Broad Institute

OCTOBER 29, 2024

New drug triggers rapid cell death in cancer models By Karen Zusi-Tran October 29, 2024 Breadcrumb Home New drug triggers rapid cell death in cancer models BRD-810 inhibits the MCL1 protein and reactivates apoptosis in tumor cells, displaying therapeutic potential in animal models. By Karen Zusi-Tran October 29, 2024 Credit: National Cancer Institute Human cells with acute myelocytic leukemia (AML) in the pericardial fluid.

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BioPharma Drive: Drug Pricing

OCTOBER 16, 2024

The results provide the first clinical evidence of RNA editing, a burgeoning field that's drawn interest from biotechs and pharmaceutical companies alike.

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Science Daily: Pharmacology News

OCTOBER 22, 2024

Polar bears in some parts of the high Arctic are developing ice buildup and related injuries to their feet. The changes appear to be an unexpected consequence of climate change, related to changing conditions in a warming Arctic.

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Nvidia Developer: Drug Discovery

OCTOBER 2, 2024

A groundbreaking drug-repurposing AI model could bring new hope to doctors and patients trying to treat diseases with limited or no existing treatment options. A groundbreaking drug-repurposing AI model could bring new hope to doctors and patients trying to treat diseases with limited or no existing treatment options. Called TxGNN, this zero-shot tool helps doctors find new uses for existing drugs for conditions that might otherwise go untreated.

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Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Practical Cheminformatics

OCTOBER 8, 2024

“Pay no attention to the man behind the curtain” - The Wizard of Oz Introduction Recently, a few groups have proposed general-purpose large language models (LLMs) like ChatGPT , Claude , and Gemini as tools for generating molecules. This idea is appealing because it doesn't require specialized software or domain-specific model training. One can provide the LLM with a relatively simple prompt like the one below, and it will respond with a list of SMILES strings.

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Drug Target Review

OCTOBER 30, 2024

Imagine being able to create an in vitro replica of a diseased organ to study the molecular mechanism underlying the illness. Now take a step further: envision testing drugs in these organoids to identify the ones that can treat disease safely and effectively without needing to run expensive clinical trials first. Further still, think about implanting these mini organs into the patient to restore lost function.

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BioPharma Drive: Drug Pricing

OCTOBER 22, 2024

Early study data from Wave Life Sciences suggests how editing RNA may yield viable medicines. Large and small drugmakers say such results are just the start.

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RNA Science 141

Science Daily: Pharmacology News

OCTOBER 17, 2024

A major new study reveals that carbon dioxide emissions from forest fires have surged by 60 percent globally since 2001, and almost tripled in some of the most climate-sensitive northern boreal forests.

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Nvidia Developer: Drug Discovery

OCTOBER 30, 2024

The integration of AI in drug discovery is revolutionizing the way researchers approach the development of new treatments for various diseases. Traditional. The integration of AI in drug discovery is revolutionizing the way researchers approach the development of new treatments for various diseases. Traditional methods are often time-consuming and costly, with the process of bringing a new drug to market taking up to 15 years and costing between $1–2B.

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Drugs.com

OCTOBER 25, 2024

FRIDAY, Oct. 25, 2024 -- Some Americans should get more than one shot of the updated COVID vaccines because their age or certain health conditions make them more vulnerable to severe infections, U.S. health officials advised this week.Six months.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Patent Watch

OCTOBER 8, 2024

A recent study published in Drug Discovery Today highlights the potential of artificial intelligence (AI) in revolutionizing drug discovery and development processes[1]. The research, conducted by a team from the University of Cambridge and AstraZeneca, explores how AI can be leveraged to enhance various aspects of pharmaceutical research, from target identification to clinical trials.

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Broad Institute

OCTOBER 30, 2024

Researchers map communities of single cells in metastatic breast cancers By Corie Lok October 30, 2024 Breadcrumb Home Researchers map communities of single cells in metastatic breast cancers The team compared different single-cell and spatial profiling methods to explore the diversity of cells in metastatic breast cancer biopsies. By Sarah C.P. Williams October 30, 2024 Credit: Cecil Fox, National Cancer Institute, National Institutes of Health Human breast cancer tissue with cancer cells (purp

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BioPharma Drive: Drug Pricing

OCTOBER 4, 2024

An experimental Alzheimer’s therapy from Cassava Sciences is still being tested in two Phase 3 studies, even as the company has come under regulatory scrutiny.

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Science Daily: Pharmacology News

OCTOBER 10, 2024

Researchers developed a rating system to evaluate the plausibility of climate model simulations in the IPCC's latest report, and show that models that lead to potentially catastrophic warming are to be taken seriously.

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Research 143

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Nvidia Developer: Drug Discovery

OCTOBER 23, 2024

Pharmaceutical research demands fast, efficient simulations to predict how molecules interact, speeding up drug discovery. Jiqun Tu, a senior developer. Pharmaceutical research demands fast, efficient simulations to predict how molecules interact, speeding up drug discovery. Jiqun Tu, a senior developer technology engineer at NVIDIA, and Ellery Russell, tech lead for the Desmond engine at Schrödinger, explore advanced GPU optimization techniques designed to accelerate molecular dynamics simulati

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The ChEMBL-og

OCTOBER 23, 2024

In the quest to develop new drugs, understanding the 3D structure of molecules is crucial. Resources like the Protein Data Bank in Europe (PDBe) and the Cambridge Structural Database (CSD) provide these 3D blueprints for many biological molecules. However, researchers also need to know how these molecules interact with their biological target – their bioactivity.

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Small Molecule Drugs Research Science 117

Drug Patent Watch

OCTOBER 9, 2024

The pharmaceutical industry plays a crucial role in global healthcare, providing essential medications that improve and save lives. Within this industry, generic pharmaceuticals are particularly important due to their affordability and accessibility.

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Pharmaceuticals Drugs 121

Broad Institute

OCTOBER 3, 2024

Largest-ever genetic study of epilepsy finds possible therapeutic targets By Ari Navetta October 3, 2024 Breadcrumb Home Largest-ever genetic study of epilepsy finds possible therapeutic targets Scientists have uncovered new genetic links to different types of epilepsy, which could lead to more tailored treatments. By Ari Navetta October 3, 2024 Credit: Ricardo Job-Reese, Broad Communications Related people Benjamin Neale Related programs Stanley Center for Psychiatric Research Related news DNA

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

BioPharma Drive: Drug Pricing

OCTOBER 17, 2024

Vyalev’s clearance is the second victory for AbbVie in Parkinson’s this year, following an April readout for a drug acquired through its Cerevel buyout.

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Drugs 136

Science Daily: Pharmacology News

OCTOBER 23, 2024

Researchers have used artificial intelligence to design thousands of new DNA switches that can precisely control the expression of a gene in different cell types. Their new approach opens the possibility of controlling when and where genes are expressed in the body, for the benefit of human health and medical research, in ways never before possible.

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Drugs.com

OCTOBER 28, 2024

MONDAY, Oct. 28, 2024 -- More than 20% of people in the continental United States might have drinking water contaminated with “forever chemicals,” a new study suggests.Between 75 and 95 million Americans rely on groundwater that contains det.

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addgene Blog

OCTOBER 3, 2024

If the fall colors are inspiring you to paint your cells in equally vivid colors, you'll want to check out the 34 new preps available in the Addgene viral vector repository! This includes the first Addgene prep packaged in the AAV9-X1.1 serotype.

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Packaging 118

Drug Patent Watch

OCTOBER 16, 2024

Biosimilars, which are biologic drugs that are highly similar to an already approved biologic drug, are transforming the pharmaceutical industry. As patents for original biologic drugs expire, biosimilars are becoming increasingly important, offering more affordable treatment options for patients and healthcare systems.

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Broad Institute

OCTOBER 23, 2024

To help his daughter living with an ultra-rare disorder, this dad brought together a squad of genetic detectives By Leah Eisenstadt October 23, 2024 Breadcrumb Home To help his daughter living with an ultra-rare disorder, this dad brought together a squad of genetic detectives The Broadbent family worked closely with scientists to discover the unique genetic cause of their daughter’s disease, highlighting the need to examine noncoding parts of the genome when diagnosing rare genetic disorders.

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BioPharma Drive: Drug Pricing

OCTOBER 31, 2024

In an investor presentation, executives hinted at the possibility of seeking an accelerated approval of trontinemab if it can significantly lower levels of amyloid in a Phase 3 trial.

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Trials Drugs 124

Science Daily: Pharmacology News

OCTOBER 3, 2024

Comamonadacae is a family of bacteria often found growing on plastics in water. New study finds a bacterium in this family can break down the plastic for food. Researchers also identified the enzyme the bacterium use to degrade plastic. The discovery opens new possibilities for developing bacteria-based engineering solutions to help clean up difficult-to-remove plastic waste.

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Engineering Research 143

Drugs.com

OCTOBER 25, 2024

FRIDAY, Oct. 25, 2024 -- As the popularity of GLP-1 meds like Wegovy and Zepbound grows, fewer Americans are turning to weight-loss surgeries to trim their waistlines, a new report finds.Prescriptions of this GLP-1 class of diabetes and weight-loss.

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Policy Prescription

OCTOBER 22, 2024

Harvard doctors and public health experts recommend using the website PharmacyChecker.com to find international online pharmacies to order more affordable prescription drugs for personal importation when domestic savings strategies fail. They offer this advice in a new article in the Journal of the American Medical Association. Article Review The article, Strategies to Help Patients Navigate High Prescription Drug Costs , offers very digestible and evidence-driven guidance for clinicians to bet

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Drug Patent Watch

OCTOBER 17, 2024

Regulatory Considerations for Biosimilar Analytical Similarity Assessments Biosimilars, or follow-on biologics, are biopharmaceuticals that are highly similar to an already approved biological product.

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Broad Institute

OCTOBER 28, 2024

New machine learning-based single-cell search engine makes cell annotation faster, more efficient By Corie Lok October 28, 2024 Breadcrumb Home New machine learning-based single-cell search engine makes cell annotation faster, more efficient In a Q&A, machine learning expert Mehrtash Babadi introduces Cell Annotation Service, a search engine for single-cell data that he and his group have developed for biologists.

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BioPharma Drive: Drug Pricing

OCTOBER 7, 2024

The Cambridge, Massachusetts-based biotech is using what it calls ligand-siRNA conjugates to reach drug targets in the kidney, which historically have been difficult to reach with RNA therapies.

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RNA Therapies Drugs 127

Science Daily: Pharmacology News

OCTOBER 30, 2024

A new study unveils a surprising discovery: a substantial amount of meltwater is temporarily stored within the Greenland Ice Sheet during summer months. For the first time, an international group of researchers was able to quantify meltwater with positioning data. The finding challenges current models of how ice sheets contribute to global sea level rise.

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International Research 138

Drugs.com

OCTOBER 22, 2024

TUESDAY, Oct. 22, 2024 -- Expanded access to addiction treatment and the overdose-reversal med naloxone likely prompted a 37% reduction in OD deaths linked to opioids taken with meth or other stimulant drugs, a new study suggests.OD death rates.

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