ASPET

JANUARY 25, 2024

3,4-Methylenedioxymethamphetamine (MDMA) has shown efficacy as a medication adjunct for treating post-traumatic stress disorder (PTSD). However, MDMA is also used in non-medical contexts that pose risk for cardiovascular and neurological complications. It is well established that MDMA exerts its effects by stimulating transporter-mediated release of the monoamines, 5-hydroxytryptamine (5-HT), norepinephrine, and dopamine.

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Drugs Research 184

Science Daily: Pharmacology News

JANUARY 26, 2024

Compared to robots, human bodies are flexible, capable of fine movements, and can convert energy efficiently into movement. Drawing inspiration from human gait, researchers from Japan crafted a two-legged biohybrid robot by combining muscle tissues and artificial materials. This method allows the robot to walk and pivot.

Research 131

Research 131

Broad Institute

JANUARY 22, 2024

Q&A: New approaches are needed to find better cancer drug targets By Allessandra DiCorato January 22, 2024 Breadcrumb Home Q&A: New approaches are needed to find better cancer drug targets Bill Sellers, head of Broad’s Cancer Program, talks about how to discover new classes of genetic dependencies that could move therapies closer to curing cancer patients.

Drugs 128

Drugs Therapies Regulations RNA 128

BioPharma Drive: Drug Pricing

JANUARY 22, 2024

New details of the proposed acquisitions show there were multiple interested buyers, which, according to some analysts, could set the stage for more dealmaking.

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Drugs 128

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Antidote

JANUARY 26, 2024

Colorectal cancer (often shortened simply to colon cancer) is the fourth-most commonly diagnosed cancer in the United States, and it is estimated that around 150,000 Americans are diagnosed each year. While the average age of diagnosis is 66, young adults are getting diagnosed in higher numbers every year, and researchers are still unsure as to why.

Research 122

Research 122

Drugs.com

JANUARY 24, 2024

WEDNESDAY, Jan. 24, 2024 (Healthday News) -- The U.S. Food and Drug Administration has told drugmakers to add a boxed warning to a type of cancer treatment called CAR-T therapy, saying the treatment itself may sometimes cause a secondary.

Therapies 122

Therapies FDA Treatment Drugs 122

BioPharma Drive: Drug Pricing

JANUARY 23, 2024

A black box warning for secondary T cell malignancies should be added to the labeling of all six approved CAR-T therapies, the agency said.

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Therapies FDA 125

Drug Target Review

JANUARY 23, 2024

What innovative approaches and technologies are anticipated to reshape immuno-oncology treatments in 2024? Immuno-oncology, notably through checkpoint inhibitors, has significantly reshaped cancer treatment over the past decade. The current shift focuses on enhancing their efficacy by addressing the crucial need for robust T cell responses, an apparent bottleneck for broader impact.

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Treatment Immune Response Vaccine Therapies 122

Science Daily: Pharmacology News

JANUARY 26, 2024

An interdisciplinary team of researchers has developed a soft implantable device with dozens of sensors that can record single-neuron activity in the brain stably for months.

Research 120

Research 120

Antidote

JANUARY 25, 2024

Recruiting patients for clinical trials is a common challenge for study sponsors conducting research. For this reason, it is often a wise strategy to work with an agency that specializes in outreach. These agencies excel at helping sponsors achieve their research goals within defined timelines and budgets.

Clinical Trials 120

Clinical Trials Trials Research 120

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

BioPharma Drive: Drug Pricing

JANUARY 26, 2024

The opinion would allow Abecma to be prescribed after two standard therapies and is the latest sign of CAR-T’s growing use in earlier cancer treatment.

Therapies 122

Therapies Treatment 122

Drugs.com

JANUARY 25, 2024

THURSDAY, Jan. 25, 2024 -- The maker of Robitussin has recalled eight lots of Robitussin Honey CF Max Day Adult and Robitussin Honey CF Max Nighttime Adult cough syrups.The products, which are made by Haleon, may be contaminated with a.

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Production 119

Science Daily: Pharmacology News

JANUARY 25, 2024

An international group of leading scientists call for an urgent change in the governance of urban expansion as the world's cities continue to grow at unprecedented rates.

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Government International 119

Drug Target Review

JANUARY 26, 2024

Researchers from Columbia University and the US Department of Energy (DOE)’s Brookhaven National Laboratory have elucidated a method to produce large quantities of the receptor that the SARS-CoV-2 spike protein uses to bind to the surface of human cells. Coronaviruses use the homotrimeric spike glycoprotein, comprising a S1 subunit and S2 subunit in each spike monomer, on the envelope to bind to their cellular receptors.

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Production DNA Virus Protein Expression 114

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

BioPharma Drive: Drug Pricing

JANUARY 24, 2024

An 11-year-old boy born deaf can hear after receiving Lilly's genetic medicine. Others, including biotechs in China and Regeneron in the U.S., are taking aim at the same drug target.

Therapies 122

Therapies Treatment Drugs 122

Drugs.com

JANUARY 22, 2024

MONDAY, Jan. 22, 2024 -- Depression affects half of the 6 million Americans who struggle with debilitating heart failure. Now, research shows that two leading modes of treatment -- antidepressants and an approach called behavioral activation.

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Therapies Treatment Research 115

Science Daily: Pharmacology News

JANUARY 26, 2024

Ground-penetrating radar on board NASA's Mars Perseverance rover has confirmed that the Jezero Crater, formed by an ancient meteor impact just north of the Martian equator, once harbored a vast lake and river delta. Over eons, sediment deposition and erosion within the crater shaped the geologic formations visible on the surface today. The discovery of lake sediments reinforces the hope that traces of life might be found in soil and rock samples collected by Perseverance.

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Drug Patent Watch

JANUARY 22, 2024

A recent article published in Health Affairs, delves into the Federal Trade Commission’s (FTC) concerns regarding the inclusion of improper patents in the FDA’s Orange Book by pharmaceutical manufacturers. The… The post Legislative Proposals to Tackle Improper Pharmaceutical Patents in the Orange Book appeared first on DrugPatentWatch - Make Better Decisions.

Pharmaceuticals 114

Pharmaceuticals 114

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

BioPharma Drive: Drug Pricing

JANUARY 22, 2024

Trodelvy didn’t outperform chemotherapy in a large study of people with a common lung tumor, a setback that sent company shares down by double digits.

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Drugs.com

JANUARY 23, 2024

TUESDAY, Jan. 23, 2024 -- If you or someone close to you suffers from severe allergic reactions, you have probably heard there are new recommendations out that offer guidance on the diagnosis, management and treatment of anaphylaxis.The latest.

Treatment 115

Treatment 115

Science Daily: Pharmacology News

JANUARY 25, 2024

The intricate dance of nature often unfolds in mysterious ways, hidden from the naked eye. At the heart of this enigmatic tango lies a vital partnership: the symbiosis between plants and a type of fungi known as arbuscular mycorrhizal (AM) fungi. New groundbreaking research delves into this partnership, revealing key insights that deepen our understanding of plant-AM fungi interactions and could lead to advances in sustainable agriculture.

Research 111

Research 111

Codon

JANUARY 21, 2024

Introduction The intentional infection of human beings with pathogens under study has been going on for centuries. In 1796, an English physician named Edward Jenner inoculated an 8-year-old boy against smallpox with cowpox lesions he retrieved from the hands of a dairymaid. Today, refined versions of these human challenge studies have become standard practice in testing vaccines for vector-borne diseases (e.g., yellow fever, malaria, and dengue), evaluating new drugs or treatments, and studying

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Vaccine Trials Disease Treatment 109

Drug Target Review

JANUARY 25, 2024

Researchers from the Cleveland Clinic, led by Dr Ofer Reizes and Dr Justin Lathia, have developed a therapeutic peptide that disrupts the molecular processes behind aggressive cancer cell growth. These findings offer a novel strategy for developing targeted treatments for triple-negative breast cancer, which currently has no approved options. Dr Reizes, the Laura J Fogarty Endowed Chair for Uterine Cancer Research, commented: “It’s devastating that we currently have such limited options to help

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Treatment Clinical Trials Science Research 105

Drugs.com

JANUARY 24, 2024

WEDNESDAY, Jan. 24, 2024 -- Strange visual disturbances occur early in about 10% of Alzheimer's cases, and when this happens it almost always signals the impending arrival of the disease, a new study finds.The condition is called posterior cortical.

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Disease 114

Science Daily: Pharmacology News

JANUARY 25, 2024

Data gathered through years of observation reveal an innocuous-seeming ant is disrupting an ecosystem in East Africa, illustrating the complex web of interactions among ants, trees, lions, zebras and buffaloes.

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KIF1A

JANUARY 20, 2024

#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. KAND Resources KAND is a complex disorder, and each patient may experience a wide variety of symptoms that require evaluation by different specialists.

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DNA RNA Disease Research 105

Perficient: Drug Development

JANUARY 23, 2024

DI or Dependency Injection is a complex topic, not just in Optimizely CMS, but in general in.net core implementations. Some aspects we get, like the different ways dependencies can be injected and which is better over others, while some leave us scratching our heads. Often times we end up doing a lot of troubleshooting, digging into internal code and finding the right alternatives to DI, to get things to work.

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International Engineering 104

Drugs.com

JANUARY 25, 2024

THURSDAY, Jan. 25, 2024 -- Reiterating a warning first issued in November, the U.S. Food and Drug Administration is urging Americans to stay away from supplements containing tianeptine, known on the street as "gas station heroin.

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Production FDA Drugs 109

Science Daily: Pharmacology News

JANUARY 24, 2024

Scientists have found a way to reprogram T cells to fight aging. After using them to eliminate specific cells in mice, the scientists discovered they lived healthier lives and didn't develop aging-associated conditions like obesity and diabetes. Just one dose provided young mice with lifelong benefits and rejuvenated older mice.

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ASPET

JANUARY 26, 2024

Neuropathic pain is a pressing unmet medical need requiring novel non-opioid based therapeutic approaches. Using unbiased transcriptomic analysis, we found that the expression of Gpr31 , a G protein-coupled receptor, increased in the dorsal horn of the spinal cord in rats with traumatic nerve injury-induced neuropathic pain. Daily intrathecal injections of si Gpr31 reversed behavioral hypersensitivities in a time-dependent manner.

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Small Molecule Drugs 100

Chemical Biology and Drug Design

JANUARY 24, 2024

Compound 9i, a derivative of harmine with anticancer activity, was synthesized and characterized. The results of molecular docking and molecular dynamics simulations the complex (9i and DYRK1A kinase) was compact and stable. In addition, Compound 9i may be useful as a pro-oxidant for cancers caused by Ras over-activation. Abstract Modifications at the harmine (HAM) 9-N position demonstrated effective antitumor activity in previous studies.

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Treatment Research 100

Drugs.com

JANUARY 24, 2024

WEDNESDAY, Jan. 24, 2024 -- Heart disease remains the United States’ top cause of death, but progress is being made and more lives are being saved, a new report finds.There were 931,578 heart-related deaths in 2021, an increase of less than 3,000.

Disease 105

Disease 105

Science Daily: Pharmacology News

JANUARY 24, 2024

Analysis of the remains of 24 individuals from the Wilamaya Patjxa and Soro Mik'aya Patjxa burial sites in Peru shows that early human diets in the Andes Mountains were composed of 80 percent plant matter and 20 percent meat.

Research 105

Research 105