Broad Institute

APRIL 2, 2024

Scientists link certain gut bacteria to lower heart disease risk By Allessandra DiCorato April 2, 2024 Breadcrumb Home Scientists link certain gut bacteria to lower heart disease risk Study finds several species of cholesterol-metabolizing bacteria in people with lower cholesterol levels. By Allessandra DiCorato April 2, 2024 Credit: Ahmed Mohamed Rod-shaped Oscillibacter sp. bacteria take up fluorescently labeled cholesterol (here shown in green).

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Science Daily: Pharmacology News

APRIL 1, 2024

ChatGPT-4, an artificial intelligence program designed to understand and generate human-like text, outperformed internal medicine residents and attending physicians at two academic medical centers at processing medical data and demonstrating clinical reasoning.

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International 127

ASPET

APRIL 5, 2024

Triple Negative Breast Cancer (TNBC) is the most aggressive type of breast cancer and is associated with high probability of metastasis and poor prognosis. Chemotherapeutics and surgery remain the most common options for TNBC patients; however chemotherapeutic resistance and relapse of tumors limit the progression free survival and patient life span.

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Treatment Clinical Trials Trials Drugs 100

Chemical Biology and Drug Design

APRIL 3, 2024

The present review explores the intricate relationship between autophagy and proteostasis in the pathogenesis of neurodegenerative diseases along with the therapeutic interventions to mitigate the same. Abstract Neurodegenerative disorders are devastating disorders characterized by gradual loss of neurons and cognition or mobility impairment. The common pathological features of these diseases are associated with the accumulation of misfolded or aggregation of proteins.

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Disease Treatment Research 100

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

Treatment

BioPharma Drive: Drug Pricing

APRIL 1, 2024

The FDA could soon expand use of two multiple myeloma cell therapies as well as a top-selling medicine from Sanofi and Regeneron, while Pfizer’s years of gene therapy work might finally pay dividends.

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Science Daily: Pharmacology News

APRIL 5, 2024

Certain RNA molecules in the nerve cells in the brain last a life time without being renewed. Neuroscientists have now demonstrated that this. RNAs are generally short-lived molecules that are constantly reconstructed to adjust to environmental conditions. The research group hopes to decipher the complex aging process of the brain and gain a better understanding of related degenerative diseases.

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RNA Disease Research 123

Antidote

APRIL 4, 2024

Before it is released onto the market, the development of any new drug or medical device must undergo rigorous testing , part of which involves clinical trials. Clinical trials are integral to making sure that any new therapy is both safe and effective for individuals, and volunteers are a vital part of the process.

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Clinical Trials Trials Therapies Marketing 119

Drugs.com

APRIL 1, 2024

MONDAY, April 1, 2024 -- Vaccine protection against mpox fades quickly in the human immune system, even in people who’ve received the full two-dose regimen, a new real-world study shows.Antibody levels fell to low or near zero within the first.

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Vaccine 116

Science Daily: Pharmacology News

APRIL 4, 2024

Densely packed, fast-moving stars at the Milky Way's center can collide with each other. New research uses simulations to explore the outcomes of these collisions. Some collisions are more like 'violent high fives' while others are full-on mergers.

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Research 122

ASPET

APRIL 5, 2024

The oncogenic protein tyrosine phosphatase PTP4A3 is frequently overexpressed in human ovarian cancers and is associated with poor patient prognosis. PTP4A3 is thought to regulate multiple oncogenic signaling pathways, including STAT3, SRC, and ERK. The objective of this study was to generate ovarian cancer cells with genetically depleted PTP4A3; to assess their tumorigenicity; to examine their cellular phenotype; and to uncover changes in their intracellular signaling pathways and cytokine rele

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Bioinformatics Therapies Regulations 100

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

Clinical Trials

BioPharma Drive: Drug Pricing

APRIL 5, 2024

The FDA’s clearance comes three weeks after a panel of advisers endorsed expanded use of Abecma despite safety concerns raised by the agency.

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FDA Therapies 120

Drugs.com

APRIL 4, 2024

THURSDAY, April 4, 2024 (HealthDayNews) -- Following disappointing trial results, the maker of a controversial ALS drug said it is pulling the medication off the market. In a statement issued Thursday, Amylyx Pharmaceuticals said that Relyvrio.

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Marketing Drugs Pharmaceuticals Trials 111

Science Daily: Pharmacology News

APRIL 3, 2024

A fungus devastating frogs and toads on nearly every continent may have an Achilles heel. Scientists have discovered a virus that infects the fungus, and that could be engineered to save the amphibians.

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Engineering Virus 119

ASPET

APRIL 2, 2024

Bromine domain protein 2 (BRD2), a member of the Bromodomain and extraterminal domain (BET) protein family, is a crucial epigenetic regulator with significant function in various diseases and cellular processes. The central function of BRD2 is modulating gene transcription by binding to acetylated lysine residues on histones and transcription factors.

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Disease Regulations Virus Research 100

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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

Clinical Trials

Drug Target Review

APRIL 4, 2024

What are the key findings of the preclinical study regarding the neurophysiological brain state in a Parkinson’s disease psychosis (PDP) model? The animal model is based on creating a dopamine-deficient state, by a specific lesion of dopaminergic cells, and then exposing it to repeated substitution therapy with L-DOPA. This creates a condition which mimics the state in advanced PD in humans.

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Disease Treatment Licensing Licensing 105

Drugs.com

APRIL 4, 2024

TUESDAY, April 2, 2024 -- Expecting or new mothers are much more likely these days to be diagnosed with anxiety, depression and post-traumatic stress disorder, new research shows. However, more women are also getting treated for these problems.

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Research 111

Science Daily: Pharmacology News

APRIL 2, 2024

Australia could soon see megadroughts that last for more than 20 years, according to new modelling. The researchers' bleak findings are before factoring in human impact on the climate since the Industrial Revolution. According to the scientists, the findings paint a worrying picture of future droughts in Australia that are far worse than anything in recent experience.

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Research 121

BioPharma Drive: Drug Pricing

APRIL 3, 2024

The startup claims to have a more efficient way to develop biologic drugs that treat disease by turning on cellular pathways, rather than blocking them.

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Drugs Disease 114

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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

Clinical Trials

Drug Target Review

APRIL 3, 2024

Can you tell us about your journey in the field of STEM and the challenges you encountered along the way? Everything started in school with an experiment on isolating DNA from bananas. Making a little tangle of DNA visible to the eye and understanding that this is the basis of complex organisms, which might be altered in disease, was the defining moment for my future path in life sciences.

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Science Clinical Development Treatment DNA 105

Drugs.com

APRIL 4, 2024

WEDNESDAY, April 3, 2024 -- Microwaves could offer an alternative to surgery for some people with thyroid cancer, a new study suggests. Microwave ablation, which uses heat to destroy tumors, more effectively targeted thyroid cancers on multiple.

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Treatment 111

Science Daily: Pharmacology News

APRIL 1, 2024

Engineers have created a brain-computer interface that doesn't require calibration for each user, paving the way for widespread clinical applicability.

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Engineering 128

Cytel

APRIL 2, 2024

Data monitoring committees (DMCs) review ongoing clinical trial data to make recommendations regarding trial conduct based on risk-benefit. DMCs are an essential component to ensuring the integrity and safety of clinical trials. New draft guidance published by the U.S. FDA on the use of DMCs in clinical trials provides six major updates to the FDA’s expectations regarding DMC structure and practice.

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Clinical Trials Trials FDA Clinical Development 104

Perficient: Drug Development

APRIL 1, 2024

In the Optimizely Search & Navigation admin view, administrators can set a certain weight of different properties (title, content, summary, or document content). When an user searches for a keyword that matches to a property’s value, the higher weight of that property will make the matching pages to be more likely to appear at the top of the search result.

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Drugs.com

APRIL 1, 2024

MONDAY, April 1, 2024 -- For folks who have battled alcohol dependency for years, any treatment that could curb or block alcohol cravings would be a huge advance.Now, research in mice is giving a glimmer of hope that just such a therapy might be.

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Therapies Treatment Research 105

Science Daily: Pharmacology News

APRIL 4, 2024

Scientists have discovered a new cause for asthma that sparks hope for treatment that could prevent the life-threatening disease.

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Disease Treatment 137

BioPharma Drive: Drug Pricing

APRIL 1, 2024

The development of cancer vaccines has provided some hope in the battle against cancer worldwide; however, there are still many challenges to overcome when developing these life-saving treatments.

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Vaccine Treatment 103

FDA Law Blog: Biosimilars

APRIL 2, 2024

By Sara W. Koblitz — Every year, federal agencies submit a budget request to Congress to fund various agency initiatives, and every year FDA includes a list of legislative proposals that it would like to see come out of Congress. This year is no different , and in fact some of the requests on this year’s list are repeat offenders from last year’s. And though FDA may not have gotten everything that it wanted last year, reviewing and reflecting on these lists of legislative proposals provides im

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FDA Biosimilars Production Marketing 103

Drugs.com

APRIL 4, 2024

TUESDAY, April 2, 2024 -- A total eclipse of the sun is coming up next week, and many folks don’t know that watching it unprotected can cause permanent eye damage, a new survey finds. Nearly 30% of Americans don’t know that looking.

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Science Daily: Pharmacology News

APRIL 5, 2024

The CHEOPS space telescope is providing new information on the mysterious exoplanet WASP-76b. This ultra-hot giant is characterized by an asymmetry between the amount of light observed on its eastern terminator -- the fictitious line that separates its night side from its day side -- and that observed on its western terminator. This peculiarity is thought to be due to a 'glory', a luminous phenomenon similar to a rainbow, which occurs if the light from the star -- the 'sun' around which the exop

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BioPharma Drive: Drug Pricing

APRIL 2, 2024

Stalking horse bidder Merz Therapeutics could get rights to Acorda’s three marketed drugs if its $185 million proposal holds.

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Marketing Drugs 117

Drug Patent Watch

MARCH 31, 2024

A recent study published in JAMA Health Forum sheds light on the impact of biosimilar competition on patient out-of-pocket (OOP) costs for biologic drugs in the United States.

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Biosimilars Drugs Research 100

Drugs.com

APRIL 4, 2024

WEDNESDAY, April 3, 2024 -- When a soldier is rushed to medical care following a blast or other injury to the head, time is crucial in deciding just how extensive that injury is. Now, the U.S. Army has announced that the U.S. Food and Drug.

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FDA Drugs 98

Science Daily: Pharmacology News

APRIL 4, 2024

During archaeological excavations in the Schoningen open-cast coal mine in 1994, the discovery of the oldest, remarkably well-preserved hunting weapons known to humanity caused an international sensation. Spears and a double-pointed throwing stick were found lying between animal bones about ten meters below the surface in deposits at a former lakeshore.

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International 104