Drug Discovery World
NOVEMBER 20, 2023
Raquel Sanches-Kuiper , Vice President of Science and Applications at Evonetix, and Clare Whitewoods , Marketing Communications Manager at Evonetix, look at the benefits synthetic DNA brings to pharmaceutical development. Engineering biology is reshaping the world, from enabling the rapid development of vaccines to providing alternatives to petroleum fuels.
Science Daily: Pharmacology News
NOVEMBER 21, 2023
Recent research has shown that engravings in a cave in La Roche-Cotard (France), which has been sealed for thousands of years, were actually made by Neanderthals. The findings reveal that the Neanderthals were the first humans with an appreciation of art.
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NIOSH Science Blog: Drugs
NOVEMBER 20, 2023
In May, the U.S. Surgeon General, Vice Admiral Vivek Murthy, MD, MBA, released Our Epidemic of Loneliness and Isolation: The U.S. Surgeon General’s Advisory on the Healing Effects of Social Connection and Community calling for a whole-of-society approach to address the epidemic of loneliness and isolation.1 Below we briefly highlight information from the Advisory and its implications for worker well-being.
Chemical Biology and Drug Design
NOVEMBER 22, 2023
Imidazo[1,2-a]pyridine-chalcone conjugates with antikinetoplastid activity. Abstract A library of imidazo[1,2-a]pyridine-appended chalcones were synthesized and characterized using 1 H NMR, 13 C NMR and HRMS. The synthesized analogues were screened for their antikinetoplastid activity against Trypanosoma cruzi , Trypanosoma brucei brucei , Trypanosoma brucei rhodesiense and Leishmania infantum.
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Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.
Drug Discovery World
NOVEMBER 24, 2023
The University of Queensland’s re-engineered clamp platform has produced a vaccine that is equally safe and virus-neutralising as an approved Covid vaccine considered among the best in its class. The pivotal proof-of-concept testing clears the way to progress the Clamp2 technology in a range of research programmes. Project leader, Associate Professor Keith Chappell, said the preliminary clinical trial results were an ‘exciting reward’ for the team’s continued dedication and the community’s wi
BioPharma Drive: Drug Pricing
NOVEMBER 21, 2023
The partnership is another investment by the biotech subsidiary in artificial intelligence for drug discovery and development, continuing an industry trend.
Drug Discovery Digest brings together the best content for drug research and development professionals from the widest variety of industry thought leaders.
Chemical Biology and Drug Design
NOVEMBER 21, 2023
SNX10 shRNA expression was transfected into AGS cells, and Rop intervention was given. qRT-PCR, CCK8, wound healing assay, transwell assay, and western blot were used to clarify the effects of Rop on the proliferation and metastasis of SNX10/SRC/STAT3 pathway in gastric cancer cells. Our results suggest that Rop shows a potential role in preventing proliferation and metastasis of gastric cancer.
Drug Discovery World
NOVEMBER 24, 2023
Patrick Speedie , Co-Founder & Co-CEO of IN-PART , explores why a global approach is needed for the best science to prosper and the lessons industry can take from the Covid-19 pandemic. The Covid-19 pandemic unequivocally demonstrated the power of industry-academia collaboration, with the fastest ever development, testing and approval of a life-saving vaccine.
Science Daily: Pharmacology News
NOVEMBER 22, 2023
When you eagerly dig into a long-awaited dinner, signals from your stomach to your brain keep you from eating so much you'll regret it -- or so it's been thought.
Drugs.com
NOVEMBER 21, 2023
TUESDAY, Nov. 21, 2023 -- Peaches, nectarines and plums tainted with Listeria have caused one death and put 10 people in the hospital with food poisoning across seven states, federal officials say. The Listeria outbreak also has caused one.
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Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.
Chemical Biology and Drug Design
NOVEMBER 20, 2023
GAA slows the progression of osteoarthritis by blocking the ER stress and NF-κB pathway. Abstract Osteoarthritis (OA) is a prevalent degenerative pathology, however, there exists a lack of cost-effective pharmacological interventions that efficaciously inhibit its progression. ganoderic acid A (GAA), a triterpenoid derived from Ganoderma lucidum, possesses antiapoptotic and -inflammatory effects.
Drug Discovery World
NOVEMBER 23, 2023
Niven R. Narain , PhD, President and CEO of BPGbio asks how a better calibre of biobanks in life sciences can lead to more drugs making it to market. Artificial Intelligence (AI) has become a popular buzzword in the drug discovery and development lexicon but not all approaches to AI-driven drug discovery produce meaningful insights that translate into real compounds which ultimately demonstrate clinical efficacy in human trials.
Perficient: Drug Development
NOVEMBER 21, 2023
Greetings, Fellow Developers, Enthusiasts, and Friends! I am thrilled to embark on a journey of exploration and learning with you as I dive into the fascinating world of Spring Boot. As I navigate this powerful framework, I’ve decided to document my experiences, insights, and newfound knowledge in a blog series. The Motivation Behind the Series: The primary motivation for initiating this blog series stems from a desire to not only solidify my understanding of Spring Boot but also to create
BioPharma Drive: Drug Pricing
NOVEMBER 21, 2023
Studying somatic mutations could be “the next wave of opportunity” to develop more precise medicines, said Mike Stratton, one of Quotient’s scientific co-founders.
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Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic
Chemical Biology and Drug Design
NOVEMBER 20, 2023
We employed a combined strategy involving molecular docking-based virtual screening, molecular dynamics (MD) simulation, and MM/GBSA free energy calculation on existing FDA-approved drugs. Sorafenib and glimepiride simultaneously downregulated c-Maf protein expression to induce G1 phase arrest and apoptosis in myeloma cells. Abstract Multiple myeloma (MM) is a prevalent plasma cell malignancy in the blood system that remains incurable.
Drug Discovery World
NOVEMBER 22, 2023
The San Antonio Breast Cancer Symposium (SABCS) and the American Association for Cancer Research (AACR), an SABCS cosponsor, will award two researchers for their significant contributions to breast cancer research at SABCS 2023, 5-9 December, at the Henry B González Convention Center in San Antonio, Texas. 2023 AACR Distinguished Lectureship in Breast Cancer Research Dr Kornelia Polyak is the recipient of the 2023 AACR Distinguished Lectureship in Breast Cancer Research.
Science Daily: Pharmacology News
NOVEMBER 21, 2023
When bacteria build communities, they cooperate and share nutrients across generations. Researchers have been able to demonstrate this for the first time using a newly developed method. This innovative technique enables the tracking of gene expression during the development of bacterial communities over space and time.
Drug Target Review
NOVEMBER 24, 2023
Researchers have explored systems that can deliver drugs directly to tumours in hope to reduce chemotherapy side effects. The use of nanoparticles, which are around the size of a virus particle, is a very promising delivery method for overcoming chemotherapy issues. Therapeutic and diagnostic nanoparticles typically fall into two categories: inorganic nanoparticles (eg, gold, silica, iron oxide, etc) and organic nanoparticles (eg, polymeric, liposomes, micelles, etc). 1 Dr Ninh (Irene) La-Beck,
Chemical Biology and Drug Design
NOVEMBER 20, 2023
The HIV-1 Gag MA domain binds not only to phosphatidylinositol 4,5-bisphosphate (Di-C 7 -PIP2 derivative is in use), a cell membrane component but also to another phospholipid, cardiolipin (Tetra-C 7 -CL derivative), with two phosphate ester bonds and four fatty acid moieties. Abstract The human immunodeficiency virus type 1 (HIV-1) Gag protein is responsible for facilitating HIV-1 virion assembly and budding.
Drug Discovery World
NOVEMBER 22, 2023
Biotechnology company Genentech has entered into a partnership with software group NVIDEA to use generative AI to discover and develop new therapeutics. The collaboration will see experts from each company optimise and accelerate Genentech’s proprietary algorithms with goals to transform the discovery and development of new medicines. NVIDIA will work with Genentech to accelerate these models on NVIDIA DGX Cloud , which provides dedicated instances of AI supercomputing and software.
Drugs.com
NOVEMBER 22, 2023
WEDNESDAY, Nov. 22, 2023 -- The last thing a holiday host wants is to have guests get food poisoning from the feast they’ve set. That’s why food safety is particularly important as people prepare for holiday festivities, poison control.
BioPharma Drive: Drug Pricing
NOVEMBER 22, 2023
The company said it had not found “a viable alternative” to closing down in the months since it hit a clinical setback and laid off staff.
Drug Target Review
NOVEMBER 24, 2023
Dr Jeff Lichtman, Jeremy R Knowles Professor of Molecular and Cellular Biology at Harvard University, has pioneered a field known as ‘connectomics’, creating maps of the brain in an attempt to understand this organ that has nearly 100 billion neurons communicating across trillions of synapses. Lichtman’s ultimate goal is to form a ‘connectome’, a whole-mammalian brain map that accounts for every neural connection.
Drug Discovery World
NOVEMBER 20, 2023
The latest episode of the DDW Highlights podcast is now available to listen to below. DDW’s Megan Thomas narrates five key stories of the week to keep DDW subscribers up-to-date on the latest industry updates. The breaking news this week was certainly the first regulatory approval for Casgevy, not only the first gene therapy approved for sickle cell disease, but also the first therapy to use CRISPR gene editing.
Drugs.com
NOVEMBER 18, 2023
FRIDAY, Nov. 17, 2023 -- Here's another casualty of the pandemic: Gains made against another scourge, HIV. Progress made in fighting HIV/AIDS across all segments of society was eroded during the crisis, according to a report led by researchers at.
BioPharma Drive: Drug Pricing
NOVEMBER 20, 2023
Called Evinova, the unit will operate as a separate business within AstraZeneca, which sees digital health solutions as a market primed for growth.
Drug Target Review
NOVEMBER 20, 2023
A team of scientists at Mass General Brigham in the US has developed a visualisation tool combining high-speed cameras, that can detect changes happening in a billionth of a second, and FDA-approved fluorescent injections to distinguish tumour tissue from normal tissue across several cancer types. The researchers reported that this technique was over 97 percent accurate across tumour types.
Drug Discovery World
NOVEMBER 20, 2023
Cerevance has dosed the first patient in its ASCEND Phase II study to assess the efficacy and safety of CVN424 as a monotherapy in early-stage Parkinson’s disease. In February 2023 the company expanded its Series B funding round, raising a total of $116 million. “We are delighted to announce the commencement of our ASCEND study in individuals who have recently been diagnosed with Parkinson’s disease and not yet received levodopa treatment,” said Craig Thompson, Chief Executive Officer of
Drugs.com
NOVEMBER 18, 2023
FRIDAY, Nov. 17 (Healthday News) -- The U.S. Food and Drug Administration said Friday it has found early evidence that cinnamon may be the source of high levels of lead in fruit puree pouches that have now sickened 34 children. The agency, in.
BioPharma Drive: Drug Pricing
NOVEMBER 20, 2023
The regulator plans to convene an advisory panel to discuss an expanded indication for Abecma, presenting another hurdle for Bristol Myers and partner 2seventy bio.
Science Daily: Pharmacology News
NOVEMBER 21, 2023
Contrary to the commonly-held view, the brain does not have the ability to rewire itself to compensate for the loss of sight, an amputation or stroke, for example, say scientists. The researchers argue that the notion that the brain, in response to injury or deficit, can reorganize itself and repurpose particular regions for new functions, is fundamentally flawed -- despite being commonly cited in scientific textbooks.
Drug Discovery World
NOVEMBER 24, 2023
AstraZeneca has announced that the National Institute for Health and Care Excellence (NICE) has recommended Imfinzi (durvalumab) in combination with gemcitabine and cisplatin (chemotherapy) for NHS use in England and Wales for the first-line treatment of adults with locally advanced, unresectable, or metastatic biliary tract cancer (BTC). 1 There remains a significant unmet need for new treatment options in BTC, a group of rare and aggressive cancers that occur in the bile ducts and gallbladder,
Drugs.com
NOVEMBER 18, 2023
FRIDAY, Nov. 17, 2023 -- A young woman working at a Massachusetts cannabis-processing facility who developed new-onset asthma and later died of a fatal asthma attack is the first such fatality in the burgeoning industry, a new report.
BioPharma Drive: Drug Pricing
NOVEMBER 21, 2023
Surging demand for GLP-1 agonists has put medtech firms like Medtronic under pressure, even as they argue the hit to their businesses will be minimal.
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