Sat.Nov 18, 2023 - Fri.Nov 24, 2023

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Neanderthals were the world's first artists, research reveals

Science Daily: Pharmacology News

Recent research has shown that engravings in a cave in La Roche-Cotard (France), which has been sealed for thousands of years, were actually made by Neanderthals. The findings reveal that the Neanderthals were the first humans with an appreciation of art.

Research 143
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Search algorithm reveals nearly 200 new kinds of CRISPR systems

Broad Institute

Search algorithm reveals nearly 200 new kinds of CRISPR systems By Allessandra DiCorato November 23, 2023 Breadcrumb Home Search algorithm reveals nearly 200 new kinds of CRISPR systems By analyzing bacterial data, researchers have discovered thousands of rare new CRISPR systems that have a range of functions and could enable gene editing, diagnostics, and more.

RNA 135
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Roche’s Genentech partners with Nvidia in AI drug deal

BioPharma Drive: Drug Pricing

The partnership is another investment by the biotech subsidiary in artificial intelligence for drug discovery and development, continuing an industry trend.

Drugs 131
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Social Connection and Worker Well-being

NIOSH Science Blog: Drugs

In May, the U.S. Surgeon General, Vice Admiral Vivek Murthy, MD, MBA, released Our Epidemic of Loneliness and Isolation: The U.S. Surgeon General’s Advisory on the Healing Effects of Social Connection and Community calling for a whole-of-society approach to address the epidemic of loneliness and isolation.1 Below we briefly highlight information from the Advisory and its implications for worker well-being.

Research 130
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From Diagnosis to Delivery: How AI is Revolutionizing the Patient Experience

Speaker: Simran Kaur, Founder & CEO at Tattva Health Inc.

The healthcare landscape is being revolutionized by AI and cutting-edge digital technologies, reshaping how patients receive care and interact with providers. In this webinar led by Simran Kaur, we will explore how AI-driven solutions are enhancing patient communication, improving care quality, and empowering preventive and predictive medicine. You'll also learn how AI is streamlining healthcare processes, helping providers offer more efficient, personalized care and enabling faster, data-driven

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From the first bite, our sense of taste helps pace our eating

Science Daily: Pharmacology News

When you eagerly dig into a long-awaited dinner, signals from your stomach to your brain keep you from eating so much you'll regret it -- or so it's been thought.

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Flagship-backed microbiome biotech Evelo to shut down

BioPharma Drive: Drug Pricing

The company said it had not found “a viable alternative” to closing down in the months since it hit a clinical setback and laid off staff.

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Introduction to My Spring Boot Blog Series: Embarking on a Learning Journey Together

Perficient: Drug Development

Greetings, Fellow Developers, Enthusiasts, and Friends! I am thrilled to embark on a journey of exploration and learning with you as I dive into the fascinating world of Spring Boot. As I navigate this powerful framework, I’ve decided to document my experiences, insights, and newfound knowledge in a blog series. The Motivation Behind the Series: The primary motivation for initiating this blog series stems from a desire to not only solidify my understanding of Spring Boot but also to create

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Sophisticated swarming: Bacteria support each other across generations

Science Daily: Pharmacology News

When bacteria build communities, they cooperate and share nutrients across generations. Researchers have been able to demonstrate this for the first time using a newly developed method. This innovative technique enables the tracking of gene expression during the development of bacterial communities over space and time.

Research 119
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One Death, 10 Hospitalizations in Listeria Outbreak Tied to Peaches, Plums

Drugs.com

TUESDAY, Nov. 21, 2023 -- Peaches, nectarines and plums tainted with Listeria have caused one death and put 10 people in the hospital with food poisoning across seven states, federal officials say. The Listeria outbreak also has caused one.

Hospitals 116
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How Machine Learning Drives Clinical Trial Efficiency

Clinical trial data management is increasingly challenging as studies grow in complexity. Quickly accessing and analyzing study data is vital for assessing trial progress and patient safety. In this paper, we explore real-time data access and analysis for proactive study management. We investigate using adverse event (AE) data to monitor safety and discuss a clinical analytics platform that supports collaboration and data review workflows.

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AstraZeneca creates digital health unit, with big-name partnerships already in place

BioPharma Drive: Drug Pricing

Called Evinova, the unit will operate as a separate business within AstraZeneca, which sees digital health solutions as a market primed for growth.

Marketing 120
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The effectiveness of nanoparticles in chemotherapy

Drug Target Review

Researchers have explored systems that can deliver drugs directly to tumours in hope to reduce chemotherapy side effects. The use of nanoparticles, which are around the size of a virus particle, is a very promising delivery method for overcoming chemotherapy issues. Therapeutic and diagnostic nanoparticles typically fall into two categories: inorganic nanoparticles (eg, gold, silica, iron oxide, etc) and organic nanoparticles (eg, polymeric, liposomes, micelles, etc). 1 Dr Ninh (Irene) La-Beck,

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AI finds formula on how to predict monster waves

Science Daily: Pharmacology News

Using 700 years' worth of wave data from more than a billion waves, scientists have used artificial intelligence to find a formula for how to predict the occurrence of these maritime monsters. Long considered myth, freakishly large rogue waves are very real and can split apart ships and even damage oil rigs.

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Avoid Food Poisoning This Holiday Season

Drugs.com

WEDNESDAY, Nov. 22, 2023 -- The last thing a holiday host wants is to have guests get food poisoning from the feast they’ve set. That’s why food safety is particularly important as people prepare for holiday festivities, poison control.

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Deliver Fast, Flexible Clinical Trial Insights with Spotfire

Clinical research has entered a new era, one that requires real-time analytics and visualization to allow trial leaders to work collaboratively and to develop, at the click of a mouse, deep insights that enable proactive study management. Learn how Revvity Signals helps drug developers deliver clinical trial data insights in real-time using a fast and flexible data and analytics platform to empower data-driven decision-making.

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Quotient emerges from Flagship with plan to explore somatic mutations

BioPharma Drive: Drug Pricing

Studying somatic mutations could be “the next wave of opportunity” to develop more precise medicines, said Mike Stratton, one of Quotient’s scientific co-founders.

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Novel technique to distinguish tumours from normal tissue

Drug Target Review

A team of scientists at Mass General Brigham in the US has developed a visualisation tool combining high-speed cameras, that can detect changes happening in a billionth of a second, and FDA-approved fluorescent injections to distinguish tumour tissue from normal tissue across several cancer types. The researchers reported that this technique was over 97 percent accurate across tumour types.

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'Dolomite Problem': 200-year-old geology mystery resolved

Science Daily: Pharmacology News

For 200 years, scientists have failed to grow a common mineral in the laboratory under the conditions believed to have formed it naturally. Now, researchers have finally pulled it off, thanks to a new theory developed from atomic simulations. Their success resolves a long-standing geology mystery called the 'Dolomite Problem.' Dolomite -- a key mineral in the Dolomite mountains in Italy, Niagara Falls, the White Cliffs of Dover and Utah's Hoodoos -- is very abundant in rocks older than 100 milli

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COVID Pandemic Set Back U.S. Efforts to Fight HIV

Drugs.com

FRIDAY, Nov. 17, 2023 -- Here's another casualty of the pandemic: Gains made against another scourge, HIV. Progress made in fighting HIV/AIDS across all segments of society was eroded during the crisis, according to a report led by researchers at.

Research 111
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Clinical Data Like You´ve Never Seen It Before: Why Spotfire Is the Leading Tool for Clinical Analytics

Clinical development organizations face a wide array of challenges when it comes to data, many of which can impact the operational effectiveness of their clinical trials. In this whitepaper, experts from Revvity Signals explore how solutions like TIBCO® Spotfire® enable better, more streamlined studies. The whitepaper also features a success story from Ambrx, a leading biopharmaceutical company, detailing how it has leveraged Spotfire to tackle data quality and collaboration challenges in clinic

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Medtronic CEO downplays impact of obesity drugs on procedures, devices

BioPharma Drive: Drug Pricing

Surging demand for GLP-1 agonists has put medtech firms like Medtronic under pressure, even as they argue the hit to their businesses will be minimal.

Drugs 111
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Documenting the mammalian brain using machine learning

Drug Target Review

Dr Jeff Lichtman, Jeremy R Knowles Professor of Molecular and Cellular Biology at Harvard University, has pioneered a field known as ‘connectomics’, creating maps of the brain in an attempt to understand this organ that has nearly 100 billion neurons communicating across trillions of synapses. Lichtman’s ultimate goal is to form a ‘connectome’, a whole-mammalian brain map that accounts for every neural connection.

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'Strange metal' is strangely quiet in noise experiment

Science Daily: Pharmacology News

Experiments have provided the first direct evidence that electricity seems to flow through 'strange metals' in an unusual liquid-like form.

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FDA Looking at Cinnamon as Source of Lead in Fruit Puree Products

Drugs.com

FRIDAY, Nov. 17 (Healthday News) -- The U.S. Food and Drug Administration said Friday it has found early evidence that cinnamon may be the source of high levels of lead in fruit puree pouches that have now sickened 34 children. The agency, in.

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Bristol Myers faces FDA delay on cancer cell therapy decision

BioPharma Drive: Drug Pricing

The regulator plans to convene an advisory panel to discuss an expanded indication for Abecma, presenting another hurdle for Bristol Myers and partner 2seventy bio.

Therapies 111
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A comprehensive update on genetic inheritance, epigenetic factors, associated pathology, and recent therapeutic intervention by gene therapy in schizophrenia

Chemical Biology and Drug Design

Dopaminergic pathways influence positive and negative symptoms. Upregulation of the D1 receptor in the striatal region results in positive signs, while downregulation of the D2 receptor in PFC results in negative symptoms. Abstract Schizophrenia is a severe psychological disorder in which reality is interpreted abnormally by the patient. The symptoms of the disease include delusions and hallucinations, associated with extremely disordered behavior and thinking, which may affect the daily lives o

Therapies 100
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First comprehensive look at effects of 2020-2021 California megafires on terrestrial wildlife habitat

Science Daily: Pharmacology News

In 2020 and 2021, California experienced fire activity unlike anything recorded in the modern record. When the smoke cleared, the amount of burned forest totaled ten times more than the annual average going back to the late 1800s. We know that wildlife in western forests evolved with changing habitat and disturbances like wildfire. Each species responds differently, some benefiting from openings, others losing critical habitat.

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First Asthma-Linked Death Highlights Hazards at Marijuana-Processing Plants

Drugs.com

FRIDAY, Nov. 17, 2023 -- A young woman working at a Massachusetts cannabis-processing facility who developed new-onset asthma and later died of a fatal asthma attack is the first such fatality in the burgeoning industry, a new report.

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Drug Discovery Industry Roundup with Barry Bunin — November 21, 2023

Collaborative Drug

Drug Discovery Industry Roundup with Barry Bunin — November 17, 2023

Drugs 99
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Design and synthesis of imidazo[1,2?a]pyridine?chalcone conjugates as antikinetoplastid agents

Chemical Biology and Drug Design

Imidazo[1,2-a]pyridine-chalcone conjugates with antikinetoplastid activity. Abstract A library of imidazo[1,2-a]pyridine-appended chalcones were synthesized and characterized using 1 H NMR, 13 C NMR and HRMS. The synthesized analogues were screened for their antikinetoplastid activity against Trypanosoma cruzi , Trypanosoma brucei brucei , Trypanosoma brucei rhodesiense and Leishmania infantum.

Research 100