Science Daily: Pharmacology News

NOVEMBER 26, 2024

The cost of reversing the effects of climate change -- restoring melted polar sea ice, for example -- quickly climbs nearly fourfold soon after a tipping point is crossed, according to new work. Much work has been done to explore the environmental costs tied to climate change. But this new study marks the first time researchers have quantified the costs of controlling tipping points before and after they unfold.

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Codon

NOVEMBER 8, 2024

An opinion essay by Liyam Chitayat The cells within our body are the remnants of an ancient alliance. In a 1967 paper called “ On the Origin of Mitosing Cells ,” American evolutionary biologist Lynn Margulis proposed an idea that, upon first hearing, seems ludicrous. Her paper, in fact, was rejected by 12 different journals before it was published.

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Nvidia Developer: Drug Discovery

NOVEMBER 13, 2024

The ability to compare the sequences of multiple related proteins is a foundational task for many life science researchers. This is often done in the form of a. The ability to compare the sequences of multiple related proteins is a foundational task for many life science researchers. This is often done in the form of a multiple sequence alignment (MSA), and the evolutionary information retrieved from these alignments can yield insights into protein structure, function, and evolutionary history.

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BioPharma Drive: Drug Pricing

NOVEMBER 18, 2024

The agency's openness to a targeted pivotal study shows it’s still willing to consider accelerated clearance for Duchenne gene therapies despite questions about their effectiveness.

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Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Practical Cheminformatics

NOVEMBER 16, 2024

Introduction Dataset splitting is one topic that doesn’t get enough attention when discussing machine learning (ML) in drug discovery. The data is typically divided into training and test sets when developing and evaluating an ML model. The model is trained on the training set, and its performance is assessed on the test set. If hyperparameter tuning is required, a validation set is also included.

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Drugs.com

NOVEMBER 18, 2024

MONDAY, Nov. 18, 2024 -- Drugs already taken by millions of diabetes patients appear to also help slash asthma attacks by up to 70%, new British research shows.The two drugs are metformin, one of the most widely used diabetes medications, and the.

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NIOSH Science Blog: Drugs

NOVEMBER 7, 2024

Introduction No Shave November is a great opportunity to grow out your beard for a good cause. But if you rely on a tight-fitting respirator for work, that extra facial hair could pose a safety concern. Respirators protect workers from harmful particles, but their effectiveness depends on forming a tight seal against your skin. So, what does that mean for your growing beard during No Shave November?

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Broad Institute

NOVEMBER 21, 2024

Researchers identify source of a brain cancer’s deadly transformation By Corie Lok November 21, 2024 Breadcrumb Home Researchers identify source of a brain cancer’s deadly transformation Slow-growing glioma tumors become more aggressive when their cells shift identities and acquire new genetic mutations. By Wynne Parry November 21, 2024 Credit: Castro Lab, Michigan Medicine, Ann Arbor Glioma tumor cells seen under a microscope Related news Targeted drug treatment leads tumor cells to imitate vir

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BioPharma Drive: Drug Pricing

NOVEMBER 6, 2024

Pioneers like Alnylam Pharmaceuticals have led the RNA interference field for years. Now, a crop of young biotechs is building on that foundation by taking the drugmaking technology in new directions.

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Antidote

NOVEMBER 20, 2024

Being a caregiver is one of the most selfless and demanding roles you can take on. Whether you're looking after a parent, spouse, child, or loved one, juggling all of the daily responsibilities that come with it can quickly feel overwhelming. With so much focus on taking care of others, it’s easy to put yourself and your needs on the back burner. While your focus is understandably on your loved one, it’s important to remember that your own well-being matters too.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drugs.com

NOVEMBER 20, 2024

WEDNESDAY, Nov. 20, 2024 -- Rates of postpartum depression have more than doubled in little over a decade among American women, a new analysis shows. While about 1 in every 10 new moms (9.4%) suffered postpartum depression in 2010, that number rose.

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Science Daily: Pharmacology News

NOVEMBER 26, 2024

A striking new phenomenon is emerging: distinct regions are seeing repeated heat waves that are so extreme, they fall far beyond what any model of global warming can predict or explain. A new study provides the first worldwide map of such regions, which show up on every continent except Antarctica like giant, angry skin blotches.

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Perficient: Drug Development

NOVEMBER 21, 2024

In this blog, we will explore how to create a custom date range picker in Vue.js that is both functional and visually appealing. We’ll also explore advanced customizations such as custom date formatting, controlling calendar visibility, and managing custom CSS classes. Benefits of Using a Custom Date Range Picker in Vue.js Creating a custom date range picker in Vue.js not only enhances the user interface but also provides users with flexibility in selecting date ranges.

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Broad Institute

NOVEMBER 6, 2024

Study reveals how cancer immunotherapy may cause heart inflammation in some patients By Leah Eisenstadt November 6, 2024 Breadcrumb Home Study reveals how cancer immunotherapy may cause heart inflammation in some patients Myocarditis is driven by a different immune response than the anti-tumor one, suggesting that the serious complication could one day be managed without halting cancer therapy.

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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BioPharma Drive: Drug Pricing

NOVEMBER 21, 2024

Howard Chang will take over as chief scientific officer and senior VP of research as the biotech searches for more ways to overcome the looming loss of exclusivity for some of its top-selling medicines.

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NIOSH Science Blog: Drugs

NOVEMBER 21, 2024

This is the second blog post in our series celebrating Native American Heritage Month. It provides a general description of the American Indian and Alaska Native (AI/AN) workforce using the NIOSH Employed Labor Force (ELF) Query System. Read the first blog post here. AI/AN workers are employed in various occupations and industries. Understanding where many AI/AN people work will help focus efforts to enhance workplace safety and health where AI/AN workers are employed.

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Drugs.com

NOVEMBER 28, 2024

THURSDAY, Nov. 28, 2024 -- Geoffrey Pointing says its hard to describe the distress of an asthma or COPD flare-up.“Honestly, when you're having a flare up, it's very difficult to tell anybody how you feel - you can hardly breathe,” Pointing, 77, of.

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Science Daily: Pharmacology News

NOVEMBER 8, 2024

Scientists believe individuals of the most recently discovered 'hominin' group (the Denisovans) that interbred with modern day humans passed on some of their genes via multiple, distinct interbreeding events that helped shape early human history. Scientists outline evidence suggesting that several Denisovan populations, who likely had an extensive geographical range from Siberia to Southeast Asia and from Oceania to South America, were adapted to distinct environments.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

FDA Law Blog: Biosimilars

NOVEMBER 11, 2024

By Deborah L. Livornese & JP Ellison — On November 8, 2024, FDA issued a proposed order to remove the oral decongestant ingredient phenylephrine (including both phenylephrine hydrochloride and phenylephrine bitartrate) (collectively, PE) from the OTC monograph on the basis of a lack of effectiveness. FDA also noted that it has concluded that no safety signal was identified for oral PE at doses permitted under the monograph.

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Broad Institute

NOVEMBER 6, 2024

Q&A: How a partnership between physicians and researchers aims to make cancer drugs safer By Leah Eisenstadt November 6, 2024 Breadcrumb Home Q&A: How a partnership between physicians and researchers aims to make cancer drugs safer Broad and Mass General researcher Alexandra-Chloé Villani and Mass General oncologist Kerry Reynolds describe their pioneering effort to better understand, diagnose, and manage dangerous complications from cancer immunotherapy.

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BioPharma Drive: Drug Pricing

NOVEMBER 15, 2024

At an event hosted by BioPharma Dive, drugmaker executives and investors discussed the importance of focus, smart spending and maintaining lines of sight to the clinic.

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Perficient: Drug Development

NOVEMBER 19, 2024

This post is the third in a series of four about estimating project hours. Part 1: Sandbagging & Lowballing Part 2: Dependencies & Creep Part 3: Assumptions & Uncertainty Part 4: The Emotional Conclusion The emotional finale is here! Don’t worry, this isn’t about curling up in a ball and crying – we’ve already done that. This final installment of my series on project estimating is all about navigating the emotions of everyone involved and trying to avoid frustration.

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Drugs.com

NOVEMBER 27, 2024

WEDNESDAY, Nov. 27, 2024 -- Already the go-to drug of choice for millions with type 2 diabetes, metformin might also fight lung cancer if those patients have it as well, new research shows.Metformin appears to help boost the benefits of.

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Science Daily: Pharmacology News

NOVEMBER 20, 2024

Researchers have discovered evidence of the oldest alphabetic writing in human history. The writing was etched onto clay cylinders discovered during a dig at an ancient Syrian city.

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KIF1A

NOVEMBER 30, 2024

“She was diagnosed at one month old, via genetic testing, and only given and expectancy of ‘6months to 4yrs, but expect it to be closer to 18months or less’–we were devastated.” A message from Ada’s family in Sidney, Ohio, USA: Ada’s only been with us 9months, but she’s a spunky little girl that brings a smile to the face of everyone she meets.

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FDA Law Blog: Biosimilars

NOVEMBER 6, 2024

By Sara W. Koblitz — The fight between Jazz, Avadel, and FDA over narcolepsy drug sodium oxybate has been a long and arduous one. Starting in 2022 with a patent certification requirement, both Jazz and Avadel have sued FDA over this drug, with Jazz most recently bringing suit challenging FDA’s decision that Avadel’s Lumryz (sodium oxybate) is clinically superior to Jazz’s Xywav (sodium oxybate) in 2023.

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BioPharma Drive: Drug Pricing

NOVEMBER 21, 2024

The startup, Pep2Tango, is combining four methods of accelerating weight loss into one medicine in the hopes of developing a treatment that can improve upon drugs like Wegovy and Zepbound.

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Perficient: Drug Development

NOVEMBER 12, 2024

Healthcare leaders are engaging us in a variety of discussions to explore intelligent automation’s role for complex business challenges, ranging from efforts to enhance consumer trust and use artificial intelligence (AI) in effective ways, to navigating change that comes with prior authorization mandates. This series shares key insights coming from those discussions.

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Drugs.com

NOVEMBER 26, 2024

TUESDAY, Nov. 26, 2024 -- The outgoing Biden administration will propose that pricey GLP-1 obesity medications such as semaglutide (Wegovy), and tirzepatide (Zepbound) be covered by Medicare and Medicaid.However, the move would have to be approved.

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Science Daily: Pharmacology News

NOVEMBER 15, 2024

More time spent sitting, reclining or lying down during the day may increase the risk of cardiovascular disease (CVD) and death, according to a new study. More than roughly 10-and-a-half hours of sedentary behavior per day was significantly linked with future heart failure (HF) and cardiovascular (CV) death, even among people meeting recommended levels of exercise.

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Quanticate

NOVEMBER 21, 2024

An efficacy endpoint in oncology is a characteristic or variable that measures how beneficial a treatment is to a patient’s feeling, function, and survival in a clinical trial. They are essential for assessing whether new cancer therapies are safe and efficacious [1]. Endpoints may serve different purposes, from evaluating survival rates to monitoring tumour size, as well as monitoring patient symptoms.

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KIF1A

NOVEMBER 30, 2024

“We are beyond proud of how resilient Emma is and continues to be. Despite everything working against her, she is the happiest little girl that can brighten up any room with just her smile.” A message from Emma’s family in Calgary, Alberta, Canada: Emma, born in June 2019, was a happy and healthy baby. As she started nearing her 1st birthday we noticed she had fallen behind in her milestones.

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BioPharma Drive: Drug Pricing

NOVEMBER 11, 2024

Negative drug results cost AbbVie billions of dollars in market value and convinced analysts that Bristol Myers had placed a better bet in buying Karuna Therapeutics.

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