September, 2023

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To Really Impact Healthcare Costs Look Beyond Drug Prices

Forbes: Drug Truths

At a time when the opportunities for discovering and developing new medicines is the greatest in our history, we will be doing less. What we really should be doing is investing more in order to generate new medicines thus reducing downstream healthcare costs.

Drugs 264
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GDC-6599

Drug Hunter

A First-in-Class TRPA1 Antagonist Overcomes Toxicity Hurdles to Become Cough Candidate Genentech’s GDC-6599 is the first oral TRP Ankyrin 1 (TRPA1) antagonist to reach Ph. IIa ( NCT05660850 ) for chronic cough after preclinical studies and a Ph. I trial showed it was well-tolerated, in contrast to prior molecules. The transient receptor potential (TRP) family of ion channels has been the subject of intensive drug discovery efforts due to their critical role in the development and progression of

Trials 315
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Early Career Researcher Toolbox: Free Online Molecular Biology Tools

addgene Blog

Primer design. Plasmid mapping. DNA sequence analysis. We all have our favorite tools for tackling these particular tasks, but they tend to be scattered about the internet. To help you keep your virtual molecular biology toolbox organized, today’s post features a list of free online molecular biology tools all in one place.

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Scientists reveal cellular changes unique to early Alzheimer’s disease

Broad Institute

Scientists reveal cellular changes unique to early Alzheimer’s disease By Allessandra DiCorato September 28, 2023 Breadcrumb Home Scientists reveal cellular changes unique to early Alzheimer’s disease A study of brain tissue from living adults provides a rare look into the earliest stages of the neurodegenerative disease and highlights cell types involved in plaque production.

Disease 144
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Counterfeit Pills Fuel Rising Number of Fatal Drug Overdoses

Drugs.com

FRIDAY, Sept. 1, 2023 -- A growing number of overdose deaths in the United States involve counterfeit pills, health officials reported Thursday. Overdose deaths involving counterfeit pills were twice as common in the latter half of 2021 as they were.

Drugs 135
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Clinical trial phases: What’s the difference?

Antidote

Clinical trials are how researchers advance their knowledge about potential new treatments, including medications, medical devices, and lifestyle interventions. Clinical trials are divided into phases , each with a distinct duration, purpose, and number of volunteers needed. Before any new treatment becomes available on the market, it must go through this process, as required by the FDA.

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New RSV vaccines can be powerful tools, but rollout poses test

BioPharma Drive: Drug Pricing

Public health officials, as well as drugmakers, are trying to raise awareness of RSV among older adults at risk, and convince them to get an additional respiratory shot alongside those for COVID and flu.

Vaccine 128
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New optogenetic tools for cytoskeleton and membrane control

addgene Blog

Optogenetics gives you the power to control cells or organisms with the flip of a switch. You may be familiar with popular light-sensitive ion channels used to control activities like neuronal signaling — think of a mouse with an LED brain implant or a worm wiggling back and forth under blue light — but there’s a lot more to optogenetics than neuronal activity.

Research 126
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New research alliance with Novo Nordisk to identify therapeutic targets for type 2 diabetes and cardiometabolic diseases

Broad Institute

New research alliance with Novo Nordisk to identify therapeutic targets for type 2 diabetes and cardiometabolic diseases By Allessandra DiCorato September 6, 2023 Breadcrumb Home New research alliance with Novo Nordisk to identify therapeutic targets for type 2 diabetes and cardiometabolic diseases The collaboration aims to identify disease-modifying interventions, with the goal of improving standards of care for people living with type 2 diabetes and cardiac fibrosis By Broad Communications Sep

Disease 136
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FDA Adds Warning to Ozempic Label About Risk for Blocked Intestines

Drugs.com

WEDNESDAY, Sept. 27, 2023 -- Ozempic, a type 2 diabetes drug that has increasingly been used to help with weight loss, will now be labeled as having the potential to block intestines. The U.S. Food and Drug Administration recently made the label.

FDA 124
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Groundwater depletion rates in India could triple in coming decades as climate warms, study shows

Science Daily: Pharmacology News

A new study finds that farmers in India have adapted to warming temperatures by intensifying the withdrawal of groundwater used for irrigation. If the trend continues, the rate of groundwater loss could triple by 2080, further threatening India's food and water security. Reduced water availability in India due to groundwater depletion and climate change could threaten the livelihoods of more than one-third of the country's 1.4 billion residents and has global implications.

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9 common misconceptions about clinical trial participation

Antidote

Connecting patients with clinical research opportunities is our mission here at Antidote, but often, we find that misconceptions can serve as barriers to achieving this goal. It’s important to carefully weigh the pros and cons of participating in a clinical trial but to do this effectively, it’s critical to have accurate information.

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Startup AIRNA emerges from stealth to bring RNA editing to a rare disease

BioPharma Drive: Drug Pricing

AIRNA is one of several biotechs to debut plans for target alpha-1 antitrypsin deficiency in recent years, with competitors such as AlveoGene, Wave Life Sciences and Arrowhead Pharmaceuticals.

RNA 122
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Family Farms: When Working From Home Can Put Children at Risk

NIOSH Science Blog: Drugs

Agriculture ranks among the most hazardous industries for workers,[1] but since many farms share work and home spaces, it is also one of the few industries in which family members are also at risk for fatal and nonfatal injuries. Every day, 33 children in the United States are seriously injured in agricultural-related incidents, and every three days a child dies on a farm.[2] However, over 60% of children impacted by a farm incident were not working when the injury occurred.[3] Adult supervision

Research 118
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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New machine learning techniques boost predictions for virtual drug screening with less data

Broad Institute

New machine learning techniques boost predictions for virtual drug screening with less data By Corie Lok September 10, 2023 Breadcrumb Home New machine learning techniques boost predictions for virtual drug screening with less data Schmidt Center researchers have found a way to improve kernel methods, which are a simpler alternative to neural networks, for biomedical applications.

Drugs 130
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Many Americans Frustrated in Search for Low-Cost COVID Boosters

Drugs.com

FRIDAY, Sept. 22, 2023 -- Americans seeking out the new COVID boosters are finding themselves held back by insurance entanglements and supply delays. Some insurers have balked at covering the vaccines, with people arriving at shot appointments only.

Vaccine 122
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Women in Stem with Dr Emily Leproust

Drug Target Review

Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? I started my journey in chemistry – first as an undergraduate and then in my PhD programme at the University of Houston, where I focused on organic chemistry and nucleic acids chemistry. After that, I spent over a decade at a large instrument and genomics company working in, and then leading, research and development.

DNA 116
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A World Alzheimer's Month resource roundup

Antidote

Alzheimer’s disease, the most prevalent type of dementia , is diagnosed in more than 6 million Americans. Estimates project that by 2050, 13 million individuals will be diagnosed with Alzheimer’s disease. This condition ranks among the top 10 causes of death in the United States, profoundly impacting those diagnosed, their loved ones, and their caregivers.

Disease 119
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Daiichi Sankyo, with new data, to seek FDA approval of lung cancer drug

BioPharma Drive: Drug Pricing

The HER3-targeting treatment could become the next antibody-drug conjugate to emerge from Daiichi Sankyo’s laboratories, after the AstraZeneca-partnered Enhertu.

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Data – The Lifeblood of Intelligence Automation

Perficient: Drug Development

With all the hype around artificial intelligence (AI), AI can feel complicated, distant, or foreign. But guess what? It’s not new news and it doesn’t need to be complicated; it’s just a revolution of how we leverage data! Let’s take a quick dive into the data-driven universe of AI (i.e., intelligence automation). This article breaks down how data powers intelligence automation.

Marketing 115
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Improving the Drug Development Process with Organ-Chips

Fierce BioTech

To predict whether new therapeutics will be safe and effective for humans, drug developers first test them in animal- and cell-based models as well as computational tools that are designed to appro | An introduction to Organ-on-a-Chip technology and how it can improve the quality of drugs entering the clinic.

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Just 23% of U.S. Adults 'Definitely' Plan to Get New COVID Shot

Drugs.com

WEDNESDAY, Sept. 27, 2023 -- Just 23% of American adults say they 'definitely' will get the new COVID-19 vaccine, while another 23% say they will 'probably' get it, according to a new poll, which also finds interest in the shot falls along partisan.

Vaccine 119
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How organoids can redefine pre-clinical research

Drug Target Review

Organoid technologies are becoming an invaluable solution for preclinical research, with the ability to augment the development of personalised medicine, drug discovery and gene therapies. These 3D cultured structures that are derived from healthy individuals or patients’ cells, such as human pluripotent stem cells (hPSCs) 1 or adult stem cells (ADSCs) 2 are changing the paradigm of scientific understanding.

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Talk of the Towne episode 08: ZERO Prostate Cancer

Antidote

Antidote’s podcast, Talk of the Towne , hosted by Antidote’s Senior Clinical Informatics Manager, Dr. Richard Towne, is an interview series featuring members of Antidote's partner network. During each episode, Rich and his guests take a closer look at particular therapeutic areas, the latest research developments, and specific pain points that impact the patient population.

Research 116
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Biogen, continuing executive revamp, finds a new research head

BioPharma Drive: Drug Pricing

Jane Grogan, an industry veteran who worked at Genentech for over 15 years, will take over the role starting Oct. 2. She’ll fill a seat that's lacked a permanent replacement since the departure of Al Sandrock.

Research 119
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New Pesticides and Applied Testing: Advancing Sustainable Agriculture

biobide

Pesticides are a vital tool in safeguarding the world’s food supply. The need to protect crops from pests, disease, and weeds has existed for centuries, with the Roman’s having used ash, crushed cypress leaves and diluted urine to protect their crops. Nowadays, pest control methods and the chemicals used are a great deal more sophisticated. It is estimated that without crop protection, which includes the use of pesticides, half of the world’s food crops would be lost.

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#ScienceSaturday: September 30, 2023

KIF1A

#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. KIF1A-Related Research In the rare disease space, a common and straightforward question is: How rare is the disease?

Disease 111
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Scientists Spot Gene Mutation Linked to Esophageal Cancer

Drugs.com

FRIDAY, Sept. 22, 2023 -- Researchers have found a gene mutation linked to esophageal cancer, which could lead to better prevention and treatment strategies. Investigators from Case Western Reserve University in Ohio found the mutation, potentially.

Treatment 119
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Bioengineered instrument reveals hidden cancer cells

Drug Target Review

Cancer cells can elude the body’s immune defences by manipulating a group of molecules known as mucins, which are typically helpful and widespread. Mucins are proteins covered in sugar that primarily protect the body against physical harm and pathogens. However, cancer cells exploit mucins to support their survival. While the concept of removing mucins from cancer cells seems promising, mucins are present in various forms on all mammalian cells.

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A Novel Pancreatic Cancer Early Diagnostic Technology

Crown Bioscience

The incidence of pancreatic cancer has been rising by about 1% per year over the past few decades, and it now accounts for ~3% of all cancers and 7% of cancer mortality in the U.S. Pancreatic cancer is now the third leading cause of cancer-related death, and it is exceptionally lethal in part because it is challenging to detect at an early stage. By the time signs and symptoms appear, the disease has often already reached an advanced stage and metastasized.

Disease 111
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FDA approves updated COVID boosters from Pfizer, Moderna

BioPharma Drive: Drug Pricing

Pfizer and Moderna, which have seen slowing demand for their coronavirus vaccines, expect to make the reformulated shots available in the U.S. in the coming days.

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Novel Tank Diving Test with Zebrafish

biobide

Zebrafish ( Danio rerio ) has been used as a New Alternative Model (NAM) for the last 40 years. This organism conserves approximately 70% of gene homology with humans, in addition to having the benefit of possessing fast development, high fecundity, feasible maintenance, and ease of manipulation. This NAM complies with the 3Rs principle (Replacement, Reduction and Refinement), since it is possible to perform multiple assays on embryos.

Drugs 112
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#ScienceSaturday: September 23, 2023

KIF1A

#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. KIF1A-Related Research RAB3 phosphorylation by pathogenic LRRK2 impairs trafficking of synaptic vesicle precursors During the COVID-19 epidemic many of us experienced how devastating shipping disruptions were; industri