Drug Discovery World
JUNE 18, 2024
Researchers have developed a new antibiotic that reduced or eliminated drug-resistant bacterial infections in mouse models of acute pneumonia and sepsis while sparing healthy microbes in the gut. The drug, called lolamicin, also warded off secondary infections with Clostridioides difficile, and was effective against more than 130 multidrug-resistant bacterial strains in cell culture.
Broad Institute
JUNE 14, 2024
Some CRISPR screens may be missing cancer drug targets By Allessandra DiCorato June 14, 2024 Breadcrumb Home Some CRISPR screens may be missing cancer drug targets Current CRISPR guides don’t work equally well in cells from people of all ancestries, which could lead to false negative results. By Allessandra DiCorato June 14, 2024 Credit: Ricardo Job-Reese, Broad Communications CRISPR/Cas9 gene editing has made possible a multitude of biomedical experiments including studies that systematically t
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BioPharma Drive: Drug Pricing
JUNE 27, 2024
A growing cohort of biotechs, from Biohaven to Neurocrine to Jazz, hope research on ion channels will bring them new drugs and big business — much like it has done for Vertex.
Science Daily: Pharmacology News
JUNE 4, 2024
Have you ever wished you could understand what your dog is trying to say to you? Researchers are exploring the possibilities of AI, developing tools that can identify whether a dog's bark conveys playfulness or aggression.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drugs.com
JUNE 28, 2024
FRIDAY, June 28, 2024 -- As a summer wave of COVID infections rolls across the country, U.S. health officials have recommended that all Americans over the age of 6 months get one of the updated COVID vaccines when they become available this.
Antidote
JUNE 10, 2024
Also known as endometrial carcinoma or uterine cancer, endometrial cancer occurs when the cells that line the uterus begin growing uncontrollably. Though the mortality rates are relatively low due to the high rate of early detection, it is a cancer that impacts nearly 70,000 people every year.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Broad Institute
JUNE 18, 2024
Simple test for flu could improve diagnosis and surveillance By Allessandra DiCorato June 18, 2024 Breadcrumb Home Simple test for flu could improve diagnosis and surveillance A low-cost CRISPR-based paper strip test distinguishes between influenza types and can be reprogrammed to recognize different viruses including the H5N1 bird flu virus. By Allessandra DiCorato June 18, 2024 Credit: Jon Arizti-Sanz SHINE, a rapid diagnostic test developed by Pardis Sabeti's lab in 2020, uses paper strips an
BioPharma Drive: Drug Pricing
JUNE 17, 2024
One expert described trial results presented at EULAR last week as “unprecedented.” But reports of relapses in some patients drew questions about the therapies’ ultimate potential.
Science Daily: Pharmacology News
JUNE 13, 2024
With their 'T-REX' method, researchers developed a glassy, amber-like polymer that can be used for long-term storage of DNA, such as entire human genomes or digital files such as photos.
FDA Law Blog: Biosimilars
JUNE 13, 2024
By Sara W. Koblitz — As we have noted for the last year or so, the FTC has been on a mission to clean up the Orange Book by removing what it deems to be “improper” patents. The FTC has put out policy statements, challenged patent listings, tapped Congress, appeared on talk shows, and filed amicus briefs all in the span of the last 8 months. It seems like all that work is paying off.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Drugs.com
JUNE 20, 2024
THURSDAY, June 20, 2024 -- Seven different kinds of microplastics have been discovered in human penises for the first time.The tiny fragments, formed when plastic products break down in the environment, were found in four of five samples of penis.
Drug Discovery World
JUNE 19, 2024
KYV-101, a fully human anti-CD19 chimeric antigen receptor (CAR) T-cell product candidate, has been used to treat a 69-year-old patient suffering from treatment-refractory stiff-person syndrome (SPS). The therapy was given as part of a named-patient use in Germany for critically ill individuals who fail conventional therapies. SPS is a rare, progressive neurological autoimmune disorder causing debilitating muscle stiffness in the torso, arms, and legs, impacting the ability to walk or move.
NIOSH Science Blog: Drugs
JUNE 5, 2024
Each June, we bring a little extra attention to safety issues by highlighting National Safety Month®. For each week of the month, the National Safety Council (NSC) identifies a theme to focus on. This blog highlights select research and prevention efforts from the National Institute for Occupational Safety and Health (NIOSH) and NSC in this year’s focus areas of safety engagement; roadway safety; risk reduction; and slips, trips and falls.
BioPharma Drive: Drug Pricing
JUNE 21, 2024
Peter Marks’ decision to override the objections of agency staff and broaden use of Elevidys could have a “lasting impact” on gene therapy as well as the FDA, one analyst wrote.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Science Daily: Pharmacology News
JUNE 5, 2024
A recent study provides new insights into how fathers' diets and overweight can affect their children's health even before conception. The findings of the study can help develop preventive health measures for men wishing to become fathers: The healthier the father's diet, the lower the risk for their children to develop obesity or diseases such as diabetes later in life.
Drug Patent Watch
JUNE 20, 2024
In the high-stakes world of pharmaceuticals, patents play a pivotal role in safeguarding intellectual property and ensuring a return on investment for drug developers. The journey of a drug patent is a complex and intricate one, spanning from the initial filing to its eventual expiry.
Drugs.com
JUNE 24, 2024
MONDAY, June 24, 2024 -- Following state legislation passed in 2021 that essentially banned abortion in Texas, the rate of infant deaths rose by almost 13%, compared to a much smaller 1.8% rise nationwide, a new study finds.The number of Texan.
FDA Law Blog: Biosimilars
JUNE 12, 2024
By Sara W. Koblitz & Jeffrey N. Gibbs — It’s been over a year and a half since Over-the-Counter (“OTC”) hearing aids became legal, and it’s not clear that they’ve made the difference in hearing loss treatment that Congress anticipated. (FDA once estimated that OTC hearing aids would save patients over $3000.) A recent GAO Report hasn’t found that OTC hearing aids have had much impact.
Perficient: Drug Development
JUNE 27, 2024
In 1968, psychiatrist Stephen Karpman modeled what he called the Drama Triangle. With this, he illustrated dysfunctional mindsets that can derail social interactions. The three roles defined in this model are the rescuer (hero), persecutor (villain), and victim. This is another view of the lies we tell ourselves. Since the dawn of history, we’ve loved stories.
BioPharma Drive: Drug Pricing
JUNE 6, 2024
The agency is seeking input from an advisory panel on whether donanemab is effective across different groups of Alzheimer's patients, and on an unusual dosing strategy used by Lilly.
Science Daily: Pharmacology News
JUNE 13, 2024
A lack of sleep can make it extraordinarily difficult to retain information. Two new studies uncover why this is and what is happening inside the brain during sleep and sleep deprivation to help or harm the formation of memories.
Drug Patent Watch
JUNE 19, 2024
In the ever-evolving pharmaceutical landscape, savvy businesses are constantly on the lookout for untapped markets and lucrative opportunities. One area that has garnered significant attention is the realm of low-competition generic drugs.
Drugs.com
JUNE 24, 2024
MONDAY, June 24, 2024 -- Just two injections a year of a new HIV drug protected young women in Africa from infection with the sexually transmitted disease, new trial results show.In announcing the findings, Gilead Sciences Inc. said its HIV.
FDA Law Blog: Biosimilars
JUNE 10, 2024
By Sarah Wicks & Anne K. Walsh — Among FDA-regulated establishments and stakeholders, there is one word that makes everyone go on edge – the dreaded FDA “inspection.” In an effort to clarify for industry and alleviate some of the stress associated with these activities, last week the FDA issued a draft guidance aimed at providing recommendations on how to handle inspections under FDA’s Bioresearch Monitoring (BIMO) program.
Fierce BioTech
JUNE 5, 2024
Drive or take the metro in any direction within Montgomery County, Maryland, and you'll come across a life science company responsible for a major innovation. | Drive or take the metro in any direction within Montgomery County, Maryland, and you'll come across a life science company responsible for a major innovation.
BioPharma Drive: Drug Pricing
JUNE 7, 2024
A vote against MDMA-assisted therapy set back a high-profile treatment. Proponents argue the panel offered few solutions to longstanding problems, making the path forward unclear.
Science Daily: Pharmacology News
JUNE 20, 2024
Adults with a history of low back pain went nearly twice as long without a recurrence of their back pain if they walked regularly, a world-first study has found.
Drug Patent Watch
JUNE 12, 2024
Sure, here’s a more detailed explanation with examples: Drug Patent Duration Drug patents are granted by the United States Patent and Trademark Office (USPTO) for a period of 20 years… Source
Drugs.com
JUNE 25, 2024
TUESDAY, June 25, 2024 -- A well-established cholesterol-lowering drug appears to significantly slow the progression of a diabetes-related eye disease, a new trial shows. Fenofibrate (Tricor) has been approved since 2004 as a means of lowering.
Crown Bioscience
JUNE 6, 2024
In a significant development, the US Food and Drug Administration’s (FDA) Center for Drug Evaluation and Research (CDER) approved 55 new drugs in 2023. This marks the second-highest count in the past 30 years, with the highest being 59 new drug approvals in 2018 and represents an impressive 50% increase in drugs approved in 2022.
Perficient: Drug Development
JUNE 4, 2024
Various deployment methods, including cloud-based (e.g., CloudHub) and on-premises, are available to meet diverse infrastructure needs. GitHub, among other tools, supports versioning and code backup, while CI/CD practices automate integration and deployment processes, enhancing code quality and speeding up software delivery. GitHub Actions, an automation platform by GitHub, streamlines building, testing, and deploying software workflows directly from repositories.
BioPharma Drive: Drug Pricing
JUNE 4, 2024
A group of independent experts wasn't convinced by clinical trial data from company Lykos Therapeutics, which is seeking FDA approval of MDMA-assisted treatment for post-traumatic stress disorder.
Science Daily: Pharmacology News
JUNE 5, 2024
Eating a poor quality diet might lead to brain changes that are associated with depression and anxiety. This is according to a first-of-its-kind study into the brain chemistry and structure, and diet quality of 30 volunteers.
Drug Patent Watch
JUNE 17, 2024
The article “The devil is in the divisional: an analysis of divisional patents, deadlines, declarations and suggestions for future practice” by Mieke Filler provides a comprehensive analysis of the strategic use of divisional patents in the pharmaceutical sector to delay generic and biosimilar market entry.
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