July, 2024

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Prime editing efficiently corrects cystic fibrosis mutation in human lung cells

Broad Institute

Prime editing efficiently corrects cystic fibrosis mutation in human lung cells By Allessandra DiCorato July 10, 2024 Breadcrumb Home Prime editing efficiently corrects cystic fibrosis mutation in human lung cells The approach targets the most common genetic cause of the disease and could enable a one-time treatment as effective as existing daily therapies.

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Generation X and millennials in US have higher risk of developing 17 cancers compared to older generations

Science Daily: Pharmacology News

A new large study suggests incidence rates continued to rise in successively younger generations in 17 of the 34 cancer types, including breast, pancreatic, and gastric cancers. Mortality trends also increased in conjunction with the incidence of liver (female only), uterine corpus, gallbladder, testicular, and colorectal cancers.

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Artiva prices $167M IPO, riding optimism for autoimmune cell therapy

BioPharma Drive: Drug Pricing

The offering comes days after the publication of a paper showing what analysts said was early proof that “off-the-shelf” cell therapies can treat inflammatory diseases.

Therapies 129
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Where's the Synthetic Blood?

Codon

Dr. Keith Neeves gives a history of blood transfusions and explains why it will be difficult to scale up the creation of synthetic blood for Issue 03 of Asimov Press. We are mostly blood. Of the 36 trillion cells in the human body, 32 trillion are blood cells. These blood cells synchronize the delivery of oxygen to every tissue in your body, fight pathogens, and heal wounds.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Talk of the Towne episode 11: American Kidney Fund

Antidote

In the latest installment of Talk of the Towne, we sat down with Melanie Paris, M.A., MPH, the Senior Director of Strategic Partnerships and Kidney Disease Education at the American Kidney Fund (AKF). In the discussion, we got her insights into the types of kidney disease, treatment disparities, and the importance of clinical research in the field. She also shared many valuable resources for individuals and their loved ones living with kidney disease, which are linked here.

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Study Finds Big Shift in Who's Using GLP-1 Meds Like Ozempic

Drugs.com

TUESDAY, July 23, 2024 -- The boom in using GLP-1 drugs like Ozempic to treat obesity has resulted in a bust regarding the drugs’ original purpose, which was to treat type 2 diabetes, a new study finds. New prescriptions for these drugs have d.

Drugs 119

More Trending

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Virus that causes COVID-19 is widespread in wildlife, scientists find

Science Daily: Pharmacology News

SARS-CoV-2, the virus responsible for COVID-19, is widespread among wildlife species, according to new research. The virus was detected in six common backyard species, and antibodies indicating prior exposure to the virus were found in five species, with rates of exposure ranging from 40 to 60 percent depending on the species.

Virus 140
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10 clinical trials to watch in the second half of 2024

BioPharma Drive: Drug Pricing

Study results are expected for a pair of closely watched obesity drugs, while key tests await for a high-priced AbbVie acquisition and one of 2023’s largest IPOs.

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The Curse of Perfection – Toil and Trouble

Perficient: Drug Development

“Double, double toil and trouble,” is a line repeated by the witches in Macbeth as they lay out the ominous prophecies of greatness and dire consequences for the titular character. Macbeth’s ambition envisions a perfect ending though desperate actions and moral weakness ruin it. So too are the misguided actions in pursuit of perfection which can set expectations and pressure that lead to unwanted results.

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Women in STEM with Juliet Williams

Drug Target Review

What inspired you to pursue a career in STEM and can you tell us about how your career journey unfolded? An early introduction to STEM in the classroom sparked my passion for biology and I’m grateful for the exposure to different scientific concepts and contexts at a young age. I wanted to make a tangible impact on the world through biology and was drawn to the challenge of scientific discovery, which led me to pursue a career in the biotech/pharma industry.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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FDA Approves Another Blood Test for Colon Cancer Screening

Drugs.com

MONDAY, July 29, 2024 -- The U.S. Food and Drug Administration on Monday approved a new blood test that can spot colon cancer.In late May, an FDA advisory panel had voted 7-2 that the benefits outweigh the risks when using the Guardant Health's.

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How to get into a clinical trial? Understanding inclusion and exclusion criteria

Antidote

When determining which clinical trial is the right fit , many factors must be considered. The site location, the number of required visits, and the length of the study are all important considerations, but before any of this, it is vital to consider the study's inclusion and exclusion criteria.

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A breakthrough in inexpensive, clean, fast-charging batteries

Science Daily: Pharmacology News

Scientists have created an anode-free sodium solid-state battery. This brings the reality of inexpensive, fast-charging, high-capacity batteries for electric vehicles and grid storage closer than ever.

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Revolution Medicines firms up Phase 3 trial plans with latest cancer drug data

BioPharma Drive: Drug Pricing

Updated results show the biotech's RAS inhibitor shrank pancreatic tumors in 20% to 25% of study participants, but with high rates of side effects like rash and nausea.

Trials 126
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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How to Configure ServiceNow Knowledge Articles for Microsoft Graph Connector

Perficient: Drug Development

If you use ServiceNow as your knowledge management platform, you might want to make your knowledge articles searchable and accessible from Microsoft Search. Microsoft Search is a unified search experience that helps you find what you need across your organization, including files, sites, people, and more. By connecting your ServiceNow knowledge articles to Microsoft Search, you can enable your users to find and request them directly from the Microsoft 365 apps.

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An immune factor in the brain plays critical roles in neuron function and aging

Broad Institute

An immune factor in the brain plays critical roles in neuron function and aging By Tom Ulrich July 19, 2024 Breadcrumb Home An immune factor in the brain plays critical roles in neuron function and aging Study highlights unexpected interactions between innate immune system and neurons, raises questions about additional roles for immune system in the brain with aging.

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FLiRTy Summer: All You Need to Know About the Latest COVID Variants

Drugs.com

SUNDAY, July 21, 2024 -- As yet another batch of variants fuel a COVID surge this summer, one expert offers advice on how to navigate the threat.“We've seen a bit of a seasonal pattern emerge, where we've had an uptick in COVID in the summer and t.

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What is the medical definition of obesity?

Antidote

Obesity, a condition that impacts 2 out of 5 adults in the United States , has become a significant health concern, both due to the impacts it has on individuals with the condition and the effect it can have on the overall medical system. It is estimated that obesity is responsible for nearly $1.73 billion in excess treatment costs annually, compounded by the fact that individuals with obesity are far more likely to have other conditions such as hypertension, diabetes, and osteoarthritis.

Treatment 111
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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New and improved camera inspired by the human eye

Science Daily: Pharmacology News

Computer scientists have invented a camera mechanism that improves how robots see and react to the world around them. Inspired by how the human eye works, their innovative camera system mimics the tiny involuntary movements used by the eye to maintain clear and stable vision over time.

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Pfizer thinks it found its obesity pill

BioPharma Drive: Drug Pricing

Far behind companies like Novo and Eli Lilly, Pfizer hopes the version of the drug, danuglipron, that it’s chosen to advance can break into the ultra-lucrative market for weight-loss medicines.

Marketing 124
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Raising Welfare for Lab Rodents

Codon

Xander Balwit offers concrete proposals for raising the welfare of animals used in biomedical research for our final article in Issue 03. We’ll be on a brief hiatus for the next few weeks as we prepare for the next Issue! If you’d like to write for us, send a pitch to editors@asimov.com. A hairless and obese rat grimaced at me from behind the glass—its taxidermied gaze fixed on something across the room.

Research 110
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Supercharge Customer Journeys with Salesforce OmniStudio

Perficient: Drug Development

In today’s digital landscape, delivering exceptional customer experiences is paramount. Salesforce OmniStudio empowers you to create engaging, personalized, and brand-consistent interactions across all touchpoints. This blog post delves into OmniStudio, exploring its capabilities, benefits, and how you can leverage it to elevate your customer journeys.

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Use of 'Benzo' Sedatives Like Valium, Xanax Won't Raise Dementia Risk: Study

Drugs.com

TUESDAY, July 2, 2024 -- Benzodiazepines do not appear to increase dementia risk, but could have subtle long-term effects on brain structure, a new study reports.Researchers found no link between use of the sedative drug and a higher risk of.

Drugs 119
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The Effects the ICH E6(R3) Updates Will Have on Good Clinical Practice

Quanticate

Good Clinical Practice (GCP) affects a variety of entities, including sponsors, contract research organisations (CROs), and investigator sites. It’s essential for maintaining ethical standards, high-quality outcomes and facilitating global standardisation, enabling multi-center and multinational studies, thereby streamlining the development and approval process for new medical treatments, and maintaining public trust in clinical research.

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Ant insights lead to robot navigation breakthrough

Science Daily: Pharmacology News

Have you ever wondered how insects are able to go so far beyond their home and still find their way? The answer to this question is not only relevant to biology but also to making the AI for tiny, autonomous robots. Drone-researchers felt inspired by biological findings on how ants visually recognize their environment and combine it with counting their steps in order to get safely back home.

Research 137
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Cartesian data add to progress, questions for CAR-T in autoimmune disease

BioPharma Drive: Drug Pricing

The company claimed Phase 2 study results prove the therapy’s promise treating myasthenia gravis. But shares lost more than a quarter of their value amid questions about the data.

Disease 124
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InMed’s INM-901 Demonstrates Potential as a Multi-factorial Approach to Treating Alzheimer’s Disease

Fierce BioTech

InMed’s INM-901 Demonstrates Potential as a Multi-factorial Approach to Treating Alzheimer’s Disease jpiatt Fri, 07/19/2024 - 09:56

Disease 124
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Jessie Rees Foundation and The Foundation for Excellence Both Receive $5,000 Perficient Global Grant

Perficient: Drug Development

Perficient’s Giving Employee Resource Group (ERG) recently introduced the Perficient Gives Global Grants Program , which gives colleagues the opportunity to nominate charitable organizations from around the world to receive a $5,000 donation from Perficient. After carefully evaluating each nomination, Perficient’s Giving ERG leadership team selected the first five organizations to receive a donation.

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Bird Flu Is Now Transmitting Mammal-to-Mammal: Study

Drugs.com

THURSDAY, July 25, 2024 -- The bird flu is now jumping between species of mammals, a step that draws the virus closer to hopping into human beings, a new study warns.Researchers have tracked transmission of avian influenza between dairy cows in.

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At Long Last, FDA Unveils Plan for Rare Disease Innovation Hub

FDA Law Blog: Drug Discovery

By Sarah Wicks & James E. Valentine & Frank J. Sasinowski — On July 17, 2024, FDA announced the establishment of a Rare Disease Innovation Hub (the “Hub”) to enhance and improve outcomes for patients with rare diseases and conditions by focusing on rare disease drug and biological product development across the Agency’s Center for Drug Evaluation and Research (“CDER”) and Center for Biologics Evaluation and Research (“CBER”).

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Scientists discover new T cells and genes related to immune disorders

Science Daily: Pharmacology News

Researchers have discovered several rare types of helper T cells that are associated with immune disorders such as multiple sclerosis, rheumatoid arthritis, and even asthma. The discoveries were made possible by a newly developed technology they call ReapTEC. The new T cell atlas is publicly available and should help in the development of new drug therapies for immune-mediated diseases.

Therapies 136
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Lilly drug for Alzheimer’s approved by FDA

BioPharma Drive: Drug Pricing

The drug, which Lilly will sell as Kinsunla, carries a warning for the risk of a certain kind of imaging abnormality that can be serious in rare cases.

FDA 135
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New Viral Vectors - Summer 2024

addgene Blog

What's new in Addgene's ready-to-use viral vectors repository? Quite a bit! In this post, we'll share the 20 additions we've made to our viral vectors repository since March.

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