Sat.Jan 25, 2025 - Fri.Jan 31, 2025

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Ventilation in hospitals could cause viruses to spread further

Science Daily: Pharmacology News

Increased use of ventilation and air cleaners, designed to mitigate the spread of viral infections in hospitals, is likely to have unpredictable effects and may cause viral particles to move around more, according to a new study.

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Vertex’s non-opioid pain drug gets FDA approval in milestone for company and research

BioPharma Drive: Drug Pricing

Despite high demand for an option like Journavx, doctors fear the drug’s price could be a major hangup for insurers, potentially limiting patients’ ability to access it.

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FDA Approves Journavx, First New Non-Opioid Pain Pill in Decades

Drugs.com

FRIDAY, Jan. 31, 2025 -- The U.S. Food and Drug Administration (FDA) has approved Journavx, a new pain reliever without the risks of addiction or overdose linked to drugs like Vicodin and OxyContin. The new pill, developed by Vertex.

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Highly Optimized CNS Penetrant Inhibitors of EGFR Exon20 Insertion Mutations

Covalent Modifiers

William McCoull, Clare Thomson, Erin Braybrooke, Christina Chan, Nicola Colclough, Miguel A. Corts Gonzlez, Sabina Cosulich, Nichola L. Davies, Nicolas Floch, Ryan Greenwood, David Hargreaves, Peng Huang, Thomas A. Hunt, Tony Johnson, Peter Johnstrm, Jason G. Kettle, Mikhail Kondrashov, Demetrios H. Kostomiris, Songlei Li, Andrew Lister, Scott Martin, Darren McKerrecher, Neville McLean, J.

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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Ocean-surface warming four times faster now than late-1980s

Science Daily: Pharmacology News

The study helps explain why 2023 and early 2024 saw unprecedented ocean temperatures.

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More Trending

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FDA OK's Ozempic To Protect Kidneys in Type 2 Diabetes Patients

Drugs.com

WEDNESDAY, Jan. 29, 2025 -- A popular diabetes drug just got a major new approval -- and it could be a game-changer for millions of Americans at risk for kidney failure. The U.S. Food and Drug Administration (FDA) has officially approved Ozempic to.

FDA 305
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CDD Vault Update (January 2025) - Release Notes

Collaborative Drug

We are excited to announce a new round of features associated with our Curves Add-on. If you are not yet subscribed to Curves, please contact your CDD Vault account manager or the CDD Vault Support Team to discuss enabling these features in your Vault.

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Global sea level very likely to rise between 0.5 and 1.9 meters by 2100 under high-emissions scenario

Science Daily: Pharmacology News

An interdisciplinary team of researchers has projected that if the rate of global CO2 emissions continues to increase and reaches a high emission scenario, sea levels would as a result very likely rise between 0.5 and 1.9 meters by 2100. The high end of this projection's range is 90 centimeters higher than the latest United Nations' global projection of 0.6 to 1.0 meters.

Research 353
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A new, non-opioid pain drug is here. Getting it to patients could be agony.

BioPharma Drive: Drug Pricing

After decades of research, Vertex Pharmaceuticals now has an approved pain medication. Can one of the world’s most powerful biotechs contend with a healthcare system that’s long favored opioids?

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Vitamin Deficiencies Common in Type 2 Diabetes

Drugs.com

WEDNESDAY, Jan. 29, 2025 -- Hidden hunger -- low levels of essential vitamins or minerals -- is common among people with type 2 diabetes, a new evidence review saysOverall, as many as 45% of type 2 diabetics are suffering multiple deficiencies in.

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Total syntheses of cyclohelminthol I–IV reveal a new cysteine-selective covalent reactive group

Covalent Modifiers

DOI Thomas T. Paulsen, Anders E. Kiib, Gustav J. Wrmer, Stephan M. Hacker and Thomas B. Poulsen Chemical Science, 2025 [link] Biocompatible covalent reactive groups (CRGs) play pivotal roles in several areas of chemical biology and the life sciences, including targeted covalent inhibitor design and preparation of advanced biologic drugs, such as antibodydrug conjugates.

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The big chill: Is cold-water immersion good for our health?

Science Daily: Pharmacology News

In a comprehensive systematic review and meta-analysis, researchers have taken a deep dive into the effects of cold-water immersion on health and wellbeing. Analyzing data from 11 studies with 3177 participants, researchers found that cold-water immersion may lower stress, improve sleep quality, and boost quality of life.

Research 323
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Enhertu, with new FDA OK, set to supplant chemo in HER2-low breast cancer

BioPharma Drive: Drug Pricing

The clearance is a step forward in AstraZeneca and Daiichi Sankyo’s plan to position antibody-drug conjugates like Enhertu ahead of chemotherapy in a variety of tumors.

FDA 317
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Kansas Reports Largest Tuberculosis Outbreak in U.S. History

Drugs.com

TUESDAY, Jan. 28, 2025 -- Kansas health officials are fighting the largest tuberculosis (TB) outbreak in U.S. history, with 67 confirmed cases since new year began.The outbreak includes 60 active cases in Wyandotte County and seven in Johnson.

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When is a Confirmatory Trial “Underway” or Conducted with “Due Diligence” Enough for Accelerated Approval? FDA Explains Its New Authorities

FDA Law Blog: Drug Discovery

By Mark A. Tobolowsky & Charles G. Raver & James E. Valentine We recently blogged about a new December 2024 draft guidance about accelerated approval (the December 2024 draft guidance). That post largely focused on endpoints as well as the broader context for when accelerated approval is appropriate. However, as we note in that post, the design, timing of initiation, and timely conduct of confirmatory trials are also important considerations in FDAs determination of whether accelerated

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Lightsails could reach distant star systems

Science Daily: Pharmacology News

A team of scientists has made the first experimental measurements of laser-induced motions of miniature lightsails in the lab.

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FDA clears use of Ozempic to protect kidney health

BioPharma Drive: Drug Pricing

The approval adds a new indication for GLP-1 drugs and gives Novo an advantage over Lilly’s rival diabetes drug Mounjaro, which hasn’t yet proven it can improve outcomes in kidney disease.

FDA 257
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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CIA Now Backs Lab Leak Theory for COVID-19, But Confidence Remains Low

Drugs.com

MONDAY, Jan. 27, 2025 -- After years of speculation, the CIA has weighed in yet again: A lab leak is now considered the likely origin of the COVID pandemic. However, the agency admits it has "low confidence" in its conclusion and says both a.

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Combination of Metabolomics and Bioinformatics to Reveal the Mechanism of Luteolin in the Treatment of Cervical Cancer

Chemical Biology and Drug Design

The remarkable therapeutic potential of luteolin against cervical cancer can be ascribed to its profound influence on amino acid and nucleotide metabolism, substantiated by the seamless integration of metabolomics, bioinformatics, and molecular docking techniques in this comprehensive investigation. ABSTRACT The incidence of cervical cancer is high among women globally.

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Polar bear population decline the direct result of extended 'energy deficit' due to lack of food

Science Daily: Pharmacology News

U of T Scarborough researchers have directly linked population decline in polar bears living in Western Hudson Bay to shrinking sea ice caused by climate change.

Research 309
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Are we overlooking something critical in cell and gene therapy research?

BioPharma Drive: Drug Pricing

Taking control of O2 — ushering in the future of cell therapy research.

Therapies 245
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Rapid Blood Test Can Improve Stroke Treatment

Drugs.com

FRIDAY, Jan. 31, 2025 -- A rapid blood test could speed treatment for people whove suffered a stroke related to brain bleeding, a new study says.Stroke victims with brain bleeds have nearly seven times higher blood levels of a brain protein called.

Treatment 263
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Polyphyllin VII Enhances the Sensitivity of Prostate Cancer Cells to Docetaxel by Promoting Mitochondrial Dysfunction and Inducing Ferroptosis

Chemical Biology and Drug Design

This study investigates the effects and mechanisms of combining Polyphyllin VII (PPVII) with Docetaxel (DTX) in the treatment of prostate cancer (Pca). Experiments were conducted using DTX-sensitive DU-145 cells and DTX-resistant DU145/DTX cells. The results indicate that PPVII significantly enhanced the inhibitory effect of DTX, reduced cell viability, and promoted apoptosis and cell cycle arrest.

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Low-level traffic air pollution linked to liver damage and fatty liver disease

Science Daily: Pharmacology News

Low levels of traffic-related air pollution harms the liver and may raise the risk of metabolic-associated fatty liver disease, a new study in mice suggests.

Disease 307
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23andMe considers a sale as cash runs low

BioPharma Drive: Drug Pricing

The testing company ended last year with $79 million and told investors it will need to raise money to fund its operations and financial commitments.

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Weight Loss Boosts Long-Term Health of Kids With Obesity

Drugs.com

TUESDAY, Jan. 28, 2025 -- Helping kids with obesity drop pounds can have a huge impact on their future health.When these children and teens lose weight, they are less likely to have type 2 diabetes, high blood pressure and elevated cholesterol as.

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Cover Image

Chemical Biology and Drug Design

Cover Image molekuul_be/Shutterstock.

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