October, 2024

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AI Uses Zero-Shot Learning to Find Existing Drugs for Treating Rare Diseases

Nvidia Developer: Drug Discovery

A groundbreaking drug-repurposing AI model could bring new hope to doctors and patients trying to treat diseases with limited or no existing treatment options. A groundbreaking drug-repurposing AI model could bring new hope to doctors and patients trying to treat diseases with limited or no existing treatment options. Called TxGNN, this zero-shot tool helps doctors find new uses for existing drugs for conditions that might otherwise go untreated.

Disease 145
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Researchers flip genes on and off with AI-designed DNA switches

Science Daily: Pharmacology News

Researchers have used artificial intelligence to design thousands of new DNA switches that can precisely control the expression of a gene in different cell types. Their new approach opens the possibility of controlling when and where genes are expressed in the body, for the benefit of human health and medical research, in ways never before possible.

DNA 139
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Machine learning guides researchers to new synthetic genetic switches

Broad Institute

Machine learning guides researchers to new synthetic genetic switches By Tom Ulrich October 23, 2024 Breadcrumb Home Machine learning guides researchers to new synthetic genetic switches A new method allows precise activation or repression of genes in specific cells and tissues. By Sarah C.P. Williams October 23, 2024 Credit: Natalie Velez, Broad Communications, from Gosai and Castro et al 2024.

Research 136
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An Alzheimer’s drugmaker is accused of data manipulation. Should its trials be stopped?

BioPharma Drive: Drug Pricing

An experimental Alzheimer’s therapy from Cassava Sciences is still being tested in two Phase 3 studies, even as the company has come under regulatory scrutiny.

Trials 144
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Silly Things Large Language Models Do With Molecules

Practical Cheminformatics

“Pay no attention to the man behind the curtain” - The Wizard of Oz Introduction Recently, a few groups have proposed general-purpose large language models (LLMs) like ChatGPT , Claude , and Gemini as tools for generating molecules. This idea is appealing because it doesn't require specialized software or domain-specific model training. One can provide the LLM with a relatively simple prompt like the one below, and it will respond with a list of SMILES strings.

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CDC Says Some People May Need Extra Dose of COVID Vaccine

Drugs.com

FRIDAY, Oct. 25, 2024 -- Some Americans should get more than one shot of the updated COVID vaccines because their age or certain health conditions make them more vulnerable to severe infections, U.S. health officials advised this week.Six months.

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Paws of polar bears sustaining ice-related injuries in a warming Arctic

Science Daily: Pharmacology News

Polar bears in some parts of the high Arctic are developing ice buildup and related injuries to their feet. The changes appear to be an unexpected consequence of climate change, related to changing conditions in a warming Arctic.

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New drug triggers rapid cell death in cancer models

Broad Institute

New drug triggers rapid cell death in cancer models By Karen Zusi-Tran October 29, 2024 Breadcrumb Home New drug triggers rapid cell death in cancer models BRD-810 inhibits the MCL1 protein and reactivates apoptosis in tumor cells, displaying therapeutic potential in animal models. By Karen Zusi-Tran October 29, 2024 Credit: National Cancer Institute Human cells with acute myelocytic leukemia (AML) in the pericardial fluid.

Drugs 133
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Wave sees RNA editing validation in early trial results

BioPharma Drive: Drug Pricing

The results provide the first clinical evidence of RNA editing, a burgeoning field that's drawn interest from biotechs and pharmaceutical companies alike.

RNA 143
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ChEMBL brings drug bioactivity data to the Protein Data Bank in Europe

The ChEMBL-og

In the quest to develop new drugs, understanding the 3D structure of molecules is crucial. Resources like the Protein Data Bank in Europe (PDBe) and the Cambridge Structural Database (CSD) provide these 3D blueprints for many biological molecules. However, researchers also need to know how these molecules interact with their biological target – their bioactivity.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Weight-Loss Surgeries Decline 25% as More Americans Turn to GLP-1 Meds

Drugs.com

FRIDAY, Oct. 25, 2024 -- As the popularity of GLP-1 meds like Wegovy and Zepbound grows, fewer Americans are turning to weight-loss surgeries to trim their waistlines, a new report finds.Prescriptions of this GLP-1 class of diabetes and weight-loss.

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Optimizing Drug Discovery with CUDA Graphs, Coroutines, and GPU Workflows

Nvidia Developer: Drug Discovery

Pharmaceutical research demands fast, efficient simulations to predict how molecules interact, speeding up drug discovery. Jiqun Tu, a senior developer. Pharmaceutical research demands fast, efficient simulations to predict how molecules interact, speeding up drug discovery. Jiqun Tu, a senior developer technology engineer at NVIDIA, and Ellery Russell, tech lead for the Desmond engine at Schrödinger, explore advanced GPU optimization techniques designed to accelerate molecular dynamics simulati

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Wastewater bacteria can breakdown plastic for food

Science Daily: Pharmacology News

Comamonadacae is a family of bacteria often found growing on plastics in water. New study finds a bacterium in this family can break down the plastic for food. Researchers also identified the enzyme the bacterium use to degrade plastic. The discovery opens new possibilities for developing bacteria-based engineering solutions to help clean up difficult-to-remove plastic waste.

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Researchers map communities of single cells in metastatic breast cancers

Broad Institute

Researchers map communities of single cells in metastatic breast cancers By Corie Lok October 30, 2024 Breadcrumb Home Researchers map communities of single cells in metastatic breast cancers The team compared different single-cell and spatial profiling methods to explore the diversity of cells in metastatic breast cancer biopsies. By Sarah C.P. Williams October 30, 2024 Credit: Cecil Fox, National Cancer Institute, National Institutes of Health Human breast cancer tissue with cancer cells (purp

Research 127
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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RNA editing: emerging from CRISPR’s shadow

BioPharma Drive: Drug Pricing

Early study data from Wave Life Sciences suggests how editing RNA may yield viable medicines. Large and small drugmakers say such results are just the start.

RNA 141
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3 Key Insurance Takeaways from InsureTech Connect 2024

Perficient: Drug Development

The 2024 InsureTech Connect (ITC) conference was truly exhilarating, with key takeaways impacting the insurance industry. Each year, it continues to improve, offering more relevant content, valuable industry connections, and opportunities to delve into emerging technologies. This year’s event was no exception, showcasing the importance of personalization to the customer, tech-driven relationship management, and AI-driven underwriting processes.

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New Hope Against a Rare, Aggressive Form of Thyroid Cancer

Drugs.com

MONDAY, Oct. 28, 2024 -- Most thyroid cancers are slow-moving and, if caught early, curable. But some patients can present with what's known as an anaplastic thyroid carcinoma (ATC) -- a rare and very aggressive tumor with a very poor prognosis.

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New JAMA Article Recommends Personal Drug Importation To Help American Patients Afford Prescription Drugs

Policy Prescription

Harvard doctors and public health experts recommend using the website PharmacyChecker.com to find international online pharmacies to order more affordable prescription drugs for personal importation when domestic savings strategies fail. They offer this advice in a new article in the Journal of the American Medical Association. Article Review The article, Strategies to Help Patients Navigate High Prescription Drug Costs , offers very digestible and evidence-driven guidance for clinicians to bet

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Global carbon dioxide emissions from forest fires increase by 60 percent

Science Daily: Pharmacology News

A major new study reveals that carbon dioxide emissions from forest fires have surged by 60 percent globally since 2001, and almost tripled in some of the most climate-sensitive northern boreal forests.

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To help his daughter living with an ultra-rare disorder, this dad brought together a squad of genetic detectives

Broad Institute

To help his daughter living with an ultra-rare disorder, this dad brought together a squad of genetic detectives By Leah Eisenstadt October 23, 2024 Breadcrumb Home To help his daughter living with an ultra-rare disorder, this dad brought together a squad of genetic detectives The Broadbent family worked closely with scientists to discover the unique genetic cause of their daughter’s disease, highlighting the need to examine noncoding parts of the genome when diagnosing rare genetic disorders.

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After rejections, AbbVie secures approval for Parkinson’s drug

BioPharma Drive: Drug Pricing

Vyalev’s clearance is the second victory for AbbVie in Parkinson’s this year, following an April readout for a drug acquired through its Cerevel buyout.

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New Viral Vectors - Fall 2024

addgene Blog

If the fall colors are inspiring you to paint your cells in equally vivid colors, you'll want to check out the 34 new preps available in the Addgene viral vector repository! This includes the first Addgene prep packaged in the AAV9-X1.1 serotype.

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Fatal Opioid-Meth Overdoses Have Fallen in U.S. by More Than a Third

Drugs.com

TUESDAY, Oct. 22, 2024 -- Expanded access to addiction treatment and the overdose-reversal med naloxone likely prompted a 37% reduction in OD deaths linked to opioids taken with meth or other stimulant drugs, a new study suggests.OD death rates.

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Assumptions & Uncertainty : Project Estimating (Part 3)

Perficient: Drug Development

This post is the third in a series of four about estimating project hours. Part 1: Sandbagging & Lowballing Part 2: Dependencies & Creep Part 3: Assumptions & Uncertainty Coming Soon: Part 4: The Emotional Conclusion In this third installment of my blog series on project estimates, let’s dive headfirst into the murky waters of assumptions and uncertainty!

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Men and women process pain differently, study finds

Science Daily: Pharmacology News

According to new research, men and women rely on different biological systems for pain relief, which could help explain why our most powerful pain medications are often less effective in women.

Research 138
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Largest-ever genetic study of epilepsy finds possible therapeutic targets

Broad Institute

Largest-ever genetic study of epilepsy finds possible therapeutic targets By Ari Navetta October 3, 2024 Breadcrumb Home Largest-ever genetic study of epilepsy finds possible therapeutic targets Scientists have uncovered new genetic links to different types of epilepsy, which could lead to more tailored treatments. By Ari Navetta October 3, 2024 Credit: Ricardo Job-Reese, Broad Communications Related people Benjamin Neale Related programs Stanley Center for Psychiatric Research Related news DNA

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Roche weighs whether speedy approval path is open for latest Alzheimer’s drug

BioPharma Drive: Drug Pricing

In an investor presentation, executives hinted at the possibility of seeking an accelerated approval of trontinemab if it can significantly lower levels of amyloid in a Phase 3 trial.

Trials 120
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Overcoming Barriers to Generative AI in Life Sciences R&D

Fierce BioTech

| While artificial intelligence is on everyone’s minds and in many R&D plans, adoption of generative AI has been slow so far in life sciences.

Science 118
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1 in 5 Americans' Drinking Water Tainted With PFAS Chemicals

Drugs.com

MONDAY, Oct. 28, 2024 -- More than 20% of people in the continental United States might have drinking water contaminated with “forever chemicals,” a new study suggests.Between 75 and 95 million Americans rely on groundwater that contains det.

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Organoids: the versatile platform for discovery and regeneration

Drug Target Review

Imagine being able to create an in vitro replica of a diseased organ to study the molecular mechanism underlying the illness. Now take a step further: envision testing drugs in these organoids to identify the ones that can treat disease safely and effectively without needing to run expensive clinical trials first. Further still, think about implanting these mini organs into the patient to restore lost function.

Treatment 105
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Why do we love carbs? The origins predate agriculture and maybe even our split from Neanderthals

Science Daily: Pharmacology News

A new study reveals how the duplication of the salivary amylase gene may not only have helped shape human adaptation to starchy foods, but may have occurred as far back as more than 800,000 years ago, long before the advent of farming.

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New diagnostic approach for bacterial infections shows promise in the clinic

Broad Institute

New diagnostic approach for bacterial infections shows promise in the clinic By Leah Eisenstadt October 21, 2024 Breadcrumb Home New diagnostic approach for bacterial infections shows promise in the clinic In a pilot study with patient samples, the technology performed as well as the current gold-standard methods, yielding accurate results within hours instead of days.

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Judo Bio debuts with $100M and a plan to take RNA drugs to the kidney

BioPharma Drive: Drug Pricing

The Cambridge, Massachusetts-based biotech is using what it calls ligand-siRNA conjugates to reach drug targets in the kidney, which historically have been difficult to reach with RNA therapies.

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