Forbes: Drug Truths

SEPTEMBER 11, 2023

But, make no mistake – the IRA will have a major impact on biopharma R&D and, as a result, fewer important medicines will be available.

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Drug Discovery World

SEPTEMBER 15, 2023

Advanced Therapies Europe took place from 9-12 September 2023 in Portugal. DDW’s Megan Thomas asked attendees: What is most important to scale from discovery to commercialisation of cell and gene therapies (CGTs)? Joel Eichmann, Co-Founder, Green Elephant Biotech It always comes down to time-to-market and risk minimisation. To cover these, it is critical to choose [.

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addgene Blog

SEPTEMBER 12, 2023

Primer design. Plasmid mapping. DNA sequence analysis. We all have our favorite tools for tackling these particular tasks, but they tend to be scattered about the internet. To help you keep your virtual molecular biology toolbox organized, today’s post features a list of free online molecular biology tools all in one place.

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Broad Institute

SEPTEMBER 10, 2023

New machine learning techniques boost predictions for virtual drug screening with less data By Corie Lok September 10, 2023 Breadcrumb Home New machine learning techniques boost predictions for virtual drug screening with less data Schmidt Center researchers have found a way to improve kernel methods, which are a simpler alternative to neural networks, for biomedical applications.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

Forbes: Drug Truths

SEPTEMBER 11, 2023

But, make no mistake – the IRA will have a major impact on biopharma R&D and, as a result, fewer important medicines will be available.

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Drug Discovery World

SEPTEMBER 14, 2023

Ernesto Staroswiecki, Senior Manager, R&D, at Beckman Coulter Life Sciences takes readers through common lab automation myths. Many clinical and research laboratories today are having to do more with less: faced with ongoing staffing shortages, increased workloads, and budgetary constraints, many laboratory managers are feeling the stress, which is where the benefits of automation can be truly realised for labs in both academia and industry.

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Drugs.com

SEPTEMBER 15, 2023

FRIDAY, Sept. 15, 2023 -- Good oral health is one of the keys to healthy aging, but a sobering new study shows that many U.S. nursing home residents have significant dental issues. Close to two in every 10 residents have missing teeth, about 8%.

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Antidote

SEPTEMBER 14, 2023

Alzheimer’s disease, the most prevalent type of dementia , is diagnosed in more than 6 million Americans. Estimates project that by 2050, 13 million individuals will be diagnosed with Alzheimer’s disease. This condition ranks among the top 10 causes of death in the United States, profoundly impacting those diagnosed, their loved ones, and their caregivers.

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Drug Discovery World

SEPTEMBER 12, 2023

Twist Bioscience and Ono Pharmaceutical will combine their efforts to discover and develop novel antibodies for the treatment of autoimmune diseases. Under the terms of the agreement, Twist will use its ‘Library of Libraries’ to conduct research activities to discover novel antibodies against targets identified by Ono. Twist also recently entered a research collaboration with Cancer Research Horizons.

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BioPharma Drive: Drug Pricing

SEPTEMBER 11, 2023

Pfizer and Moderna, which have seen slowing demand for their coronavirus vaccines, expect to make the reformulated shots available in the U.S. in the coming days.

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Clinical Trials

Drugs.com

SEPTEMBER 14, 2023

THURSDAY, Sept. 14, 2023 -- An oral vaccine for COVID-19 appears to produce the sort of immune response that could quickly stamp out a developing infection, according to results from a small-scale primate study. Some monkeys given an experimental.

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Drug Target Review

SEPTEMBER 11, 2023

Cancer cells can elude the body’s immune defences by manipulating a group of molecules known as mucins, which are typically helpful and widespread. Mucins are proteins covered in sugar that primarily protect the body against physical harm and pathogens. However, cancer cells exploit mucins to support their survival. While the concept of removing mucins from cancer cells seems promising, mucins are present in various forms on all mammalian cells.

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Drug Discovery World

SEPTEMBER 14, 2023

In the In Conversation With series, a part of the free DDW podcast, DDW speaks with members of the drug discovery industry about their work and how it helps turn science into business. In this episode, Megan Thomas is in conversation with Shelley Ackerman, a biological engineer turned immunologist with a passion for drug discovery and development.

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BioPharma Drive: Drug Pricing

SEPTEMBER 12, 2023

Arialys Therapeutics launched Tuesday with $58 million in funding from a group of life sciences investors that includes Johnson & Johnson’s venture arm.

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Drugs.com

SEPTEMBER 13, 2023

WEDNESDAY, Sept. 13, 2023 -- Using both tobacco and marijuana is tied to significantly higher odds for depression and anxiety, a new study suggests. Among nearly 54,000 U.S. adults, those who used both substances experienced anxiety or depression.

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biobide

SEPTEMBER 15, 2023

Pesticides are a vital tool in safeguarding the world’s food supply. The need to protect crops from pests, disease, and weeds has existed for centuries, with the Roman’s having used ash, crushed cypress leaves and diluted urine to protect their crops. Nowadays, pest control methods and the chemicals used are a great deal more sophisticated. It is estimated that without crop protection, which includes the use of pesticides, half of the world’s food crops would be lost.

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Drug Discovery World

SEPTEMBER 14, 2023

As the second quarter of 2023 draws to a close, DDW’s Megan Thomas reviews key updates and results from three top pharmaceutical companies. Business updates Pfizer reported second quarter 2023 revenues totalling $12.7 billion, a decrease of $15.0 billion, or 54%, compared to the prior year quarter, reflecting an operational decline of $14.7 billion, or 53%, primarily due to a decrease in Paxlovid and Comirnaty revenues globally, as well as an unfavorable impact of foreign exchange of $283 mil

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Crown Bioscience

SEPTEMBER 13, 2023

The incidence of pancreatic cancer has been rising by about 1% per year over the past few decades, and it now accounts for ~3% of all cancers and 7% of cancer mortality in the U.S. Pancreatic cancer is now the third leading cause of cancer-related death, and it is exceptionally lethal in part because it is challenging to detect at an early stage. By the time signs and symptoms appear, the disease has often already reached an advanced stage and metastasized.

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Disease 111

Drugs.com

SEPTEMBER 11, 2023

MONDAY, Sept. 11, 2023 -- The U.S. Food and Drug Administration on Monday gave the green light to new COVID boosters for Americans, setting the stage for the updated vaccines to become available within days. The COVID-19 shots from Pfizer and.

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FDA Approval FDA Vaccine Drugs 119

Broad Institute

SEPTEMBER 10, 2023

Broad Institute welcomes Kedrick Perry as new Chief Equity Officer By Corie Lok September 11, 2023 Breadcrumb Home Broad Institute welcomes Kedrick Perry as new Chief Equity Officer A proven leader in diversity, equity, and inclusion in research and higher education, Perry joined Broad in September. By Broad Communications September 11, 2023 Kedrick Perry leads the Inclusion, Diversity, Equity, and Allyship Office at Broad.

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Drug Discovery World

SEPTEMBER 11, 2023

Artificial intelligence (AI) technology has the potential to revolutionise drug discovery and pharma companies need to make plans for a future in which AI is frequently utilised in research, says ResearchAndMarkets.com. However, the change AI will bring about in drug discovery will take some time, according to the ‘Global Markets for Artificial Intelligence in Drug Discovery’ report.

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Drug Patent Watch

SEPTEMBER 12, 2023

In the world of patents, the right to exclude others from using or selling an invention is granted only during the patent’s validity. Once a patent expires, this exclusivity vanishes.… The post Understanding Patent Term Extensions: An Overview appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs.com

SEPTEMBER 14, 2023

THURSDAY, Sept. 14, 2023 -- People have long talked about having near-death experiences in which they felt they were looking down on themselves while others tried to save them. Now, researchers have documented some of those experiences. In a study.

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BioPharma Drive: Drug Pricing

SEPTEMBER 13, 2023

The biotech is telling investors it expects to launch as many as 15 new products in five years, a bold goal that will require a lot to go right to pull off.

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Drug Discovery World

SEPTEMBER 11, 2023

Ariceum Therapeutics, a biotech company developing radiopharmaceutical products for the diagnosis and treatment of certain hard-to-treat cancers, has dosed the first patient with its first-in-class lead molecule, satoreotide, targeting extensive stage small cell lung cancer (ES-SCLC), at the Murdoch University Health Center in Perth, Australia. Ariceum has initiated its multicentre, open label Phase Ib study which will investigate the safety and tolerability of the ‘theranostic pair’ of somato

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Drug Patent Watch

SEPTEMBER 12, 2023

In a recent STAT article Sanofi CEO Paul Hudson discusses the potential of artificial intelligence (AI) in the pharmaceutical industry. While some in the industry have been hesitant to embrace… The post From Expert AI to Snackable AI: A New Era in Pharma, as Seen by Sanofi’s CEO appeared first on DrugPatentWatch - Make Better Decisions.

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Drugs.com

SEPTEMBER 12, 2023

TUESDAY, Sept. 12, 2023 -- Following on an approval granted Monday by the U.S. Food and Drug Administration, an expert panel from the Centers for Disease Control and Prevention late Tuesday also signed off on new COVID boosters for Americans. Final.

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addgene Blog

SEPTEMBER 14, 2023

I spent about seven years working in research labs, and then pivoted to writing full-time in mid-2020. As I left the ivory tower and walked down into its foothills, I began to have conversations with many people who eagerly follow progress in synthetic biology, and want to be involved, but are overwhelmed by its vague and ill-defined contours. (Many of them are software engineers, surprisingly, who have deep technical knowledge but little biology experience.

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Drug Discovery World

SEPTEMBER 15, 2023

Replicate Bioscience has dosed the first participant in a Phase I trial of its RBI-4000 vaccine for the prevention of rabies. The trial, which marks the first time a human has been dosed with Replicate’s srRNA technology, will serve as a benchmark for utility in this indication and other complex infectious diseases and provide foundational insights to inform future clinical trials, most notably in oncology and autoimmune disease.

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BioPharma Drive: Drug Pricing

SEPTEMBER 14, 2023

Since 2019, Generate has raised nearly $700 million in private financing and has now brought a monoclonal antibody into Phase 1 testing.

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Drugs.com

SEPTEMBER 13, 2023

WEDNESDAY, Sept. 13, 2023 -- A large number of drugs used to treat everything from multiple sclerosis to blood cancers to rheumatoid arthritis may cause a rare but often-fatal condition called progressive multifocal leukoencephalopathy (PML). But a.

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FDA Law Blog: Drug Discovery

SEPTEMBER 10, 2023

By Mark A. Tobolowsky — CDER, CBER, and the Oncology Center of Excellence recently published a final guidance document titled “ Considerations for the Use of Real-World Data and Real-World Evidence to Support Regulatory Decision-Making for Drug and Biological Products ” as another part of its real-world evidence (“RWE”) Program. This finalized a draft guidance issued in December 2021, largely similar in substance.

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Drug Discovery World

SEPTEMBER 15, 2023

News round-up for 11-15 September by DDW Digital Content Editor Diana Spencer. Spanning artificial intelligence, theranostics, radiopharmaceuticals, quantum simulation and small regulatory RNA, the top stories this week all cover cutting-edge technologies and techniques making a huge impact on modern drug discovery and development. The headlines: Pharma must embrace an AI future says new report Artificial intelligence (AI) technology has the potential to revolutionise drug discovery and pharma c

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On Medicine

SEPTEMBER 12, 2023

Why is this research necessary? The Russian invasion of Ukraine started in February 2022 and is the largest European ground offensive since World War II. Countless civilians have been killed, and millions of children, women, and elderly people have fled the country. One study found that adolescents living in war-torn regions of Ukraine were at increased risk of experiencing depression, anxiety, and post-traumatic stress symptoms than those in the peaceful areas.

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