February, 2024

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Lessons from Monte Carlo Models: Why Drug Development is Hard

DrugBaron

“There is more than one way to skin a cat” is a rather gruesome British idiom, but its sentiment surely applies to running a successful pharmaceutical portfolio. It is now more than a decade since Francesco De Rubertis, together with Kevin Johnson and Michele Olier, coined the term “asset-centric” investing to describe the approach to portfolio creation that still underpins the strategy at Medicxi.

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The brain is 'programmed' for learning from people we like

Science Daily: Pharmacology News

Our brains are 'programmed' to learn more from people we like -- and less from those we dislike. This has been shown by researchers in cognitive neuroscience in a series of experiments.

Research 141
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50 years after founding, NIDA urges following science to move beyond stigma

National Institute on Drug Abuse: Nora's Blog

50 years after founding, NIDA urges following science to move beyond stigma area Thu, 02/01/2024 - 11:20 Nora's Blog February 1, 2024 Image NIDA Image In 2024, NIDA celebrates its 50th anniversary. On May 14, 1974, an act of Congress established the National Institute on Drug Abuse (NIDA), and since then NIDA has led the world in funding and conducting research on drug use and addiction.

Science 130
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Optimizing OpenFold Training for Drug Discovery

Nvidia Developer: Drug Discovery

Predicting 3D protein structures from amino acid sequences has been an important long-standing question in bioinformatics. In recent years, deep. Predicting 3D protein structures from amino acid sequences has been an important long-standing question in bioinformatics. In recent years, deep learning–based computational methods have been emerging and have shown promising results.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Study finds youth-onset diabetes is a genetically distinct form of the disorder

Broad Institute

Study finds youth-onset diabetes is a genetically distinct form of the disorder By Claire Hendershot February 16, 2024 Breadcrumb Home Study finds youth-onset diabetes is a genetically distinct form of the disorder Researchers suggest diabetes exists in multiple forms on a spectrum of varying genetic factors and symptoms. By Claire Hendershot February 16, 2024 Image by Ricardo Job-Reese, Broad Communications.

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Alnylam change to heart drug trial sparks doubts, sinking shares

BioPharma Drive: Drug Pricing

Analysts pressed Alnylam executives on the reasons for the changes to HELIOS-B, a Phase 3 study in ATTR amyloidosis with cardiomyopathy that is important to the company’s future.

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Scandinavia's first farmers slaughtered the hunter-gatherer population, study finds

Science Daily: Pharmacology News

Following the arrival of the first farmers in Scandinavia 5,900 years ago, the hunter-gatherer population was wiped out within a few generations, according to a new study. The results, which are contrary to prevailing opinion, are based on DNA analysis of skeletons and teeth found in what is now Denmark.

DNA 141
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Seniors, FDA Has 5 Medication Tips to Keep You Safe

Drugs.com

MONDAY, Feb. 19, 2024 -- When settling into your senior years, you need to be especially careful when taking medicines, herbal remedies and supplements, the U.S. Food and Drug Administration says.That’s because older adults are likely to use.

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Accelerating Drug Discovery at Receptor.AI with NVIDIA BioNeMo Cloud APIs

Nvidia Developer: Drug Discovery

The quest for new, effective treatments for diseases that remain stubbornly resistant to current therapies is at the heart of drug discovery. This traditionally. The quest for new, effective treatments for diseases that remain stubbornly resistant to current therapies is at the heart of drug discovery. This traditionally long and expensive process has been radically improved by AI techniques like deep learning, empowered by the rise of accelerated computing.

Drugs 124
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Largest and most diverse genome-wide association study of type 2 diabetes reveals new genetic factors

Broad Institute

Largest and most diverse genome-wide association study of type 2 diabetes reveals new genetic factors By Claire Hendershot February 19, 2024 Breadcrumb Home Largest and most diverse genome-wide association study of type 2 diabetes reveals new genetic factors By studying a diversity of participants, scientists find nearly 150 new locations in the genome linked to type 2 diabetes risk.

DNA 126
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Venture firm Scion Life Sciences launches with $310M to back new biotechs

BioPharma Drive: Drug Pricing

The new firm intends to carefully select its startups and fund them for the long haul. “We're not a company formation factory,” said Aaron Kantoff, the firm’s co-founder.

Science 126
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Joining a clinical trial: Helpful hints for discussions with loved ones

Antidote

Individuals living with an illness are likely well-versed in the art of discussing difficult topics with their family and friends. However, for those who are considering taking part in a clinical trial, there may be extra questions to consider when sharing their intent to enroll.

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What turned Earth into a giant snowball 700m years ago? Scientists now have an answer

Science Daily: Pharmacology News

Inspired during field work in South Australia's Flinders Ranges, geoscientists have proposed that all-time low volcanic carbon dioxide emissions triggered a 57 million year-long global 'Sturtian' ice age.

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Eye Ointments Sold at Walmart, CVS Recalled Due to Infection Risk

Drugs.com

TUESDAY, Feb. 27, 2024 -- Eye ointment products made in India and sold in the United States at Walmart, CVS and other retailers are being recalled due to a danger of infection.Brassica Pharma Pvt. Ltd., of Maharastra, India, said it is recalling.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Zigs & Zags – The Opposite of a Great Idea Can Also be a Great Idea

Perficient: Drug Development

I get a lot of enjoyment from the creative and innovative side of the work I do. Helping clients or my teams break out of the day-to-day and explore the unexpected. I’ve discussed innovation myths before and how to use lateral thinking to expand your pool of ideas in unexpected ways. One of my favorite aspects is seeing how random great ideas can be!

Marketing 116
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Genetic risk prediction for 10 chronic diseases moves closer to the clinic

Broad Institute

Genetic risk prediction for 10 chronic diseases moves closer to the clinic By Corie Lok February 19, 2024 Breadcrumb Home Genetic risk prediction for 10 chronic diseases moves closer to the clinic As part of a nationwide collaboration, Broad Clinical Labs researchers have optimized 10 polygenic scores for use in clinical research as part of a study on how to implement genetic risk prediction for patients.

Disease 124
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Viking data suggest obesity drug could rival Zepbound, Wegovy

BioPharma Drive: Drug Pricing

The biotech’s drug led to significant weight loss in a Phase 2 trial, causing shares to double as analysts compared results to the marks set by drugs from Eli Lilly and Novo Nordisk.

Drugs 122
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How 3D human tissue models are transforming drug discovery

Drug Target Review

What specific limitations in mirroring diseases in humans are commonly observed when using animal models for preclinical research? The standard animal model paradigm for drug discovery does not translate well to effects in patients for a number of reasons. For one, animal models require disease induction, either genetic or surgical modifications, diet, or application of a disease inducing agent or toxin, yet this is nothing like how diseases progress in humans, which typically take years to deve

Drugs 116
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Method identified to double computer processing speeds

Science Daily: Pharmacology News

Scientists introduce what they call 'simultaneous and heterogeneous multithreading' or SHMT. This system doubles computer processing speeds with existing hardware by simultaneously using graphics processing units (GPUs), hardware accelerators for artificial intelligence (AI) and machine learning (ML), or digital signal processing units to process information.

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Oregon Man Struck by Bubonic Plague Likely Got It From Pet Cat

Drugs.com

WEDNESDAY, Feb. 14, 2024 -- An Oregonian who was diagnosed with the bubonic plague -- the disease that killed millions of Europeans in the Middle Ages -- probably got it from an infected pet cat, health officials said. The patient and all close.

Disease 119
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Do You Have An Enterprise Data Strategy?

Perficient: Drug Development

This time of year, I like to talk about updating the data strategy for the new year to include new business goals and new technology and in doing so I sometimes forget that there are still many companies that do not have a data strategy to update. What is a Data Strategy and why do I need one? Most organizations have multiple data management initiatives underway including master data management, data governance, data migration, data modernization, OLTP operational data cleanup, data ingestion, a

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Global survey of gut microbes uncovers 18 new bacterial species and clues to antibiotic resistance

Broad Institute

Global survey of gut microbes uncovers 18 new bacterial species and clues to antibiotic resistance By Leah Eisenstadt February 29, 2024 Breadcrumb Home Global survey of gut microbes uncovers 18 new bacterial species and clues to antibiotic resistance Researchers examined scat from hundreds of animals around the world and pinpointed genes that could fuel drug-resistant infections.

Hospitals 116
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NEJM paper fills in details on ‘remarkable’ CAR-T result in autoimmune disease

BioPharma Drive: Drug Pricing

The full results spotlight cell therapy’s potential to treat lupus and other inflammatory conditions, but also the problems drug developers must solve first.

Disease 124
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Scaling Phage Therapy

Codon

Tom Ireland writes about the companies and technologies that are reimagining phage therapy. Read it on our website here. Illustration by David S. Goodsell, RCSB Protein Data Bank and Scripps Research. doi: 10.2210/rcsb_pdb/goodsell-gallery-048 The Virus that Cures It’s been over 25 years since the science magazine Discover first ran an extraordinary article about how a long-forgotten medical treatment, used in the former Soviet country of Georgia, could save us from the growing threat of u

Therapies 115
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Ice cores provide first documentation of rapid Antarctic ice loss in the past

Science Daily: Pharmacology News

Researchers have uncovered the first direct evidence that the West Antarctic Ice Sheet shrunk suddenly and dramatically at the end of the Last Ice Age, around eight thousand years ago. The evidence, contained within an ice core, shows that in one location the ice sheet thinned by 450 meters -- that's more than the height of the Empire State Building -- in just under 200 years.

Research 139
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Scientists Develop Sensor That Tests Saliva for Breast Cancer

Drugs.com

TUESDAY, Feb. 13, 2024 -- Mammograms are a lifesaving misery for middle-aged women, but a new tool could make getting a breast cancer screening as easy as spitting.Literally.A new hand-held biosensor can detect breast cancer biomarkers from a tiny.

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Perficient’s Thoughts on use of GenAI in Commerce Solutions

Perficient: Drug Development

Revolutionizing B2C Commerce: The Impact of Generative AI In the dynamic landscape of commerce and consumer-driven markets, Business-to-Consumer (B2C) organizations are increasingly turning to generative AI to revolutionize their operations and enhance customer experiences. Generative AI, a subset of artificial intelligence, empowers these organizations to create content, personalize interactions, and optimize various aspects of their business processes.

Marketing 115
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#WhyIScience Q&A: A software engineer develops computational tools for psychiatric and brain research

Broad Institute

#WhyIScience Q&A: A software engineer develops computational tools for psychiatric and brain research By Claire Hendershot February 21, 2024 Breadcrumb Home #WhyIScience Q&A: A software engineer develops computational tools for psychiatric and brain research Khalid Shakir talks about his work analyzing large single-cell datasets, his excitement around AI, and the importance of mentorship and community in science.

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Iovance, with approval of ‘TIL’ cell therapy, readies for complex launch

BioPharma Drive: Drug Pricing

The biotech set a price of roughly $515,000 per patient for its therapy Amtagvi, the first to be approved based on a decades-old technique of using tumor-infiltrating lymphocytes.

Therapies 117
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Finding the Right Fit—Is Your Respirator “The One”?

NIOSH Science Blog: Drugs

Finding the right fit is one of the most important parts of a relationship. You don’t just grab any old fish from the sea that swims by and hope for the best. First, it’s necessary to test the waters and ensure you’re simpatico before settling on a partner. It’s Valentine’s Day, and yes, this advice could apply to your romantic life, but we also love to use today to show our love of respirators and we love to play matchmaker on your behalf as well.

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Study challenges the classical view of the origin of the Antarctic Circumpolar Current and warns of its vulnerability

Science Daily: Pharmacology News

The Circumpolar Current works as a regulator of the planet's climate. Its origins were thought to have caused the formation of the permanent ice in Antarctica about 34 million years ago. Now, a study has cast doubt on this theory, and has changed the understanding of how the ice sheet in Antarctic developed in the past, and what this could mean in the future as the planet's climate changes.

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Weight-Loss Med Zepbound Lowers High Blood Pressure in Obese People

Drugs.com

MONDAY, Feb. 5, 2024 -- The weight-loss drug Zepbound provides more health benefits than dropping pounds and controlling diabetes, a new study shows.It also appears to help people with obesity manage their high blood pressure, results show.Patients.

Drugs 119
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Salesforce: A Growth Mindset for 2024 and Beyond

Perficient: Drug Development

We’re in Our #GrowthEra It’s a new year, and with that, there is always change. One of those changes is that I’m now leading Perficient’s Salesforce business unit as the Managing Director. I’ve had the opportunity to work in the Salesforce ecosystem for 8+ years with top-notch talent. Our team continues to do amazing work for our clients, maximizing the value they’ve invested in the Salesforce platform, bringing innovation to life, and driving business outcomes.