Broad Institute

MARCH 14, 2024

Scientists generate new targeted protein degradation system that tunes a cell’s own proteins By Leah Eisenstadt March 14, 2024 Breadcrumb Home Scientists generate new targeted protein degradation system that tunes a cell’s own proteins Researchers have engineered a compact degron tag that can be precisely edited into a cell’s genome, enabling scientists to trigger the rapid breakdown of native target proteins.

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Science Daily: Pharmacology News

MARCH 14, 2024

A healthier diet is associated with a reduced dementia risk and slower pace of aging, according to a new study. The findings show that a diet-dementia association was at least partially facilitated by multi-system processes of aging. Until now, the biological mechanism of this protection was not well understood.

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BioPharma Drive: Drug Pricing

MARCH 14, 2024

Rezdiffra’s clearance is a turning point in the fight against the liver disease. But its sales potential is unclear, and competition could emerge from popular weight loss drugs.

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Antidote

MARCH 12, 2024

For many people, participating in a research study presents an interesting opportunity with many benefits to volunteering. While there are many types of clinical research, all with distinct goals and timelines, trial volunteers will follow a similar path when taking part. Read on to learn more about the process.

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Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

Drugs.com

MARCH 14, 2024

THURSDAY, March 14, 2024 -- The blockbuster weight-loss medication Zepbound (tirzepatide) appears to help folks quickly shed pounds regardless of how overweight they are, or how long they've lived being overweight or obese. Those are the findings.

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BioPharma Drive: Drug Pricing

MARCH 11, 2024

Publicly traded companies raised nearly $10 billion in follow-on stock offerings in January and February, a financing surge that’s driving a “sector recovery,” the investment bank said.

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Antidote

MARCH 14, 2024

Receiving a multiple sclerosis (MS) diagnosis can feel overwhelming and isolating for many. MS is a neurodegenerative disease that often involves challenging symptoms — but knowing what to expect and what resources are available can help.

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Disease 116

Drugs.com

MARCH 12, 2024

TUESDAY, March 12, 2024 -- Women who've gone through menopause and hope that supplemental vitamin D plus calcium might shield them from disease may be disappointed by new data.A follow-up analysis of data from the landmark Women's Health Initiative.

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Disease 116

Science Daily: Pharmacology News

MARCH 15, 2024

A new study challenges the current model of the universe by showing that, in fact, it has no room for dark matter.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

BioPharma Drive: Drug Pricing

MARCH 14, 2024

The funding for the startup, which partnered with Bristol Myers Squibb last year, adds to a surge of recent investments in developers of antibody-drug conjugates.

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Drug Target Review

MARCH 13, 2024

Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? To be honest, this is something I have never taken the time to reflect on until now. At first thought, I would say my journey in the field of STEM has been an exciting and rewarding experience. However, when I get to really think back on my journey throughout STEM, it has honestly been quite a rollercoaster ride with many bumps along the way.

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Drugs.com

MARCH 11, 2024

MONDAY, March 11, 2024 -- Following disappointing trial results, the maker of a controversial ALS drug may pull the medication off the market. In a statement issued Friday, Amylyx Pharmaceuticals said that Relyvrio failed to help patients in a.

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Science Daily: Pharmacology News

MARCH 13, 2024

The quadrupedal robot ANYmal went back to school and has learned a lot. Researchers used machine learning to teach it new skills: the robot can now climb over obstacles and successfully negotiate pitfalls.

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Research 131

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

BioPharma Drive: Drug Pricing

MARCH 15, 2024

The company expects initial uptake of Rezdiffra, which costs $47,400 per year, to be slow as doctors and insurers establish the protocols needed to find patients eligible for treatment.

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Perficient: Drug Development

MARCH 14, 2024

Last week, I attended TrailblazerDX in San Francisco, where the content was all about Salesforce Data Cloud and AI! There were over 300 sessions to attend, from technical talks to hands-on workshops where attendees could learn how to build copilots and how to use the latest Salesforce platform features directly from product managers , architects, and fellow developers.

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Drugs.com

MARCH 13, 2024

WEDNESDAY, March 13, 2024 — Nurses who specialize in anesthesia have issued new guidelines to reduce the risk that patients taking weight-loss drugs like Ozempic or Wegovy throw up during surgery."These medications have exploded in.

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Science Daily: Pharmacology News

MARCH 13, 2024

Soil stores 80 percent of carbon on earth, yet with increasing cycles of drought, that crucial reservoir is cracking and breaking down, releasing even more greenhouse gases creating an amplified feedback loop that could accelerate climate change.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

BioPharma Drive: Drug Pricing

MARCH 12, 2024

Physicians are preparing for tough conversations with patients on Amylyx Pharmaceuticals’ drug, Relyvrio, while holding out hope it still may help some with the disease.

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Drug Target Review

MARCH 11, 2024

A collaboration between the University of Twente in the Netherlands and Rousselot has revealed the dynamics between biomaterial purity and the fidelity of 3D cancer models. Their joint study illuminated the profound impact of endotoxins on the accuracy and efficacy of these models, marking a significant breakthrough in cancer research. Through experimentation, contrasting research-grade gelatine, inherently infused with endotoxins, with an ultra-low endotoxin-level gelatine, they revealed that t

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Perficient: Drug Development

MARCH 12, 2024

User Acceptance Testing (UAT) is the final stage before launching new functionality. What should be an exciting time can turn to frustration and exhaustion. Over the years, I have found tactics that can improve the UAT outcome. UAT involves key business stakeholders validating the system prior to go-live. My background is primarily around website and portal rebuilds and this focuses on these types of launches.

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Science Daily: Pharmacology News

MARCH 14, 2024

Inspired by the classic drinking bird toy, scientists have developed an engine that efficiently converts energy from water evaporation into electricity to power small electronics. The device produces energy outputs exceeding 100 volts -- much higher than other techniques that generate electricity from water -- and can operate for several days using only 100 milliliters of water as fuel, according to a new study.

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BioPharma Drive: Drug Pricing

MARCH 11, 2024

Justin Klee and Joshua Cohen spoke to BioPharma Dive about the next steps for their company, which is considering pulling its only product from market after the drug failed a confirmatory study in ALS.

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Drug Target Review

MARCH 12, 2024

Scientists from the Skaggs School of Pharmacy and Pharmaceutical Sciences at the University of California San Diego have discovered thousands of bile acids. The study’s findings offer new insights into the biochemical language microbes use to influence distant organ systems, which could revolutionise the way researchers approach disease. Dr Pieter Dorrestein, senior author, professor at the Skaggs School and professor of pharmacology and paediatrics at UC San Diego School of Medicine, stated: “B

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KIF1A

MARCH 9, 2024

#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. Meet our Guest Bloggers! This spring we’ve been quite fortunate to be joined by 6 Master’s students from Columbia University, who have been contributing to our creation of community resources as part of the

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Science Daily: Pharmacology News

MARCH 12, 2024

A large find of dinosaur tracks and fossilized plants and tree stumps in far northwestern Alaska provides new information about the climate and movement of animals near the time when they began traveling between the Asian and North American continents roughly 100 million years ago.

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BioPharma Drive: Drug Pricing

MARCH 14, 2024

Pressed by lawmakers, the lobbying group is also “taking steps” to end its relationship with Wuxi-AppTec, a major contract manufacturer to the biopharmaceutical industry.

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Drugs.com

MARCH 12, 2024

TUESDAY, March 12, 2024 -- They're cheap, easy to buy and now new research shows they have become the buzz of choice for American teens. Delta-8-THC products, which include gummies and vapes, are legal in 22 states and Washington, D.C. There is no.

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