Broad Institute

APRIL 2, 2024

Scientists link certain gut bacteria to lower heart disease risk By Allessandra DiCorato April 2, 2024 Breadcrumb Home Scientists link certain gut bacteria to lower heart disease risk Study finds several species of cholesterol-metabolizing bacteria in people with lower cholesterol levels. By Allessandra DiCorato April 2, 2024 Credit: Ahmed Mohamed Rod-shaped Oscillibacter sp. bacteria take up fluorescently labeled cholesterol (here shown in green).

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Science Daily: Pharmacology News

APRIL 11, 2024

New hypothesis paper builds on a growing scientific consensus that Parkinson's disease route to the brain starts in either the nose or the gut and proposes that environmental toxicants are the likely source.

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Disease 144

BioPharma Drive: Drug Pricing

APRIL 8, 2024

Recent biotech company acquisitions have put emerging schizophrenia treatments in focus. But many development hurdles still stand in the way of new medicines for the brain.

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Treatment Drugs 136

Drugs.com

APRIL 26, 2024

FRIDAY, April 26, 2024 -- Clostridioides difficile (C. difficile) is a leading cause of illness and death, especially for frail and hospitalized Americans. Now, a new study suggests that the leading antibiotic used to fight it, vancomycin, may be.

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Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Codon

APRIL 9, 2024

Wendi Yan writes about the discovery of artemisinin, a medicine that has saved millions of lives, for Issue 01. Drawing on recently published Chinese texts, Wendi’s reporting provides a more comprehensive telling of this discovery than has previously been described. When her father gave Tu the name “Youyou,” he started with characters from the Chinese classic Book of Odes: “The deer bleat: ‘yōu yōu’ while eating wild ‘hāo’” (&#

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NIOSH Science Blog: Drugs

APRIL 10, 2024

Struck-by injuries are the leading cause of nonfatal injuries and second most common cause of fatalities among construction workers. From 2011 to 2022, there were 1,462 fatal occupational injuries that occurred at road construction sites.[1] Of these, 68% (n=1,000) were among workers in the construction industry (See figure) followed by workers in transportation and warehousing (11%; n=168) and professional and business services (9%; n=132) industries.

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International 121

Science Daily: Pharmacology News

APRIL 18, 2024

Land subsidence is overlooked as a hazard in cities, according to new research. Scientists used satellite data that accurately and consistently maps land movement across China.

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Research 142

BioPharma Drive: Drug Pricing

APRIL 18, 2024

It’s “early innings” in the obesity drug race, said Metsera CEO Clive Meanwell, whose company has acquired a portfolio of medicines it aims to test in combination.

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Drugs 126

Drugs.com

APRIL 24, 2024

WEDNESDAY, April 24, 2024 -- Long-term daily use of aspirin has been known to prevent colon cancer, but up to now it’s been unclear why that is.Now, researchers think they understand how aspirin acts against colon cancer, a new study says.Aspirin.

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Science Research 124

Antidote

APRIL 4, 2024

Before it is released onto the market, the development of any new drug or medical device must undergo rigorous testing , part of which involves clinical trials. Clinical trials are integral to making sure that any new therapy is both safe and effective for individuals, and volunteers are a vital part of the process.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

NIOSH Science Blog: Drugs

APRIL 26, 2024

Each year, on April 28, we pause to recognize Workers’ Memorial Day and honor those whose death or suffering resulted from exposure to hazards at work. Words are not enough when it comes to change. Research has shown that the health and safety of workers relies on active and intentional involvement in ways that take into consideration workplace hazards, work arrangements and environment, employer-worker relationships, the workers themselves, and their families.

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Research 117

LifeSciVC

APRIL 24, 2024

By Aimee Raleigh, Principal at Atlas Venture, as part of the From The Trenches feature of LifeSciVC Ever wondered what goes into diligencing a new idea, program, company, or platform? While each diligence is unique and every investor will have their own approach, below are some considerations that may be more “typical” in a diligence. I will emphasize the obvious disclaimer before diving in – this framework is merely meant to be exemplary and there are always nuances and exceptions unique to eac

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Science Daily: Pharmacology News

APRIL 17, 2024

Even if CO2 emissions were to be drastically cut down starting today, the world economy is already committed to an income reduction of 19% until 2050 due to climate change, a new study finds. These damages are six times larger than the mitigation costs needed to limit global warming to two degrees. Based on empirical data from more than 1,600 regions worldwide over the past 40 years, scientists assessed future impacts of changing climatic conditions on economic growth and their persistence.

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BioPharma Drive: Drug Pricing

APRIL 10, 2024

The first medicine approved for PPD, Sage’s Zulresso, never gained traction. The company is in the midst of launching its second, but long-standing challenges could slow uptake.

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Treatment Drugs 126

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drugs.com

APRIL 22, 2024

MONDAY, April 22, 2024 -- Even though fentanyl-linked fatal overdoses are soaring among young adults, a new survey of American college students found that just 1 in 7 knew how to administer the overdose antidote drug naloxone.Many who took the.

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Drugs 122

Antidote

APRIL 23, 2024

Equitable access to medical care is valuable for everyone, and an important part of this equation is health literacy. Health literacy encompasses not just access to medical care, but also the ability to understand and use medical guidance. This can include anything from a doctor’s suggestions, to medication dosage information, and aftercare guidance.

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Perficient: Drug Development

APRIL 29, 2024

We’ve all heard of servant leadership. The concept of “being a servant” to your teams and treating employees as critical individuals to be cultivated and empowered, has strong merit. However, many organizations fall short, with those at the top of the hierarchy viewing employees as interchangeable cogs in the corporate machine. Instead of diving deep into the theories, practices, and benefits of servant leadership, I will focus on a specific, related principle or mind-set: being unobtrusive.

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LifeSciVC

APRIL 26, 2024

Venture creation in biotech is witnessing a sustained contraction. After the pandemic bubble’s over-indulgence, the venture ecosystem appears to have reset its pace of launching new startups. According to the latest Pitchbook data, venture creation in biotech hit its slowest quarterly pace in eight years during 1Q 2024. With just over 60 new biotechs raising their first round of financing, the sector’s company formation activity has slowed 50-60% from its historic peak in 2021.

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DNA Science Marketing Clinical Trials 110

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Science Daily: Pharmacology News

APRIL 24, 2024

Cells constantly navigate a dynamic environment, facing ever-changing conditions and challenges. But how do cells swiftly adapt to these environmental fluctuations? A new study is answering that question by challenging our understanding of how cells function. A team of researchers suggests that cells possess a previously unknown information processing system that allows them to make rapid decisions independent of their genes.

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Research 141

BioPharma Drive: Drug Pricing

APRIL 18, 2024

The start of a so-called rolling review formally begins an FDA evaluation of a closely watched drug that’s important to the biotech’s future, but faces questions about its sales potential.

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FDA Drugs 121

Drugs.com

APRIL 24, 2024

WEDNESDAY, April 24, 2024 -- A budget-busting 3.6 million Medicare recipients could now be eligible for coverage of the weight-loss drug Wegovy, a new KFF analysis says.That’s because the U.S. Food and Drug Administration has approved the use of.

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Drugs 119

Drug Target Review

APRIL 19, 2024

Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? In the STEM area, I was born as a physicist, which was – among many other things – the inception of looking at the world from many different points of view to get the big picture without losing the fascination with mystery. This eventually translated into looking at my life from many points of view, without fear of change, which opened many opportunities.

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KIF1A

APRIL 13, 2024

#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. KIF1A-Related Research Clinical exome sequencing uncovers genetic disorders in neonates with suspected hypoxic–ischemic encephalopathy: A retrospective analysis Brain injuries and developmental disorders can be difficu

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Perficient: Drug Development

APRIL 11, 2024

Documentation is a crucial part of your analytics implementation. From your Solution Design Reference document to your internal wiki for all resources, making sure that you can write and edit your documentation is key to ensuring a cohesive and thorough understanding of your implementation. With effective documentation, you can: Prevent knowledge gaps among team members and assist in onboarding efforts.

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International 109

Science Daily: Pharmacology News

APRIL 9, 2024

Researchers have discovered a simple, but effective, strategy to help people reduce their feelings of anger. Disposing of a piece of paper containing your written thoughts on the cause of your anger can effectively neutralize it. This process is like a Japanese tradition called hakidashisara, in which people write their negative thoughts on a plate then destroy it.

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Science Research 141

BioPharma Drive: Drug Pricing

APRIL 15, 2024

Treatment appeared to result in functional and cognitive gains in people with the neurological disorder. Three participants experienced lower extremity weakness, however.

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Therapies Treatment 122

Drugs.com

APRIL 18, 2024

THURSDAY, April 18, 2024 -- Antipsychotics can substantially increase dementia patients’ risk of many serious health problems, a new study warns.

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The ChEMBL-og

APRIL 16, 2024

We are delighted to announce the release of ChEMBL 34, which includes a full update to drug and clinical candidate drug data. This version of the database, prepared on 28/03/2024 contains: 2,431,025 compounds (of which 2,409,270 have mol files) 3,106,257 compound records (non-unique compounds) 20,772,701 activities 1,644,390 assays 15,598 targets 89,892 documents Data can be downloaded from the ChEMBL FTP site: [link] Please see ChEMBL_34 release notes for full details of all changes in this rel

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KIF1A

APRIL 6, 2024

#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. KIF1A-Related Research Genetic Alterations in a Large Population of Italian Patients Affected by Neurodevelopmental Disorders We often talk about genetic disorders in the context of mutations that change a protein̵

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DNA Medical Schools Therapies Research 111

Perficient: Drug Development

APRIL 25, 2024

SUGCON (Sitecore User Group Conference) Europe 2024 was the second SUGCON I’ve attended, with the first just being six months ago in Minneapolis. There are few things that remind me how much I love my job more than being surrounded by the Sitecore Community. I’ve developed real friendships with folks from literally every corner of the world and it’s only once or twice a year we get the whole “Sitecore Family” together.

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Science Daily: Pharmacology News

APRIL 23, 2024

Researchers describe the steps they took to manipulate DNA and proteins -- essential building blocks of life -- to create cells that look and act like cells from the body. This accomplishment, a first in the field, has implications for efforts in regenerative medicine, drug delivery systems and diagnostic tools.

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BioPharma Drive: Drug Pricing

APRIL 1, 2024

The FDA could soon expand use of two multiple myeloma cell therapies as well as a top-selling medicine from Sanofi and Regeneron, while Pfizer’s years of gene therapy work might finally pay dividends.

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Drugs.com

APRIL 29, 2024

MONDAY, April 29, 2024 -- Global vaccination efforts have saved an estimated 154 million lives, including 101 million infants, a new study led by the World Health Organization (WHO) shows.Immunization has contributed more to the health and survival.

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