Sat.Nov 18, 2023 - Fri.Nov 24, 2023

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Neanderthals were the world's first artists, research reveals

Science Daily: Pharmacology News

Recent research has shown that engravings in a cave in La Roche-Cotard (France), which has been sealed for thousands of years, were actually made by Neanderthals. The findings reveal that the Neanderthals were the first humans with an appreciation of art.

Research 359
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Roche’s Genentech partners with Nvidia in AI drug deal

BioPharma Drive: Drug Pricing

The partnership is another investment by the biotech subsidiary in artificial intelligence for drug discovery and development, continuing an industry trend.

Drugs 315
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Many Primary Care Docs Unaware of Biologic Asthma Meds

Drugs.com

TUESDAY, Nov. 21, 2023 -- Biologic drugs to treat asthma have been around for two decades, but a surprising number of family doctors still aren’t prescribing them to kids and adults. A new survey found that more than two in five primary care.

Doctors 299
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Drug Discovery Industry Roundup with Barry Bunin — November 21, 2023

Collaborative Drug

Drug Discovery Industry Roundup with Barry Bunin — November 17, 2023

Drugs 262
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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From the first bite, our sense of taste helps pace our eating

Science Daily: Pharmacology News

When you eagerly dig into a long-awaited dinner, signals from your stomach to your brain keep you from eating so much you'll regret it -- or so it's been thought.

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One Death, 10 Hospitalizations in Listeria Outbreak Tied to Peaches, Plums

Drugs.com

TUESDAY, Nov. 21, 2023 -- Peaches, nectarines and plums tainted with Listeria have caused one death and put 10 people in the hospital with food poisoning across seven states, federal officials say. The Listeria outbreak also has caused one.

Hospitals 290
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Lysine-Reactive N-Acyl-N-aryl Sulfonamide Warheads: Improved Reaction Properties and Application in the Covalent Inhibition of an Ibrutinib-Resistant BTK Mutant

Covalent Modifiers

Masaharu Kawano, Syunsuke Murakawa, Kenji Higashiguchi, Kenji Matsuda, Tomonori Tamura, and Itaru Hamachi Journal of the American Chemical Society 2023 DOI: 10.1021/jacs.3c08740 The covalent inhibition of a target protein has gained widespread attention in the field of drug discovery. Most of the current covalent drugs utilize the high reactivity of cysteines toward modest electrophiles.

Drugs 208
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Sophisticated swarming: Bacteria support each other across generations

Science Daily: Pharmacology News

When bacteria build communities, they cooperate and share nutrients across generations. Researchers have been able to demonstrate this for the first time using a newly developed method. This innovative technique enables the tracking of gene expression during the development of bacterial communities over space and time.

Research 307
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AstraZeneca creates digital health unit, with big-name partnerships already in place

BioPharma Drive: Drug Pricing

Called Evinova, the unit will operate as a separate business within AstraZeneca, which sees digital health solutions as a market primed for growth.

Marketing 284
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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Avoid Food Poisoning This Holiday Season

Drugs.com

WEDNESDAY, Nov. 22, 2023 -- The last thing a holiday host wants is to have guests get food poisoning from the feast they’ve set. That’s why food safety is particularly important as people prepare for holiday festivities, poison control.

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Search algorithm reveals nearly 200 new kinds of CRISPR systems

Broad Institute

Search algorithm reveals nearly 200 new kinds of CRISPR systems By Allessandra DiCorato November 23, 2023 Breadcrumb Home Search algorithm reveals nearly 200 new kinds of CRISPR systems By analyzing bacterial data, researchers have discovered thousands of rare new CRISPR systems that have a range of functions and could enable gene editing, diagnostics, and more.

RNA 135
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AI finds formula on how to predict monster waves

Science Daily: Pharmacology News

Using 700 years' worth of wave data from more than a billion waves, scientists have used artificial intelligence to find a formula for how to predict the occurrence of these maritime monsters. Long considered myth, freakishly large rogue waves are very real and can split apart ships and even damage oil rigs.

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Quotient emerges from Flagship with plan to explore somatic mutations

BioPharma Drive: Drug Pricing

Studying somatic mutations could be “the next wave of opportunity” to develop more precise medicines, said Mike Stratton, one of Quotient’s scientific co-founders.

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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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COVID Pandemic Set Back U.S. Efforts to Fight HIV

Drugs.com

FRIDAY, Nov. 17, 2023 -- Here's another casualty of the pandemic: Gains made against another scourge, HIV. Progress made in fighting HIV/AIDS across all segments of society was eroded during the crisis, according to a report led by researchers at.

Research 278
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Social Connection and Worker Well-being

NIOSH Science Blog: Drugs

In May, the U.S. Surgeon General, Vice Admiral Vivek Murthy, MD, MBA, released Our Epidemic of Loneliness and Isolation: The U.S. Surgeon General’s Advisory on the Healing Effects of Social Connection and Community calling for a whole-of-society approach to address the epidemic of loneliness and isolation.1 Below we briefly highlight information from the Advisory and its implications for worker well-being.

Research 130
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'Dolomite Problem': 200-year-old geology mystery resolved

Science Daily: Pharmacology News

For 200 years, scientists have failed to grow a common mineral in the laboratory under the conditions believed to have formed it naturally. Now, researchers have finally pulled it off, thanks to a new theory developed from atomic simulations. Their success resolves a long-standing geology mystery called the 'Dolomite Problem.' Dolomite -- a key mineral in the Dolomite mountains in Italy, Niagara Falls, the White Cliffs of Dover and Utah's Hoodoos -- is very abundant in rocks older than 100 milli

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Medtronic CEO downplays impact of obesity drugs on procedures, devices

BioPharma Drive: Drug Pricing

Surging demand for GLP-1 agonists has put medtech firms like Medtronic under pressure, even as they argue the hit to their businesses will be minimal.

Drugs 265
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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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FDA Looking at Cinnamon as Source of Lead in Fruit Puree Products

Drugs.com

FRIDAY, Nov. 17 (Healthday News) -- The U.S. Food and Drug Administration said Friday it has found early evidence that cinnamon may be the source of high levels of lead in fruit puree pouches that have now sickened 34 children. The agency, in.

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Introduction to My Spring Boot Blog Series: Embarking on a Learning Journey Together

Perficient: Drug Development

Greetings, Fellow Developers, Enthusiasts, and Friends! I am thrilled to embark on a journey of exploration and learning with you as I dive into the fascinating world of Spring Boot. As I navigate this powerful framework, I’ve decided to document my experiences, insights, and newfound knowledge in a blog series. The Motivation Behind the Series: The primary motivation for initiating this blog series stems from a desire to not only solidify my understanding of Spring Boot but also to create

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'Strange metal' is strangely quiet in noise experiment

Science Daily: Pharmacology News

Experiments have provided the first direct evidence that electricity seems to flow through 'strange metals' in an unusual liquid-like form.

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Bristol Myers faces FDA delay on cancer cell therapy decision

BioPharma Drive: Drug Pricing

The regulator plans to convene an advisory panel to discuss an expanded indication for Abecma, presenting another hurdle for Bristol Myers and partner 2seventy bio.

Therapies 265
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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First Asthma-Linked Death Highlights Hazards at Marijuana-Processing Plants

Drugs.com

FRIDAY, Nov. 17, 2023 -- A young woman working at a Massachusetts cannabis-processing facility who developed new-onset asthma and later died of a fatal asthma attack is the first such fatality in the burgeoning industry, a new report.

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The effectiveness of nanoparticles in chemotherapy

Drug Target Review

Researchers have explored systems that can deliver drugs directly to tumours in hope to reduce chemotherapy side effects. The use of nanoparticles, which are around the size of a virus particle, is a very promising delivery method for overcoming chemotherapy issues. Therapeutic and diagnostic nanoparticles typically fall into two categories: inorganic nanoparticles (eg, gold, silica, iron oxide, etc) and organic nanoparticles (eg, polymeric, liposomes, micelles, etc). 1 Dr Ninh (Irene) La-Beck,

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First comprehensive look at effects of 2020-2021 California megafires on terrestrial wildlife habitat

Science Daily: Pharmacology News

In 2020 and 2021, California experienced fire activity unlike anything recorded in the modern record. When the smoke cleared, the amount of burned forest totaled ten times more than the annual average going back to the late 1800s. We know that wildlife in western forests evolved with changing habitat and disturbances like wildfire. Each species responds differently, some benefiting from openings, others losing critical habitat.

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Data infrastructure excellence changing the shape of biopharma manufacturing

BioPharma Drive: Drug Pricing

Biopharma companies capture data across a variety of different fronts and, so this data must be managed effectively in order to unlock business efficiencies and drive improvements.

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Pill-sized Device Tracks Breathing, Heart Rate From Inside the Body

Drugs.com

MONDAY, Nov. 20, 2023 -- A new 'technopill' can safely monitor a person’s vital signs from inside their bodies, researchers report. The vitals-monitoring (VM) Pill works by tracking the small vibrations in the body associated with lungs.

Research 277