BioPharma Drive: Drug Pricing

AUGUST 29, 2023

The list includes the top-selling blood thinners Eliquis and Xarelto, as well as the arthritis drug Enbrel and heart failure medicine Entresto.

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Drugs 117

Broad Institute

AUGUST 31, 2023

Evolved prime editors are smaller and more efficient for therapeutic applications By Corie Lok August 31, 2023 Breadcrumb Home Evolved prime editors are smaller and more efficient for therapeutic applications Researchers have evolved the editing machine at the heart of the prime editing system, which can make a wide range of changes to the genome. By Sarah C.P.

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Drugs.com

AUGUST 31, 2023

THURSDAY, Aug. 31, 2023 – The U.S. Department of Health and Human Services has asked the U.S. Drug Enforcement Agency to reclassify marijuana as a less dangerous drug under the Controlled Substances Act, a move that could potentially expand.

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Drugs 122

Antidote

AUGUST 30, 2023

At the outset, many people may experience apprehension when considering joining a clinical trial. Opting to participate in a research study is a personal one — but it can also be quite gratifying. Various types of clinical studies play a pivotal role in ensuring the approval of life-saving medications and treatments. For this to happen, we need volunteers to take part.

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Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Drug Target Review

AUGUST 30, 2023

Advancing drug discovery for pain disorders: human iPSC-based approach Drug discovery relies on the use of relevant model systems. Most new targets have been discovered using animal models, which while useful, are not sufficiently predictive of human safety and efficacy. We have developed a unique approach for using human induced pluripotent stem cells for target validation from a list of targets from real-world data and whole-genome sequencing.

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Perficient: Drug Development

AUGUST 31, 2023

Responsibilities, Skills, Scope and More. The tutorial provides basic concepts of Kotlin. Our Kotlin tutorial includes. What is Kotlin? Pre-Requisites Features of Kotlin Kotlin Architecture What is Kotlin? Kotlin is a programming language introduced by JetBrains in 2011. Kotlin is free, has been free and will remain free. It is developed under the Apache 2.0 license.

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Broad Institute

AUGUST 31, 2023

Schizophrenia gene mutation causes many changes in the mouse brain By Leah Eisenstadt August 31, 2023 Breadcrumb Home Schizophrenia gene mutation causes many changes in the mouse brain A study of a genetic mouse model of schizophrenia supports two long-debated hypotheses, and unveils additional new clues about the biological roots of the disorder. By Leah Eisenstadt August 31, 2023 Credit: Susanna Hamilton, Broad Communications Researchers studied the effects of a schizophrenia gene mutation in

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RNA Medical Schools Research Science 143

Drugs.com

AUGUST 30, 2023

WEDNESDAY, Aug. 30, 2023 -- Narcan, a lifesaving medication that reverses opioid overdose, will be available on U.S. drugstore shelves and online starting next week. People who want to carry Narcan, the nasal spray version of naloxone, will be able.

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Drugs 122

Translation

AUGUST 31, 2023

Halo was proud to host Bayer Crop Science ’s third year of Grants4Ag. Grants4Ag is Bayer’s annual initiative providing funding and expertise to researchers developing novel solutions in agriculture. As part of Bayer’s CropKey approach to crop protection innovation, this year’s awards focused on transformative R&D and breakthrough technologies for next-gen crop protection solutions.

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Drug Target Review

AUGUST 31, 2023

In the pursuit of a remedy for Alzheimer’s disease, a frontier in medical science is illuminating a glimmer of hope. Stem cell therapies have already demonstrated their prowess in treating diverse cancers and ailments linked to the blood and immune system. In an innovative proof-of-concept investigation, researchers at the University of California San Diego have revealed the potential of stem cell transplants as a promising therapeutic avenue against Alzheimer’s disease.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Perficient: Drug Development

AUGUST 28, 2023

Introduction to Feign Client: In the world of software, microservices are like building blocks that help make programs more flexible and scalable. But for these blocks to work together, they need to talk to each other effectively. Imagine each block sharing information, asking for help, and working together smoothly. Meet Feign Client, a super useful tool for microservices.

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Packaging 105

BioPharma Drive: Drug Pricing

AUGUST 29, 2023

A broadened clearance for Reblozyl in myelodysplastic syndromes should help Bristol Myers offset the looming loss of revenue from top-selling medicines set to soon lose market exclusivity.

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FDA Law Blog: Biosimilars

AUGUST 24, 2023

Hyman, Phelps & McNamara, P.C. (“HP&M”) is is proud to announce that 14 of the Firm’s attorneys have been selected to the 2024 edition of The Best Lawyers in America®. Newly recognized this year are attorneys Josephine M. Torrente (FDA Law), Michelle L. Butler (FDA Law), Sara W. Koblitz (FDA Law), Allyson B. Mullen (FDA Law), and Anne K. Walsh (FDA Law), as well as McKenzie E.

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Drugs.com

AUGUST 30, 2023

WEDNESDAY, Aug. 30, 2023 -- Sudden cardiac arrest may not come on so suddenly after all. Fully 50% of people who experienced a sudden cardiac arrest had a telling symptom 24 hours before, and these symptoms are different in men than women, a new.

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

PLOS: DNA Science

AUGUST 24, 2023

As autumn looms, we’re enjoying the last bites of sweet, juicy watermelon. Conventional agriculture has molded our fruits and veggies to suit our palates, gradually crafting domesticated Citrullus lanatus from three ancestral melon species. But the process may have also removed valuable traits. Researchers at the Boyce Thompson Institute in Ithaca, New York, have analyzed genomes of watermelon and its ancestors, revealing traits that early breeders may have inadvertently removed in their q

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Drug Target Review

AUGUST 29, 2023

Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? My STEM journey started with a genuine love for biology back in middle school. As I progressed through high school and then Haverford College, I got hands-on lab experience at other institutions like the NIH-NCI and the Bio21 institute in Melbourne, Australia.

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Perficient: Drug Development

AUGUST 28, 2023

An innovation wildcard is a team member who is there to add a unique perspective that the rest of the team may not have. This person can be within the organization or pulled from outside. They may have deep expertise in other areas, or they may be new and more likely to question everything. Innovation demands new ideas and ways of thinking. Adding a wildcard player to the team will help the creativity process.

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BioPharma Drive: Drug Pricing

AUGUST 31, 2023

Two founding executives are leaving Sage alongside a major restructuring announced weeks after the FDA approved the medicine, Zurzuvae, for much narrower use than the company had hoped.

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FDA Approval FDA Drugs 110

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Antidote

AUGUST 21, 2023

Before any new treatment is able to be approved, it is required to go through the vigorous testing process known as clinical trials. These trials are aimed at determining whether or not a drug, medical device, therapy, or other type of intervention is safe and effective for the public.

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Drugs.com

AUGUST 28, 2023

MONDAY, Aug. 28, 2023 -- About half of older adults (52 percent) have heard of the new vaccines against respiratory syncytial virus (RSV), Arexvy and Abrysvo, according to the National Poll on Healthy Aging released online on Aug. 22.

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Broad Institute

AUGUST 17, 2023

#WhyIScience Q&A: A computational biologist helps build datasets for genetic disease diagnosis By Corie Lok August 17, 2023 Breadcrumb Home #WhyIScience Q&A: A computational biologist helps build datasets for genetic disease diagnosis Katherine Chao talks about her work managing the Genome Aggregation Database (gnomAD) and the importance of diverse datasets in rare disease diagnosis.

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Drug Target Review

AUGUST 25, 2023

What makes RRx-001 a first-in-class hypoxia-activated therapeutic, and how does its dual mechanism of action differ from traditional cancer treatments? Most, if not all, traditional cancer treatments are single minded. Their mechanisms of action are completely consistent no matter the tissue or environment in which they find themselves. RRx-001 (nibrozetone) is different because in tissues where 3 “Hs” are present, namely hypoxia (low oxygen), hyperaemia (over-vascularisation), and high hydrogen

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Small Molecule Virus International Clinical Trials 98

Perficient: Drug Development

AUGUST 24, 2023

The transition from a wholesale-centric business model to include a new direct-to-consumer (D2C) approach presents lucrative opportunities alongside a suite of technical and operational intricacies to consider. While the move brings manufacturing companies closer to end consumers, it also requires several considerations spanning content creation, post-purchase support, and overall brand experience.

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BioPharma Drive: Drug Pricing

AUGUST 23, 2023

The company doesn’t know if the needles have caused retinal vasculitis in some people receiving its geographic atrophy drug Syfovre, but is no longer recommending their use.

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Drugs 98

PLOS: DNA Science

AUGUST 17, 2023

The Maui firestorm was so vast and fast that most identification of human remains will come from bits of persisting DNA from mitochondria. The “Powerhouse of the Cell” Most people likely last encountered mitochondria in high school biology class. The footprint-shaped “powerhouse of the cell” releases energy from breaking the chemical bonds that hold together nutrient molecules.

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DNA Disease Science Research 98

Drugs.com

AUGUST 31, 2023

THURSDAY, Aug. 31, 2023 -- When factoring in why children get asthma, a child's neighborhood may be important to consider. New research finds that living in a neighborhood during early childhood that has better access to resources was associated.

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SCIENMAG: Medicine & Health

AUGUST 17, 2023

Julie Carrier, professor and head of the University of Tennessee Department of Biosystems Engineering and Soil Science, was awarded the James R. and Karen A. Gilley Academic Leadership Award during the annual international meeting of the American Society of Agricultural and Biological Engineers (ASABE) in July.

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Drug Target Review

AUGUST 24, 2023

The focus of this study is on Growth Differentiation Factor-15 (GDF-15), a cytokine known for its critical role in feto-maternal tolerance, which has now been found to be hijacked by tumours to evade immune attack. We will explore how GDF-15 impacts the tumour microenvironment and hinders the infiltration of T cells into the tumour, as well as the implications of neutralising GDF-15 to reverse its inhibitory effects and sensitise tumours to anti-PD-1 treatment.

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Broad Institute

AUGUST 16, 2023

Nuclear DNA influences variation in mitochondrial DNA By Allessandra DiCorato August 16, 2023 Breadcrumb Home Nuclear DNA influences variation in mitochondrial DNA Whole genomes from hundreds of thousands of people reveal new complexity in how the nuclear and mitochondrial genomes interact, which may influence how cells produce energy. By Allessandra DiCorato August 16, 2023 Credit: Sonja Vasiljeva, Broad Communications The energy-producing machines inside cells, called mitochondria, have their

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BioPharma Drive: Drug Pricing

AUGUST 10, 2023

The deal will help fund a cell-based treatment that completed Phase 1 testing last year and is designed to provide a “functional cure” for patients with HIV infections.

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Therapies Treatment 97

Antidote

AUGUST 16, 2023

Primary sclerosing cholangitis (PSC) is a condition that impacts the bile ducts of the liver, causing them to become inflamed and ultimately scar. It primarily affects young and middle-aged men, and 80% of patients with PBC also have inflammatory bowel disease (IBD).

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Drugs.com

AUGUST 31, 2023

THURSDAY, Aug. 31, 2023 -- If a loved one were living with addiction, a majority of Americans say they would know how to get help. About 71% of 2,200 respondents to an American Psychiatric Association poll said they would know how to assist a friend.

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Perficient: Drug Development

AUGUST 24, 2023

In the dynamic world of web development, where user expectations are higher than ever and application complexity continues to grow. The need for efficient data retrieval and flexible APIs has become paramount. Enter GraphQL, a revolutionary query language for APIs that is reshaping how data is requested, fetched, and managed. In this comprehensive exploration, we’ll dive deep into the essence of GraphQL, its core principles, benefits, and real-world applications.

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