Drug Discovery World

SEPTEMBER 12, 2024

New research has shown that Ellorarxine, a novel drug compound developed by biotech Nevrargenics, provides a robust neuroprotective effect and reduces neuronal death in cell models of neurodegenerative disease. The peer reviewed study published in Frontiers in Neuroscience was conducted by academics at Aberdeen and Durham Universities in the UK. Based on the results, the company has secured approval from the Medicines and Healthcare products Regulatory Agency (MHRA) to run a human study in the

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Science Daily: Pharmacology News

SEPTEMBER 11, 2024

Researchers have created microscale robots less than 1 millimeter in size that are printed as a 2D hexagonal 'metasheet' but, with a jolt of electricity, morph into preprogrammed 3D shapes and crawl.

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BioPharma Drive: Drug Pricing

SEPTEMBER 12, 2024

The offerings by Bicara, Zenas and MBX give a glimpse into what industry insiders describe as a backlog of mature startups waiting for the right opportunity to test public markets.

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Drugs.com

SEPTEMBER 12, 2024

THURSDAY, Sept. 12, 2024 -- It could be a real breakthrough for people at risk for HIV infection: A shot given every six months that reduces their risk by a whopping 96%.That's according to new trial results released Thursday by Gilead Sciences.

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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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Drug Discovery World

SEPTEMBER 12, 2024

In the In Conversation With series, a part of the free DDW podcast, DDW speaks with members of the drug discovery industry about their work and how it helps turn science into business. In this episode, Megan Thomas is in conversation with Dr Friso Postma, Vice President of AI Drug Discovery at BioXcel Therapeutics. Thanks to BioXcel’s AI platform, the company was able to repurpose previous drugs to obtain FDA approval for its acute treatment for agitation associated with schizophr

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Science Daily: Pharmacology News

SEPTEMBER 9, 2024

Scientists have developed a new AI algorithm that can separate brain patterns related to a particular behavior. This work promises to improve brain-computer interfaces and aid with the discovery of new brain patterns.

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Drugs.com

SEPTEMBER 11, 2024

WEDNESDAY, Sept. 11, 2024 -- Widespread and easy access to guns is the reason behind the shockingly high rate of firearm deaths in the United States, and not any rise in mental health problems suffered by perpetrators, a new study shows.The United.

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Drug Discovery World

SEPTEMBER 13, 2024

News round-up for 9-13 September by DDW Senior Digital Content Editor Diana Spencer. This week, DDW has opened registrations for its webinar ‘ The latest advancements driving neuroscience drug discovery research ’, so our news highlights focus on developments in neuroscience, including a novel drug that has been shown to reduce neuronal death, and a potential disease-modifying treatment for dementia.

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Science Daily: Pharmacology News

SEPTEMBER 9, 2024

Researchers have developed a robotic leg with artificial muscles. Inspired by living creatures, it jumps across different terrains in an agile and energy-efficient manner.

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BioPharma Drive: Drug Pricing

SEPTEMBER 12, 2024

Spun out of research at Nationwide Children’s Hospital, Vironexis claims it will be the first company to start a study testing a cancer drug delivered via the adeno-associated viruses commonly used in genetic medicines.

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Drugs.com

SEPTEMBER 13, 2024

FRIDAY, Sept. 13, 2024 -- Humans could learn a few medical tips from their gorilla cousins, a new study says.Four plants used by wild gorillas in Gabon have antibacterial and antioxidant properties, researcher reported Sept. 11 in the journal PLOS.

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Drug Discovery World

SEPTEMBER 13, 2024

QL Biopharm, a clinical stage biopharmaceutical company developing biologic drugs for the treatment of metabolic diseases, has shared Phase Ic clinical data for its lead drug candidate ZT002. The data was presented at the European Association for the Study of Diabetes (EASD) Annual Meeting 2024, Madrid, Spain. The presentation was titled ‘ZT002, a novel ultra long-acting GLP-1 receptor agonist in adults with overweight or obesity: A randomised, placebo-controlled, multiple ascending dose Phase I

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Science Daily: Pharmacology News

SEPTEMBER 13, 2024

In a new study, researchers have determined through both statistical analysis and in experiments that soil pH is a driver of microbial community composition -- but that the need to address toxicity released during nitrogen cycling ultimately shapes the final microbial community.

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FDA Law Blog: Biosimilars

SEPTEMBER 11, 2024

By John W.M. Claud — Last week, FDA revised one of its two guidances relating to nitrosamines, Control of Nitrosamine Impurities in Human Drugs. Nitrosamines are impurities that can form during drug manufacturing and are considered potentially potent carcinogens. One specific kind of nitrosamines called N-nitrosamine drug substance-related impurities, or NDSRIs, are especially vexing to FDA and to industry because they mimic the structure of the specific active pharmaceutical ingredients (API),

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Drugs.com

SEPTEMBER 13, 2024

FRIDAY, Sept. 13, 2024 -- Initially approved to treat type 2 diabetes, Ozempic and Mounjaro also can help people with type 1 diabetes lose weight and control their blood sugar levels, a new study finds.Overweight or obese type 1 diabetics taking.

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Drug Discovery World

SEPTEMBER 13, 2024

A Dupixent (dupilumab) pivotal study (ADEPT) in bullous pemphigoid (BP) has met the primary and all key secondary endpoints evaluating its investigational use in adults with moderate-to-severe disease. In the study, five times more Dupixent patients achieved sustained disease remission compared to those on placebo. Sustained disease remission was defined as complete clinical remission with completion of oral corticosteroids (OCS) taper by week 16 without relapse and no rescue therapy use during

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Science Daily: Pharmacology News

SEPTEMBER 9, 2024

Out-of-body experiences, such as near-death experiences, can have a 'transformative' effect on people's ability to experience empathy and connect with others, new research explains.

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Drug Patent Watch

SEPTEMBER 11, 2024

The pharmaceutical industry has witnessed significant advancements in recent years, particularly in the realm of nanotechnology. This innovative field has revolutionized the way drugs are developed, manufactured, and delivered to patients.

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Drugs.com

SEPTEMBER 13, 2024

FRIDAY, Sept. 13, 2024 -- Ozempic and its weight-loss cousin, Wegovy, outperform another longstanding weight-loss drug that targets the same hormone associated with blood sugar and appetite, a new study finds.Ozempic and Wegovy (semaglutide).

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Drug Discovery World

SEPTEMBER 13, 2024

Oxford Nanopore Technologies has joined the PROGRESS study to support improved outcomes for childhood leukaemias in Ghana. The consortium so far includes Yemaachi Biotech, Pediatric Oncology Units at Korle Bu Teaching Hospital, Komfo Anokye Teaching Hospital and Greater Accra Regional Hospital, and institutions like Newcastle University, UK. It aims to leverage world-class expertise and technology to address the pressing issue of childhood cancer in Africa, with a view to setting a new standard

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Science Daily: Pharmacology News

SEPTEMBER 11, 2024

Since their invention in the 1920s, jungle gyms and monkey bars have become both fixtures of playgrounds and symbols of childhood injury that anxious caretakers want removed. Anthropologists mark 100 years of the iconic playground equipment by arguing that risky play exercises a biological need passed on from apes and early humans for children to independently test and expand their physical and cognitive abilities in a context in which injury is possible but avoidable.

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Drug Patent Watch

SEPTEMBER 12, 2024

In the labyrinthine world of pharmaceuticals, where the cost of life-saving medications can often feel like a roll of the dice, the FDA is implementing a strategy that aims to bring some much-needed transparency and affordability to the market. This strategy, known as the ‘Rule of Three,’ is a game-changer in the battle against soaring drug prices.

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Drugs.com

SEPTEMBER 11, 2024

WEDNESDAY, Sept. 11, 2024 -- The weight-loss drug liraglutide helped obese children lower their BMI and reach a healthier weight, researchers report.The findings, published Tuesday in the New England Journal of Medicine and presented.

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Drug Discovery World

SEPTEMBER 9, 2024

Dr Mutlu Dogruel, Vice President of AI Solutions at Cresset, examines AI’s transformative potential, highlights the current challenges and introduces a series of potential solutions to implement AI in the drug discovery landscape successfully. The use of artificial intelligence (AI) is creating a paradigm shift in drug discovery and optimisation processes, allowing for the analysis of large-scale datasets, the design of new molecules, and the prediction of drug properties more efficiently.

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Science Daily: Pharmacology News

SEPTEMBER 13, 2024

Most rechargeable batteries that power portable devices, such as toys, handheld vacuums and e-bikes, use lithium-ion technology. But these batteries can have short lifetimes and may catch fire when damaged. To address stability and safety issues, researchers have designed a lithium-sulfur (Li-S) battery that features an improved iron sulfide cathode.

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BioPharma Drive: Drug Pricing

SEPTEMBER 13, 2024

During an investor presentation Thursday, executives admitted to being overly optimistic their vaccine could wrest significant market share away from GSK's and Pfizer's products this year.

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Drugs.com

SEPTEMBER 13, 2024

FRIDAY, Sept. 13, 2024 -- Over 5 million Americans could benefit if the U.S. Food and Drug Administration approves the "magic mushroom" psychedelic psilocybin as a treatment for depression, researchers estimate.“While our analysis is a crucial f.

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Drug Discovery World

SEPTEMBER 9, 2024

NRG Therapeutics has been awarded a non-dilutive grant from Target ALS Foundation to support its discovery programme for amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease or motor neurone disease. It is one of five recipients of the 2024 In Vivo Target Validation grants in collaboration with Biospective. The In Vivo Target Validation Program aims to generate high-quality data on candidate therapeutics in animal models of ALS, to provide access to in-kind funding for a resou

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Science Daily: Pharmacology News

SEPTEMBER 12, 2024

A landslide in a remote part of Greenland caused a 200 meter (650 foot) mega-tsunami that sloshed back and forth across a fjord for nine days, generating vibrations throughout Earth, according to a new study. The study concluded that this movement of water was the cause of a mysterious, global seismic signal that lasted for nine days and puzzled seismologists in September 2023.

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Fierce BioTech

SEPTEMBER 13, 2024

Navigating today’s rapidly evolving clinical trial landscape can be tough. | With intricate protocols and shifting regulatory demands, it’s more difficult than ever to find and keep participants, as well as gather reliable data.

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Drugs.com

SEPTEMBER 11, 2024

WEDNESDAY, Sept. 11, 2024 -- As fears of the consequences of an unintended pregnancy rose after Roe v. Wade was overturned in 2022, rates of surgical sterilization rose in those states most affected by the decision, new research shows. Rates of.

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Drug Discovery World

SEPTEMBER 12, 2024

Glasgow, UK-based ILC Therapeutics has successfully completed a fundraise of £2.5 ($3.2) million. The company develops hybrid interferons, a new drug class engineered for improved therapeutic profiles across multiple indications. The money will support the continued pre-clinical development of the company’s two lead assets, Alfacyte and Dermacyte, as they move towards the clinic.

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Science Daily: Pharmacology News

SEPTEMBER 11, 2024

It's a dogma taught in every introductory biology class: Proteins are composed of combinations of 20 different amino acids, arranged into diverse sequences like words. But researchers trying to engineer biologic molecules with new functions have long felt limited by those 20 basic building blocks and strived to develop ways of putting new building blocks -- called non-canonical amino acids -- into their proteins.

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Perficient: Drug Development

SEPTEMBER 9, 2024

Sitecore Content Hub is a world-class platform for centralizing and managing content across various channels. It helps businesses organize and streamline often chaotic, messy content operations. It does this by providing an architecture or schema for content and its interconnections. A schema defines how different types of assets are structured, organized, related to each other.

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