Drug Discovery World

SEPTEMBER 30, 2024

Experts from Cancer Research UK Children’s Brain Tumour Centre of Excellence in Cambridge, UK are set to share around £3.2 ($4.2) million to find and test better and less toxic ways to treat children’s brain tumours. The funding announcement comes during Childhood Cancer Awareness Month. Brain tumours are the leading cause of cancer death in children and those that do survive often face life-changing side effects as a result of their treatment.

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Drug Discovery Today

OCTOBER 4, 2024

Sandwich, Kent, UK. 24th September 2024 A group of former Pfizer employees have successfully created their own businesses based at and supported by Discovery Park, a thriving life sciences community in Kent.

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Nvidia Developer: Drug Discovery

OCTOBER 2, 2024

A groundbreaking drug-repurposing AI model could bring new hope to doctors and patients trying to treat diseases with limited or no existing treatment options. A groundbreaking drug-repurposing AI model could bring new hope to doctors and patients trying to treat diseases with limited or no existing treatment options. Called TxGNN, this zero-shot tool helps doctors find new uses for existing drugs for conditions that might otherwise go untreated.

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Science Daily: Pharmacology News

OCTOBER 3, 2024

Comamonadacae is a family of bacteria often found growing on plastics in water. New study finds a bacterium in this family can break down the plastic for food. Researchers also identified the enzyme the bacterium use to degrade plastic. The discovery opens new possibilities for developing bacteria-based engineering solutions to help clean up difficult-to-remove plastic waste.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

OCTOBER 4, 2024

Biotechnology company LoQus23 Therapeutics has closed its £35 million (c.$43 million) Series A financing. The financing round was led by Forbion, alongside existing investors SV Health Investors’ Dementia Discovery Fund (DDF) and Novartis Venture Fund (NVF). Forbion General Partner Rogier Rooswinkel will join LoQus23’s Board of Directors. LoQus23 was founded in 2019 by Entrepreneurs in Residence at DDF Dr David Reynolds, Dr Caroline Benn, and Dr Ruth McKernan CBE, FMedSci and seeded by SV’s Deme

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Drug Discovery Today

OCTOBER 3, 2024

Kate Shaw, founder and CEO of Innovative Trials, a global clinical trial patient recruitment and retention company, has been crowned a top ‘Woman in Pharma’ at the Pharma Industry Awards UK. She was given the award at a ceremony in Birmingham on Wednesday 18th September.

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Science Daily: Pharmacology News

OCTOBER 2, 2024

Dolphins are extremely playful, but little is known about how they -- and other marine mammals -- communicate during playtime. New research shows that bottlenose dolphins (Tursiops truncates) use the 'open mouth' facial expression -- analogous to a smile -- to communicate during social play. The dolphins almost always use the facial expression when they are in their playmate's field of view, and when playmates perceived a 'smile,' they responded in kind 33% of the time.

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Research 122

Drug Discovery World

OCTOBER 3, 2024

The US Food and Drug Administration (FDA) has announced seven new clinical trial grants awarded under the Orphan Products Grants Program for clinical trials to address the unmet needs of people affected by rare diseases. In total, clinical researchers will receive approximately $17.2 million over the next four years. Newly funded projects: Palvella Therapeutics received $2.6 million to fund a Phase III study of PTX-022 (Sirolimus) for the treatment of microcystic lymphatic malformations.

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Drug Discovery Today

OCTOBER 2, 2024

Scientists have developed new potential therapies that selectively remove aggregated tau proteins, which are associated with Alzheimer’s disease, and improve symptoms of neurodegeneration in mice.

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Drugs.com

OCTOBER 3, 2024

THURSDAY, Oct. 3, 2024, HealthDay News -- The Southern Hemisphere's flu season is winding down, and new data shows this year's flu shot was 34.5% effective in keeping folks there who got influenza from needing hospital care. Most (68.3%) of those.

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Science Daily: Pharmacology News

OCTOBER 2, 2024

U.S. tropical cyclones, including hurricanes, indirectly cause thousands of deaths for nearly 15 years after a storm. Researchers estimate an average U.S. tropical cyclone indirectly causes 7,000 to 11,000 excess deaths. All told, they estimate tropical storms since 1930 have contributed to between 3.6 million and 5.2 million deaths in the U.S. -- more than all deaths nationwide from motor vehicle accidents, infectious diseases, or battle deaths in wars during the same period.

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Drug Discovery World

OCTOBER 3, 2024

This article is sponsored by SGS. Join SGS’s Health Science team at booth 5D82 to explore their integrated drug development solutions, from analytical testing to clinical research, formulation and manufacturing development. SGS is excited to announce its participation as an exhibitor where it will present its extensive range of quality and compliance services for the health science industry.

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BioPharma Drive: Drug Pricing

SEPTEMBER 30, 2024

The Swiss pharma is paying Regor Therapeutics $850 million to buy a pair of prospects it sees as potential successors to blockbuster medicines from Pfizer and Eli Lilly.

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Drugs.com

OCTOBER 3, 2024

THURSDAY, Oct. 3, 2024 -- Americans who turn to online pharmacies to find cheaper versions of expensive prescription medications, especially opioids, may instead be buying themselves dangerous drugs that could trigger an overdose, U.S. health.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Science Daily: Pharmacology News

OCTOBER 1, 2024

A research team systematically analyzed 40 empirical studies, the majority of which had found that outdoor air pollution is associated with differences in children's brains. These differences include volumes of white matter, which is associated with cognitive function, connections throughout the brain and even early markers for Alzheimer's.

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Drug Discovery World

OCTOBER 3, 2024

New data from the Phase III BouNDless trial and its ongoing open-label extension (OLE) support the long-term efficacy of ND0612 in people with Parkinson’s disease (PD) experiencing motor fluctuations. The new clinical trial data was shared at the 2024 International Congress of Parkinson’s Disease and Movement Disorders (MDS). ND0612 is being studied as a 24-hour, continuous, subcutaneous (SC) infusion of liquid levodopa/carbidopa (LD/CD).

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addgene Blog

OCTOBER 3, 2024

If the fall colors are inspiring you to paint your cells in equally vivid colors, you'll want to check out the 34 new preps available in the Addgene viral vector repository! This includes the first Addgene prep packaged in the AAV9-X1.1 serotype.

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Packaging 103

Drugs.com

OCTOBER 2, 2024

WEDNESDAY, Oct. 2, 2024 -- Scientists say they've discovered a protein that seems crucial to the onset of age-related macular degeneration (AMD), a common cause of blindness in older people.The research is in its very early stages, but it might.

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Science Daily: Pharmacology News

OCTOBER 3, 2024

The extinction of hundreds of bird species caused by humans over the last 130,000 years has led to substantial reductions in avian functional diversity -- a measure of the range of different roles and functions that birds undertake within the environment -- and resulted in the loss of approximately 3 billion years of unique evolutionary history, according to a new study.

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Drug Discovery World

OCTOBER 3, 2024

Bayer AG and Asklepios BioPharmaceutical (AskBio) have announced a new strategic collaboration with Belief BioMed (BBM) to explore the potential for new gene therapies. Under the terms of the contract, the companies will combine efforts and experience in gene therapy technology to explore potential therapies in diseases that may be treatable using a liver-targeted approach.

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BioPharma Drive: Drug Pricing

OCTOBER 3, 2024

Removal of Lilly’s in-demand drugs from the FDA’s shortage list ramps up pressure on the companies selling compounded versions.

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Drugs.com

OCTOBER 1, 2024

TUESDAY, Oct. 1, 2024 -- A new law just passed in California makes it the first state to tell public schools they may no longer serve foods that contain six artificial dyes linked to health and behavior problems among children.Gov. Gavin Newsom.

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Science Daily: Pharmacology News

OCTOBER 3, 2024

According to a new study, colonies of ants began farming fungi when an asteroid struck Earth 66 million years ago. This asteroid impact caused a global mass extinction but also created ideal conditions for fungi to thrive. Innovative ants began cultivating the fungi, creating an evolutionary partnership that became even more tightly intertwined 27 million years ago and continues to this day.

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Drug Discovery World

OCTOBER 2, 2024

The Cystic Fibrosis Antimicrobial Resistance (CF AMR) Syndicate has announced the first cohort of drug discovery projects to receive its Collaborative Discovery Programme (CDP) funding. The £3 ($3.9) million programme, funded by LifeArc, will support six early-stage novel antimicrobial projects over two years to accelerate new treatments for lung infections in people with CF.

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Drug Patent Watch

OCTOBER 1, 2024

In the complex world of intellectual property and pharmaceutical development, understanding the intricacies of patent term extension (PTE) is crucial for innovators and businesses alike. One of the most critical aspects of PTE is calculating the regulatory review period, which can significantly impact the lifespan and profitability of a patented product.

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Drugs.com

OCTOBER 1, 2024

TUESDAY, Oct. 1, 2024 -- Food left in the stomach or stool left in the bowel can impede a doctor's ability to successfully perform an endoscopy or colonoscopy.Now, research finds this scenario is more likely if the patient is taking popular new.

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Science Daily: Pharmacology News

OCTOBER 3, 2024

Government subsidies for business practices and processes should be approached with caution, even when they seem to be environmentally friendly, writes a group of scientists and economists. They argue that subsidies can alter market pressures, leading to unintended consequences that not only perpetuate harmful subsidies over time but also diminish the overall effectiveness of those intended to promote environmental sustainability.

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Drug Discovery World

OCTOBER 2, 2024

Three drugs have been granted ‘rare paediatric disease designation’ (RPDD) in the US by the Food and Drug Administration (FDA). The FDA grants RPDD for serious or life-threatening diseases that affect fewer than 200,000 people in the United States and primarily affect patients less than 18 years of age. ETD001 ETD001 is a novel, first in class blocker of the epithelial sodium channel (ENaC) aimed at treating people with cystic fibrosis (pwCF) without current effective therapies.

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Drug Patent Watch

OCTOBER 1, 2024

Have you ever wondered why some medications seem to cost an arm and a leg, while others are surprisingly affordable? The answer often lies in the complex world of drug patents. Let’s dive into the fascinating realm of pharmaceutical intellectual property and explore when drug patents expire. Drug patents are a crucial aspect of the pharmaceutical industry.

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Drugs.com

OCTOBER 3, 2024

THURSDAY, Oct. 3, 2024 -- Japanese researchers have successfully used a transplant of human stem cells to close a hole in a key part of a monkey's retina. They say the achievement could pave the way for better treatment of small gaps that form in.

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Science Daily: Pharmacology News

OCTOBER 3, 2024

Toddlers in the UK obtain nearly half (47%) of their calories from ultra-processed foods (UPFs), and this rises to 59% by the age of seven, according to a new study. The most common UPFs consumed by the toddlers -- who were 21 months when their parents recorded their diets -- were flavored yogurts and wholegrain breakfast cereals, products typically seen as healthy.

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Drug Discovery World

OCTOBER 4, 2024

News round-up for 30 Sept – 4 Oct by DDW Senior Digital Content Editor Diana Spencer. The theme of the news highlights this week is funding, with companies raising considerable levels of private investment, alongside new funding grants to advance the development of therapeutics for lung infections in cystic fibrosis, paediatric brain cancer, and rare diseases.

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Broad Institute

SEPTEMBER 30, 2024

Q&A: How Terra became a backbone of public health pathogen surveillance By Allessandra DiCorato September 30, 2024 Breadcrumb Home Q&A: How Terra became a backbone of public health pathogen surveillance Bronwyn MacInnis and Daniel Park reflect on how Terra, a scalable and secure open-source platform for biomedical data management and analysis, is making genomics accessible to public health labs.

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Drugs.com

OCTOBER 1, 2024

TUESDAY, Oct. 1, 2024 -- While rare, heart-related side effects sometimes follow a COVID-19 vaccine shot, new research shows that's more than offset by heart-healthy benefits.Folks who are fully vaccinated are significantly less likely to develop.

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