Sat.Oct 28, 2023 - Fri.Nov 03, 2023

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Tracking the FDA’s meeting on Vertex, CRISPR’s sickle cell therapy

BioPharma Drive: Drug Pricing

Expert advisers are reviewing the companies’ case for approval of what could be the first medicine based on the gene editing technology. Follow their discussion here.

Therapies 323
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Humans are disrupting natural 'salt cycle' on a global scale, new study shows

Science Daily: Pharmacology News

A new paper revealed that human activities are making Earth's air, soil and freshwater saltier, which could pose an 'existential threat' if current trends continue. Geologic and hydrologic processes bring salts to Earth's surface over time, but human activities such as mining and land development are rapidly accelerating this natural 'salt cycle.

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New A-Fib Ablation Therapy Benefits Women as Much as Men

Drugs.com

THURSDAY, Nov. 2, 2023 -- A procedure to treat the irregular heart rhythm condition known as atrial fibrillation (a-fib) works just as well for women as it does for men, new research shows. The technology, called pulsed field ablation (PFA), can be.

Therapies 325
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CDD Presenting at COMP Together, November 14 – UCSF Campus

Collaborative Drug

CDD Presenting at COMP Together, November 14 -UCSF campus

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Vertex, CRISPR therapy for sickle cell passes FDA panel test

BioPharma Drive: Drug Pricing

The high-profile meeting focused on the theoretical risks of CRISPR gene editing, as both the FDA and its advisory committee appeared convinced by the efficacy of the companies’ exa-cel treatment.

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More Trending

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New Antibiotic, Zoliflodacin, Seeking Approval, Tackles Drug-Resistant Gonorrhea in Trial

Drugs.com

FRIDAY, Nov. 3, 2023 -- The first new antibiotic for gonorrhea — the second most common sexually transmitted disease — has shown promise in a clinical trial. That news should come as a relief to public health experts, because gonorrhea.

Trials 317
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Upcoming Webinar: FAIR (meta)-Data & Assay Annotation

Collaborative Drug

Upcoming Webinar 12-08-23: FAIR (meta)-Data & Assay Annotation

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Moderna adjusts to changing outlook for COVID vaccine demand

BioPharma Drive: Drug Pricing

The company recorded a net loss in the third quarter as it “resizes” its manufacturing footprint, and now expects revenue to come in at low end of its previous guidance.

Vaccine 300
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Protein interaction causing rare but deadly vaccine-related clotting found

Science Daily: Pharmacology News

A mechanism that led some patients to experience cases of deadly clotting following some types of Covid-19 vaccination has been identified in new research.

Vaccine 267
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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More Eyedrops Recalled Due to Infection Danger

Drugs.com

THURSDAY, Nov. 2, 2023 -- Cardinal Health, Inc. is voluntarily recalling certain LEADER brand eyedrops because they may cause eye infections. The U.S. Food and Drug Administration informed the Dublin, Ohio, company that agency investigators found.

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Drug Discovery Industry Roundup with Barry Bunin — November 3, 2023

Collaborative Drug

Drug Discovery Industry Roundup with Barry Bunin — November 3, 2023

Drugs 288
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Novo, Lilly buoyed by fast-growing GLP-1 drug sales

BioPharma Drive: Drug Pricing

The rival companies reported strong quarterly sales growth for their latest products, which could face off as weight loss treatments next year.

Treatment 287
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Rats have an imagination, new research suggests

Science Daily: Pharmacology News

Researchers have developed a novel system to probe a rat's thoughts, finding that animals can control their brain activity to imagine remote locations.

Research 264
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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COVID Meds Like Paxlovid Will Soon Have Big Price Tags

Drugs.com

MONDAY, Oct. 30, 2023 -- Americans have been getting COVID treatments such as Paxlovid for free, but that’s about to end. The medications will enter the private market this week, the Associated Press reported. The price for a five-day course.

Treatment 279
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CDD Vault Update (November 2023)

Collaborative Drug

Handling Non-Numeric Values in a Data Import File Often, data files which are being imported into CDD Vault will contain certain text values in columns that are being mapped to numeric fields/readouts. Examples include “ND” for “Not Determined” or “N/A” for “Not Applicable”.

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Sarepta gene therapy for Duchenne misses main goal of key study

BioPharma Drive: Drug Pricing

Yet Sarepta said it still plans to ask the FDA to expand regulatory clearance of Elevidys, which was granted an accelerated approval by the FDA in June.

Therapies 277
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Nanowire 'brain' network learns and remembers 'on the fly'

Science Daily: Pharmacology News

Like a collection of 'Pick Up Sticks', this neural network has passed a critical step for developing machine intelligence. For the first time, a physical neural network has successfully been shown to learn and remember 'on the fly', in a way inspired by and similar to how the brain's neurons work. The result opens a pathway for developing efficient and low-energy machine intelligence for more complex, real-world learning and memory tasks.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Study Confirms Effectiveness of Newer Arthritis Meds, JAK inhibitors

Drugs.com

WEDNESDAY, Nov. 1, 2023 -- Newer oral medications for rheumatoid arthritis (RA) do work quite well in the "real world," despite some doubts that they would, according to a new study. The study, of 622 adults with RA, found that most were doing well.

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CDD Vault Update (October 2023)

Collaborative Drug

Visualization: Highlight/Star Your Favorite Molecules Users may now select/star “favorite” Molecules in a CDD Vault Visualization session.

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Sangamo to cut jobs again with planned business overhaul

BioPharma Drive: Drug Pricing

The gene therapy company will move headquarters and reduce its workforce by 40%, while seeking partners for its Fabry and cell therapy research.

Therapies 273
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The remains of an ancient planet lie deep within Earth

Science Daily: Pharmacology News

The remnants of an ancient planet that collided with Earth to form the Moon lie deep within the earth, according to a new model.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Too Much Salt Could Raise Your Odds for Diabetes

Drugs.com

FRIDAY, Nov. 3, 2023 -- Put down the saltshaker — especially if you’re at risk of type 2 diabetes. While the condition brings to mind the need to avoid sugar, a new study links it to frequent salt consumption. “We already know.

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Pervasive aggregation and depletion of host and viral proteins in response to cysteine-reactive electrophilic compounds

Covalent Modifiers

Ashley R Julio, Flowreen Shikwana, Cindy Truong, Nikolas R Burton, Emil Dominguez, Alexandra Turmon, Jian Cao, Keriann Backus bioRxiv 2023.10.30.564067; doi: [link] Protein homeostasis is tightly regulated, with damaged or misfolded proteins quickly eliminated by the proteasome and autophagosome pathways. By co-opting these processes, targeted protein degradation technologies enable pharmacological manipulation of protein abundance.

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BioMarin to replace CEO Bienaimé with Genentech veteran

BioPharma Drive: Drug Pricing

The rare disease drug developer is turning to former Genentech head Alexander Hardy as the launch of its Roctavian gene therapy stumbles.

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In a surprising finding, light can make water evaporate without heat

Science Daily: Pharmacology News

At the interface of water and air, light can, in certain conditions, bring about evaporation without the need for heat, according to a new study.

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Simple Antibiotic Switch for Pneumonia Patients Could Prevent Hospital Infection

Drugs.com

THURSDAY, Nov. 2, 2023 -- A new study on Clostridioides difficile infections finds that choosing an alternative antibiotic for high-risk patients with pneumonia can reduce infection risk. C. diff infections can be deadly, and they are often.

Hospitals 264