Science Daily: Pharmacology News
FEBRUARY 10, 2025
Short snouts and a flat profile -- within a span of 100 years, humans have significantly changed the shape of the skulls of German domestic pigs. This is likely down to new breeding practices introduced at the beginning of the 20th century. The researchers analyzed 3D scans of 135 skulls of wild boars and domestic pigs from the early 20th and 21st centuries.
Covalent Modifiers
FEBRUARY 10, 2025
DOI Ansgar Oberheide, Maxime van den Oetelaar, Jakob Scheele, Jan Borggrfe, Semmy Engelen, Michael Sattler, Christian Ottmann, Peter Cossar and Luc Brunsveld RSC Med Chem 2025 [link] Protein-protein interactions (PPIs) are key regulators of various cellular processes. Modulating PPIs with small molecules has gained increasing attention in drug discovery, particularly targeting the 14-3-3 protein family, which interacts with several hundred client proteins and plays a central role in cellular net
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Codon
FEBRUARY 13, 2025
One of the ultimate aims of protein design has long been to build entirely new enzymes — proteins that perform specific chemical reactions — from scratch. These molecular machines power various cellular processes, from converting sugar into energy to switching genes on and off. Both Cas9 and hydrolases (widely used in the dairy and laundry industries) are also enzymes.
Drugs.com
FEBRUARY 10, 2025
MONDAY, Feb. 10, 2025 -- Yes, rare cases of vision issues have arisen in people taking popular GLP-1 weight loss drugs, but the jury's out on whether the medications caused the eye trouble, according to a new small study.The study reviewed the.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Science Daily: Pharmacology News
FEBRUARY 12, 2025
Climate scientists present a realistic supercomputer simulation that resolves the complex interactions between fire, vegetation, smoke and the atmosphere. The authors find that increasing greenhouse gas emissions will likely increase the global lightning frequency by about 1.6% per degree Celsius global warming, with regional hotspots in the eastern United States, Kenya, Uganda and Argentina.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
addgene Blog
FEBRUARY 13, 2025
Early CRISPR applications were often limited by the low editing efficiency of homology-directed repair (HDR) , the pathway for resolving DNA double-strand breaks (DSBs) preferred by researchers. Compared to non-homologous end joining (NHEJ) , HDR occurs at a relatively low frequency, especially in nondividing cells. Scientists everywhere wistfully imagined being able to specify and correct single-base mutations without introducing DSBs at all.
Drugs.com
FEBRUARY 14, 2025
FRIDAY, Feb. 14, 2025 -- There appears to be limited evidence supporting the use of epidural steroid injections for certain types of chronic lower back pain, new guidance from the American Academy of Neurology (AAN) finds. Epidural steroid.
Science Daily: Pharmacology News
FEBRUARY 13, 2025
Who hasn't been there? The big meal is over, you're full, but the craving for sweets remains. Researchers have now discovered that what we call the 'dessert stomach' is rooted in the brain. The same nerve cells that make us feel full after a meal are also responsible for our craving for sweets afterwards.
BioPharma Drive: Drug Pricing
FEBRUARY 10, 2025
The drug is cleared to treat complicated intra-abdominal infections, including those caused by tough-to-control, gram-negative bacteria.
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
Drug Patent Watch
FEBRUARY 10, 2025
Streamlining the Generic Drug Supply Chain: Best Practices to Improve Efficiency and Patient Access As the generic drug industry continues to grow, it's becoming increasingly clear that the traditional supply chain model is no longer sustainable. With the rise of complex generics, regulatory pressures, and increasing demand for affordable medicines, it's time to rethink the way we approach the generic drug supply chain.
Drugs.com
FEBRUARY 10, 2025
MONDAY, Feb. 10, 2025 -- The head of the United Nations AIDS agency (UNAIDS) is warning that a major spike in HIV infections and deaths could occur if the U.S. follows through on freezing foreign aid for HIV programs.UNAIDS Executive Director.
Science Daily: Pharmacology News
FEBRUARY 10, 2025
Researchers have developed a new AI algorithm, called Torque Clustering, that significantly improves how AI systems independently learn and uncover patterns in data, without human guidance.
Collaborative Drug
FEBRUARY 14, 2025
We are excited to announce a new round of features associated with our Curves Add-on. If you are not yet subscribed to Curves, please contact your CDD Vault account manager or the CDD Vault Support Team to discuss enabling these features in your Vault.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drug Patent Watch
FEBRUARY 11, 2025
The Dark Side of Innovation: How Companies Use Drug Patents to Block Competitors As we celebrate the breakthroughs in medical research and the development of life-saving treatments, it's essential to acknowledge the complex landscape of pharmaceutical innovation. Behind the scenes, companies are employing clever tactics to protect their intellectual property and block competitors from entering the market.
Drugs.com
FEBRUARY 11, 2025
TUESDAY, Feb. 11, 2025 -- Ozempic, Wegovy, Saxenda, Trulicity: These and other GLP1-RA diabetes/weight-loss meds can also boost outcomes for folks battling chronic kidney disease, new research shows.Compared to another common class of kidney.
Science Daily: Pharmacology News
FEBRUARY 12, 2025
Scientists have just detected a neutrino that is thirty times more energetic than any previously detected anywhere in the world. This exceptional discovery opens up new perspectives for understanding extreme energy phenomena in the Universe and the origin of cosmic rays.
Collaborative Drug
FEBRUARY 12, 2025
Drug Discovery Industry Roundup with Barry Bunin February 10th, 2025
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
BioPharma Drive: Drug Pricing
FEBRUARY 12, 2025
A small semaglutide trial suggests the medicine's suppression of appetite may extend to alcohol, but larger tests are needed to establish a conclusive benefit.
Drugs.com
FEBRUARY 14, 2025
FRIDAY, Feb. 14, 2025 -- With certain government data currently being withheld, removed, or restored but partially redacted on the websites of the U.S. Centers for Disease Control and Prevention and Food and Drug Administration, the American Cancer.
Science Daily: Pharmacology News
FEBRUARY 14, 2025
Humanity may not be extraordinary but rather the natural evolutionary outcome for our planet and likely others, according to a new model for how intelligent life developed on Earth.
Drug Patent Watch
FEBRUARY 12, 2025
Accelerating Generic Drug Development: Strategies for Success As a pharmaceutical professional, you know how crucial it is to navigate the complex landscape of generic drug development. With the increasing demand for affordable medications, generic drug manufacturers are under pressure to expedite their development timelines without compromising on quality.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
BioPharma Drive: Drug Pricing
FEBRUARY 13, 2025
Backed by Goldman Sachs, Novo Nordisk’s parent company and others, Newleos Therapeutics debuted Thursday with $94 million and a plan to develop drugs for brain function and health.
Drugs.com
FEBRUARY 10, 2025
MONDAY, Feb. 10, 2025 -- About 2 million baked goods have been recalled over concerns of potential contamination with Listeria monocytogenes, according to federal safety regulators.The recall went into effect on Jan. 7, 2025, and was upgraded on.
Science Daily: Pharmacology News
FEBRUARY 13, 2025
Ancient Egyptian mummified bodies smell 'woody,' 'spicy' and 'sweet', finds a new study, revealing new details about mumification practices.
Drug Patent Watch
FEBRUARY 13, 2025
The Unsung Heroes of Generic Drug Development: The Power of Partnerships As we navigate the complex landscape of pharmaceuticals, it's easy to overlook the crucial role that partnerships play in bringing affordable, life-saving medications to market. But the truth is, partnerships are the backbone of generic drug development, and their impact cannot be overstated.
Drug Target Review
FEBRUARY 10, 2025
In the rapidly advancing field of cell therapies, Dr Jason Bock has emerged as a leader, known for his innovative approach to optimising the development process. With over 25 years of experience in therapeutics, Bock has played a pivotal role in shaping the future of cell therapies, particularly through his work at CTMC. In a recent conversation, he shared his vision for transforming the development and commercialisation of novel cell therapies, focusing on cutting-edge approaches like tumour in
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