Biopharma Has No Choice But To Comply With Price Controls
Forbes: Drug Truths
NOVEMBER 8, 2023
Medicare will save money but there will be fewer new medicines.
Sat.Nov 04, 2023 - Fri.Nov 10, 2023
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Designing cities for 21st-century weather
Science Daily: Pharmacology News
NOVEMBER 10, 2023
Researchers have investigated how changes in urban land and population will affect future populations' exposures to weather extremes under climate conditions at the end of the 21st century. They used a data-driven model to predict how urban areas across the country will grow by 2100, and found that how a city is laid out or organized spatially has the potential to reduce population exposures to future weather extremes.
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What if a CRISPR cure isn’t such an easy choice?
BioPharma Drive: Drug Pricing
NOVEMBER 8, 2023
A gene editing therapy developed by Vertex Pharmaceuticals and CRISPR Therapeutics can mute sickle cell disease’s most damaging symptoms. Yet treatment may not be as simple as its dramatic benefit makes it seem.
Blood Clot Risk From Contraceptive Pills Ends Soon After Women Stop Taking Them
Drugs.com
NOVEMBER 10, 2023
FRIDAY, Nov. 10, 2023 -- Women and their doctors have long known that taking birth control pills can elevate the risk for a blood clot. Now, some good news: That added risk will disappear within a few weeks of stopping an oral contraceptive, a new.
Bridging Innovation & Patient Care: The Growing Role of AI
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Assessing Squarates as Amine-Reactive Probes
Covalent Modifiers
NOVEMBER 9, 2023
Katherine I. Taylor, Jordan S. Ho, Hallie O. Trial, Alan W. Carter, and Laura L. Kiessling Journal of the American Chemical Society 2023 DOI: 10.1021/jacs.2c05691 Probes that covalently label protein targets facilitate the identification of ligand-binding sites. Lysine residues are prevalent in the proteome, making them attractive substrates for covalent probes.
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Lilly weight loss drug approved by FDA
BioPharma Drive: Drug Pricing
NOVEMBER 8, 2023
The pharmaceutical company will sell the GLP-1 drug, branded as Zepbound, at a list price about 20% lower than Novo Nordisk's competing drug Wegovy.
FDA Approves First Vaccine for Chikungunya Virus, Ixchiq
Drugs.com
NOVEMBER 10, 2023
FRIDAY, Nov. 10, 2023 (Healthday News) -- The first vaccine to prevent infection with the chikungunya virus was approved by the U.S. Food and Drug Administration on Thursday. The single-dose shot, known as Ixchiq, is approved for adults who are at.
Use of pyridazinediones for tuneable and reversible covalent cysteine modification applied to peptides, proteins and hydrogels
Covalent Modifiers
NOVEMBER 6, 2023
Léa N. C. Rochet, Calise Bahou, Jonathan P. Wojciechowski, Ilias Koutsopetras, Phyllida Britton, Richard J. Spears, ORCID logo a Ioanna A. Thanasi, Baihao Shao, Lisha Zhong, Dejan-Krešimir Bučar, Abil E. Aliev, Michael J. Porter, Molly M. Stevens, James R. Baker, and Vijay Chudasama Chem. Sci. 2023 [link] Reversible cysteine modification has been found to be a useful tool for a plethora of applications such as selective enzymatic inhibition, activity-based protein profiling and/or cargo release
Greenland's glacier retreat rate has doubled over past two decades
Science Daily: Pharmacology News
NOVEMBER 9, 2023
A new study documents how Greenland's peripheral glaciers have changed from 1890 to 2022. Using satellite images and a unique archive of historical aerial photos, researchers documented changes in the lengths of more than 1,000 of the country's glaciers over the past 130 years. Although glaciers in Greenland have experienced retreat throughout the last century, the rate of their retreat has rapidly accelerated over the last two decades.
From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience
Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.
The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven
CAR-T biotech Cargo Therapeutics prices $281M IPO
BioPharma Drive: Drug Pricing
NOVEMBER 10, 2023
Cargo Therapeutics is the seventh oncology biotech to successfully price an IPO this year.
Wegovy, Ozempic Probably Won't Harm Vision in People With Diabetes, Study Finds
Drugs.com
NOVEMBER 9, 2023
THURSDAY, Nov. 9, 2023 (HealthDay) -- There's good news for people with diabetes who are turning to drugs like Ozempic and Wegovy to treat their disease and lose weight: The drugs probably will not harm their vision. Semaglutide (the generic name.
Dual-Probe Activity-Based Protein Profiling Reveals Site-Specific Differences in Protein Binding of EGFR-Directed Drugs
Covalent Modifiers
NOVEMBER 9, 2023
Wouter van Bergen, Jan Fiala, Albert J.R. Heck, Marc P. Baggelaar bioRxiv 2023.10.19.562725; doi: [link] Comparative, dose-dependent analysis of interactions between small molecule drugs and their targets, as well as off-targets, in complex proteomes is crucial for selecting optimal drug candidates. The affinity of small molecules for targeted proteins is largely dictated by interactions between amino acid side chains and these drugs.
Crust-forming algae are displacing corals in tropical waters worldwide
Science Daily: Pharmacology News
NOVEMBER 6, 2023
Over the past few decades, algae have been slowly edging corals out of their native reefs across the globe by blocking sunlight, wearing the corals down physically, and producing harmful chemicals. But in recent years, a new type of algal threat has surfaced in tropical regions like the Caribbean -- one that spreads quickly and forms a crust on top of coral and sponges, suffocating the organisms underneath and preventing them from regrowing.
How Machine Learning Drives Clinical Trial Efficiency
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
An obesity drug biotech gets buy-in from Eli Lilly, venture firms
BioPharma Drive: Drug Pricing
NOVEMBER 7, 2023
Startup OrsoBio raised $60 million in a Series A round co-led by Longitude Capital and Enavate Sciences, and joined by the pharma’s venture arm.
Majority of Workers at America's Nursing Homes Unvaccinated Against Flu, COVID
Drugs.com
NOVEMBER 9, 2023
THURSDAY, Nov. 9, 2023 -- Health care workers at America’s nursing homes are woefully under-vaccinated for both flu and COVID-19, threatening their own health and that of the frail elderly patients under their care, a new report.
Covalent 14-3-3 Molecular Glues and Heterobifunctional Molecules Against Nuclear Transcription Factors and Regulators
Covalent Modifiers
NOVEMBER 7, 2023
Qian Shao , Tuong Nghi Duong , Inji Park , Daniel K Nomura bioRxiv 2023.11.06.565850; doi: [link] 14-3-3 proteins have the unique ability to bind and sequester a multitude of diverse phosphorylated signaling proteins and transcription factors. Many previous studies have shown that 14-3-3 interactions with specific phosphorylated substrate proteins can be enhanced through small-molecule natural product or fully synthetic molecular glue interactions.
A step closer to injection-free diabetes care: Innovation in insulin-producing cells
Science Daily: Pharmacology News
NOVEMBER 6, 2023
A team has developed a new step to improve the process for creating insulin-producing pancreatic cells from a patient's own stem cells, bringing the prospect of injection-free treatment closer for people with diabetes.
Deliver Fast, Flexible Clinical Trial Insights with Spotfire
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Atara’s cell therapy approach to MS falls short in study
BioPharma Drive: Drug Pricing
NOVEMBER 9, 2023
Shares in the biotech tumbled by 75% as results from a Phase 2 trial showed more improvement in participants given a placebo.
Marijuana Use Could Raise Odds for Heart Attack, Heart Failure
Drugs.com
NOVEMBER 7, 2023
MONDAY, Nov. 6, 2023 -- People who regularly smoke medical marijuana may be increasing their risk for a heart attack, heart failure or stroke, new research suggests. One study found that cannabis use among older patients increases the risk of heart.
Graph Neural Networks for Identifying Protein-Reactive Compounds
Covalent Modifiers
NOVEMBER 7, 2023
Cano Gil, V. H.; Rowley, C. N. ChemRxiv 2023. [link] The identification of protein-reactive electrophilic compounds is critical to the design of new covalent modifier drugs, screening for toxic compounds, and the exclusion of reactive compounds from high throughput screening. In this work, we employ traditional and graph machine learning algorithms to classify molecules being reactive towards proteins or nonreactive.
Any activity is better for your heart than sitting -- even sleeping
Science Daily: Pharmacology News
NOVEMBER 9, 2023
Replacing sitting with as little as a few minutes of moderate exercise a day tangibly improves heart health, according to new research.
Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Biogen, Sage set price of postpartum depression pill at $15,900
BioPharma Drive: Drug Pricing
NOVEMBER 7, 2023
The price is below what some analysts had predicted and significantly less than $34,000 Sage initially set for its earlier postpartum infusion, Zulresso.
U.S. Syphilis Cases in Newborns Rose 10-fold Over a Decade
Drugs.com
NOVEMBER 7, 2023
TUESDAY, Nov. 7, 2023 -- An old scourge, syphilis, is returning with a vengeance in the United States, affecting not only adults but also the most vulnerable -- newborns. Rates of congenital syphilis soared 10-fold between 2012 and 2022, according.
A guide to clinical trial phases [infographic]
Antidote
NOVEMBER 9, 2023
Before any new treatment or therapy is able to be used by the patient population, it must go through the process of a clinical trial — this is the case for any new prescription drug, but also true for over-the-counter medications, medical devices, and more.
450-million-year-old organism finds new life in Softbotics
Science Daily: Pharmacology News
NOVEMBER 6, 2023
Researchers have used fossil evidence to engineer a soft robotic replica of pleurocystitids, a marine organism that existed nearly 450 million years ago and is believed to be one of the first echinoderms capable of movement using a muscular stem.
Flagship expands into Asia-Pacific with new Singapore hub
BioPharma Drive: Drug Pricing
NOVEMBER 7, 2023
The biotech company creator hopes its new office will help its portfolio companies grow and strike partnerships in the region.
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