Sat.Sep 09, 2023 - Fri.Sep 15, 2023

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NY Times Gets It Wrong On Impact Of Price Controls On New Drugs

Forbes: Drug Truths

But, make no mistake – the IRA will have a major impact on biopharma R&D and, as a result, fewer important medicines will be available.

Drugs 274
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Early Career Researcher Toolbox: Free Online Molecular Biology Tools

addgene Blog

Primer design. Plasmid mapping. DNA sequence analysis. We all have our favorite tools for tackling these particular tasks, but they tend to be scattered about the internet. To help you keep your virtual molecular biology toolbox organized, today’s post features a list of free online molecular biology tools all in one place.

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BRIM closes a $45.8 million rights issue early to accelerate its pipeline of regenerative peptides

Drug Discovery Today

Taipei, Taiwan, 13th September 2023 / Sciad Newswire / BRIM Biotechnology, Inc. ("BRIM," TPEx 6885), a clinical-stage biotechnology company focusing on developing regenerative peptides for ophthalmology and degenerative joint diseases, announced today that 22,500 shares have been issued at a premium of NT$65 (~US$2.03), raising a total of NT$1.4625 billion (~US$45.8 million).

Disease 113
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New machine learning techniques boost predictions for virtual drug screening with less data

Broad Institute

New machine learning techniques boost predictions for virtual drug screening with less data By Corie Lok September 10, 2023 Breadcrumb Home New machine learning techniques boost predictions for virtual drug screening with less data Schmidt Center researchers have found a way to improve kernel methods, which are a simpler alternative to neural networks, for biomedical applications.

Drugs 130
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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The Inflation Reduction Act Will Lead To Fewer New Medicines

Forbes: Drug Truths

But, make no mistake – the IRA will have a major impact on biopharma R&D and, as a result, fewer important medicines will be available.

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A review of recent advancements in Actinium?225 labeled compounds and biomolecules for therapeutic purposes

Chemical Biology and Drug Design

A radiobiological modelization of 225 Ac-based alpha-emitter radiopharmaceuticals and targeted alpha therapy (TAT). 225 Ac can be considered as best radionuclide because it offers novel therapeutic strategies for advanced and late-stage cancer treatment with a large variety of biomolecules. Abstract In nuclear medicine, cancers that cannot be cured or can only be treated partially by traditional techniques like surgery or chemotherapy are killed by ionizing radiation as a form of therapeutic tre

Therapies 100

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Daiichi Sankyo, with new data, to seek FDA approval of lung cancer drug

BioPharma Drive: Drug Pricing

The HER3-targeting treatment could become the next antibody-drug conjugate to emerge from Daiichi Sankyo’s laboratories, after the AstraZeneca-partnered Enhertu.

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A COVID Vaccine-by-Mouth Could Be on the Way

Drugs.com

THURSDAY, Sept. 14, 2023 -- An oral vaccine for COVID-19 appears to produce the sort of immune response that could quickly stamp out a developing infection, according to results from a small-scale primate study. Some monkeys given an experimental.

Vaccine 119
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Chemerin and IL?17 are potential predictors and Chemerin silencing alleviates inflammatory response and bone remodeling in chronic rhinosinusitis

Chemical Biology and Drug Design

In this study, it was suggested that Chemerin or IL-17 were positively correlated with Lund-Mackay and Lund-Kennedy scores of CRS patients, and they showed high predictive values for CRS. In addition, the knockdown of Chemerin was found to alleviate inflammation and bone remodeling in Staphylococcus aureus -induced CRS rabbits. These findings provide reference methods for CRS diagnosis, treatment, and prognosis.

RNA 100
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IChemE announces 2023 Global Awards finalists

Drug Discovery Today

Professional excellence, positive environmental impact, process safety and societal benefit are among the key qualities being celebrated by the Institution of Chemical Engineers (IChemE) as it announces the finalists for its 2023 Global Awards.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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A World Alzheimer's Month resource roundup

Antidote

Alzheimer’s disease, the most prevalent type of dementia , is diagnosed in more than 6 million Americans. Estimates project that by 2050, 13 million individuals will be diagnosed with Alzheimer’s disease. This condition ranks among the top 10 causes of death in the United States, profoundly impacting those diagnosed, their loved ones, and their caregivers.

Disease 119
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Depression Risk Rises in Folks Who Use Both Marijuana & Tobacco

Drugs.com

WEDNESDAY, Sept. 13, 2023 -- Using both tobacco and marijuana is tied to significantly higher odds for depression and anxiety, a new study suggests. Among nearly 54,000 U.S. adults, those who used both substances experienced anxiety or depression.

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FDA approves updated COVID boosters from Pfizer, Moderna

BioPharma Drive: Drug Pricing

Pfizer and Moderna, which have seen slowing demand for their coronavirus vaccines, expect to make the reformulated shots available in the U.S. in the coming days.

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Bioengineered instrument reveals hidden cancer cells

Drug Target Review

Cancer cells can elude the body’s immune defences by manipulating a group of molecules known as mucins, which are typically helpful and widespread. Mucins are proteins covered in sugar that primarily protect the body against physical harm and pathogens. However, cancer cells exploit mucins to support their survival. While the concept of removing mucins from cancer cells seems promising, mucins are present in various forms on all mammalian cells.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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New Pesticides and Applied Testing: Advancing Sustainable Agriculture

biobide

Pesticides are a vital tool in safeguarding the world’s food supply. The need to protect crops from pests, disease, and weeds has existed for centuries, with the Roman’s having used ash, crushed cypress leaves and diluted urine to protect their crops. Nowadays, pest control methods and the chemicals used are a great deal more sophisticated. It is estimated that without crop protection, which includes the use of pesticides, half of the world’s food crops would be lost.

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Dental Issues Plague America's Nursing Home Residents

Drugs.com

FRIDAY, Sept. 15, 2023 -- Good oral health is one of the keys to healthy aging, but a sobering new study shows that many U.S. nursing home residents have significant dental issues. Close to two in every 10 residents have missing teeth, about 8%.

Nurses 119
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New startup Arialys takes aim at the immune system, hoping to create neuropsychiatry drugs

BioPharma Drive: Drug Pricing

Arialys Therapeutics launched Tuesday with $58 million in funding from a group of life sciences investors that includes Johnson & Johnson’s venture arm.

Science 119
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A Novel Pancreatic Cancer Early Diagnostic Technology

Crown Bioscience

The incidence of pancreatic cancer has been rising by about 1% per year over the past few decades, and it now accounts for ~3% of all cancers and 7% of cancer mortality in the U.S. Pancreatic cancer is now the third leading cause of cancer-related death, and it is exceptionally lethal in part because it is challenging to detect at an early stage. By the time signs and symptoms appear, the disease has often already reached an advanced stage and metastasized.

Disease 111
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Broad Institute welcomes Kedrick Perry as new Chief Equity Officer

Broad Institute

Broad Institute welcomes Kedrick Perry as new Chief Equity Officer By Corie Lok September 11, 2023 Breadcrumb Home Broad Institute welcomes Kedrick Perry as new Chief Equity Officer A proven leader in diversity, equity, and inclusion in research and higher education, Perry joined Broad in September. By Broad Communications September 11, 2023 Kedrick Perry leads the Inclusion, Diversity, Equity, and Allyship Office at Broad.

Doctors 111
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FDA Approves New COVID Booster Shots

Drugs.com

MONDAY, Sept. 11, 2023 -- The U.S. Food and Drug Administration on Monday gave the green light to new COVID boosters for Americans, setting the stage for the updated vaccines to become available within days. The COVID-19 shots from Pfizer and.

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The Codon Guide to Synthetic Biology

addgene Blog

I spent about seven years working in research labs, and then pivoted to writing full-time in mid-2020. As I left the ivory tower and walked down into its foothills, I began to have conversations with many people who eagerly follow progress in synthetic biology, and want to be involved, but are overwhelmed by its vague and ill-defined contours. (Many of them are software engineers, surprisingly, who have deep technical knowledge but little biology experience.

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FDA’s New RWE Guidance Provides Recommendations for Sponsors Conducting Non-Interventional Real-World Studies and Describes the Potential to Use RWE for Initial Approvals in One Limited Circumstance

FDA Law Blog: Drug Discovery

By Mark A. Tobolowsky — CDER, CBER, and the Oncology Center of Excellence recently published a final guidance document titled “ Considerations for the Use of Real-World Data and Real-World Evidence to Support Regulatory Decision-Making for Drug and Biological Products ” as another part of its real-world evidence (“RWE”) Program. This finalized a draft guidance issued in December 2021, largely similar in substance.

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Teaching recovery techniques plus parenting: a cluster randomized controlled trial in Ukrainian schools in Ternopil (TRUST)

On Medicine

Why is this research necessary? The Russian invasion of Ukraine started in February 2022 and is the largest European ground offensive since World War II. Countless civilians have been killed, and millions of children, women, and elderly people have fled the country. One study found that adolescents living in war-torn regions of Ukraine were at increased risk of experiencing depression, anxiety, and post-traumatic stress symptoms than those in the peaceful areas.

Trials 107
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CDC Panel Gives Support to New COVID Booster Shots

Drugs.com

TUESDAY, Sept. 12, 2023 -- Following on an approval granted Monday by the U.S. Food and Drug Administration, an expert panel from the Centers for Disease Control and Prevention late Tuesday also signed off on new COVID boosters for Americans. Final.

Disease 116
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Moderna aims for the stars again with ambitious drug development plan

BioPharma Drive: Drug Pricing

The biotech is telling investors it expects to launch as many as 15 new products in five years, a bold goal that will require a lot to go right to pull off.

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Drug Target Review – Issue 3 2023

Drug Target Review

This Drug Target Review issue explores cutting-edge topics such as artificial intelligence (AI), regenerative medicine, and neuroscience, guided by leading experts in the field. Dr Olga Chechneva from Shriners Children’s Northern California reveals the intricate interactions of brain cells, while shedding light on how neurons stimulate the brain’s microglia.

Vaccine 105
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Discovering Sitecore PowerShell Extension – Part 1

Perficient: Drug Development

Discovering Sitecore PowerShell Reports Sitecore PowerShell is a popular and powerful module that can be used as a development accelerator. It allows Developers, Content Authors, and Marketers to automate various tasks like content creation, audits, correction, etc. Apart from infinite possible usage with custom scripts, SPE already has provided a lot of ammunition in existing package.

Packaging 105
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40% of Patients Recall Some Consciousness During Near Death Experiences

Drugs.com

THURSDAY, Sept. 14, 2023 -- People have long talked about having near-death experiences in which they felt they were looking down on themselves while others tried to save them. Now, researchers have documented some of those experiences. In a study.

Research 116
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Flagship-backed Generate raises $273M as its first drugs move to the clinic

BioPharma Drive: Drug Pricing

Since 2019, Generate has raised nearly $700 million in private financing and has now brought a monoclonal antibody into Phase 1 testing.

Drugs 122
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Making hydrogen from waste plastic could pay for itself

Science Daily: Pharmacology News

Researchers have found a way to harvest hydrogen from plastic waste using a low-emissions method that generates graphene as a by-product, which could help offset production costs.

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Upcoming Webinar: Navigate Your Headless Commerce Journey With SAP Commerce Cloud

Perficient: Drug Development

Mark Your Calendars Date: Wednesday, October 25th | Time: 11:00 AM – 12:00 PM CT Are you ready to take your e-commerce game to the next level? Join us for an illuminating session hosted by Perficient’s seasoned commerce experts. We’re here to demystify complexities, share real-world success stories, and provide you with actionable advice to steer your migration to SAP Commerce Cloud.

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Red Cross Appeals for Donors During National Blood Shortage

Drugs.com

MONDAY, Sept. 11, 2023 -- The American Red Cross said Monday that it urgently needs blood donations because the national blood supply has dropped nearly 25% since early August. Back-to-back climate-related disasters have hampered blood collection.

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How to Ask the Right Questions at an Authority Meeting

Cytel

As a drug developer, you have to live with the answers and comments you get from regulatory authorities. Therefore, it’s essential that you choose your questions carefully and avoid questions you don’t need answers to.