Science Daily: Pharmacology News
OCTOBER 22, 2024
Polar bears in some parts of the high Arctic are developing ice buildup and related injuries to their feet. The changes appear to be an unexpected consequence of climate change, related to changing conditions in a warming Arctic.
Broad Institute
OCTOBER 29, 2024
New drug triggers rapid cell death in cancer models By Karen Zusi-Tran October 29, 2024 Breadcrumb Home New drug triggers rapid cell death in cancer models BRD-810 inhibits the MCL1 protein and reactivates apoptosis in tumor cells, displaying therapeutic potential in animal models. By Karen Zusi-Tran October 29, 2024 Credit: National Cancer Institute Human cells with acute myelocytic leukemia (AML) in the pericardial fluid.
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Nvidia Developer: Drug Discovery
OCTOBER 30, 2024
The integration of AI in drug discovery is revolutionizing the way researchers approach the development of new treatments for various diseases. Traditional. The integration of AI in drug discovery is revolutionizing the way researchers approach the development of new treatments for various diseases. Traditional methods are often time-consuming and costly, with the process of bringing a new drug to market taking up to 15 years and costing between $1–2B.
BioPharma Drive: Drug Pricing
OCTOBER 22, 2024
Early study data from Wave Life Sciences suggests how editing RNA may yield viable medicines. Large and small drugmakers say such results are just the start.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Practical Cheminformatics
OCTOBER 8, 2024
“Pay no attention to the man behind the curtain” - The Wizard of Oz Introduction Recently, a few groups have proposed general-purpose large language models (LLMs) like ChatGPT , Claude , and Gemini as tools for generating molecules. This idea is appealing because it doesn't require specialized software or domain-specific model training. One can provide the LLM with a relatively simple prompt like the one below, and it will respond with a list of SMILES strings.
Drugs.com
OCTOBER 25, 2024
FRIDAY, Oct. 25, 2024 -- Some Americans should get more than one shot of the updated COVID vaccines because their age or certain health conditions make them more vulnerable to severe infections, U.S. health officials advised this week.Six months.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Broad Institute
OCTOBER 30, 2024
Researchers map communities of single cells in metastatic breast cancers By Corie Lok October 30, 2024 Breadcrumb Home Researchers map communities of single cells in metastatic breast cancers The team compared different single-cell and spatial profiling methods to explore the diversity of cells in metastatic breast cancer biopsies. By Sarah C.P. Williams October 30, 2024 Credit: Cecil Fox, National Cancer Institute, National Institutes of Health Human breast cancer tissue with cancer cells (purp
Nvidia Developer: Drug Discovery
OCTOBER 2, 2024
A groundbreaking drug-repurposing AI model could bring new hope to doctors and patients trying to treat diseases with limited or no existing treatment options. A groundbreaking drug-repurposing AI model could bring new hope to doctors and patients trying to treat diseases with limited or no existing treatment options. Called TxGNN, this zero-shot tool helps doctors find new uses for existing drugs for conditions that might otherwise go untreated.
BioPharma Drive: Drug Pricing
OCTOBER 16, 2024
The results provide the first clinical evidence of RNA editing, a burgeoning field that's drawn interest from biotechs and pharmaceutical companies alike.
The ChEMBL-og
OCTOBER 23, 2024
In the quest to develop new drugs, understanding the 3D structure of molecules is crucial. Resources like the Protein Data Bank in Europe (PDBe) and the Cambridge Structural Database (CSD) provide these 3D blueprints for many biological molecules. However, researchers also need to know how these molecules interact with their biological target – their bioactivity.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drugs.com
OCTOBER 25, 2024
FRIDAY, Oct. 25, 2024 -- As the popularity of GLP-1 meds like Wegovy and Zepbound grows, fewer Americans are turning to weight-loss surgeries to trim their waistlines, a new report finds.Prescriptions of this GLP-1 class of diabetes and weight-loss.
Science Daily: Pharmacology News
OCTOBER 17, 2024
A major new study reveals that carbon dioxide emissions from forest fires have surged by 60 percent globally since 2001, and almost tripled in some of the most climate-sensitive northern boreal forests.
Broad Institute
OCTOBER 23, 2024
To help his daughter living with an ultra-rare disorder, this dad brought together a squad of genetic detectives By Leah Eisenstadt October 23, 2024 Breadcrumb Home To help his daughter living with an ultra-rare disorder, this dad brought together a squad of genetic detectives The Broadbent family worked closely with scientists to discover the unique genetic cause of their daughter’s disease, highlighting the need to examine noncoding parts of the genome when diagnosing rare genetic disorders.
Nvidia Developer: Drug Discovery
OCTOBER 23, 2024
Pharmaceutical research demands fast, efficient simulations to predict how molecules interact, speeding up drug discovery. Jiqun Tu, a senior developer. Pharmaceutical research demands fast, efficient simulations to predict how molecules interact, speeding up drug discovery. Jiqun Tu, a senior developer technology engineer at NVIDIA, and Ellery Russell, tech lead for the Desmond engine at Schrödinger, explore advanced GPU optimization techniques designed to accelerate molecular dynamics simulati
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
BioPharma Drive: Drug Pricing
OCTOBER 4, 2024
An experimental Alzheimer’s therapy from Cassava Sciences is still being tested in two Phase 3 studies, even as the company has come under regulatory scrutiny.
Perficient: Drug Development
OCTOBER 29, 2024
The 2024 InsureTech Connect (ITC) conference was truly exhilarating, with key takeaways impacting the insurance industry. Each year, it continues to improve, offering more relevant content, valuable industry connections, and opportunities to delve into emerging technologies. This year’s event was no exception, showcasing the importance of personalization to the customer, tech-driven relationship management, and AI-driven underwriting processes.
Drugs.com
OCTOBER 28, 2024
MONDAY, Oct. 28, 2024 -- Most thyroid cancers are slow-moving and, if caught early, curable. But some patients can present with what's known as an anaplastic thyroid carcinoma (ATC) -- a rare and very aggressive tumor with a very poor prognosis.
Science Daily: Pharmacology News
OCTOBER 10, 2024
Researchers developed a rating system to evaluate the plausibility of climate model simulations in the IPCC's latest report, and show that models that lead to potentially catastrophic warming are to be taken seriously.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Broad Institute
OCTOBER 3, 2024
Largest-ever genetic study of epilepsy finds possible therapeutic targets By Ari Navetta October 3, 2024 Breadcrumb Home Largest-ever genetic study of epilepsy finds possible therapeutic targets Scientists have uncovered new genetic links to different types of epilepsy, which could lead to more tailored treatments. By Ari Navetta October 3, 2024 Credit: Ricardo Job-Reese, Broad Communications Related people Benjamin Neale Related programs Stanley Center for Psychiatric Research Related news DNA
Policy Prescription
OCTOBER 22, 2024
Harvard doctors and public health experts recommend using the website PharmacyChecker.com to find international online pharmacies to order more affordable prescription drugs for personal importation when domestic savings strategies fail. They offer this advice in a new article in the Journal of the American Medical Association. Article Review The article, Strategies to Help Patients Navigate High Prescription Drug Costs , offers very digestible and evidence-driven guidance for clinicians to bet
BioPharma Drive: Drug Pricing
OCTOBER 17, 2024
Vyalev’s clearance is the second victory for AbbVie in Parkinson’s this year, following an April readout for a drug acquired through its Cerevel buyout.
Drug Target Review
OCTOBER 30, 2024
Imagine being able to create an in vitro replica of a diseased organ to study the molecular mechanism underlying the illness. Now take a step further: envision testing drugs in these organoids to identify the ones that can treat disease safely and effectively without needing to run expensive clinical trials first. Further still, think about implanting these mini organs into the patient to restore lost function.
Drugs.com
OCTOBER 28, 2024
MONDAY, Oct. 28, 2024 -- More than 20% of people in the continental United States might have drinking water contaminated with “forever chemicals,” a new study suggests.Between 75 and 95 million Americans rely on groundwater that contains det.
Science Daily: Pharmacology News
OCTOBER 16, 2024
According to new research, men and women rely on different biological systems for pain relief, which could help explain why our most powerful pain medications are often less effective in women.
Broad Institute
OCTOBER 21, 2024
New diagnostic approach for bacterial infections shows promise in the clinic By Leah Eisenstadt October 21, 2024 Breadcrumb Home New diagnostic approach for bacterial infections shows promise in the clinic In a pilot study with patient samples, the technology performed as well as the current gold-standard methods, yielding accurate results within hours instead of days.
addgene Blog
OCTOBER 3, 2024
If the fall colors are inspiring you to paint your cells in equally vivid colors, you'll want to check out the 34 new preps available in the Addgene viral vector repository! This includes the first Addgene prep packaged in the AAV9-X1.1 serotype.
BioPharma Drive: Drug Pricing
OCTOBER 24, 2024
Newly published data show the therapy reduced the rate of swelling attacks in people with hereditary angioedema, but didn't silence questions about its commercial outlook.
Perficient: Drug Development
OCTOBER 15, 2024
This post is the third in a series of four about estimating project hours. Part 1: Sandbagging & Lowballing Part 2: Dependencies & Creep Part 3: Assumptions & Uncertainty Coming Soon: Part 4: The Emotional Conclusion In this third installment of my blog series on project estimates, let’s dive headfirst into the murky waters of assumptions and uncertainty!
Drugs.com
OCTOBER 30, 2024
WEDNESDAY, Oct. 30, 2024 -- In the highest tally ever recorded for tuberculosis cases, the World Health Organization reported Tuesday that over 8 million people worldwide were diagnosed with the lung disease last year.Of that number, 1.25 million.
Science Daily: Pharmacology News
OCTOBER 17, 2024
A new study reveals how the duplication of the salivary amylase gene may not only have helped shape human adaptation to starchy foods, but may have occurred as far back as more than 800,000 years ago, long before the advent of farming.
FDA Law Blog: Biosimilars
OCTOBER 27, 2024
By Deborah L. Livornese & John W.M. Claud & Charles D. Snow — On October 21, 2024, the Alliance for Natural Health USA (“ANH”), and Meditrend Inc., a homeopathic drug company, filed a complaint on behalf of the homeopathic drug industry against FDA in the District Court for the District of Columbia (“D.D.C.”). This lawsuit presents an interesting reading of the statute at issue, one that is diametrically opposed to that of FDA.
Science Daily: Pharmacology News
OCTOBER 21, 2024
Plants the world over are absorbing about 31% more carbon dioxide than previously thought, according to a new assessment. The research is expected to improve Earth system simulations that scientists use to predict the future climate, and spotlights the importance of natural carbon sequestration for greenhouse gas mitigation.
Science Daily: Pharmacology News
OCTOBER 30, 2024
A new study unveils a surprising discovery: a substantial amount of meltwater is temporarily stored within the Greenland Ice Sheet during summer months. For the first time, an international group of researchers was able to quantify meltwater with positioning data. The finding challenges current models of how ice sheets contribute to global sea level rise.
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