Sat.Sep 23, 2023 - Fri.Sep 29, 2023

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FDA Adds Warning to Ozempic Label About Risk for Blocked Intestines

Drugs.com

WEDNESDAY, Sept. 27, 2023 -- Ozempic, a type 2 diabetes drug that has increasingly been used to help with weight loss, will now be labeled as having the potential to block intestines. The U.S. Food and Drug Administration recently made the label.

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Scientists reveal cellular changes unique to early Alzheimer’s disease

Broad Institute

Scientists reveal cellular changes unique to early Alzheimer’s disease By Allessandra DiCorato September 28, 2023 Breadcrumb Home Scientists reveal cellular changes unique to early Alzheimer’s disease A study of brain tissue from living adults provides a rare look into the earliest stages of the neurodegenerative disease and highlights cell types involved in plaque production.

Disease 144
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Recent Highlights in Covalent Drug Discovery

Drug Hunter

In Wednesday’s Flash Talk webinar, we covered recent highlights in covalent drug discovery, with lots of great questions from the audience. The webinar and recording are available below to everyone thanks to our sponsor, Revvity Signals, and the slides are available for download to Premium members at the bottom. The talk covered: Covalent drugs that break the toxicity stigma Case studies from notable recent covalent molecules Covalent drugs to watch Some of the highlights mentioned in the talk i

Drugs 130
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Clinical trial phases: What’s the difference?

Antidote

Clinical trials are how researchers advance their knowledge about potential new treatments, including medications, medical devices, and lifestyle interventions. Clinical trials are divided into phases , each with a distinct duration, purpose, and number of volunteers needed. Before any new treatment becomes available on the market, it must go through this process, as required by the FDA.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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New optogenetic tools for cytoskeleton and membrane control

addgene Blog

Optogenetics gives you the power to control cells or organisms with the flip of a switch. You may be familiar with popular light-sensitive ion channels used to control activities like neuronal signaling — think of a mouse with an LED brain implant or a worm wiggling back and forth under blue light — but there’s a lot more to optogenetics than neuronal activity.

Research 125
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FDA staff hold ‘major concerns’ with Brainstorm ALS therapy, documents show

BioPharma Drive: Drug Pricing

Agency scientists flagged numerous issues with Brainstorm’s stem cell treatment ahead of a high-profile Wednesday meeting of expert FDA advisers.

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Just 23% of U.S. Adults 'Definitely' Plan to Get New COVID Shot

Drugs.com

WEDNESDAY, Sept. 27, 2023 -- Just 23% of American adults say they 'definitely' will get the new COVID-19 vaccine, while another 23% say they will 'probably' get it, according to a new poll, which also finds interest in the shot falls along partisan.

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Women in Stem with Dr Emily Leproust

Drug Target Review

Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? I started my journey in chemistry – first as an undergraduate and then in my PhD programme at the University of Houston, where I focused on organic chemistry and nucleic acids chemistry. After that, I spent over a decade at a large instrument and genomics company working in, and then leading, research and development.

DNA 116
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PTC to lay off more staff following drug setback in Europe

BioPharma Drive: Drug Pricing

The biotech is expanding cuts it announced a few months ago after the EMA decided against renewing a conditional clearance for its drug Translarna.

Drugs 124
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#ScienceSaturday: September 23, 2023

KIF1A

#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. KIF1A-Related Research RAB3 phosphorylation by pathogenic LRRK2 impairs trafficking of synaptic vesicle precursors During the COVID-19 epidemic many of us experienced how devastating shipping disruptions were; industri

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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New Antibiotic, Ceftobiprole, Could Help Fight Resistant Staph Infections

Drugs.com

THURSDAY, Sept. 28, 2023 -- New research shows that an antibiotic effective for bacterial pneumonia also appears to fight treatment-resistant staph infections. The drug is ceftobiprole. It appeared successful in fighting methicillin-resistant staph.

Treatment 115
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Human neuronal cells: possibilities in drug safety testing

Drug Target Review

Human derived induced pluripotent stem cells (hiPSCs) have revolutionised research and are increasingly used for toxicology screening and disease modelling. Early detection of neurotoxicity induced by potential new therapies is a major challenge, and hiPSC-neuronal cells may provide a solution. These cells demonstrate considerable promise for uncovering drug-induced perturbations to neuronal function such as seizure, and their use extends further to sedation, anti-epileptic drug discovery and mo

Drugs 111
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Roche bets on Ionis RNA medicines with neuroscience deal

BioPharma Drive: Drug Pricing

The Swiss drugmaker is restocking its pipeline by buying into preclinical Ionis medicines for Alzheimer’s and Huntington’s diseases.

RNA 122
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CDD Vault Update (September 2023)

Collaborative Drug

Fun with Ketcher New keyboard shortcuts have been added to the structure editor. Cycle through menu options and easily lookup abbreviations while still being able to assign the same atom to multiple locations.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Unsafe Neighborhoods Have Higher Levels of Child Abuse

Drugs.com

MONDAY, Sept. 25, 2023 -- Having safer neighborhoods, where families feel less stress, can help prevent child abuse, according to new research that supports this long-suspected theory. When parents feel higher levels of stress or hopelessness about.

Research 116
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Measuring Patent Value Indicators

Drug Patent Watch

“Measuring Patent Value Indicators with Patent Renewal Information” aims to address the research gap by constructing a dynamic model that incorporates both ex ante and ex post patent value indicators.… The post Measuring Patent Value Indicators appeared first on DrugPatentWatch - Make Better Decisions.

Research 110
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Eisai’s Alzheimer’s drug Leqembi approved in Japan

BioPharma Drive: Drug Pricing

Eisai and Biogen’s anti-amyloid drug is still undergoing regulatory reviews in the EU, U.K. and elsewhere.

Drugs 119
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Perficient Principal’s Articles on Composable Featured in CMS Wire

Perficient: Drug Development

In the ever-evolving realm of digital transformation, staying ahead of the curve is paramount. This is where Composable Architecture steps in, reshaping the way businesses construct and manage their digital landscapes. We’re excited to introduce you to two illuminating articles recently featured on CMSWire.com, “The Heart of Composable Architecture,” and “Navigating the Long Tail of Composable in the Martech Landscape” Both articles were penned by Perficient’s own

Marketing 110
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Is the First Cure for Advanced Rabies Near?

Drugs.com

THURSDAY, Sept. 28, 2023 -- Rabies virus is incurable and almost always fatal once it has invaded the central nervous system, with the victim doomed to suffer a horrible death. But researchers now think they’ve found an effective and simple.

Virus 111
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A turtle time capsule: DNA found in ancient shell

Science Daily: Pharmacology News

Paleontologists discover possible DNA remains in fossil turtle that lived 6 million years ago in Panama, where continents collide.

DNA 108
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ProQR sale of eye drugs comes undone over employment contracts

BioPharma Drive: Drug Pricing

Laboratoires Théa terminated its planned purchase of ProQR’s sepofarsen after certain ProQR personnel opted against working for the French company.

Drugs 119
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New Alternative Methodologies and Their Applications in Drug Discovery and Development

biobide

Within the field of Drug Discovery and Development the term “ New Alternative Methodologies ” (NAMs) refers to the use of new and innovative testing methods that come to replace traditional animal models. In addition to ethical constraints and animal welfare distress regarding the use of animals such as rodents in preclinical testing, there are a number of obstacles encountered in the traditional testing methods.

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FDA Panel Says No to Experimental ALS Drug, NurOwn

Drugs.com

THURSDAY, Sept. 28, 2023 – An advisory panel to the U.S. Food and Drug Administration on Wednesday voted resoundingly against recommending, NurOwn, a stem cell-based experimental treatment for ALS. Although the FDA isn't bound by the votes of.

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CDD Attending Biotech Networks Scientific Speed Networking Event: DC Area OCT 11 2023

Collaborative Drug

Biotech Networks Scientific Speed Networking: DC Area October 11th 2023

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BrainStorm’s ALS therapy not effective, FDA panel finds

BioPharma Drive: Drug Pricing

Expert advisers to the agency voted 17-1 that Brainstorm's clinical trial data did not show the company's stem cell treatment was effective for treating ALS.

Therapies 116
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Tough Conversations – Addressing Things Head On

Perficient: Drug Development

I’ve always had an intrapreneurial spirit in the jobs I’ve held. In some roles, I have been given autonomy with the ability to set North Star goals and chase them. In other roles, I’ve found myself building up consensus and bubbling ideas upward. This has involved some tough conversations. If you’ve checked my other blog posts , I tend to focus on innovation , creativity , corporate culture , project management , and organizational change management.

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Common Plastics Chemical Tied to Higher Odds for Postpartum Depression

Drugs.com

TUESDAY, Sept. 26, 2023 -- Moms with higher prenatal levels of plastics chemicals known as phthalates may face a slightly increased risk of postpartum depression, according to a new study.

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New study definitively confirms Gulf Stream weakening, understanding the changes could help predict future trends in extreme events

Science Daily: Pharmacology News

The Gulf Stream transport of water through the Florida Strait has slowed by 4% over the past four decades, with a 99% certainty that this weakening is more than expected from random chance, according to a new study.

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Intercept, after biotech rollercoaster ride, agrees to buyout by Alfasigma

BioPharma Drive: Drug Pricing

Once valued at more than $7 billion, the liver drug company couldn’t secure a long-sought FDA approval in NASH and last month said it would abandon that research.

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Advances in nursing assessment: a fundamental step in patient care

On Medicine

Nursing assessments Nursing assessments are the basis for making diagnoses and interventions that meet the needs of the patient. Therefore, any error, lack of information or use of inadequate instruments can affect the next steps in the nursing care process, affecting the quality of care, safety and patient satisfaction. Despite their relevance, nurses perceive nursing assessments as an administrative burden due to the increase in duplicated items.

Nurses 101
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Fast-Acting Investigational Nasal Spray May Ease Rapid Heartbeat

Drugs.com

WEDNESDAY, Sept. 27, 2023 -- Up to 2 million people in the U.S. experience rapid-fire heartbeats from time to time, and many end up in the hospital for treatment. But an investigational nasal spray may help folks with paroxysmal supraventricular.

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New study provides evidence for more effective brain-based treatment of chronic back pain

Science Daily: Pharmacology News

A new study may provide key answers to how to help people experiencing chronic back pain. The study examined the critical connection between the brain and pain for treating chronic pain. Specifically, they looked at the importance of pain attributions, which are people's beliefs about the underlying causes of their pain, to reduce chronic back pain severity.

Treatment 101
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Structure boosted by early data for experimental obesity drug

BioPharma Drive: Drug Pricing

Shares in the biotech surged on Phase 1 trial results for an oral GLP-1 drug Structure is developing, reflecting investor enthusiasm for the weight loss medicines.

Drugs 115