 ubiquitin ligase.
Opioid OD Rescue Drug Narcan Will Reach Drug Store Shelves Next Week
Drugs.com
AUGUST 30, 2023
WEDNESDAY, Aug. 30, 2023 -- Narcan, a lifesaving medication that reverses opioid overdose, will be available on U.S. drugstore shelves and online starting next week. People who want to carry Narcan, the nasal spray version of naloxone, will be able.
From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Golgi Neurosciences Partners with CDD Vault to Drive Innovation in Neurodegenerative Disease Treatment
Collaborative Drug
AUGUST 29, 2023
Milano, Italy and San Francisco, USA, August 29th, 2023 - Golgi Neurosciences S.r.l., a new Italian incubator dedicated to the discovery and development of small molecule-based treatments for neurodegenerative diseases, announced today that it has adopted Collaborative Drug Discovery’s CDD Vault as its platform of choice for managing drug discovery data.
Nearly half of dog owners are hesitant to vaccinate their pets
Science Daily: Pharmacology News
AUGUST 31, 2023
A new study found that more than half of people who own dogs expressed some level of canine vaccine hesitancy -- i.e. skepticism about vaccinating their pets against rabies and other diseases. An estimated 45 percent of US households own a dog; according to the survey results, nearly 40 percent of dog owners believe that canine vaccines are unsafe, more than 20 percent believe these vaccines are ineffective, and 30 percent consider them to be medically unnecessary.
Bristol Myers gets key FDA approval for bone marrow disease drug
BioPharma Drive: Drug Pricing
AUGUST 29, 2023
A broadened clearance for Reblozyl in myelodysplastic syndromes should help Bristol Myers offset the looming loss of revenue from top-selling medicines set to soon lose market exclusivity.
More LRRK2 On-Target Toxicity?
Drug Hunter
AUGUST 15, 2023
LRRK2 has been a hotly pursued drug target for Parkinson’s Disease based on human genetics. Clinical advancement of LRRK2 inhibitors was initially stalled by concerns about on-target lung findings in primates, but these were ameliorated by a Merck/Genentech/Pfizer/MJFF study showing that these lung changes were reversible, and Biogen/Denali has currently a small molecule (BIIB122/DNL151) in Ph.
How Machine Learning Drives Clinical Trial Efficiency
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Cardiac Arrest: Many People Experience Warning Signs the Day Before
Drugs.com
AUGUST 30, 2023
WEDNESDAY, Aug. 30, 2023 -- Sudden cardiac arrest may not come on so suddenly after all. Fully 50% of people who experienced a sudden cardiac arrest had a telling symptom 24 hours before, and these symptoms are different in men than women, a new.
Poorer Neighborhoods Linked to Higher Asthma Rates in Kids
Drugs.com
AUGUST 31, 2023
THURSDAY, Aug. 31, 2023 -- When factoring in why children get asthma, a child's neighborhood may be important to consider. New research finds that living in a neighborhood during early childhood that has better access to resources was associated.
Poll: Only Half of Older Adults Have Heard of the New RSV Vaccines, Arexvy and Abrysvo
Drugs.com
AUGUST 28, 2023
MONDAY, Aug. 28, 2023 -- About half of older adults (52 percent) have heard of the new vaccines against respiratory syncytial virus (RSV), Arexvy and Abrysvo, according to the National Poll on Healthy Aging released online on Aug. 22.
Do Most Americans Know How to Help Loved Ones Battling Addictions? New Poll Says Yes
Drugs.com
AUGUST 31, 2023
THURSDAY, Aug. 31, 2023 -- If a loved one were living with addiction, a majority of Americans say they would know how to get help. About 71% of 2,200 respondents to an American Psychiatric Association poll said they would know how to assist a friend.
Deliver Fast, Flexible Clinical Trial Insights with Spotfire
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Gene-Tweaked Stem Cells Offer Hope Against Sickle Cell Disease
Drugs.com
AUGUST 31, 2023
THURSDAY, Aug. 31, 2023 -- A type of gene therapy that precisely "edits" a key bit of DNA might offer a new way to treat sickle cell disease -- a painful inherited condition that largely strikes Black children and adults. That's according to a new.
Sage, reeling from depression drug decision, to lay off 40% of workforce
BioPharma Drive: Drug Pricing
AUGUST 31, 2023
Two founding executives are leaving Sage alongside a major restructuring announced weeks after the FDA approved the medicine, Zurzuvae, for much narrower use than the company had hoped.
Doctors Pulled Live Worm From Australian Woman's Brain
Drugs.com
AUGUST 29, 2023
TUESDAY, Aug. 29, 2023 -- Doctors plucked a wriggling roundworm from the brain of an Australian woman in the world's first-known case of human infection with a parasite common in some pythons. The woman, who had been experiencing worsening symptoms.
Eat Your Veggies: Writing 'Produce Prescriptions' Could Boost Patients' Health
Drugs.com
AUGUST 29, 2023
TUESDAY, Aug. 29, 2023 -- An apple a day may be just what the doctor ordered. New research on “produce prescription” programs finds that when access to free fruits and vegetables is offered, recipients see measurable benefits in health and.
Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
First-Time Dads Often Experience Dip in Relationship Satisfaction
Drugs.com
AUGUST 31, 2023
THURSDAY, Aug. 31, 2023 -- Most fathers experience a decline in relationship satisfaction that can last for years after the baby is born, new research shows. “A good couple relationship during the transition to parenthood is important for parents'.
Infertility Treatment May Put Women at Greater Risk for Stroke
Drugs.com
AUGUST 31, 2023
THURSDAY, Aug. 31, 2023 – Scientists have spotted an elevated risk of stroke in women who became pregnant after fertility treatments. Although the absolute number of strokes reported in the new study were low, women seeking fertility treatment.
Novo, continuing deal streak, buys another obesity drug startup
BioPharma Drive: Drug Pricing
AUGUST 30, 2023
The acquisition of Embark Biotech, which Novo helped found, gives the company another prospect to add to its arsenal of weight-loss medicines.
Bat study reveals how the brain is wired for collective behavior
Science Daily: Pharmacology News
AUGUST 30, 2023
Researchers used wireless neural recording and imaging devices to 'listen in' on the hippocampal brain activity of groups of Egyptian fruit bats as they flew freely within a large flight room. The researchers were surprised to find that, in this social setting, the bat's 'place' neurons encoded not only the animal's location, but also information about the presence or absence of other bats, and even the identity of bats in their path.
Expanding the impact of CAR T cell therapy: An immunotherapy strategy against all blood cancers
Science Daily: Pharmacology News
AUGUST 31, 2023
A broad new strategy could hold hope for treating virtually all blood cancers with CAR T cell therapy, which is currently approved for five subtypes of blood cancer. Scientists have demonstrated the potential efficacy of this approach a preclinical study.
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