November, 2023

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Neanderthals were the world's first artists, research reveals

Science Daily: Pharmacology News

Recent research has shown that engravings in a cave in La Roche-Cotard (France), which has been sealed for thousands of years, were actually made by Neanderthals. The findings reveal that the Neanderthals were the first humans with an appreciation of art.

Research 359
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What if a CRISPR cure isn’t such an easy choice?

BioPharma Drive: Drug Pricing

A gene editing therapy developed by Vertex Pharmaceuticals and CRISPR Therapeutics can mute sickle cell disease’s most damaging symptoms. Yet treatment may not be as simple as its dramatic benefit makes it seem.

Therapies 326
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New A-Fib Ablation Therapy Benefits Women as Much as Men

Drugs.com

THURSDAY, Nov. 2, 2023 -- A procedure to treat the irregular heart rhythm condition known as atrial fibrillation (a-fib) works just as well for women as it does for men, new research shows. The technology, called pulsed field ablation (PFA), can be.

Therapies 325
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CDD Vault Update (November 2023)

Collaborative Drug

Handling Non-Numeric Values in a Data Import File Often, data files which are being imported into CDD Vault will contain certain text values in columns that are being mapped to numeric fields/readouts. Examples include “ND” for “Not Determined” or “N/A” for “Not Applicable”.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Future floods: Global warming intensifies heavy rain -- even more than expected

Science Daily: Pharmacology News

The intensity and frequency of extreme rainfall increases exponentially with global warming, a new study finds. The analysis shows that state-of-the-art climate models significantly underestimate how much extreme rainfall increases under global warming -- meaning that extreme rainfall could increase quicker than climate models suggest.

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Brittle stars can learn just fine -- even without a brain

Science Daily: Pharmacology News

We humans are fixated on big brains as a proxy for smarts. But headless animals called brittle stars have no brains at all and still manage to learn through experience, new research reveals. These shy marine creatures have no brain to speak of -- just nerve cords running down each of their five wiggly arms. But that seems to be enough to learn by association, researchers report.

Research 339
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From the first bite, our sense of taste helps pace our eating

Science Daily: Pharmacology News

When you eagerly dig into a long-awaited dinner, signals from your stomach to your brain keep you from eating so much you'll regret it -- or so it's been thought.

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Scientists build tiny biological robots from human cells

Science Daily: Pharmacology News

Scientists have created tiny moving biological robots from human tracheal cells that can encourage the growth of neurons across artificial 'wounds' in the lab. Using patients' own cells could permit growth of Anthrobots that assist healing and regeneration in the future with no nead for immune suppression.

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Lost brain function restored in mice after stroke

Science Daily: Pharmacology News

Researchers have succeeded in restoring lost brain function in mouse models of stroke using small molecules that in the future could potentially be developed into a stroke recovery therapy.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Designing cities for 21st-century weather

Science Daily: Pharmacology News

Researchers have investigated how changes in urban land and population will affect future populations' exposures to weather extremes under climate conditions at the end of the 21st century. They used a data-driven model to predict how urban areas across the country will grow by 2100, and found that how a city is laid out or organized spatially has the potential to reduce population exposures to future weather extremes.

Research 324
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Roche’s Genentech partners with Nvidia in AI drug deal

BioPharma Drive: Drug Pricing

The partnership is another investment by the biotech subsidiary in artificial intelligence for drug discovery and development, continuing an industry trend.

Drugs 323
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Low-intensity fires reduce wildfire risk by 60%, according to study by Columbia and Stanford researchers

Science Daily: Pharmacology News

High-intensity, often catastrophic, wildfires have become increasingly frequent across the Western U.S. Researchers quantified the value of managed low-intensity burning to dramatically reduce the risk of such fires for years at a time.

Research 318
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New Antibiotic, Zoliflodacin, Seeking Approval, Tackles Drug-Resistant Gonorrhea in Trial

Drugs.com

FRIDAY, Nov. 3, 2023 -- The first new antibiotic for gonorrhea — the second most common sexually transmitted disease — has shown promise in a clinical trial. That news should come as a relief to public health experts, because gonorrhea.

Trials 317
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Pharma benefited from basing business overseas. An international tax effort could spur a rethink.

BioPharma Drive: Drug Pricing

U.S. tax law changes enacted six years ago slashed large pharma companies' rates and saved them billions. Now, a push for an international floor could disrupt their R&D accounting.

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World’s first CRISPR medicine approved in UK for sickle cell, beta thalassemia

BioPharma Drive: Drug Pricing

Clearance of Vertex Pharmaceuticals and CRISPR Therapeutics' Casgevy in the U.K. comes ahead of expected regulatory decisions in the U.S. and Europe.

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Moderna adjusts to changing outlook for COVID vaccine demand

BioPharma Drive: Drug Pricing

The company recorded a net loss in the third quarter as it “resizes” its manufacturing footprint, and now expects revenue to come in at low end of its previous guidance.

Vaccine 310
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An astronomical waltz reveals a sextuplet of planets

Science Daily: Pharmacology News

Astronomers have found a key new system of six transiting planets orbiting a bright star in a harmonic rhythm. This rare property enabled the team to determine the planetary orbits which initially appeared as an unsolvable riddle.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Sophisticated swarming: Bacteria support each other across generations

Science Daily: Pharmacology News

When bacteria build communities, they cooperate and share nutrients across generations. Researchers have been able to demonstrate this for the first time using a newly developed method. This innovative technique enables the tracking of gene expression during the development of bacterial communities over space and time.

Research 307
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Lilly weight loss drug approved by FDA

BioPharma Drive: Drug Pricing

The pharmaceutical company will sell the GLP-1 drug, branded as Zepbound, at a list price about 20% lower than Novo Nordisk's competing drug Wegovy.

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Migraine? Reach for Prescription Meds, Not Ibuprofen

Drugs.com

THURSDAY, Nov. 30, 2023 -- Migraine sufferers would do better to talk to their doctor about a prescription drug than reaching for a bottle of ibuprofen, a new study finds.Drugs like triptans, ergots and anti-emetics can be two to five times more.

Doctors 299
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Early Promise for Stem Cell Therapy to Curb MS

Drugs.com

TUESDAY, Nov. 28, 2023 -- Stem cells injected into the brains of multiple sclerosis patients appear to protect them against further damage from the degenerative disease, a new study shows.MS occurs when the body’s own immune system attacks and.

Therapies 299
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Many Primary Care Docs Unaware of Biologic Asthma Meds

Drugs.com

TUESDAY, Nov. 21, 2023 -- Biologic drugs to treat asthma have been around for two decades, but a surprising number of family doctors still aren’t prescribing them to kids and adults. A new survey found that more than two in five primary care.

Doctors 299
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FDA investigating cancer risk linked to CAR-T cell therapy

BioPharma Drive: Drug Pricing

The agency said the benefit of approved treatments like Gilead’s Yescarta still outweighs any such risk, but the alert could slow drugmaker efforts to develop the treatments for wider use.

Therapies 297
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Flagship-backed microbiome biotech Evelo to shut down

BioPharma Drive: Drug Pricing

The company said it had not found “a viable alternative” to closing down in the months since it hit a clinical setback and laid off staff.

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AI finds formula on how to predict monster waves

Science Daily: Pharmacology News

Using 700 years' worth of wave data from more than a billion waves, scientists have used artificial intelligence to find a formula for how to predict the occurrence of these maritime monsters. Long considered myth, freakishly large rogue waves are very real and can split apart ships and even damage oil rigs.

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Anthos blood thinner bests Xarelto on safety in mid-stage study

BioPharma Drive: Drug Pricing

Trial results add to evidence that so-called Factor XIa inhibitors could have less bleeding risk than currently available oral anticoagulants like Xarelto.

Trials 296
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Forbion-backed biotech raises $138M to develop ALS drug

BioPharma Drive: Drug Pricing

The Series A round for three-year-old startup VectorY is one of the largest private financings in Europe this year, Forbion said.

Drugs 296
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Novo, Lilly buoyed by fast-growing GLP-1 drug sales

BioPharma Drive: Drug Pricing

The rival companies reported strong quarterly sales growth for their latest products, which could face off as weight loss treatments next year.

Treatment 296
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AstraZeneca creates digital health unit, with big-name partnerships already in place

BioPharma Drive: Drug Pricing

Called Evinova, the unit will operate as a separate business within AstraZeneca, which sees digital health solutions as a market primed for growth.

Marketing 294