Drug Discovery World

MAY 19, 2023

Pancreatic cancer cells can change their ‘diet’ to keep growing, by switching from the sugar glucose to a back-up fuel called uridine, new research has revealed. The findings suggest that blocking the availability of uridine using new drugs could become a new treatment strategy for the most common and aggressive form of pancreatic cancer. The researchers believe uridine could help fuel other cancers too – such as lung, stomach and brain cancer.

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Forbes: Drug Truths

MAY 15, 2023

In the midst of the Covid-19 pandemic, when thousands of people were dying on a daily basis, the hopes of the world rested on the biopharmaceutical industry for rapidly finding vaccines, antibodies and therapeutants.

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Drug Hunter

MAY 31, 2023

This article compiles 20+ recent small molecules of general interest in the news in April 2023, with structures where they are available. Capacity Bio’s MAS Receptor Agonists with $35M Raised for FIH Clinical Trials MAS modulator from WO2022165189 example 107 New start-up Capacity Bio backed by RA Capital, Insight Partners, and Remiges Ventures with $35 million funding is working on taking first-in-class mitophagy agonists into clinical trials, which are expected to start in 2024.

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Drug Patent Watch

MAY 16, 2023

On NPR’s All Things Considered, Sydney Lupkin asked DrugPatentWatch if drug patents could be used to identify injector pens which could then be swapped to fix drug shortages. Referring to… The post NPR and DrugPatentWatch – Can drug injector pens be swapped? appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs 116

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Science Daily: Pharmacology News

MAY 18, 2023

Fifty-three percent of the world's largest freshwater lakes are in decline, storing less water than they did three decades ago, according to a new study. The study analyzed satellite observations dating back decades to measure changes in water levels in nearly 2,000 of the world's biggest lakes and reservoirs. It found that climate change, human consumption and sedimentation are responsible.

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ProRelix Research

MAY 31, 2023

Introduction: Clinical trials are a crucial component of the pharmaceutical and medical research industry, aimed at evaluating the safety and effectiveness of new drugs, treatments, or medical devices before they […] The post Successful Clinical Trial With ProRelix Research: Phase 1, 2, 3 & 4 Clinical Trial Services at … appeared first on ProRelix Research.

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Antidote

MAY 25, 2023

Lupus is a chronic, autoimmune disease that can be extremely difficult to identify and treat. Lupus can occur in anyone , and symptoms can range from mild to life threatening. Consequently, raising awareness and promoting early diagnosis is so important to identify and manage this condition.

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Drug Hunter

MAY 21, 2023

This “journal club” article highlights five recent articles of general interest to drug discovery scientists, including reviews on therapeutic areas of interest, principles and areas of medicinal chemistry and pharmacology, and a synthetic transformation worth keeping in mind. 1. A “Magic Chloro” Med. Chem. Review D. Chiodi and Y. Ishihara (Vividion) J.

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Trials Drugs 144

Drug Patent Watch

MAY 22, 2023

Introducing DrugChatter.com: Empowering Access to Biopharmaceutical Drug Insights through AI Chat We are pleased to introduce DrugChatter.com, a groundbreaking platform that redefines the way professionals obtain concise, cited information on… The post DrugChatter.com: AI Chat for Biopharmaceutical Drug Insights appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs 105

Science Daily: Pharmacology News

MAY 31, 2023

Even without nerves, plants can sense when something touches them and when it lets go, a study has found. In a set of experiments, individual plant cells responded to the touch of a very fine glass rod by sending slow waves of calcium signals to other plant cells, and when that pressure was released, they sent much more rapid waves. While scientists have known that plants can respond to touch, this study shows that plant cells send different signals when touch is initiated and ended.

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drug Channels

MAY 24, 2023

In The Top Pharmacy Benefit Managers of 2022: Market Share and Trends for the Biggest Companies , I shared Drug Channels Institute's analysis showing that three pharmacy benefit managers (PBMs)—the Caremark business of CVS Health, the Express Scripts business of Cigna, and the OptumRx business of UnitedHealth Group—accounted for about 80% of total equivalent prescription claims in 2022.

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Drug Discovery World

MAY 31, 2023

Immuno-oncology company Aulos Bioscience has revealed interim results from an ongoing Phase I/II trial of monoclonal antibody AU-007 in solid tumours. The data indicate that AU-007 is well tolerated in patients with unresectable locally advanced or metastatic cancer and there are early signs of anti-tumour activity. AU-007 is a human IgG1 monoclonal antibody designed using artificial intelligence to harness the power of interleukin-2 (IL-2) to eradicate solid tumours.

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Pharmacokinetics Trials Clinical Trials Treatment 130

KIF1A

MAY 24, 2023

What do worms, a classroom full of students, and members of the KAND family community have in common? A lot more than you’d think! In this blog post, KIF1A.ORG Chief Science Officer Dr. Dominique Lessard describes a unique cross disciplinary experience with multiple scientific stakeholders in the rare disease space, all focused around our holistic understanding of KAND.

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Drug Hunter

MAY 22, 2023

We couldn’t include everything in Molecules of the Month, but here’s a round-up of up of 16 additional molecules of potential interest that we didn’t have space for in April, including a highly selective caspase inhibitor from a non-catalytic cysteine, a GPR40 AgoPAM from BMS with activity on GLP-1, a few examples of both on- and off-target toxicities, and several clinical candidates. 1.

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Drugs Trials Disease 133

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Antidote

MAY 22, 2023

Participating in a clinical trial can be a worthwhile opportunity for any individual. Whether taking part as a healthy volunteer or enrolling in a study for a specific condition, being a medical research participant can provide the chance to be more involved in medical treatments, gain access to potential new therapies, and pave the way for medical breakthroughs to take place.

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Drug Policy Alliance

MAY 19, 2023

St. Paul, MN – May 18, 2023 – Today, Governor Tim Walz signed Senate File 2909, the House Omnibus Judiciary and Public Safety Finance bill. In addition to expanding access to harm reduction services, including drug checking services, this bill will make giving away and possessing all drug paraphernalia, as well as any contained residue, legal.

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Drugs 98

Drug Channels

MAY 23, 2023

In 2022, the PBM market remained highly consolidated—although there were some intriguing share shifts among the largest players. Below, you’ll find Drug Channels Institute's latest estimates of pharmacy benefit manager (PBM) market share based on equivalent prescription claims. I also provide commentary on recent market developments and offer some helpful tips for interpreting the figures.

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Drug Discovery World

MAY 31, 2023

This is the latest episode of the free DDW narrated podcast, “ Innovating now to reinvent the future of drug discovery”. It covers three articles written for Volume 23, Issue 2 – Spring 2022 of DDW. They are called “ Predictive biomarkers in the age of spatial biology ”, “ Exploiting the microbiome to drive nature – inspired innovation ”, and “ Animal research: reinventing the norm ”.

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Drugs Clinical Development Research Animal Testing 130

KIF1A

MAY 20, 2023

#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dominique Lessard and Dr. Dylan Verden of KIF1A.ORG summarize newly published KIF1A-related research and highlight progress in rare disease research and therapeutic development. KIF1A-Related Research Optogenetic control of kinesins and dynein reveals their specific roles in vesicular transport KIF1A is only one of over 40 kinesin motor proteins in mammals, so why do KI

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Drug Hunter

MAY 21, 2023

This article highlights six recent articles of interest in the field of targeted protein degradation including but not limited to potentially new ligases, recruiting motifs, and a discussion on the feasibility of CNS-penetrant degraders. 1. “Reinstating targeted protein degradation with DCAF1 PROTACs in CRBN PROTAC resistant settings” Novartis, Basel, CH + Cambridge, MA BioRxiv , April 14, 2023 This Novartis study identified a novel non-covalent ligand for the E3 ligase receptor DCAF1 for use in

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Antidote

MAY 18, 2023

Clinical Trials Day takes place on May 20 each year, and is a day to celebrate the thousands of medical research volunteers who participate in trials for a wide range of conditions. It's also a day to raise awareness of the fact that even more volunteers are needed to push medical research forward.

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Drug Policy Alliance

MAY 24, 2023

Minnesota Becomes 2nd State to Officially Support Overdose Prevention Centers msutton Wed, 2023-05-24 17:54 Wed, 05/24/2023 - 17:54

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Drug Patent Watch

MAY 13, 2023

Annual Drug Patent Expirations for BANZEL Banzel is a drug marketed by Eisai Inc and is included in two NDAs. It is available from one supplier. There is one patent… The post New patent expiration for Eisai Inc drug BANZEL appeared first on DrugPatentWatch - Make Better Decisions.

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Drug Discovery World

MAY 31, 2023

This is the latest episode of the free DDW narrated podcast, “ Innovating now to reinvent the future of drug discovery”. It covers three articles written for Volume 23, Issue 2 – Spring 2022 of DDW. They are called “ Predictive biomarkers in the age of spatial biology ”, “ Exploiting the microbiome to drive nature – inspired innovation ”, and “ Animal research: reinventing the norm ”.

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Drugs Clinical Development Research 130

Drug Channels

MAY 10, 2023

Yesterday’s reflections on Asembia’s Specialty Pharmacy Summit included a link to the general session slides. My portion of the deck included an updated mapping of vertical integration among insurers, PBMs, specialty pharmacies, and providers within U.S. drug channels. Many readers asked for a standalone version of this infamous chart. So, for your viewing and slide making pleasure, below you’ll find my latest illustration of the major vertical business relationships among the largest companies.

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Drug Hunter

MAY 18, 2023

Dian Su’s journey from chemistry and proteomics to the DMPK of drug conjugates Following a different path comes naturally to Dian Su, Senior Director of DMPK at Bicycle Therapeutics. From a childhood in a small village in China’s northeast Shandong province to her work examining the drug metabolism and pharmacokinetics (DMPK) of antibody-drug conjugates (ADCs) and Bicycle toxin conjugates ® (BTCs), Dian has always looked to forge something new.

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Antidote

MAY 10, 2023

One of the questions most frequently asked by patients is, “Do I have to pay to participate in a clinical trial?” While patients typically will not incur expenses for taking part in a research study, in some instances, they may be responsible for copays and payments towards their deductible depending on their insurance plan.

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FDA Law Blog: Biosimilars

MAY 8, 2023

By Lisa M. Baumhardt, Senior Medical Device Regulation Expert & Philip Won & Gail H. Javitt — FDA recently published a long-awaited draft guidance aimed at reducing the need for prior FDA authorization of modifications to artificial intelligence/machine learning (AI/ML)-enabled device software functions (ML-DSFs). The draft guidance, “Marketing Submission Recommendations for a Predetermined Change Control Plan for Artificial Intelligence/Machine Learning (AI/ML)-Enabled Device Software

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Drug Patent Watch

MAY 15, 2023

Annual Drug Patent Expirations for EXFORGE+HCT Exforge Hct is a drug marketed by Novartis and is included in one NDA. It is available from one supplier. There are two patents… The post New patent expiration for Novartis drug EXFORGE HCT appeared first on DrugPatentWatch - Make Better Decisions.

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Drug Discovery World

MAY 31, 2023

Discover the groundbreaking findings from a study on bispecific T-cell engagers conducted by The Jackson Laboratory. This case study delves into the tools available for assessing cytokine release and tumour growth inhibition. Explore the implications of donor-specific responses and how this knowledge can optimise the development of immunomodulatory therapeutics.

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Drug Channels

MAY 16, 2023

Last August , I warned you about alternative funding programs (AFPs) –the shady schemes by which commercial plan sponsors drop drug coverage in order to grab charity support intended for uninsured and indigent patients. I’m sad to report that the manipulation of charitable patient assistance programs continues to expand. As you will see below, employers have significantly ramped up their adoption of AFPs, while health plans seem more skeptical.

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ProRelix Research

MAY 15, 2023

Clinical Research Organizations (CROs) are companies that provide support to the pharmaceutical and biotech industries by managing various aspects of the drug development process and conducting clinical trials. In this […] The post Clinical Research Organizations: Importance, Services, Selection Process and Future. appeared first on ProRelix Research.

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Antidote

MAY 3, 2023

Every May is dedicated to Skin Cancer Awareness Month — a national observance designed to raise awareness around skin cancer and encourage people to practice smart prevention tactics as spring transitions into summer. Though skin cancer is the most common type of cancer , forming good sun safety habits can have a direct link to a reduction in its prevalence.

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Science Daily: Pharmacology News

MAY 25, 2023

There is a massive, mineral-rich region in the Pacific Ocean -- about twice the size of India -- called the Clarion-Clipperton Zone (CCZ), which has already been divided up and assigned to companies for future deep-sea mining. To better understand what may be at risk once companies start mining, a team of biologists has built the first 'CCZ checklist' by compiling all the species records from previous research expeditions to the region.

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