Drug Discovery World

SEPTEMBER 20, 2024

The DDW Fall issue asks if the gut microbiome can unlock new therapeutics for mental health disorders, places a spotlight on oncology, and includes an exclusive guide on the benefits and advances in cell line development. Other features in the Fall issue include: Beyond CRISPR–what anew tool offers gene editing How the UK could become a leader in cannabinoid research How mRNA’s tiny cousin could treat thousands of rare diseases DDW FALL 2024 The post DDW Fall 2024 appeared first on Drug Discover

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Science Daily: Pharmacology News

SEPTEMBER 17, 2024

Consuming moderate amounts of coffee and caffeine regularly may offer a protective effect against developing multiple cardiometabolic diseases, including type 2 diabetes, coronary heart disease and stroke, according to new research.

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BioPharma Drive: Drug Pricing

SEPTEMBER 19, 2024

Industry insiders hope the Fed’s decision to cut rates for the first time in years will boost biotech investment. But the long-awaited move won’t cure all that ails the sector, others cautioned.

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Chemical Biology and Drug Design

SEPTEMBER 16, 2024

This study identified MAPK9 as the directly binding target of baicalein by the DNA-programmed affinity labeling method and tested the binding affinity as 89.7 nM by surface plasmon resonance. Baicalein stabilized MAPK9 to induce apoptosis in hepatocarcinoma cells, which would be helpful to understand and use baicalein in hepatocarcinoma therapy. ABSTRACT Hepatocellular carcinoma (HCC) is a significant global health concern.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Drug Discovery World

SEPTEMBER 20, 2024

A new multinational clinical trial will investigate whether a novel treatment can help slow the progression of chronic kidney disease (CKD). The EASi-KIDNEY trial will evaluate whether vicadrostat, also known as BI 690517, improves clinical outcomes when it is given in combination with existing treatments. The trial will run in 15-20 countries around the world, with around 11,000 people expected to participate.

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Science Daily: Pharmacology News

SEPTEMBER 20, 2024

A new, wide-ranging exploration of human remains casts doubt on a long-standing theory in archaeology known as the Kurgan hypothesis -- which, among other claims, suggests that humans first domesticated horses as early as the fourth millennium B.C.

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BioPharma Drive: Drug Pricing

SEPTEMBER 20, 2024

The decision against Syfovre’s approval follows efforts by Apellis to have reviewers reevaluate clinical evidence multiple times and, according to an analyst, will lead to a restructuring of the company’s operations in Europe.

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Drug Discovery World

SEPTEMBER 17, 2024

DDW’s Megan Thomas looks at a day in the life of Liam Tremble, Principal Scientist at Poolbeg Pharma. 1. Where do you work, and can you tell us what you’re working on at the moment?  I work at Poolbeg Pharma, where we are developing novel treatments for diseases with unmet medical needs and large addressable markets, with programmes in oncology, infectious diseases and endocrinology.

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Science Daily: Pharmacology News

SEPTEMBER 19, 2024

A new study provides a list of the wildlife species present at the market from which SARS-CoV-2, the virus responsible for the COVID-19 pandemic, most likely arose in late 2019. The study is based on a new analysis of metatranscriptomic data released by the Chinese Center for Disease Control and Prevention (CDC). The data come from more than 800 samples collected in and around the Huanan Seafood Wholesale market beginning on January 1, 2020, and from viral genomes reported from early COVID-19 pa

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Drugs.com

SEPTEMBER 16, 2024

MONDAY, Sept. 16, 2024 -- Tiny puffs from asthma inhalers could be causing big climate problems for Mother Earth, a new study warns.Each inhaler dose contains some of the most potent greenhouse gases known, and they are adding up, researchers.

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Research 119

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Perficient: Drug Development

SEPTEMBER 18, 2024

This post is the second in a series of four about estimating project hours. Part 1: Sandbagging & Lowballing Part 2: Dependencies & Creep Coming Soon: Part 3: Assumptions & Uncertainty Part 4: The Emotional Conclusion Continuing our dive into project estimating, let’s talk about two more problem areas: dependencies and project creep. These two can turn your pristine project plan into a tangled mess.

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Production 116

Drug Discovery World

SEPTEMBER 20, 2024

Kyverna Therapeutics has revealed continued positive results for its CAR-T therapy KYV-101 in B cell-driven autoimmune diseases. The clinical trial results and case studies were presented in posters and a company-sponsored symposium at the 40 th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS). The case reports demonstrate disease modification across trials and durability in some patients extending beyond one year and a well-tolerated safety profile.

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Science Daily: Pharmacology News

SEPTEMBER 19, 2024

Researchers have uncovered key insights into the dangerous phenomenon of 'river avulsion,' offering a way to predict when and where rivers may suddenly and dramatically change course.

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Drugs.com

SEPTEMBER 16, 2024

MONDAY, Sept. 16, 2024 -- Fatty liver disease linked to diabetes and obesity can easily progress to liver cirrhosis, but new research suggests that GLP-1 medicines like Ozempic can help stop that. In a new decades-long study, veterans with diabetes.

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

BioPharma Drive: Drug Pricing

SEPTEMBER 15, 2024

Final follow-up results suggest Opdivo and Yervoy could be close to a cure for some people with advanced melanoma, shifting how doctors administer follow-up care.

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Drug Discovery World

SEPTEMBER 19, 2024

Arsenal Biosciences has closed an oversubscribed $325 million Series C financing round to support its development of CAR T-cell therapies for solid tumours. The funding round included new investors ARCH Venture Partners, Milky Way Investments Group, Regeneron Ventures, NVentures (NVIDIA’s venture capital arm), Luma Group, funds and accounts advised by T Rowe Price Associates, Rock Springs Capital, among others.

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Science Daily: Pharmacology News

SEPTEMBER 17, 2024

Van Gogh's brushstrokes in 'The Starry Night' create an illusion of sky movement so convincing it led researchers to wonder how closely it aligns with the physics of real skies. Marine sciences and fluid dynamics specialists analyzed the painting to uncover what they call the hidden turbulence in the artwork. They used brushstrokes to examine the shape, energy, and scaling of atmospheric characteristics of the otherwise invisible atmosphere and used the relative brightness of the varying paint c

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Science Research 122

Drugs.com

SEPTEMBER 18, 2024

WEDNESDAY, Sept. 18, 2024 -- Women with early stage breast cancer may now take Kisquali, a medication already approved for advanced disease, following the U.S. Food and Drug Administration's expanded approval of the treatment, drug maker Novartis.

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Antidote

SEPTEMBER 16, 2024

Receiving a Parkinson’s diagnosis is a life-altering event that nearly 1 million people in the United States have experienced. Parkinson’s disease symptoms can vary from person to person. Receiving a diagnosis often requires several steps. In this blog, we’ll be sharing more details about the disease and discussing opportunities for individuals to get involved in Parkinson’s research.

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Drug Discovery World

SEPTEMBER 19, 2024

Scientists have pinpointed thousands of genetic changes in a gene that may increase a person’s risk of developing breast and ovarian cancer and also identified new potential therapeutic targets. Researchers from the Wellcome Sanger Institute and their collaborators focused on the ‘cancer protection’ gene RAD51C, known to increase ovarian cancer risk six-fold and risk of aggressive subtypes of breast cancer four-fold.

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Science Daily: Pharmacology News

SEPTEMBER 19, 2024

A new study offers the most detailed glimpse yet into how Earth's surface temperature has changed over the past 485 million years. The data show that Earth has been and can be warmer than today -- but humans and animals cannot adapt fast enough to keep up with human-caused climate change.

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Drugs.com

SEPTEMBER 20, 2024

FRIDAY, Sept. 20, 2024 -- The days of waiting for a flu shot at your doctor's office or local pharmacy may be over: The U.S. Food and Drug Administration on Friday approved FluMist nasal spray as the first influenza vaccine that can be.

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BioPharma Drive: Drug Pricing

SEPTEMBER 17, 2024

Summary study results show Ascendis’ drug for achondroplasia could be competitive to BioMarin's Voxzogo, which is the foundation of the latter company's growth plans.

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Drug Discovery World

SEPTEMBER 18, 2024

Scientists have discovered that a protein linked to prostate cancer is associated with more aggressive disease and could be a new target for treatment. The team at The Institute of Cancer Research, London, UK, have shown that the BCL2 protein was abundant in a subtype of advanced prostate cancer which has stopped responding to hormone therapy. The researchers estimate that around 10% of people with prostate cancer have high levels of this protein.

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Science Daily: Pharmacology News

SEPTEMBER 19, 2024

An international group of researchers says two decades of research have generated sufficient knowledge about the sources and effects of microplastics to allow world leaders to agree measures to address them. The argument comes 20 years after the first ever study to coin the term microplastics to describe the microscopic fragments of plastics in our ocean.

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Drugs.com

SEPTEMBER 20, 2024

FRIDAY, Sept. 20, 2024 -- Doctors sometimes turn to antidepressants as a means of easing older people's physical pain, but a new expert review finds there's little evidence to support the practice.Antidepressants may even come with hazards for.

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BioPharma Drive: Drug Pricing

SEPTEMBER 17, 2024

The FDA previously rejected patritumab deruxtecan over manufacturing issues. Tuesday's study data should boost the companies' case, however.

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Drug Discovery World

SEPTEMBER 17, 2024

The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. This week, DDW has opened registrations for its webinar ‘ The latest advancements driving neuroscience drug discovery research ’, so our news highlights focus on developments in neuroscience, including a novel drug that has been shown to reduce neuronal death, and a potential disease-modi

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Science Daily: Pharmacology News

SEPTEMBER 16, 2024

An experiment tested six generative large language models against students in an online introductory biomedical and health informatics course. The models scored higher than as many as three quarters of the real-world students in the class.

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Research 119

Drugs.com

SEPTEMBER 16, 2024

MONDAY, Sept. 16, 2024 -- People should prepare for the fall cold and flu season by getting the updated influenza and COVID-19 vaccinations, an infectious diseases expert says.“When my patients ask me if they should be getting a COVID vaccine this y.

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BioPharma Drive: Drug Pricing

SEPTEMBER 17, 2024

The funding will support mid-stage testing of a drug the company believes to have the potential to treat a range of neurodegenerative conditions.

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Drug Discovery World

SEPTEMBER 17, 2024

Dorte Gram, founder of Pila Pharma and a former Novo Nordisk researcher who identified the molecule that became semaglutide, the active ingredient in Ozempic and Wegovy, has raised 10 million SEK ($980,320) for a novel obesity-related study. The money will allow the company to study drug tolerance and the effects of the company’s molecule on obesity in a Phase IIa study.

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Science Daily: Pharmacology News

SEPTEMBER 19, 2024

By staring into the hellish landscape of Jupiter's moon Io -- the most volcanically active location in the solar system -- astronomers have been able to study a fundamental process in planetary formation and evolution: tidal heating.

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Drugs.com

SEPTEMBER 20, 2024

FRIDAY, Sept. 20, 2024 -- Controversial fentanyl lollipops and similar products will no longer be made by drug makers, the U.S. Food and Drug Administration has announced.Known as TIRF medications, these products contain fentanyl and are used to.

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