Sat.Sep 28, 2024 - Fri.Oct 04, 2024

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An Alzheimer’s drugmaker is accused of data manipulation. Should its trials be stopped?

BioPharma Drive: Drug Pricing

An experimental Alzheimer’s therapy from Cassava Sciences is still being tested in two Phase 3 studies, even as the company has come under regulatory scrutiny.

Trials 360
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Wastewater bacteria can breakdown plastic for food

Science Daily: Pharmacology News

Comamonadacae is a family of bacteria often found growing on plastics in water. New study finds a bacterium in this family can break down the plastic for food. Researchers also identified the enzyme the bacterium use to degrade plastic. The discovery opens new possibilities for developing bacteria-based engineering solutions to help clean up difficult-to-remove plastic waste.

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This Season's Flu Vaccine Cuts Risk of Hospitalization by Almost 35%

Drugs.com

THURSDAY, Oct. 3, 2024, HealthDay News -- The Southern Hemisphere's flu season is winding down, and new data shows this year's flu shot was 34.5% effective in keeping folks there who got influenza from needing hospital care. Most (68.3%) of those.

Hospitals 290
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Recap of 2024 CDD European Life Science Community Meeting

Collaborative Drug

Celebrating 20 Years of Pioneering Drug Discovery and Collaboration: CDD User Group Meeting.

Science 279
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Kailera Therapeutics emerges from stealth with $400M for obesity drugs

BioPharma Drive: Drug Pricing

The company’s official launch comes five months after major investors such as Atlas Venture and Bain Capital filed a Shanghai stock exchange filing for a biotech named “Hercules CM NewCo.

Drugs 300

More Trending

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GLP-1 Weight-Loss Meds Could Interfere With Endoscopy, Colonoscopy

Drugs.com

TUESDAY, Oct. 1, 2024 -- Food left in the stomach or stool left in the bowel can impede a doctor's ability to successfully perform an endoscopy or colonoscopy.Now, research finds this scenario is more likely if the patient is taking popular new.

Doctors 290
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Webinar Recap: Mastering Research Data Management for Startups

Collaborative Drug

Explore the impact of research data management on biotech R&D.

Research 277
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The top biopharma conferences in 2025

BioPharma Drive: Drug Pricing

Medical meetings often feature important clinical trial results, making them barometers of biotech and pharma companies' research progress. Here’s a list of conferences to watch in 2025.

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2-billion-year-old rock home to living microbes

Science Daily: Pharmacology News

Pockets of microbes have been found living within a sealed fracture in 2-billion-year-old rock. The rock was excavated from the Bushveld Igneous Complex in South Africa, an area known for its rich ore deposits. This is the oldest example of living microbes being found within ancient rock so far discovered. The team involved in the study built on its previous work to perfect a technique involving three types of imaging -- infrared spectroscopy, electron microscopy and fluorescent microscopy -- to

Research 337
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Mpox Vaccine's Protection Wanes Within 1 Year; Boosters Needed

Drugs.com

FRIDAY, Oct. 4, 2024 -- Antibodies provided by mpox vaccination all but disappear within six to 12 months, new research finds, underscoring the need for boosters to maintain strong protection.Mpox -- previously known as monkeypox -- is a.

Vaccine 278
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Multi-tiered chemical proteomic maps of tryptoline acrylamide–protein interactions in cancer cells

Covalent Modifiers

Njomen, E., Hayward, R.E., DeMeester, K.E. et al. Multi-tiered chemical proteomic maps of tryptoline acrylamide–protein interactions in cancer cells. Nat. Chem. (2024). [link] Covalent chemistry is a versatile approach for expanding the ligandability of the human proteome. Activity-based protein profiling (ABPP) can infer the specific residues modified by electrophilic compounds through competition with broadly reactive probes.

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FDA makes end of Zepbound, Mounjaro shortage official

BioPharma Drive: Drug Pricing

Removal of Lilly’s in-demand drugs from the FDA’s shortage list ramps up pressure on the companies selling compounded versions.

FDA 288
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Ant agriculture began 66 million years ago in the aftermath of the asteroid that doomed the dinosaurs

Science Daily: Pharmacology News

According to a new study, colonies of ants began farming fungi when an asteroid struck Earth 66 million years ago. This asteroid impact caused a global mass extinction but also created ideal conditions for fungi to thrive. Innovative ants began cultivating the fungi, creating an evolutionary partnership that became even more tightly intertwined 27 million years ago and continues to this day.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Even Low Levels of Radon May Raise Children's Risk for Leukemia

Drugs.com

FRIDAY, Oct. 4, 2024 — Growing up in a city with pockets of high radon levels, Matthew Bozigar wondered whether the radioactive gas might have anything to do with the high rates of cancer he saw around him, especially in young people. "As an e.

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Activity-Based Acylome Profiling with N-(Cyanomethyl)-N-(phenylsulfonyl)amides for Targeted Lysine Acylation and Post-Translational Control of Protein Function in Cells

Covalent Modifiers

Elizabeth M. Ryan, Michael A. Norinskiy, Amy K. Bracken, Emma E. Lueders, Xueer Chen, Qin Fu, Elizabeth T. Anderson, Sheng Zhang, and Mikail E. Abbasov Journal of the American Chemical Society 2024 DOI: 10.1021/jacs.4c09073 Lysine acylations are ubiquitous and structurally diverse post-translational modifications that vastly expand the functional heterogeneity of the human proteome.

RNA 147
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Roche turns to a startup in search for new breast cancer drugs

BioPharma Drive: Drug Pricing

The Swiss pharma is paying Regor Therapeutics $850 million to buy a pair of prospects it sees as potential successors to blockbuster medicines from Pfizer and Eli Lilly.

Drugs 281
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Bottlenose dolphins 'smile' at each other while playing

Science Daily: Pharmacology News

Dolphins are extremely playful, but little is known about how they -- and other marine mammals -- communicate during playtime. New research shows that bottlenose dolphins (Tursiops truncates) use the 'open mouth' facial expression -- analogous to a smile -- to communicate during social play. The dolphins almost always use the facial expression when they are in their playmate's field of view, and when playmates perceived a 'smile,' they responded in kind 33% of the time.

Research 324
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Scientists Get Closer to Stopping Macular Degeneration

Drugs.com

WEDNESDAY, Oct. 2, 2024 -- Scientists say they've discovered a protein that seems crucial to the onset of age-related macular degeneration (AMD), a common cause of blindness in older people.The research is in its very early stages, but it might.

Research 279
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Isocyanides inhibit bacterial pathogens by covalent targeting of essential metabolic enzymes

Covalent Modifiers

Alexandra Geißler, Howard Junca , Andreas M. Kany , Lena J. Daumann, Anna K. H. Hirsch Dietmar H. Pieper b and Stephan A. Sieber Chem. Sci., 2024 , 15, 11946-11955 [link] Isonitrile natural products, also known as isocyanides, demonstrate potent antimicrobial activities, yet our understanding of their molecular targets remains limited. Here, we focus on the so far neglected group of monoisonitriles to gain further insights into their antimicrobial mode of action (MoA).

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How Roche plans to fill a projected $8B sales gap

BioPharma Drive: Drug Pricing

Biosimilar competition to aging blockbusters will erode a large chunk of the pharma giant’s top line over the next few years.

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Stronger together: miniature robots in convoy for endoscopic surgery

Science Daily: Pharmacology News

Miniature robots on the millimeter scale often lack the strength to transport instruments for endoscopic microsurgery through the body. Scientists are now combining several millimeter-sized TrainBots into one unit and equipping them with improved 'feet'. For the first time, the team was able to perform an electric surgical procedure on a bile duct obstruction experimentally with a robotic convoy.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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California Bans 6 Artificial Dyes in Foods Served at Public Schools

Drugs.com

TUESDAY, Oct. 1, 2024 -- A new law just passed in California makes it the first state to tell public schools they may no longer serve foods that contain six artificial dyes linked to health and behavior problems among children.Gov. Gavin Newsom.

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Models of Life

Codon

2024 Statistical models of organisms have existed for decades. The earliest ones relied on simple linear regression and attempted to correlate genetic variations with observable traits or disease risks — such as drug metabolization rates or cancer susceptibility. As computational power increased and machine learning techniques advanced, the models’ sophistication grew.

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5 FDA decisions to watch in the fourth quarter

BioPharma Drive: Drug Pricing

Over the next three months, the agency could approve a rival to a fast-selling Pfizer heart drug, a much-debated lung cancer medicine and an addition to Vertex's dominant cystic fibrosis business.

FDA 195
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Research in 4 continents links outdoor air pollution to differences in children's brains

Science Daily: Pharmacology News

A research team systematically analyzed 40 empirical studies, the majority of which had found that outdoor air pollution is associated with differences in children's brains. These differences include volumes of white matter, which is associated with cognitive function, connections throughout the brain and even early markers for Alzheimer's.

Research 324
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COVID Shot Lowers Your Odds for COVID-linked Heart Trouble

Drugs.com

TUESDAY, Oct. 1, 2024 -- While rare, heart-related side effects sometimes follow a COVID-19 vaccine shot, new research shows that's more than offset by heart-healthy benefits.Folks who are fully vaccinated are significantly less likely to develop.

Vaccine 278