Sat.Sep 14, 2024 - Fri.Sep 20, 2024

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Moderate coffee and caffeine consumption is associated with lower risk of developing multiple cardiometabolic diseases, new study finds

Science Daily: Pharmacology News

Consuming moderate amounts of coffee and caffeine regularly may offer a protective effect against developing multiple cardiometabolic diseases, including type 2 diabetes, coronary heart disease and stroke, according to new research.

Disease 362
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Can the Fed’s rate cut change biotech’s ‘new normal’?

BioPharma Drive: Drug Pricing

Industry insiders hope the Fed’s decision to cut rates for the first time in years will boost biotech investment. But the long-awaited move won’t cure all that ails the sector, others cautioned.

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Polluting Puff: Asthma Inhalers Are Big Contributors to Climate Change

Drugs.com

MONDAY, Sept. 16, 2024 -- Tiny puffs from asthma inhalers could be causing big climate problems for Mother Earth, a new study warns.Each inhaler dose contains some of the most potent greenhouse gases known, and they are adding up, researchers.

Research 299
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The Complexity of Collaboration in Drug Discovery

Collaborative Drug

In a recent webinar, Janice Darlington from Collaborative Drug Discovery (CDD) with Tamsin Mansley from Optibrium discussed the importance of collaboration in drug discovery and showcased how their software platforms, CDD Vault and StarDrop , can enhance collaborative efforts.

Drugs 264
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Genetic tracing at the Huanan Seafood market further supports COVID animal origins

Science Daily: Pharmacology News

A new study provides a list of the wildlife species present at the market from which SARS-CoV-2, the virus responsible for the COVID-19 pandemic, most likely arose in late 2019. The study is based on a new analysis of metatranscriptomic data released by the Chinese Center for Disease Control and Prevention (CDC). The data come from more than 800 samples collected in and around the Huanan Seafood Wholesale market beginning on January 1, 2020, and from viral genomes reported from early COVID-19 pa

Marketing 333

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Ozempic Could Curb Progression of Diabetes-Linked Liver Disease

Drugs.com

MONDAY, Sept. 16, 2024 -- Fatty liver disease linked to diabetes and obesity can easily progress to liver cirrhosis, but new research suggests that GLP-1 medicines like Ozempic can help stop that. In a new decades-long study, veterans with diabetes.

Disease 299
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Selective Covalent Inhibiting JNK3 by Small Molecules for Parkinson's Diseases

Covalent Modifiers

Liang Ouyang, Wen Shuai, Panpan Yang, Huan Xiao, Yumeng Zhu, Faqian Bu, Aoxue Wang, Qiu Sun, Guan Wang Angewandte Chemie 2024 e202411037 [link] c-Jun N-terminal kinases (JNKs) including JNK1/2/3 are key members of mitogen-activated protein kinase family. Wherein JNK3 is specifically expressed in brain and emerges as therapeutic target, especially for neurodegenerative diseases.

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Scientists turn to human skeletons to explore origins of horseback riding

Science Daily: Pharmacology News

A new, wide-ranging exploration of human remains casts doubt on a long-standing theory in archaeology known as the Kurgan hypothesis -- which, among other claims, suggests that humans first domesticated horses as early as the fourth millennium B.C.

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ADC developed by Daiichi, Merck outperforms chemo in lung cancer trial

BioPharma Drive: Drug Pricing

The FDA previously rejected patritumab deruxtecan over manufacturing issues. Tuesday's study data should boost the companies' case, however.

Trials 294
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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FDA Approves First Flu Vaccine You Give Yourself at Home

Drugs.com

FRIDAY, Sept. 20, 2024 -- The days of waiting for a flu shot at your doctor's office or local pharmacy may be over: The U.S. Food and Drug Administration on Friday approved FluMist nasal spray as the first influenza vaccine that can be.

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Development of ketalized unsaturated saccharides as multifunctional cysteine-targeting covalent warheads

Covalent Modifiers

Dong, S., Huang, H., Li, J. et al. Commun Chem 7 , 201 (2024). [link] Multi-functional cysteine-targeting covalent warheads possess significant therapeutic potential in medicinal chemistry and chemical biology. Herein, we present novel unsaturated and asymmetric ketone (oxazolinosene) scaffolds that selectively conjugate cysteine residues of peptides and bovine serum albumin under normal physiological conditions.

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Some diabetes drugs tied to lower risk of dementia, Parkinson's disease

Science Daily: Pharmacology News

A class of drugs for diabetes may be associated with a lower risk of dementia and Parkinson's disease, according to a new study.

Disease 323
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Nura Bio gets another $68M, new CEO to advance ‘neuroprotective’ brain drugs

BioPharma Drive: Drug Pricing

The funding will support mid-stage testing of a drug the company believes to have the potential to treat a range of neurodegenerative conditions.

Drugs 288
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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FDA Expands Use of Breast Cancer Drug Kisqali

Drugs.com

WEDNESDAY, Sept. 18, 2024 -- Women with early stage breast cancer may now take Kisquali, a medication already approved for advanced disease, following the U.S. Food and Drug Administration's expanded approval of the treatment, drug maker Novartis.

FDA 290
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Efficacy of Fluoxetine and (R,S) Ketamine in Attenuating Conditioned Fear Behaviors in Male Mice [Behavioral Pharmacology]

ASPET

Post-traumatic stress disorder (PTSD) is caused by exposure to a traumatic or stressful event. Symptoms related to this disorder include persistent re-experiencing of memories and fear generalization. Current pharmacological treatments for PTSD are insufficient, with fewer than 30% of patients reporting symptom remission. This study aims to determine the efficacy of acute ( R,S) ketamine and chronic fluoxetine (FLX) in reducing fear memory and fear generalization.

Treatment 190
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Breakthrough study predicts catastrophic river shifts that threaten millions worldwide

Science Daily: Pharmacology News

Researchers have uncovered key insights into the dangerous phenomenon of 'river avulsion,' offering a way to predict when and where rivers may suddenly and dramatically change course.

Research 322
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Apellis eye drug again turned back in Europe

BioPharma Drive: Drug Pricing

The decision against Syfovre’s approval follows efforts by Apellis to have reviewers reevaluate clinical evidence multiple times and, according to an analyst, will lead to a restructuring of the company’s operations in Europe.

Drugs 280
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Expert Advice on Preparing for the Fall COVID, Flu Season

Drugs.com

MONDAY, Sept. 16, 2024 -- People should prepare for the fall cold and flu season by getting the updated influenza and COVID-19 vaccinations, an infectious diseases expert says.“When my patients ask me if they should be getting a COVID vaccine this y.

Vaccine 290
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Evaluating the potential for psilocybin as a treatment for post-traumatic stress disorder [Minireview]

ASPET

Post-traumatic stress disorder (PTSD) is a debilitating psychiatric condition that develops following exposure to a traumatic event. Individuals with this condition experience numerous physiological and behavioral alterations, including intrusive memories, avoidance of trauma-related stimuli, heightened anxiety, hypervigilance, impaired cognition, elevated resting heart rate and blood pressure, and altered neuroendocrine function, to name a few.

Treatment 189
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Beneath the brushstrokes, van Gogh's sky is alive with real-world physics

Science Daily: Pharmacology News

Van Gogh's brushstrokes in 'The Starry Night' create an illusion of sky movement so convincing it led researchers to wonder how closely it aligns with the physics of real skies. Marine sciences and fluid dynamics specialists analyzed the painting to uncover what they call the hidden turbulence in the artwork. They used brushstrokes to examine the shape, energy, and scaling of atmospheric characteristics of the otherwise invisible atmosphere and used the relative brightness of the varying paint c

Science 321
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Ascendis trial data piles pressure on BioMarin

BioPharma Drive: Drug Pricing

Summary study results show Ascendis’ drug for achondroplasia could be competitive to BioMarin's Voxzogo, which is the foundation of the latter company's growth plans.

Trials 268
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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FDA Approves First Flu Vaccine You Give Yourself at Home, FluMist

Drugs.com

FRIDAY, Sept. 20, 2024 -- The days of waiting for a flu shot at your doctor's office or local pharmacy may be over: The U.S. Food and Drug Administration on Friday approved FluMist nasal spray as the first influenza vaccine that can be.

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CDD Vault Update (September 2024 #2) - Release Notes

Collaborative Drug

Create ELN Templates: Templates are a great way to provide organization and uniformity to ELN entries, saving users time and ensuring data is easily digestible. Once an entry is ready to become a template, your Vault Administrator can publish it by clicking the template icon at the top of the page. Provide a name, decide which specific ELN fields should be included and whether to make them required or optional.

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Over nearly half a billion years, Earth's global temperature has changed drastically, driven by carbon dioxide

Science Daily: Pharmacology News

A new study offers the most detailed glimpse yet into how Earth's surface temperature has changed over the past 485 million years. The data show that Earth has been and can be warmer than today -- but humans and animals cannot adapt fast enough to keep up with human-caused climate change.

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Startup from George Church’s lab raises $75M to develop ‘supercell’ medicines

BioPharma Drive: Drug Pricing

GC Therapeutics claims it can create off-the-shelf therapies from induced pluripotent stem cells faster than by current methods with a simpler process.

Therapies 258
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Millions Worldwide Could Die From Antibiotic-Resistant Infections, Report Finds

Drugs.com

TUESDAY, Sept. 17, 2024 -- Millions more people will die annually from antibiotic-resistant infections over the next 25 years unless steps are taken to counter this growing health threat, a new study warns.The number of deaths linked to.

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