Drug Target Review

DECEMBER 20, 2024

Artificial intelligence (AI) has revolutionised many industries, yet its adoption in pharmaceutical drug development has been notably slower. Concerns surrounding data security, the complexity of AI systems, and the rigorous regulatory frameworks in this field have caused the pharmaceutical industry to approach these technologies with caution. For years, AI and machine learning (ML) were often dismissed as little more than advanced statistics with little practical value in drug development.

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Clinical Trials Trials Pharmaceuticals Drug Development 126

Science Daily: Pharmacology News

DECEMBER 25, 2024

Scientists have developed an innovative therapeutic platform by mimicking the intricate structures of viruses using artificial intelligence (AI).

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Virus 134

Drugs.com

DECEMBER 23, 2024

December 23, 2024 -- Today, the U.S. Food and Drug Administration approved the first generic referencing Victoza (liraglutide injection) 18 milligram/3 milliliter, a glucagon-like peptide-1 (GLP-1) receptor agonist indicated to improve glycemic.

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FDA Approval FDA Drugs 124

Nvidia Developer: Drug Discovery

DECEMBER 3, 2024

Antibodies have become the most prevalent class of therapeutics, primarily due to their ability to target specific antigens, enabling them to treat a wide range. Antibodies have become the most prevalent class of therapeutics, primarily due to their ability to target specific antigens, enabling them to treat a wide range of diseases, from cancer to autoimmune disorders.

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Small Molecule Disease Drugs Science 134

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

keypoint

DECEMBER 20, 2024

Meet the Keystone Symposia Fellows Class of 2025, a stellar group of post-doctoral fellows and early-career scientists who will take part in this prestigious mentorship program.

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Doctors 123

BioPharma Drive: Drug Pricing

DECEMBER 4, 2024

Results from the head-to-head study showed treatment with Zepbound resulted in 47% greater relative weight loss than Wegovy, a finding that could advantage Lilly in the companies’ market competition.

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Drug Trials Trials Treatment Marketing 125

Science Daily: Pharmacology News

DECEMBER 4, 2024

A new study sheds light on how long humans in the Americas have had relationships with the ancestors of today's dogs -- and asks an 'existential question': What is a dog?

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Drugs.com

DECEMBER 26, 2024

THURSDAY, Dec. 26, 2024 -- Migraine patients often suffer a long time before docs zero in on the best dosage for drugs designed to prevent their terrible symptoms. But a recently approved daily migraine pill called Qulipta (atogepant) appears to be.

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Drugs 119

Drug Patent Watch

DECEMBER 11, 2024

The biopharmaceutical industry has witnessed a significant surge in the number of therapeutic molecules in development, leading to a corresponding increase in the number of contract development and manufacturing organizations (CDMOs). This growth has created a competitive landscape where pharmaceutical companies must carefully evaluate and select the right CDMO partner to ensure the success of their projects.

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Chemical Biology and Drug Design

DECEMBER 29, 2024

Cover Image molekuul_be/Shutterstock.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

BioPharma Drive: Drug Pricing

DECEMBER 20, 2024

Novo shares lost nearly a quarter of their value after an experimental combination treatment called cagrisema fell short of the bar set by executives.

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Trials Treatment Drugs 120

Drug Target Review

DECEMBER 4, 2024

G protein-coupled receptors (GPCRs) represent a cornerstone of modern drug discovery due to their crucial role in regulating human physiology and their involvement in numerous diseases. Many of these receptors are key targets for addressing obesity and metabolic disorders. Confo Therapeutics , led by CEO Dr Cedric Ververken, is at the forefront of developing innovative GPCR-targeted therapies using its proprietary ConfoBody ® platform.

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Pharmacokinetics Small Molecule Therapies Immune Response 122

Science Daily: Pharmacology News

DECEMBER 20, 2024

Physician-scientists found that a subset of artificial heart patients can regenerate heart muscle, which may open the door to new ways to treat and perhaps someday cure heart failure.

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Drugs.com

DECEMBER 30, 2024

MONDAY, Dec. 30, 2024 -- Norovirus, a highly contagious stomach bug, is surging across the United States this winter, according to the latest data from the U.S. Centers for Disease Control and Prevention (CDC).The data shows 91 outbreaks of.

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Disease 116

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Clinical Trials

Broad Institute

DECEMBER 11, 2024

#WhyIScience Q&A: A computational biologists world travels have shaped her approach to research By Corie Lok December 11, 2024 Breadcrumb Home #WhyIScience Q&A: A computational biologists world travels have shaped her approach to research Wolu Chukwu talks about how she brings a community-first focus to her work in cancer genetics. By Corie Lok December 11, 2024 Credit: Allison Colorado, Broad Communications Wolu Chukwu is a computational biologist studying cancer genetics at Broad.

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Chemical Biology and Drug Design

DECEMBER 23, 2024

We have discovered a gefitinib derivative that can inhibit IDO1 enzyme activity in Hela cells, thereby inducing apoptosis in these cells. ABSTRACT Cervical cancer is the fourth most common cancer among women globally. Its development is closely linked to accelerated cell cycle progression and the inhibition of apoptosis in cervical cancer tissues. Gefitinib has demonstrated efficacy in inhibiting cervical cancer cells, and the 1,2,3-triazole structure is widely recognized for its role in inducin

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Research 100

BioPharma Drive: Drug Pricing

DECEMBER 2, 2024

The ADA recommended doctors avoid prescribing unapproved, off-brand versions of drugs like Wegovy, wading into a dispute that has gripped the FDA and compounding pharmacies over the past few months.

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Compounding Pharmacies Pharmacy Doctors FDA 120

Drug Patent Watch

DECEMBER 3, 2024

In the ever-evolving landscape of pharmaceutical research and development, a revolutionary force is reshaping the way we approach drug discovery and repurposing. This force is none other than Artificial Intelligence (AI) and Machine Learning (ML).

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Drugs Pharmaceuticals Research 90

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Clinical Trials

Science Daily: Pharmacology News

DECEMBER 4, 2024

Exposure to car exhaust from leaded gas during childhood altered the balance of mental health in the U.S. population, making generations of Americans more depressed, anxious and inattentive or hyperactive, according to researchers. They estimate that 151 million cases of psychiatric disorder over the past 75 years have resulted from American children's exposure to lead.

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Research 125

Drugs.com

DECEMBER 23, 2024

MONDAY, Dec. 23, 2024 -- The U.S. Food and Drug Administration (FDA) has approved the first prescription medication specifically for treating obstructive sleep apnea (OSA): the weight-loss drug Zepbound. In a news release published Dec. 20, the FDA.

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Codon

DECEMBER 8, 2024

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Chemical Biology and Drug Design

DECEMBER 20, 2024

Our results demonstrate the effects of LYD on cell viability, cell cycle, and apoptosis in NSCLC invitro and invivo models and explored its underlying mechanisms. Our findings suggest that LYD inhibited NSCLC cells growth by inducing G2/M arrest and subsequent apoptosis. It also inhibited the P70S6K and PS6 pathways. More interestingly, LYD also significantly activated the STING pathway in NSCLC, inducing CXCL10 and CCL5 expression, which may help overcome immunotherapy resistance.

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BioPharma Drive: Drug Pricing

DECEMBER 19, 2024

The FDA’s decision will close a lucrative market opportunity for compounding pharmacies, although the agency will give a limited grace period before taking any enforcement actions.

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Compounding Pharmacies FDA Pharmacy Marketing 113

Drug Patent Watch

DECEMBER 9, 2024

In the vast realm of pharmaceutical research and development, there’s a fascinating intersection between ancient wisdom and modern science. This intersection is where pharmacognosy meets drug patents, creating a unique landscape that shapes the future of medicine. But what exactly is pharmacognosy, and how does it relate to the complex world of drug patents?

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Drugs Drug Development Pharmaceuticals Production 92

Science Daily: Pharmacology News

DECEMBER 23, 2024

Bright, twisted light can be produced with technology similar to an Edison light bulb, researchers have shown. The finding adds nuance to fundamental physics while offering a new avenue for robotic vision systems and other applications for light that traces out a helix in space.

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Research 119

Drugs.com

DECEMBER 21, 2024

SATURDAY, Dec. 21, 2024 -- The holiday spirit is infectious, even for people suffering from dementia.But family and friends might need to make some slight adjustments to help a dementia patient better enjoy the holidays, the Alzheimers Foundation o.

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Codon

DECEMBER 12, 2024

The creation of a “mirrored” organism could “trigger severe ecological disruptions,” according to a 300-page technical report released today. Its authors claim such organisms could quickly spread across the world, fatally infect humans, and “directly drive vulnerable plant and animal species to extinction.” The report accompanies an article in Science , also released today, entitled “Confronting Risks of Mirror Life.” But what, exactly, is a mirror

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Chemical Biology and Drug Design

DECEMBER 19, 2024

The new palmitoylated derivatives of thioglycolic acid are designed to mimic microbial lipopeptides as a new class of small-molecule immunomodulators. The most active compound ( 10 ) induced a 1226-fold increase in the expression of TNF- and IL-1 mRNA and triggered a marked release of NO in isolated macrophages at 1.0M. ABSTRACT The immune system is essential for the defense against infections and is critically implicated in various disorders, including immunodeficiency, autoimmunity, inflammati

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BioPharma Drive: Drug Pricing

DECEMBER 3, 2024

While early and from a small trial, the findings suggest Janux’s method of “masking” T cell engagers could lead to differentiated results, some analysts said.

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Trials Drugs 116

Drug Patent Watch

DECEMBER 12, 2024

Identifying branded drugs with a low likelihood of generic entry has become a crucial strategy for companies looking to expand their product portfolio through in-licensing. This approach not only helps maintain market exclusivity but also ensures a steady revenue stream for pharmaceutical companies. In this comprehensive guide, we’ll explore the intricacies of identifying such drugs and leveraging them for successful in-licensing opportunities.

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Licensing Licensing Drugs Biosimilars 86

Science Daily: Pharmacology News

DECEMBER 2, 2024

Researchers have linked a specific type of body fat to the abnormal proteins in the brain that are hallmarks of Alzheimer's disease up to 20 years before the earliest symptoms of dementia appear, according to a new study. The researchers emphasized that lifestyle modifications targeted at reducing this fat could influence the development of Alzheimer's disease.

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Disease Research 125

Drugs.com

DECEMBER 20, 2024

FRIDAY, Dec. 20, 2024 -- An existing drug might be able to treat an autoimmune disorder that causes dry eye, dry mouth, fatigue and muscle or joint pain. Baricitinib (Olumiant), a drug currently used to treat rheumatoid arthritis, appears to.

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Disease Research Drugs 116

Perficient: Drug Development

DECEMBER 13, 2024

No matter the project, location, or career path, Perficient promises to challenge, champion, and celebrate every colleague on their journey to success. Perficient is a place where great minds and great companies converge to boldly advance business. Our colleagues bring fresh perspectives and innovative ideas to the table that inspire creativity, spark collaboration, and ignite change.

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