Sat.Sep 09, 2023 - Fri.Sep 15, 2023

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NY Times Gets It Wrong On Impact Of Price Controls On New Drugs

Forbes: Drug Truths

But, make no mistake – the IRA will have a major impact on biopharma R&D and, as a result, fewer important medicines will be available.

Drugs 275
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Daiichi Sankyo, with new data, to seek FDA approval of lung cancer drug

BioPharma Drive: Drug Pricing

The HER3-targeting treatment could become the next antibody-drug conjugate to emerge from Daiichi Sankyo’s laboratories, after the AstraZeneca-partnered Enhertu.

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Dental Issues Plague America's Nursing Home Residents

Drugs.com

FRIDAY, Sept. 15, 2023 -- Good oral health is one of the keys to healthy aging, but a sobering new study shows that many U.S. nursing home residents have significant dental issues. Close to two in every 10 residents have missing teeth, about 8%.

Nurses 299
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Making hydrogen from waste plastic could pay for itself

Science Daily: Pharmacology News

Researchers have found a way to harvest hydrogen from plastic waste using a low-emissions method that generates graphene as a by-product, which could help offset production costs.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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LAXAI Life Sciences Selects CDD Vault for Digital Transformation

Collaborative Drug

Hyderabad and San Francisco, September 12, 2023 - LAXAI Life Sciences, a leading Contract Research, Development, and Manufacturing Organization (CRDMO), has announced the adoption of the CDD Vault informatics platform. This strategic move underscores LAXAI’s commitment to combining science and innovation, reinforcing its clients’ competitive advantage through high-quality, efficient services.

Science 278

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A COVID Vaccine-by-Mouth Could Be on the Way

Drugs.com

THURSDAY, Sept. 14, 2023 -- An oral vaccine for COVID-19 appears to produce the sort of immune response that could quickly stamp out a developing infection, according to results from a small-scale primate study. Some monkeys given an experimental.

Vaccine 299
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Healthy lifestyle can help prevent depression -- and new research may explain why

Science Daily: Pharmacology News

A healthy lifestyle that involves moderate alcohol consumption, a healthy diet, regular physical activity, healthy sleep and frequent social connection, while avoiding smoking and too much sedentary behavior, reduces the risk of depression, new research has found.

Research 274
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Recorded Webinar: Drug Design Trends in the Age of AI

Collaborative Drug

Recorded Webinar: Drug Design Trends in the Age of AI. fragment-based drug design and full molecule-based drug design.

Drugs 264
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Flagship-backed Generate raises $273M as its first drugs move to the clinic

BioPharma Drive: Drug Pricing

Since 2019, Generate has raised nearly $700 million in private financing and has now brought a monoclonal antibody into Phase 1 testing.

Drugs 300
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Depression Risk Rises in Folks Who Use Both Marijuana & Tobacco

Drugs.com

WEDNESDAY, Sept. 13, 2023 -- Using both tobacco and marijuana is tied to significantly higher odds for depression and anxiety, a new study suggests. Among nearly 54,000 U.S. adults, those who used both substances experienced anxiety or depression.

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New evidence indicates patients recall death experiences after cardiac arrest

Science Daily: Pharmacology News

Up to an hour after their hearts had stopped, some patients revived by cardiopulmonary resuscitation (CPR) had clear memories afterward of experiencing death and had brain patterns while unconscious linked to thought and memory, report investigators.

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CDD Vault User Group Meeting – Boston, October 4

Collaborative Drug

CDD Vault User Group Meeting - Cambridge Innovation Center (CIC) Join the Collaborative Drug Discovery community to learn how CDD is being used every day

Drugs 264
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New startup Arialys takes aim at the immune system, hoping to create neuropsychiatry drugs

BioPharma Drive: Drug Pricing

Arialys Therapeutics launched Tuesday with $58 million in funding from a group of life sciences investors that includes Johnson & Johnson’s venture arm.

Science 293
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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FDA Approves New COVID Booster Shots

Drugs.com

MONDAY, Sept. 11, 2023 -- The U.S. Food and Drug Administration on Monday gave the green light to new COVID boosters for Americans, setting the stage for the updated vaccines to become available within days. The COVID-19 shots from Pfizer and.

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Genetically modified bacteria break down plastics in saltwater

Science Daily: Pharmacology News

Researchers have genetically engineered a marine microorganism to break down plastic in salt water. Specifically, the modified organism can break down polyethylene terephthalate (PET), a plastic used in everything from water bottles to clothing that is a significant contributor to microplastic pollution in oceans.

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The Inflation Reduction Act Will Lead To Fewer New Medicines

Forbes: Drug Truths

But, make no mistake – the IRA will have a major impact on biopharma R&D and, as a result, fewer important medicines will be available.

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UK biotech AlveoGene launches with plans for inhaled gene therapy

BioPharma Drive: Drug Pricing

The company is working on a treatment of alpha-1 antitrypsin deficiency, which it claims it can deliver direct to lung cells via a nebulizer.

Therapies 281
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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40% of Patients Recall Some Consciousness During Near Death Experiences

Drugs.com

THURSDAY, Sept. 14, 2023 -- People have long talked about having near-death experiences in which they felt they were looking down on themselves while others tried to save them. Now, researchers have documented some of those experiences. In a study.

Research 290
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AI foundation model for eye care to supercharge global efforts to prevent blindness

Science Daily: Pharmacology News

Researchers have developed an artificial intelligence (AI) system that has the potential to not only identify sight-threatening eye diseases but also predict general health, including heart attacks, stroke, and Parkinson's disease.

Disease 257
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Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3?/ER? Protein–Protein Interaction from Nonselective Fragments

Covalent Modifiers

Markella Konstantinidou, Emira J. Visser, Edmee Vandenboorn, Sheng Chen, Priyadarshini Jaishankar, Maurits Overmans, Shubhankar Dutta, R. Jeffrey Neitz, Adam R. Renslo, Christian Ottmann, Luc Brunsveld, and Michelle R. Arkin Journal of the American Chemical Society 2023 DOI: 10.1021/jacs.3c05161 The stabilization of protein–protein interactions (PPIs) has emerged as a promising strategy in chemical biology and drug discovery.

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Moderna aims for the stars again with ambitious drug development plan

BioPharma Drive: Drug Pricing

The biotech is telling investors it expects to launch as many as 15 new products in five years, a bold goal that will require a lot to go right to pull off.

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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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CDC Panel Gives Support to New COVID Booster Shots

Drugs.com

TUESDAY, Sept. 12, 2023 -- Following on an approval granted Monday by the U.S. Food and Drug Administration, an expert panel from the Centers for Disease Control and Prevention late Tuesday also signed off on new COVID boosters for Americans. Final.

Disease 290
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Earth's stability and ability to support civilization at risk: Six of nine planetary boundaries exceeded

Science Daily: Pharmacology News

A new study updates the planetary boundary framework and shows human activities are increasingly impacting the planet and, thereby, increasing the risk of triggering dramatic changes in overall Earth conditions.

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Phage Display of Two Distinct Warheads to Inhibit Challenging Proteins

Covalent Modifiers

Mengmeng Zheng and Jianmin Gao ACS Chemical Biology 2023 DOI: 10.1021/acschembio.3c00297 Falling in between traditional small molecules and antibodies in size, peptides are emerging as a privileged therapeutic modality, one that can harness the benefits of both small molecule and antibody drugs. To discover potential peptide therapeutics, it is highly desirable to have high throughput screening platforms that can assess peptides with diverse and non-natural functional motifs.

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2Seventy CEO Leschly to step down as company cuts staff, spending

BioPharma Drive: Drug Pricing

Citing “near-term headwinds,” the cancer cell therapy developer will lay off 176 employees and pare back some of its research spending.

Therapies 272
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Gene Test Spots Those Vulnerable to Rare but Severe Side Effect of Drugs for MS, Other Conditions

Drugs.com

WEDNESDAY, Sept. 13, 2023 -- A large number of drugs used to treat everything from multiple sclerosis to blood cancers to rheumatoid arthritis may cause a rare but often-fatal condition called progressive multifocal leukoencephalopathy (PML). But a.

Drugs 289